Результаты поиска

Does the average drug exposure in pregnant women affect pregnancy outcome? A comparison of two approaches to estimate the baseline risks of adverse pregnancy outcome.

PURPOSE: The results of observational cohort studies on drug effects on pregnancy outcome may depend among others on suitable comparison cohorts. The aim of this investigation was to compare two distinct definitions of maternal exposure status for comparison cohorts. METHODS: We performed an observational cohort study of prospectively ascertained pregnant women who spontaneously contacted the Teratology Information Service (TIS) Berlin for drug risk consultation. The only exclusion criteria were exposures to established teratogens and/or fetotoxicants. Pregnancy outcomes of 3250 women with th…

Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria.

BACKGROUND: Tick bite-induced galactose-α-1,3-galactose (α-Gal) IgE and subsequent ingestion of red meat may cause delayed severe allergic r … years, range 18-82) from the Department of Dermatology and Allergy, Charité - Universitätsmedizin, Berlin, Germany. All had been clinically diagnosed with moderate-to-severe CSU of a median duration of 2.9 years (range 0.1-50). RESULTS: Eighty of the 83 patients (96%) had undetectable (<0.1 kUA/l) serum levels of IgE against α-Gal. The levels in the re …

Methods for isolation of cell-free plasma DNA strongly affect DNA yield.

Extracellular nucleic acids are present in plasma, serum, and other body fluids and their analysis has gained increasing attention during re … system from Roche Diagnostics) to isolate DNA from 44 plasma samples in parallel at laboratories in Berlin and Munich. DNA in all samples was quantified by real-time PCR on a LightCycler 480 using three different targets (GAPDH, ß-globin, ERV). The quantities of cell-free DNA for the different isolation methods and genes varied between medians of 1.6 ng/ …

Access site management after peripheral percutaneous transluminal procedures: Neptune pad compared with conventional manual compression.

PURPOSE: To investigate the safety and efficacy of the procoagulant wound dressing Neptune Pad (Biotronik, Berlin, Germany) compared with those of conventional manual compression for access site management after peripheral percutaneous interventions. MATERIALS AND METHODS: The study was approved by the institutional ethics committee, and all patients gave written informed consent. Two hundred one consecutive patients were enrolled and were randomly assigned to be treated with the Neptune Pad (n = 100) or conventional manual compression (n = 101). Patients were followed up clinically until hos…

Significance of tumor markers during the follow-up of women without symptoms after treatment of primary breast cancer.

In Berlin, 23-24 February, 1995, during a "consensus-meeting" several German Oncological Societies ratified their guidelines for the follow-up after primary treatment of breast cancer. In women without symptoms and with no anamnestic or clinical signs for relapse or metastases routine X-ray diagnostics (except mammography), bone scintigraphy, ultrasound and other technical imaging procedures and laboratory evaluation including tumor markers are not obligatory. The relevance of continuously rising tumor markers (e.g. CEA, CA 15-3, MCA) without tumor-related symptoms or manifestation of relapse …

Imprisonment: a risk factor for HIV infection counteracting education and prevention programmes for intravenous drug users.

OBJECTIVES: To examine changes of risk behaviour and its determinants as well as risk factors for HIV infection in intravenous drug users (IVDU) with particular attention to imprisonment and its risk patterns. SETTING: In 1993 a multisite cross-sectional study was carried out by standardized questionnaires and blood/saliva samples in which 612 IVDU from Berlin were enrolled. RESULTS: Multifactorial analysis revealed that the most important risk factor for HIV infection was needle-sharing in prison. In total, 353 IVDU (58%) reported reduced risk behaviour; changes related more to injection be…

Diagnostic yield and therapeutic impact of open lung biopsy in the critically ill patient.

