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Клинические манифестации, иммунная эвакуация и последствия обезьяны для здоровья населения: проблемы и перспективы на будущее.

ВВЕДЕНИЕ: " Обезьяна " (Мпокс) является заболеванием, передаваемым главным образом в результате прямого контакта с инфицированными животными и людьми. В последнее время она вызвала интерес во всем мире в связи с ее расширением из эндемических районов в неэпидемиологические районы, что вызвало обеспокоенность по поводу ее клинических последствий. МЕТОДЫ: Был проведен всеобъемлющий обзор литературы с использованием PubMed, Scopus и Web of Science с уделением особого внимания клиническим данным, механизмам уклонения от иммунитета и докладам о состоянии здоровья населения, связанным с об

Совпадение в аннотации оригинала
INTRODUCTION: Monkeypox (Mpox) is a disease primarily transmitted through direct contact with infected animals and humans. Recently, it has … The findings underscore the varied clinical manifestations of Mpox, especially its severe impact on vulnerable populations such as HIV co-infected individuals and those with ocular involvement. The detailed analysis of immune evasion strategies reveals critical challenges in developing effective treatments and preventive measures. These insights align with existing rese …

Betting on influence: The impact of gambling advertising on the attitudes and behaviors of problem gamblers in France.

OBJECTIVE: The proliferation of gambling advertising has raised concerns about its effects on gambling behavior, particularly among vulnerable populations such as highest risk gamblers. This study examines the influence of gambling advertising on attitudes and intentions to gamble on a large sample of gamblers in France. METHOD: We used an online questionnaire in a cross-sectional design, with data collected between February 15 and April 30, 2021. Participants were recruited through a single recruitment channel, namely the client mailing list of the Française des Jeux, resulting in a final sa…

Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease?

Significant advances are being made in our understanding of basic pathophyiological and biochemical mechanisms that cause Huntington's disease (HD). There is increasing reason to believe that pathologic alterations occur in the brain for years before symptoms manifest. The "classic" hallmark of neuropathology in HD is selective neurodegeneration in which vulnerable populations of neurons degenerate while less vulnerable populations are spared. While the earliest and most striking neuropathologic changes have been found in the neostriatum, neuronal loss has been identified in many other regions…

Trauma History Questionnaire: validation with novel samples of incarcerated women and perinatal women.

Trauma exposure is associated with numerous negative outcomes, many of which are amplified within at-risk populations. Two under-researched and at-risk populations, incarcerated women and perinatal women, both report high rates of trauma, psychopathology, and PTSD compared to the general population. One common measure of trauma exposure in various populations, including incarcerated women and perinatal women, is the Trauma History Questionnaire (THQ). However, no known studies have validated the THQ within these two unique, understudied populations. Using data from two studies of incarcerated

Vaccination for Patients With Immunosuppression and Altered Immunity: A Workgroup Report from the AAAAI Adverse Reactions to Drugs, Biologics, and Vaccines Committee and the Autoimmunity and Altered Immune Response Committee.

Vaccination, a fundamental strategy for infectious disease prevention, presents unique challenges in individuals with altered immunity. These populations include individuals with inborn errors of immunity, autoimmune and inflammatory diseases, solid organ transplants, hematopoietic stem cell transplants, biologic and immunosuppressive therapies, and pregnancy. Despite concerns regarding variable vaccine responses, altered efficacy, and safety profiles, these groups remain under-represented in clinical trials. This review synthesizes current evidence on immunization outcomes in medically comple

The place of antenatal corticosteroids in late preterm and early term births.

Infants born in the late preterm period and via non-labour caesarean section in the early term period are at increased risk of respiratory morbidity when compared to their term-born counterparts. The morbidity in these infants is less frequent and severe than in early preterm infants. Antenatal corticosteroids reduce respiratory morbidity in these populations; however, the magnitude of the reduction appears to be small and predominantly in the self-limiting condition of transient tachypnoea of the neonate. The smaller benefit, along with possible harmful effects of corticosteroids, raises a qu

Historical inability to control Aedes aegypti as a main contributor of fast dispersal of chikungunya outbreaks in Latin America.

The arrival of chikungunya fever (CHIKF) in Latin American countries has been expected to trigger epidemics and challenge health systems. Historically considered as dengue-endemic countries, abundant Aedes aegypti populations make this region highly vulnerable to chikungunya virus (CHIKV) circulation. This review describes the current dengue and CHIKF epidemiological situations, as well as the role of uncontrolled Ae. aegypti and Aedes albopictus vectors in spreading the emerging CHIKV. Comments are included relating to the vector competence of both species and failures of surveillance and vec

Differential vulnerability of neurons in Huntington's disease: the role of cell type-specific features.

