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An extraction pipeline for analysis of hematopoietic stem cell transplantation data.

Many clinical studies are based on registry analyses, but exact approaches of data extraction and pre-processing are rarely included, while this is critical for reliability and reproducibility of results. We aimed to develop an open-source data extraction pipeline which generates a ready-to-analyze dataset focused on relevant determinants of outcomes after hematopoietic stem cell transplantation (HSCT). This pipeline was developed using EBMT registry data, including 54,457 allogeneic and 63,651 autologous HSCT procedures. The pipeline determines HLA matching from molecular data, assesses cytog…

Cytomegalovirus reactivation and the prevalence in autologous hematopoietic stem cell transplantation.

In this article, we comment on the article by Ben Moussa et al published discussing cytomegalovirus (CMV) reactivation in patients who have undergone autologous hematopoietic stem cell transplantation (AHSCT). CMV reactivation is a heavily discussed complication when discussing allogenic hematopoietic stem cell transplantation, but much more limited discussion in AHSCT. These issues are further complicated by a lack of concrete guidelines for CMV reactivation after AHSCT, especially viral load thresholds which have been shown to be the strongest correlation to determine the occurrence and seve…

Respiratory Virus Infections and Pulmonary Impairment After Allogeneic Hematopoietic Cell Transplantation.

BACKGROUND: Respiratory virus infections (RVIs) are common after hematopoietic cell transplantation (HCT), but their effect on pulmonary outcomes, including bronchiolitis obliterans syndrome (BOS), and mortality is poorly defined. METHODS: Prospective cohort study of 471 allogeneic HCT recipients transplanted in the pre-COVID-19 pandemic era in an academic cancer center. Participants were prospectively followed for 1 year with serial handheld spirometry, symptom questionnaires, and multiplex 11-virus PCR. Pulmonary function testing occurred at recommended intervals. Cox proportional hazard an…

Exploring cell death mechanisms in liver transplantation: implications for graft survival.

Liver transplantation (LT) has become a life-saving therapy for patients with end-stage liver disease and malignancies. However, graft survival remains a significant challenge because of LT-related stresses. Grafts are subject to several stresses, including cold preservation after procurement and during transportation, as well as warm ischemia until vascular reconstitution, which can trigger hepatic cell death. This review examines the various cell death mechanisms that influence liver graft outcomes, including apoptosis, necrosis, autophagy, and non-apoptotic inflammatory cell death. We discu

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation.

Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective treatment for patients with high-risk hematologic malignancies. Over the last decade, gut microbiota composition during allo-HCT has been associated with patients' outcomes. Treatment-related factors, in particular the use of broad-spectrum antibiotics and the conditioning regimen, frequently induce gut dysbiosis, which is associated with immune dysregulation, toxicity, and adverse outcomes, particularly after allo-HCT. Microbial metabolites further modulate immune responses and therapeutic efficacy. Emerging microbiota-t…

Continuous predictive mortality risk monitoring after allogeneic hematopoietic stem cell transplantation.

Allogeneic hematopoietic stem cell transplantation remains critical for treating high-risk hematological malignancies like leukemia. Despite advances in treatment, early mortality remains clinically significant, with approximately 6-11% of patients dying within the first 100 days after transplantation. This highlights the need for dynamic monitoring strategies beyond static pre-transplant risk assessments. This study introduces a novel, interpretable, real-time proof-of-concept monitoring framework that continuously assesses individualized mortality risk during treatment using routinely collec…

Nutritional Impact of High-Dose Melphalan in Autologous Stem Cell Transplantation.

High-dose melphalan is the standard conditioning treatment for patients undergoing autologous hematopoietic stem cell transplantation for hematological malignancies. Although effective, it often causes significant gastrointestinal side effects, such as mucositis, nausea, vomiting, and diarrhea, which can quickly affect patients' nutrition, hydration, and electrolyte balance, leading to acute malnutrition. This nutritional decline increases the risk of infections, prolongs hospital stays, and can worsen short-term recovery. Routine nutritional assessment and early support are not consistently i…

Valganciclovir for CMV Prophylaxis After PTCy-Based Allogeneic Hematopoietic Cell Transplantation.

Cytomegalovirus (CMV) reactivation is a serious complication after allogeneic hematopoietic cell transplantation (alloHCT), with heightened risk in recipients receiving post-transplant cyclophosphamide (PTCy)-based prophylaxis. Although letermovir reduces clinically significant CMV infection (csCMVi), its prohibitive cost limits access, highlighting the need for affordable alternatives. Unlike solid organ transplantation, there are no published studies reporting the utility of valganciclovir for CMV prophylaxis following PTCy-based alloHCT. The aim of this study was to evaluate the deliverabil…

The Hidden Burden: Endocrinopathies in Adolescents after Hematopoietic Stem Cell Transplantation.

Adolescents with malignant and nonmalignant diagnoses can require hematopoietic stem cell transplantation (HSCT), with the volume increasing 5% to 10% per annum in the United States. HSCT is an established therapy for malignancies, hemoglobinopathies, bone marrow failure, inborn errors of metabolism, and immunodeficiency. Gonadotoxic-conditioning regimens, immunosuppressive agents, and glucocorticoids are essential therapies required for a successful transplant course. Secondary endocrine sequelae can occur, however, including iatrogenic adrenal insufficiency, reduced bone mineral density, med…

Decreasing excess mortality after allogeneic stem cell transplantation for acute leukemia.