BACKGROUND: Open lung biopsy (OLB) is a rare procedure in intensive care units (ICUs) for therapeutic management of acute respiratory failure (ARF). The purpose of this study was to analyze the diagnostic yield, therapeutic contribution and complications of OLB in ICU patients with ARF of unclear etiology, including acute respiratory distress syndrome (ARDS) and ARDS mimics. METHODS: Retrospective study conducted in a 10-bed ICU over a 13-year period. Patients undergoing OLB for ARF with undiagnosed infiltrates on CT scan were included. ARDS was defined according to Berlin criteria, and ARDS …

Veterinary Drug Residues in Animal-Origin Food: a UPLC-MS/MS Screening Method for the Determination of 21 Beta-Agonists in Animal Lung and Liver According to Commission Implementing Regulation (EU) 2021/808.

The misuse of beta-agonist drugs as growth promoters in livestock production, highlighted by the cases of intoxication in Europe in the 1990s, has resulted in strict regulations in the European Union. These restrictions have required the development of increasingly sensitive analytical methods. In June 2022, the European Union Reference Laboratory (EURL BVL Berlin) released the Guidance Document on Minimum Method Performance Requirements (MMPRs), a technical guidance for analytical methods in residue control. The MMPRs represent the minimum concentrations that official laboratories should be a…

Pioneer of Medical Mycology: In Memory of Prof. Friedrich Staib, MD, DVM.

At the beginning of Friedrich Staib's academic career in the 1950s, medical mycology was a young discipline in Germany. He studied veterinar … epartment, which he established, at the Robert Koch Institute, Germany's public health Institute in Berlin. His work focused on improving the identification of fungi, both within hosts and the environment. His research on Cryptococcus neoformans (Staib agar indicator medium based on the virulence factor melanin for cultivation) gained him international r …

Epidemiology of Obstructive Sleep Apnea in Chile: A Systematic Review and Meta-Analysis.

UNLABELLED: Sleep apnea is a common breathing disorder that affects nearly one billion people worldwide. Despite its high prevalence and cli … nd the Epworth Sleepiness Scale were the most frequently used tools. Other instruments, such as the Berlin Questionnaire and sleep quality indices, were used less often. Only three studies employed respiratory polygraphy. The pooled prevalence of moderate-to-high risk of OSA, defined by a STOP-Bang score >3, was 25% (95% CI: 16-34%, I2= 98.4%). The most …

"Go for Gold!" or "just for fun"?-competitions at Special Olympics Unified Sports® at the National Games 2022.

Special Olympics Unified Sports® is a sports program in which individuals with and without intellectual disabilities train and compete toget … players (14 athletes and 27 partners) conducted during the 2022 Special Olympics National Games in Berlin, the findings reveal pronounced hierarchical structures along the lines of disability. Partners often adopt a reserved, supportive role, intentionally holding back their own performance in order to place athletes at the center of gameplay. This appr …

Lung ultrasound score as a tool to assess pulmonary ventilation and disease severity in patients with acute respiratory distress syndrome.

OBJECTIVE: To evaluate the effects of lung ultrasound (LUS) in assessing pulmonary ventilation status in patients with acute respiratory distress syndrome (ARDS). METHODS: A total of 35 ARDS patients aged 29-93 years, admitted to the Anesthesiology Intensive Care Unit and scheduled for chest computed tomography (CT), were retrospectively analyzed. Prior to the CT scan, arterial blood gas samples were collected, and LUS scores were obtained using a Sonostar portable ultrasound device. Based on the Berlin definition, patients were categorized into mild ARDS and moderate-to-severe ARDS groups. L…

Global research trends in biological therapy for ankylosing spondylitis: A comprehensive visualization and bibliometric study (2004-2023).

Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the spine and pelvic bones. Recently, many researchers hav … uthor, with a h-index of 16. The institution with the most articles was Charite Universitatsmedizin Berlin, and the Rheumatology journal had the highest number of publications. "janus kinase inhibitor" and "secukinumab" displayed a notable citation burst in recent years, indicating IL-17i and JAKi are research hotspots. More and more attention has been p …

Petechiae in non-fatal strangulation: Prevalence, predictors and time-dependent detectability in forensic assessment.

