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[Effect of Lappaconitine on Postoperative Pain and Serum Complement 3 and 4 Levels of Cancer Patients Undergoing Rectum Surgery].

OBJECTIVE: To explore the effect of lappaconitine on patient-controlled intravenous analgesia (PCIA) and serum complement 3 and 4 (C3 and C4 … mg) was intravenously dripped to patients in the tramadol group 30 min before ending the operation. PICA was started as soon as the end of the surgery and the total dose of tramadol was 900 mg. Pethidine (50 mg) and droperidol (2. 5 mg) was intramuscularly injected to patients in the blank control group for pain relief according to their complaints. Pa …

Sleep and behavior problems in school-aged children.

OBJECTIVES: The primary purposes of the present study were to survey the prevalence of sleep problems in school-aged children and to examine … hology. Children rated highly on parasomnias were more likely to have frequent falls and to display pica. Parasomnias and noisy sleep were inversely associated with socioeconomic status (SES). Children from lower SES families were rated higher on these factors than children from higher SES families. Enuresis/gags was the only sleep problem factor assoc …

[Preparation and application of chiral silica gel spheres based on L-glutamic].

Inorganic mesoporous silica gel spheres, which possess sufficient mechanical strength, thermal stability, and mobile phase endurance, are the most important and widely used materials for column packing in high performance liquid chromatography (HPLC). However, amorphous silica gel is generally reported as an inorganic chiral silica gel, and spherical all-inorganic chiral silica gel has not been reportedly used as the chiral stationary phase for HPLC. In this paper, inorganic spherical mesoporous silica gel was used in the method of polymerization-induced colloid aggregation (PICA), with silica…

[The contribution of "time-of-flight" MRI-angiography in the study of neurovascular interactions (hemifacial spasm and trigeminal neuralgia)].

The purpose of this study was to investigate capabilities of Magnetic Resonance Angiography (MRA) in delineating neurovascular compression w … neurovascular conflict was related to an arterial loop from the postero-inferior cerebellar artery (PICA, 21 cases, 61%) and the antero-inferior cerebellar artery (AICA, 8 cases, 23%). Vertebral artery is implicated in conflicts in 5 cases. In 2 cases MRA exploration was negative. In HFS group distance between Vth nerve emergency and neuro vascular con …

[Determination of 65 synthetic cannabinoids in whole blood by QuEChERS-ultra performance liquid chromatography- mass spectrometry].

Synthetic cannabinoids （SCs） have become the most diverse and widely abused class of new psychoactive substances in the world. Blood and uri … d in all 10 samples， specifically including ADB-BUTINACA， MDMB-4en-PINACA， MDMB-FUBICA， and 5F-MDMB-PICA with mass concentrations ranging from 1.9 to 23.1 ng/mL. The detection rates of ADB-BUTINACA and MDMB-4en-PINACA were 90% and 50%， respectively， suggesting their relatively high prevalence in China's illegal drug market. In addition， two or more SCs …

[Preparation of mesoporous covalent organic framework core-shell stationary phase and its application in the analysis of astragaloside Ⅳ content in Astragalus].

Quality control of traditional Chinese medicine （TCM） has always been a key and challenging issue in the field of its modernization research … gy， in which the SiO2 cores were fabricated using the polymerization-induced colloidal aggregation （PICA） method. The imine-linked TAPT-TA-COF@SiO2 core-shell stationary phase was subjected to comprehensive physicochemical characterization and chromatographic evaluation experiments. The analytical techniques employed included scanning electron microsco …

[Operative neurosurgery: personal view and historical backgrounds. 6. Positioning, instruments].

Important points of positioning and instruments at the time of performing microneurosurgery according to the traditional Zuerich school styl … or cerebellar artery OA-PCA/SCA bypass and occipital artery-posterior inferior cerebellar artery OA-PICA bypass. As for the operating microscope, importance of the eyepiece-lens assembly with mouthpiece was emphasized. Appropriate selection of this system enables surgery of long duration in a comfortable and non-tiring condition in terms of the arm len …

The evaluation of the association between the prevalence and patterns of computed tomography findings of cryptogenic organizing pneumonia, and neutrophil/lymphocyte and platelet/lymphocyte ratios.

