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Investigational drugs for anxiety in patients with schizophrenia.

INTRODUCTION: Anxiety is a frequent symptom of schizophrenia, which is highly associated with an increased risk of relapse and suicide. The … herapy, beyond benzodiazepines. In these past 2 years, two compounds (the anticonvulsant/anxiolytic pregabalin and the atypical antipsychotic quetiapine) were on Phase III/IV clinical trials for schizophrenia, with comorbid anxiety as a primary outcome measure. Potential for success is high, given their strong rationale and the clinical experience with both …

Towards Restoring Dopaminergic Balance in Fibromyalgia: The Untapped Potential of Nonpharmacological Interventions.

Fibromyalgia (FM) is a chronic syndrome characterized by widespread pain, cognitive dysfunction, and mood disturbances. Growing evidence suggests that dopaminergic dysregulation may play a role in the pathophysiology of FM, linking reduced dopamine function to altered pain perception, anhedonia, fatigue, and impaired cognition. While pharmacological treatments-such as duloxetine, milnacipran, and pregabalin-may influence dopamine only indirectly, dopaminergic agonists like pramipexole have shown partial efficacy. Nonpharmacological interventions, including exercise, mindfulness, cognitive beha…

Marked Improvement in Treatment-Intolerant Obsessive-Compulsive Disorder in an Adolescent Using a Glutamatergic Regimen With Dextromethorphan, Piracetam, and Goldenseal Root.

A 16-year-old boy with severe obsessive-compulsive disorder (OCD), characterized by health-focused obsessions, intrusive ruminations, dereal … 600 mg/day as a botanical CYP2D6 inhibitor to prolong dextromethorphan exposure, alongside low-dose pregabalin, risperidone, and aripiprazole for ancillary support. Within four weeks of adding goldenseal, symptoms markedly improved, meeting remission thresholds: the Patient Health Questionnaire-9 (PHQ-9) score fell to 2, GAD-7 score to 3, obsessive thoughts …

Effectiveness of Gabapentinoids in Neuropathic Pain: A Single-Center Retrospective Study at a Specialized Institution in Mexico.

BACKGROUND/OBJECTIVES: Gabapentinoids are first-line treatments for neuropathic pain (NP); however, real-world evidence regarding their safe … idepressants). Although all patients showed improvement, only 35.8% achieved "maximal improvement." Pregabalin demonstrated faster VAS reduction than gabapentin (p = 0.029), though long-term success was comparable (p = 0.30). Significantly, 100% of patients reported at least one adverse drug event (ADE), primarily somnolence (66.1%), though no serious ADEs o …

Oral use of anxiolytic, sedative, and anaesthetic medications in domestic cats (Felis catus): A scoping review.

This scoping review examined existing research on the oral administration of anxiolytic, sedative, hypnotic, dissociative, and anaesthetic medications in domestic cats, with the aim of identifying agents that could reduce stress, fear, and defensive behaviours during capture and handling. Thirty-seven studies from 1908 to 2024 were included, encompassing domestic cats sourced from pharmaceutical and university research colonies, animal shelters, client-owned and free-roaming semi-owned and unowned cats. Administered drugs included GABA derivatives (gabapentin, pregabalin), serotonin receptor m…

Delayed-Onset Postsurgical Myofascial Pain Following Axillary Artery Cannulation: A Case Report.

Chronic postsurgical pain (CPSP) is often attributed to neuropathic, genetic, or psychosocial factors, whereas musculoskeletal causes, such … onnective tissue. Based on clinical and sonographic findings, MPS was diagnosed. Treatment included pregabalin, ultrasound-guided trigger point injections (TPIs) with levobupivacaine and triamcinolone, and type II pectoral nerve blocks. Five biweekly sessions led to significant pain relief, resolution of allodynia, and improved posture. This case highlights …

Rapid Eye Movement (REM)-Predominant Central Sleep Apnea With Alpha-Delta Sleep Pattern: A Case Report.

