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The emerging role of cuproptosis in spinal cord injury.

Copper is a vital trace element integral to numerous biological processes, including iron metabolism, neurotransmitter synthesis, mitochondr … us diseases, such as cancer, metabolic disorders and neurodegenerative disorders. In the context of spinal cord injury (SCI), multiple pathological mechanisms, including oxidative stress, inflammation, and PCD could impact the patient's prognosis with SCI. This review seeks to elucidate the pathophysiological underpinnings of SCI, the mechanisms and biologica …

Протеомическая характеристика Спинала Корда Майлина в мыше.

Протеом миелина является важнейшим структурным и функциональным компонентом центральной нервной системы (ЦНС), которая подвергается динамической реконструкции на протяжении всей жизни. Патологические изменения, такие как многочисленные склерозы, нарушают целостность миелин и приводят к серьезным неврологическим расстройствам. Таким образом, для мониторинга изменений в моделях болезней необходимо установить воспроизводимый базовый уровень протеома CNS mielin. Здесь мы представляем полный набор протеомических данных очищенного спинного мозга миелин от здоровых мышей. Миелиновые фракции были изол

Совпадение в аннотации оригинала
The myelin proteome is a critical structural and functional component of the central nervous system (CNS), undergoing dynamic remodeling thr … oring alterations in disease models. Here, we present a comprehensive proteomic dataset of purified spinal cord myelin from healthy mice. Myelin fractions were isolated by preparative sucrose density centrifugation, followed by gel-free peptide separation and mass spectrometric analysis. Label-free quantification based on at least two tryptic peptides identif …

Spinal cord injury: T cells to the rescue?

Gao, Kim, and colleagues recently reported that clonal populations of CD4+ T cells could be detected in mice that underwent spinal cord injury (SCI). A subset of clones mediated enhanced motor recovery and suppressed inflammation. Further studies may point towards novel cell therapies for SCI, for which care is presently supportive only.

An Update on Spinal Cord Injury and Current Management.

» Spinal cord injury is associated with increased lifelong cost and decreased life expectancy.» Current treatment guidelines have been limited to studies of small effect sizes and limited availability of randomized control trials.» Recovery is best correlated with the initial American Spinal Injury Association impairment scale grade with A and B less likely to recover regarding ambulation as compared with C and D grades.» Surgical intervention within less than 24 hours, especially in the cervical spine, has been associated with some motor improvement.» The use of mean arterial pressure goals a…

Interaction of microglia with the microenvironment in spinal cord injury.

This article discusses the peculiarities of microglia behaviour and their interaction with other cells of the central nervous system (CNS) during neural tissue injury with a focus on spinal cord injury (SCI). Taking into account the plasticity of microglia, the influence of the microenvironment should be taken into account to establish the mechanisms determining the polarization pathways of these cells. Determination of the system of microglia interactions with other CNS cells during injury will reveal the patterns of post-traumatic microglia responses, in particular, determining both pro-infl…

Rehabilitation Considerations for Women with Spinal Cord Injury.

Although men are more commonly affected than women with spinal cord injuries (SCIs), women comprise a growing portion of the population of individuals with SCIs. Guidelines for primary care and SCI issues are generally non-sex specific, and there are differences in the medical and rehabilitation needs of women compared with men. Consideration of these differences can optimize function and health for women with SCI and improve quality of life.

Mechanisms of nitric oxide in spinal cord injury.

Spinal cord injury (SCI) is a primary lesion of the spinal cord that results from external forces or diseases, accompanied by a cascade of secondary events. Nitric oxide, an endogenous gas that functions as a signaling molecule in the human body, plays a crucial role in vasodilation of smooth muscles, regulation of blood flow and pressure, and inflammatory response. This article provides a comprehensive overview of the involvement of nitric oxide in SCI and highlights recent advances in basic research on pharmacological agents that inhibit nitric oxide elevation after SCI, offering valuable in…

Role of dendritic cells in spinal cord injury.

BACKGROUND: Inflammation can worsen spinal cord injury (SCI), with dendritic cells (DCs) playing a crucial role in the inflammatory response. They mediate T lymphocyte differentiation, activate microglia, and release cytokines like NT-3. Moreover, DCs can promote neural stem cell survival and guide them toward neuron differentiation, positively impacting SCI outcomes. OBJECTIVE: This review aims to summarize the role of DCs in SCI-related inflammation and identify potential therapeutic targets for treating SCI. METHODS: Literature in PubMed and Web of Science was reviewed using critical term…

[Prevention and Treatment of Ischemic Spinal Cord Injury].