This study presents new findings based on a large-scale analysis of butterfly genomic sequences. Focusing on species identification through … sis phisara (Moore, 1884)), Vettius prona Evans, 1955 (not Vettius phyllus (Cramer, 1777)), Vettius pica (Herrich-Schäffer, 1869) (not Vettius lafrenaye (Latreille, [1824])), and Phlebodes yalta (Evans, 1955) (not Phlebodes fuldai (E. Bell, 1930)) (Hesperiidae). The following taxa are junior subjective synonyms: Lycaena sissona W. G. Wright, 1905 of Cu …

First Clinical Nutrition Outpatient Consultation: A Review of Basic Principles in Nutritional Care of Adults with Hematologic Disease.

MethodsA bibliographic survey was carried out between 2020 and 2022 using two databases: PubMed/MEDLINE and Scientific Electronic Library On … he drugs/nutritional supplements in use; changes in the digestive tract; the presence or absence of picamalacia; and socioeconomic and lifestyle data. In addition, it is necessary to carry out laboratory evaluations, semiological assessment, anthropometric assessment, and assessment of food consumption. In the end, the nutritional approach should be co …

Randomized Study of enterade® to Reduce Diarrhea in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation.

High-dose chemotherapy frequently causes injury to the gastrointestinal mucosa, resulting in diarrhea. The purpose of the current study was to assess the tolerability and efficacy of enterade® in reducing ≥ grade 2 diarrhea (G2D) in association with high-dose melphalan followed by autologous stem cell transplantation (ASCT). We conducted a prospective, double blinded, multi-center trial in which 114 subjects were randomized to receive enterade® or placebo twice daily during the transplant hospitalization. Gastrointestinal toxicities (nausea, vomiting, oral mucositis and dysphagia) resulted in

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… These changes were associated with reduced nausea (reduced pica weight), improved body weight maintenance, and extended survival time with the administration of enterade ® (Yin et al., 2014; Yin et al., 2016; Yin et al., 2017; Gupta et al., 2020). … acid-based oral rehydration solution (aa-ors) enhanced intestinal epithelial proliferation in mice exposed to radiation Sci Rep 2016 6 37220, 1 13 27876791 10.1038/srep37220 PMC5120277 Yin L Vaught L Okunieff P Casey-Sawicki K Vidyasagar S Amino acid hydration decreases radiation-induced nausea in mice: a pica …

Common Non-Rheumatic Medical Conditions Mimicking Fibromyalgia: A Simple Framework for Differential Diagnosis.

Fibromyalgia (FM) is a chronic non-inflammatory disorder mainly characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and a constellation of other symptoms. For this reason, delineating a clear distinction between pure FM and FM-like picture attributable to other common diseases can be extremely challenging. Physicians must identify the most significant confounders in individual patients and implement an appropriate diagnostic workflow, carefully choosing a minimal (but sufficient) set of tests to be used for identifying the most plausible diseases in the specific case

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… 25-hydroxyvitamin D Iron deficiency | Vegetarian or vegan diet, celiac disease, inflammatory bowel disease, chronic bleeding, history of gastrointestinal surgery, drugs (PPIs, antiacids) | Microcytic anemia, dry/frail hair, koilonychia, atrophic glossitis, angular cheilosis, restless leg syndrome, pica … | Chronic fatigue/exercise intolerance with microcytosis or restless leg syndrome, frail hair, koilonychia, atrophic glossitis, and angular cheilosis or pica | ↓ Ferritin ↓ TSAT Magnesium deficiency | Alcoholism, diabetes mellitus, inflammatory bowel disease, chronic kidney disease, thyroid/parathyroid …

Concurrent Myelomatous Pleural Effusion and Extramedullary Mediastinal Involvement as an Initial Manifestation of Multiple Myeloma.