Central sleep apnea (CSA) occurring predominantly during rapid eye movement (REM) sleep represents an unusual clinical phenomenon, as CSA typically occurs during non-rapid eye movement (NREM) sleep. We present the case of a 32-year-old male with severe obstructive sleep apnea (OSA), with an apnea-hypopnea index (AHI) of 65.5/hr, who exhibited central apneas mainly during REM sleep (central apnea index: 35.9/hr in REM vs. 5.2/hr in NREM), along with concurrent alpha-delta sleep pattern during slow-wave sleep. The patient was taking tramadol 100 mg and pregabalin 300 mg daily for chronic back pa…

Постгерпестическая брюшная псеводохерния с непризнанными характеристиками мужского превосходства и сопутствующей фатальной виссеральной натуры: доклад по делу и обзор литературы.

Послегерпесная псевдогерния брюшной полости (PHAP) — редкое осложнение, связанное с герпесом зостером (HZ), характеризующееся переходными парезами миотомного ипсиотерана для затронутых сегментальных нервов. Клинически он проявляется как асимптоматическая слабость и выступ брюшной мышцы, имитируя грызун брюшной стенки. Хотя вирус варицелла-зостера (VZV) в первую очередь влияет на сенсорную нервную систему, частотность и прогноз моторного воздействия по-прежнему малоизмеримы. Несмотря на то, что в большинстве случаев ПХАП ограничивает себя благоприятным прогнозом, эта болезнь требует тщательного

Совпадение в аннотации оригинала
Post-herpetic abdominal pseudohernia (PHAP) is a rare complication associated with herpes zoster (HZ), characterized by transient paresis of … nal wall. The segmental hemiparesis was managed successfully with a combined administration of oral pregabalin, a voltage-gated calcium channel inhibitor, and vitamin B12, leading to significant improvement in impaired motor function within two months. We further discuss the current understanding of PHAP with an updated literature review of 94 cases thus far …

Mechanism of gabapentinoid potentiation of opioid effects on cyclic AMP signaling in neuropathic pain.

Over half of spinal cord injury (SCI) patients develop opioid-resistant chronic neuropathic pain. Safer alternatives to opioids for treatment of neuropathic pain are gabapentinoids (e.g., pregabalin and gabapentin). Clinically, gabapentinoids appear to amplify opioid effects, increasing analgesia and overdose-related adverse outcomes, but in vitro proof of this amplification and its mechanism are lacking. We previously showed that after SCI, sensitivity to opioids is reduced by fourfold to sixfold in rat sensory neurons. Here, we demonstrate that after injury, gabapentinoids restore normal sen…

Pharmacological potential of 4-dimethylamino chalcone against acute and neuropathic pain in mice.

OBJECTIVES: This work investigated the acute antinociceptive effect of a synthetic chalcone, 4-dimethylamino chalcone (DMAC), as well as its effects on vincristine-induced peripheral neuropathy (VIPN) in mice. METHODS: The inhibitory activity of myeloperoxidase was assessed by measuring HOCl formation. Formalin and hot plate tests were used to study the acute antinociceptive effect of DMAC. VIPN was induced through the administration of vincristine sulphate (0.1 mg/kg, i.p., 14 days). Then, DMSO, DMAC (10 or 30 mg/kg; i.p.), or pregabalin (10 mg/kg, i.p.) were administered for 14 consecutive …

Superior laryngeal nerve block for treatment of throat pain and cough following laryngeal herpes zoster: A case report.

BACKGROUND: Herpes zoster is caused by reactivation of latent varicella-zoster virus infection within the sensory nerve ganglion of the spin … nd the left supraglottic area. She was prescribed with 750 mg famciclovir a day for 7 d, and 150 mg pregabalin, 100 mg tramadol and 10 mg nortriptyline a day for 67 d. However, despite of these medications, she complained of pain and persistent cough. Therefore, superior laryngeal nerve block under ultrasound guidance was performed. Three days after the inte …

Management of Post-Acute Alcohol Withdrawal: A Mixed-Studies Scoping Review.

OBJECTIVE: This article reviews research on post-acute alcohol withdrawal syndrome (PAWS) management. METHOD: We conducted a PRISMA (Prefer … for negative affect and sleep symptoms, more evidence supports using gabapentinoids (gabapentin and pregabalin) and anticonvulsants (carbamazepine and oxcarbazepine). Although preliminary data support acamprosate, there were no controlled trials. Despite an older treatment trial showing some positive data for amitriptyline for mood, the clinical measures use …

Involvement of Oxidative and Endoplasmic Reticulum Stress in RDH12-Related Retinopathies.