In recent years, the widespread use of thoracic/thoracoabdominal stent grafting and a better understanding of spinal cord blood supply have led to quite a few change in measures to prevent spinal cord injury. It is essential to understand the characteristics of spinal cord blood flow, which is complicated by collateral pathways, and to strive to maintain spinal cord blood flow during surgery. It is also important to plan staged repair as much as possible in any treatment modality. Particular attention must be paid to the prevention of second attacks, especially after thoracic/thoracoabdominal …

The neurovascular unit in healthy and injured spinal cord.

The neurovascular unit (NVU) reflects the close temporal and spatial link between neurons and blood vessels. However, the understanding of the NVU in the spinal cord is far from clear and largely based on generalized knowledge obtained from the brain. Herein, we review the present knowledge of the NVU and highlight candidate approaches to investigate the NVU, particularly focusing on the spinal cord. Several unique features maintain the highly regulated microenvironment in the NVU. Autoregulation and neurovascular coupling ensure regional blood flow meets the metabolic demand according to the …

Congenital and Acquired Spinal Cord Injury and Dysfunction.

Pediatric spinal cord injury and dysfunction (SCI/D) can result from atypical embryologic development or be acquired as the result of trauma, infection, autoimmune conditions, and tumors. The age of onset and causal mechanism of SCI/D has dramatic implications for function and risk of comorbidities throughout the lifespan. Optimal care of children with SCI/D is multidisciplinary and the pediatrician is a very important member of this team. This review highlights functional prognosis and important health maintenance issues to prevent complications and maximize independence. It is intended to as…

Epidemiological profile of spinal cord injury in Brazil.

OBJECTIVE: To identify and analyze the biosocioeconomic profile associated with the occupation and education of persons with spinal cord injury (SCI) from Brazil. DESIGN: Analytical, quantitative, descriptive, cross-sectional. PARTICIPANTS: Sample composed of 618 Brazilian adults with SCI and access to the internet. SETTING: Community-based, Brazil. METHODS: An online form was developed and publicized on Brazilian social media to voluntarily register for participation in research. Pearson's Chi-squared test was used to analyze the association between categorical variables and the Kruskal W…

A Comprehensive Review of Spinal Cord Stimulator Infections.

Spinal cord stimulator (SCS) is approved to treat various pain conditions and is commonly seen in the chronic pain patient population. Due to the nature of the device and its location, infections associated with SCS have a particularly high morbidity. According to post-market data and medical device reports, 87% of patients receiving SCS implants were given perioperative antibiotics as the implantable neurostimulator or receiver pocket serve as the most common sites of infection. The most common antibiotics for surgical prophylaxis given are first-generation cephalosporins (cefalexin, cefazoli…

Effects of thymoquinone on spinal cord injury in rats.

PURPOSE: Spinal cord injury (SCI) is a condition that causes disturbances in normal sensory, motor, and autonomic functions. During SCI, damages occur such as, contusion, compression, distraction. The aim of this study was to investigate effects of the antioxidative thymoquinone on neuron and glia cells in SCI biochemically, immunohistochemically and ultrastructurally. METHODS: Male Sprague-Dawley rats were divided into Control, SCI and SCI + Thymoquinone groups. After T10- T11 laminectomy was performed, a metal weight of 15 grams was left down the spinal tube for spinal damage. Immediately a…

Spinal Cord Compression in Togo: Etiologies and Management.

BACKGROUND: Spinal cord compression etiology depends on geographic region. In sub-Saharan Africa, the etiologies are mostly infectious, and management is characterized by diagnostic delay and limited treatment modalities. In Togo, treatment was nonoperative until 2008. However, management has improved with the development of imaging and availability of specialists. We sought to report etiology and outcome of spinal cord compression since establishment of a neurosurgery unit in Togo. METHODS: A retrospective descriptive study was performed of patients admitted for spinal cord compression in th…

Inflammation: A Target for Treatment in Spinal Cord Injury.

Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that generate beneficial outcomes and have no side effects are urgently needed. SCI may be treatable if intervention is initiated promptly. Therefore, several treatment proposals are currently being evaluated. Inflammation is part of a complex physiological response to injury or harmful stimuli induced by mechanical, chemical, or immunological agents. Neuroinflammation is one of the principal secondary changes following SCI and plays a crucial role in modulating the pathological progression of acute and c…