BACKGROUND Myelomatous pleural effusion (MPE) is a rare occurrence in patients with multiple myeloma (MM). Fewer than 20 cases of MPE have been reported as an initial manifestation of MM. Extramedullary plasmacytoma (EMP) occurs in fewer than 5% patients with MM, and mediastinal EMP is even rarer, with only about 80 cases reported in the literature. We present a case study involving a patient with concurrent MPE and mediastinal EMP as an initial manifestation of MM. CASE REPORT The patient was a 74-year-old nonsmoking female with a 3-month history of exertional dyspnea and back pain. On exam,

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… Varettoni M Corso A Pica G Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: A longitudinal study on 1,003 consecutive patients Ann Oncol 2009 21 325 30 19633044 10.1093/annonc/mdp329 10. …

Массивное миэломатное плеурное извлечение с противоположной медиастинальной сменой: уникальное представление экстрамеуллярной миеломы.

Множественная миелома (ММ) — относительно распространенная порча костного мозга, в то время как в коже и мышцах, лёгких плеврах, лимфатических узлах, печени и CNS (EMD). Mielomatous плефилд (MPE) — редкое дополнительное проявление MM, в котором плеволальная жидкость почти полностью состоит из аномальных плазменных клеток. MPE и другие типы EMD связаны с плохим прогнозом, и MPE могут появиться из-за напряженной физиологии. Мы сообщаем о случае с пациентом с массивным ОРМ, появляющимся с промежуточным промежуточным сменом. Число таких случаев крайне невелико, и в настоящем докладе приводится уни

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… Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Ann Oncol. 2010;21:325–330. doi: 10.1093/annonc/mdp329. 7. …

Optic nerve head plasmacytoma as a manifestation of multiple myeloma.

Extramedullary disease in multiple myeloma is uncommon and associated with a poorer prognosis. Extramedullary disease involving the orbit is even more unusual, with optic nerve involvement being rare. We describe an optic nerve head plasmacytoma in a 45-year-old female in the setting of systemic relapsed, refractory IgA kappa multiple myeloma. The case highlights the importance of keeping extramedullary disease spread in the differential for vision loss in a patient with a history of multiple myeloma. In addition, it describes an unusual location for presentation of extramedullary disease, the

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… Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: A longitudinal study on 1003 consecutive patients. Ann Oncol. 2010;21:325–30. doi: 10.1093/annonc/mdp329. 6. …

Extraskeletal multiple myeloma presenting with an atrial mass: a case report and a review of the literature.

INTRODUCTION: Extraskeletal presentation at diagnosis or during the course of multiple myeloma is a rare event. The prognosis is usually very poor. At the moment there is no agreed gold standard for the treatment of this presentation. CASE PRESENTATION: A 79-year-old Caucasian woman was treated at our hospital for right atrial myeloma localization. Our patient showed the following signs and symptoms of congestive heart failure: dyspnea, hypotension, cyanosis and facial edema. Surgery was not considered feasible due to the extent of the disease. Our patient underwent external-beam radiation th

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… Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol. 2010;21:325–330. doi: 10.1093/annonc/mdp329. Goldberg E, Mori K. …

Emerging Insights into Granulomatous and Amyloidogenic Cardiomyopathies.

Background: Granulomatous and amyloidogenic cardiomyopathies are infiltrative conditions that can be fatal if left untreated. Among these, cardiac amyloidosis and cardiac sarcoidosis are significant but often underdiagnosed causes of heart failure, each serving as cardiac manifestations of broader systemic diseases. Advancements in imaging techniques and the emergence of novel therapies-particularly for cardiac amyloidosis-have brought these conditions into sharper focus for both clinicians and researchers. Methods: We conducted a comprehensive review of the literature by searching databases i

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… Pica S. Reant P. Abdel-Gadir A. Treibel T.A. Banypersad S.M. Maestrini V. Barcella W. Rosmini S. Bulluck H. … Pica S. Castelletti S. Piechnik S.K. Robson M.D. Native T1 mapping in transthyretin amyloidosis JACC Cardiovasc. Imaging 2014 7 157 165 10.1016/j.jcmg.2013.10.008 24412190 52. Martinez-Naharro A. Kotecha T. Norrington K. Boldrini M. Rezk T. Quarta C. Treibel T.A. Whelan C.J. Knight D.S. Kellman P. …

Leptomeningeal carcinomatosis in gastric cancer: A Review.