Retinol dehydrogenase 12 (RDH12) is expressed in photoreceptor inner segments and catalyses the reduction of all-trans retinal (atRAL) to al … ducing oxidative and endoplasmic reticulum (ER) stress, with upregulation of sXBP1, CHOP, and ATF4. Pregabalin, a retinal scavenger, attenuated atRAL-induced ER stress in the mutant RDH12 cell lines. A zebrafish rdh12 mutant model (rdh12u533 c.17_23del; p.(Val6AlafsTer5)) was generated through CRISPR-Cas9 gene editing. Mutant fish showed disrupted phagocytos …

Pain Relief in Short-Lasting Unilateral Neuralgiform Headache with Conjunctival inJection and Tearing Syndrome with Intravenous Ketamine: A Case Report.

PURPOSE: Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) is a rare form of primary headache, … , and made a diagnosis of SUNCT based on ICHD-3 beta. Numerous treatments were attempted, including pregabalin, gabapentine, nonsteroidal antiinflammatory drugs, acetaminophen, steroids, antidepressants, triptans, nerve blocks, and intravenous lidocaine with unsatisfactory results. Intravenous administration of ketamine (0.4 mg/kg) for one hour, was found to …

Biomarkers mapping of neuropathic pain in a nerve chronic constriction injury mice model.

Neuropathic pain is caused by a lesion or disease of the somatosensory nervous system and has a considerable impact on the quality of life. Neuropathic pain has a dynamic and complex aetiology and gives heterogeneous symptoms across patients; therefore, it represents an important clinical challenge. Current pharmacological treatment includes tricyclic antidepressant serotonin-noradrenaline uptake inhibitors such as duloxetine, pregabalin, and gabapentin. However, these drugs do not show efficacy in all patients suffering from neuropathic pain. In this work we used a nerve chronic constriction …

Use and safety of antiepileptic drugs in psychiatric inpatients-data from the AMSP study.

The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzn … carbamazepine (CBZ) administration consistently dropped below a rate of 10%. Lamotrigine (LTG) and pregabalin (PGB) increased in relevance after 2005 and 2010, respectively (with administration rates of up to 9%), whereas oxcarbazepine (OXC) was least prevalent (<3%). The mean rates of severe adverse drug reactions (ADRs) ranged from 6 cases per 1000 patien …

Donepezil, an Acetylcholinesterase Inhibitor, Can Attenuate Gabapentinoid-Induced Somnolence in Patients with Neuropathic Pain: A Retrospective Chart Review.

Donepezil, an oral acetylcholinesterase inhibitor, is used to treat Alzheimer's disease and reportedly attenuates opioid-induced sedation in patients with cancer pain. Neuropathic pain is often treated with gabapentinoids (pregabalin, gabapentin), but gabapentinoid-induced somnolence sometimes prevents patients from using these agents. We conducted a retrospective chart review of patients with neuropathic pain to examine whether donepezil is useful for gabapentinoid-induced somnolence. We investigated pain severity in 13 patients before and after taking gabapentinoids and donepezil, the degree…

An update on pharmacotherapy for the treatment of fibromyalgia.

INTRODUCTION: Fibromyalgia is a syndrome characterized by chronic generalized pain in addition to different symptoms such as fatigue, sleep … and none have been approved by the European Medicines Agency. According to the available evidence, pregabalin, duloxetine and milnacipran should be the drugs of choice for the treatment of this disease, followed by amitriptyline and cyclobenzaprine. Other drugs with at least one positive clinical trial include some selective serotonin reuptake inhibitors, m …

Fibromyalgia: disease synopsis, medication cost effectiveness and economic burden.

Fibromyalgia (FM) primarily affects women, and it is increasingly recognized by health care providers as more patients seek assistance for t … and nortriptyline, cyclobenzaprine (a skeletal muscle relaxant), tramadol, duloxetine, milnacipran, pregabalin and gabapentin. Corticosteroids, nonsteroidal anti-inflammatory drugs, benzodiazepines and opioid analgesics, with the exception of tramadol, are not considered efficacious. Medication selection should be individualized and influenced by the severit …