Not available.

Pathophysiological mechanisms of cell death affecting graft survival in liver transplantation.

Early allograft dysfunction (EAD) is a significant complication of liver transplantation (LT). LT remains the sole curative treatment for patients with end-stage liver disease. EAD is correlated with heightened morbidity, extended stays in intensive care units, and decreased graft survival rates. Within the clinical practice, EAD presents a substantial challenge, necessitating vigilant monitoring, heightened clinical awareness, and prompt multidisciplinary intervention to prevent progression to primary graft nonfunction and multiorgan failure. Multiple forms of programmed cell death, including

Validation of the efficacy of tympanoplasty combined with cell sheet transplantation.

OBJECTIVE: To evaluate postoperative mastoid aeration following canal wall up tympanoplasty with mastoidectomy combined with autologous nasal epithelial cell sheet transplantation into the middle ear cavity and to compare the outcomes with those of conventional canal wall up tympanoplasty with mastoidectomy. METHODS: Five patients with acquired cholesteatoma (four pars flaccida types and one pars tensa type) underwent canal wall up tympanoplasty with mastoidectomy combined with autologous cultured nasal epithelial cell sheet transplantation into the middle ear cavity (cell sheet group). Sixty

[Allogeneic Hematopoietic Stem Cell Transplantation for Children with Hyper-IgE Syndrome].

OBJECTIVE: To summarize the clinical characteristics, treatment outcomes, and prognosis of two children with STAT3 gene mutation-associated hyper-IgE syndrome(HIES) who underwent allogeneic hematopoietic stem cell transplantation(allo-HSCT). METHODS: A retrospective analysis was performed on two pediatric patients with STAT3-mutated HIES (STAT3-HIES) who received allo-HSCT. Data included baseline clinical features, transplant protocols, post-transplant outcomes, complications (graft-versus-host disease, infection, virus reactivation), serum IgE levels, and long-term follow-up. RESULTS: The t…

[The dual effects of letermovir in allogeneic hematopoietic stem cell transplantation].

Human cytomegalovirus (HCMV) infection is one of the most common and severe viral complications following allogeneic hematopoietic stem cell transplantation (allo-HSCT), significantly increasing the risk of graft-versus-host disease (GVHD) and non-relapse mortality. Letermovir, as the first inhibitor targeting the HCMV terminase complex, blocks the cleavage of viral DNA and its packaging into viral capsids, demonstrating remarkable efficacy in early post-transplant HCMV prophylaxis. It significantly reduces the incidence of clinically significant HCMV infection (csCMVi) and indirectly contribu…

Paramagnetic rim lesions on 7T MRI after autologous hematopoietic cell transplantation.

BACKGROUND: Compared to the potent efficacy of autologous hematopoietic cell transplantation (AutoHCT) on multiple sclerosis (MS) lesion activity, benefit on disability progression is less clear. Paramagnetic rim lesions (PRLs) are imaging biomarkers associated with progression. OBJECTIVES: Evaluate effect of AutoHCT on PRLs using 7T magnetic resonance imaging (MRI). METHODS: A single rater evaluated PRLs before/after AutoHCT on 7T MRI at an MS referral center. RESULTS: Seven participants were included with mean age 38.9 years and median disease duration 9 years. Median PRL count pre-transp…

Автологичная трансплантация стволовых клеток гематопоиета стабилизирует атрофию сетчатки в множестве склероза.

Автологическая трансплантация стволовых клеток гематопоиета — это эффективное лечение агрессивных множественных рефракторов склероза для лечения заболеваний. Тем не менее, его воздействие на нейродегенерацию по-прежнему недостаточно изучено, и существует мало прогнозов биомаркеров для клинических результатов после аутологической трансплантации гематопоэтических стволовых клеток. Мы изучили, смягчает ли аутологическая трансплантация стволовых клеток процесс нейродегенерации сетчатки и предвосхищают ли показатели оптической согласованности, полученные на основе сетчатки, развитие инвалидности по

Совпадение в аннотации оригинала
Autologous haematopoietic stem cell transplantation is an effective treatment for aggressive multiple sclerosis refractory to disease-modifying therapies. Yet, its impact on neurodegeneration remains underexplored, and few predictive biomarkers for clinical outcomes after autologous haematopoietic stem cell transplantation exist. We investigated whether auto…

Oligodendrocyte precursor cell transplantation attenuates inflammation after ischemic stroke in mice.

BACKGROUND: Disruption of blood-brain barrier and neuroinflammation are critical pathological features in the acute phase of ischemic stroke. This study investigates whether oligodendrocyte precursor cell transplantation can downregulate inflammation to attenuate blood-brain barrier disruption following ischemic brain injury. METHODS: Adult male Institute of Cancer Research mice (n = 60) underwent transient middle cerebral artery occlusion. Post ischemic assault, these mice received a stereotactic injection of oligodendrocyte precursor cells (6 × 105). Neurobehavioral outcomes, infarct volume…