Petechiae are a key yet inconsistently observed finding following non-fatal strangulation, and their detection is influenced by both anatomical location and time since the event. This variability complicates forensic evaluation. This retrospective cohort study analysed 541 adult cases assessed at the Violence Protection Ambulatory of Charité Berlin between 2017 and 2023. The presence of petechiae was evaluated according to location and time interval to examination. Associations with clinical symptoms and external signs were examined using logistic regression, generalised estimating equations, …

Quality of life in patients with scarring and non-scarring alopecia: An exploratory cross-sectional study.

BACKGROUND AND OBJECTIVES: Hair loss disorders impact quality of life (QoL) far beyond cosmetic issues, with previous studies showing mild to moderate impairment. This study aimed to assess QoL impairment in hair loss patients, comparing scarring and non-scarring alopecia, and to analyze possibly related influencing factors. PATIENTS AND METHODS: An exploratory cross-sectional study of 510 patients (281 with non-scarring and 229 with scarring alopecia) was conducted at the Charité -Universitätsmedizin Berlin's dermatology outpatient clinic. DLQI and PROMIS questionnaires were completed. T-tes…

Отдельные факторы, обременяющие ухаживающего за хронически больным человеком пример множественного склероза.

ВВЕДЕНИЕ: Многие специалисты обеспокоены бременем, которое ложится на тех, кто ухаживает за хронически больными пациентами. Происхождение множественного склероза и связанное с этим изменение функциональных способностей пациента, а также ресурсов, имеющихся в распоряжении опекуна, связаны с бременем, которое испытывает тот, кто ухаживает за больным. Крайне важно, чтобы при оказании помощи оценивались факторы, которые могут определять бремя, лежащее на тех, кто ухаживает за детьми. Цель этого исследования заключалась в выявлении отдельных факторов, определяющих бремя, лежащее на тех, кто ухажива

Совпадение в аннотации оригинала
INTRODUCTION: The burden on caregivers of chronically ill patients is a subject of concern for many specialists. The course of multiple scle … clerosis patients using the CBS Caregiver Burden Scale, Guy's Neurological Disability Scale (GNDS), Berlin Social Support Scale (BSSS), Antonovsky's SOC-29 Life Orientation Questionnaire, and the author's own questionnaire. The collected survey data were entered into a Microsoft Excel spreadsheet and then analyzed using Statistica 13 software. The level …

[Specialized trauma surgery: do we need it at all?].

Despite maximally motivated and professionally outstanding young talent, the particularly stressful surgical disciplines have recruitment co … ng more and more unattractive. Knife attacks and also the "truck attack" at the Breitscheidplatz in Berlin illustrate the smoldering terror situation in Germany. The Federal Criminal Police Office also recently announced that the incidence of domestic violence increased by 6.5% in 2023 alone. This cannot be mastered with specialization alone. The visibil …

Dyslexia, the Amsterdam Way.

The current aim is to illustrate our research on dyslexia conducted at the Developmental Psychology section of the Department of Psychology, University of Amsterdam, in collaboration with the nationwide IWAL institute for learning disabilities (now RID). The collaborative efforts are institutionalized in the Rudolf Berlin Center. The first series of studies aimed at furthering the understanding of dyslexia using a gamified tool based on an artificial script. Behavioral measures were augmented with diffusion modeling in one study, and indices derived from the electroencephalogram were used in o…

Drawing time-density curve with Fiji/ImageJ: An alternative approach for parametric coding of cerebral digital subtraction angiography.

BACKGROUND: Quantitative spatiotemporal analysis of digital subtraction angiography could support clinical decision making for the managemen … ves generated with commercial software on the Siemens workstation (syngo iFlow, Siemens Healthcare, Berlin, Germany) and our method. RESULTS AND COMPARISON WITH EXISTING METHOD: Sixteen patients diagnosed with acute ischemic stroke resulting from acute occlusion of the distal internal carotid artery or the first segment of the middle cerebral artery wer …