Gastric cancer is the fifth most common cancer worldwide and leptomeningeal carcinomatosis (LM) occurs in 0.06% of gastric cancers. As such, trials are difficult to power and quantitative analyses difficult to standardize. We composed a review and analysis of 47 recent cases to be used as a comprehensive resource for an oncologist faced with managing this highly morbid, rapidly fatal disease. Gold-standard of diagnosis of LM is through cerebral spinal fluid (CSF) cytology; MRI is the preferred imaging modality to identify LM. However, repeated lumbar punctures and imaging studies are often req

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… Positive for malignant cells by cytology, C- Negative for malignant cells by cytology, CSF Cerebrospinal fluid, SR Signet ring features, NR Not reported, PDA Poorly differentiated adenocarcinoma, M Male, F Female, MDA Moderately differentiated adenocarcinoma, LM Leptomeningeal, ADA Adenocarcinoma, PICA … Positive for malignant cells by cytology, C- Negative for malignant cells by cytology, CSF Cerebrospinal fluid, SR Signet ring features, NR Not reported, PDA Poorly differentiated adenocarcinoma, M Male, F Female, MDA Moderately differentiated adenocarcinoma, LM Leptomeningeal, ADA Adenocarcinoma, PICA …

First pediatric experience of SL-401, a CD123-targeted therapy, in patients with blastic plasmacytoid dendritic cell neoplasm: report of three cases.

BackgroundBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is a highly aggressive hematological malignancy with extremely poor outcome. The median overall survival for adult patients is 9-13 months. Pediatric patients are exceedingly rare with an unclear clinical course. Currently, no standardized therapy has been established, although an acute lymphoblastic leukemia type of treatment appears to be more effective in those patients who are able to tolerate aggressive chemotherapy. SL-401 is a targeted therapy directed to CD123, a protein ubiquitously expressed at high level on the surface o

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… Pagano L, Valentini CG, Pulsoni A, Fisogni S, Carluccio P, Mannelli F, Lunghi M, Pica G, Onida F, Cattaneo C, et al. Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation: an Italian multicenter study. Haematologica. 2013;98(2):239–246. doi: 10.3324/haematol.2012.072645. 3. …

Recurrent plasmacytomas after allografting in a patient with multiple myeloma.

Extramedullary recurrence in multiple myeloma patients has been reported after both autologous and allogeneic hematopoietic cell transplantation and, more recently, after treatment with so-called new drugs with potent antimyeloma activity. Only a very few sizable reports focused on its clinical presentation and its incidence, which may be highly underestimated, and most observations are based on single patients reported from several institutions. Given the unusual sites of recurrence, diagnosis may be rather difficult and delayed treatment may play a relevant role in prognosis. Here we report

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… Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Annals of Oncology. 2010;21(2):325–330. doi: 10.1093/annonc/mdp329. 10. …

Microangiopathy in multiple myeloma: a case of carfilzomib-induced secondary thrombotic microangiopathy successfully treated with plasma exchange and complement inhibition.

BACKGROUND: Thrombotic microangiopathy (TMA) is a potentially organ and life-threatening condition affecting patients with multiple myeloma (MM). Cases of proteasome inhibitor-induced TMA and specifically carfilzomib-induced TMA have been rarely reported and standards for diagnostic workup and treatment are not available. CASE PRESENTATION: We describe a case of a male MM patient under salvage therapy including proteasome inhibitor carfilzomib following chemotherapy and autologous stem cell transplantation. The patient then developed acute kidney injury with clinical and laboratory signs of T

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… Casiez C, Pica GM. Bally S [Carfilzomib-induced haemolytic and uremic syndrome: Favorable outcome with eculizumab] Nephrol Ther. 2020;16:221–224. doi: 10.1016/j.nephro.2020.03.006. 21. Bhutani D, Assal A, Mapara MY, Prinzing S, Lentzsch S. …