Abnormal expansion of a polyglutamine tract in huntingtin (Htt) protein results in Huntington's disease (HD), an autosomal dominant neurodegenerative disorder involving progressive loss of motor and cognitive function. Contrasting with the ubiquitous tissue expression of polyglutamine-expanded Htt, HD pathology is characterized by the increased vulnerability of specific neuronal populations within the striatum and the cerebral cortex. Morphological, biochemical, and functional characteristics of neurons affected in HD that might render these cells more vulnerable to the toxic effects of polygl

Addiction epidemiology in adolescents receiving inpatient psychiatric treatment.

This study sought to characterize adolescent psychiatric inpatient populations from two sites and to determine correlates of substance use disorders (SUD). Screening procedures for SUD differ substantially between these sites. A retrospective review of adolescent inpatients (n=636) revealed that the populations were similar in gender, race and age. Rates of SUD at the site with a formalized SUD screening regimen were higher (39%) than those at the other site (16.5%). Similar correlates of SUD were observed across sites, including older age, legal involvement, sexual activity, childhood disrupt

Success and failure in gonorrhea control.

This article has shown that all the necessary components for successful control of gonorrhea are available. In developed countries, general … ion of infection in the community. Innovative school- and community-based interventions targeted to vulnerable populations will further help to reduce the incidence and contribute to improvements in the sexual health of the population.

Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome.

Hospitalized preterm infants receive frequent and often prolonged exposures to antibiotics because they are vulnerable to infection. It is not known whether the short-term effects of antibiotics on the preterm infant gut microbiota and resistome persist after discharge from neonatal intensive care units. Here, we use complementary metagenomic, culture-based and machine learning techniques to study the gut microbiota and resistome of antibiotic-exposed preterm infants during and after hospitalization, and we compare these readouts to antibiotic-naive healthy infants sampled synchronously. We fi

Examining Health Literacy Levels in Homeless Persons and Vulnerably Housed Persons with Mental Health Disorders.

Health care use is high in persons who are homeless and vulnerably housed, but their health literacy (ability to read and understand health … literacy may be a potential barrier for accessing and utilizing health services and information for vulnerable populations.

Is the BCG Vaccine an Answer to Future Pandemic Preparedness?

While the development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines was rapid, time to development and implementation challenges remain that may impact the response to future pandemics. Trained immunity via bacille Calmette-Guerin (BCG) vaccination (an antigen agnostic strategy) offers a potential intervention against future novel pathogens via an existing, safe, and widely distributed vaccine to protect vulnerable populations and preserve health system capacity while targeted vaccines are developed and implemented.

Pediatric Mild Traumatic Brain Injury in the Acute Setting.

Pediatric mild traumatic brain injuries, most of which are concussions, are an increasingly common reason for presentation to emergency departments. The diagnosis of concussion has increased dramatically over the past decade, necessitating the acute care provider to have up-to-date knowledge of the definition, pathophysiology, signs and symptoms, physical examination findings, and acute management of pediatric concussion. This article also addresses populations most vulnerable to prolonged recovery from pediatric concussion and referral recommendations.

Barbiturate overdose: a case report.

Suicide patterns and rates differ in various populations and culture. It is observed from various studies that more than 90 percent of suicides are due to mental disorders. This behaviour, although often triggered by external factors, occurs in vulnerable individuals who have a neurobiological and often familial predisposition. Here, a case is reported wherein an apparently healthy married addicted male committed suicide by taking unprescribed twenty tablets of phenobarbital (60 mg) under suspicious condition.

Evaluating compliance with HeatSuite for monitoring in situ physiological and perceptual responses and personal environmental exposure.

Extreme heat events pose a significant health threat to vulnerable populations such as the elderly and those living with disease. Recent extreme heat events highlight that heat-related mortality often occurs indoors, urging a need to better understand how at-risk populations physiologically and behaviorally respond in their natural environment. However, a low-cost and scalable all-in-one solution to comprehensively monitor individuals during periods of extreme heat does not presently exist. We developed HeatSuite, a fully data-governed multimodal sensor platform, that can monitor the local env…

Association between psoriasis and cardiometabolic comorbidities in a racially and ethnically diverse low-income primary care population.

Psoriasis is associated with cardiometabolic comorbidities, including obesity, diabetes, hyperlipidaemia and hypertension. Many studies that … ggest education and intervention regarding modifiable risk factors are particularly important among vulnerable populations.

Adaptation and conservation insights from the koala genome.

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as 'vulnerable' due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala's ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect

Digital property security breaches and virtual ownership enforcement: a cyber law perspective.

INTRODUCTION: The digital age has produced new forms of property-virtual assets, Non-Fungible Tokens (NFTs), and cloud-based intellectual pr … liability exposure (p < 0.001). Rights violations and enforcement delays are more pronounced among vulnerable populations, including women, children, and marginalized communities. DISCUSSION: These results underscore the need for stronger digital property governance and more robust, rights-based liability frameworks.

Optimizing Access to the COVID-19 Vaccination for People Experiencing Homelessness.

The success of the Australian COVID-19 vaccination strategy rested on access to primary healthcare. People experiencing or at risk of homele … Blueprint document that can be used as a template for others to improve access to vaccinations for vulnerable populations.