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Improving Diagnostic Accuracy of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Through a Point-of-Care Clinical Algorithm.

Despite the increasing prevalence and median severity of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), medical education on the disease is scant, leading to a diagnostic crisis in which the majority of people with ME/CFS are undiagnosed. We created a care process algorithm in AskMayoExpert accessible to all Mayo Clinic medical providers as a source for information on diagnosis and management of ME/CFS. To evaluate whether the algorithm was associated with improved diagnostic accuracy, we compared concordance before versus after the algorithm was introduced, where concordance was…

Immunosenescence-Driven Hemodynamic Dysregulation and Cognitive Impairment in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Integrative Perspective.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disorder marked by persistent fatigue and cognitive impairments, often termed "brain fog." Emerging evidence suggests that immunosenescence, age- or stress-related deterioration of immune function, plays a pivotal role in the pathogenesis of cognitive dysfunction in ME/CFS. Immunosenescence induces chronic low-grade inflammation (inflammaging); alters T-, NK-, and B-cell function; and promotes the release of senescence-associated secretory phenotype (SASP) factors. These changes are proposed to cerebral blood flow (CBF) r…

Dynamic microclot profiling: thromboelastography advances precision management in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.

Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share overlapping symptoms, and emerging evidence implicates persistent fibrinoid microclots in their pathophysiology, contributing to impaired microcirculation. This review explores the role of microclots and evaluates thromboelastography (TEG) as a potential diagnostic tool. A comprehensive literature review was conducted using major biomedical databases. Studies indicate microclots are prevalent in both conditions. Long COVID patients demonstrate a TEG profile of increased clot strength (maximum amplitude) and reduce…

Elevated serum levels of interleukin-11 and matrix metalloproteinase-9 in myalgic encephalomyelitis/chronic fatigue syndrome.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease of unknown etiology associated with chronic severe fatigue and neurological symptoms, including dizziness, sleep disturbances, cognitive impairment and pain. There are no reliable blood biomarkers available for ME/CFS, possibly due to the lack of specific pathogenesis, even though Epstein-Barr Virus (EBV) has been suspected. We quantified the levels of interleukin-11 (IL-11) in the serum of female ME/CFS patients (n = 40; mean age 51 years) and age- and gender-matched healthy control subjects (n = 38; mean age 43), as wel…

TRIM21 promotes astrocyte-mediated neuroinflammation in experimental autoimmune encephalomyelitis by stabilizing RGMa via K33-linked ubiquitination.

Abnormal astrocytes activation contributes to disease progression in multiple sclerosis (MS), yet the regulatory mechanisms are not fully understood. Here, we found that repulsive guidance molecule a (RGMa) was significantly upregulated in astrocytes in a mouse model of experimental autoimmune encephalomyelitis (EAE). RGMa promoted the release of key inflammatory factors such as C-C motif chemokine ligand 2 (CCL2) from astrocytes. Through protein interaction screening, we identified the E3 ubiquitin ligase, tripartite motif-containing (TRIM) protein 21 (TRIM21), as a interaction protein of RGM…

Chronic Pain Prevalence, Characteristics, and Impact in United States Adults With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

PURPOSE: To determine the prevalence of chronic pain, describe characteristics of chronic pain, and examine the impact of chronic pain on quality-of-life in United States adults with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). DESIGN: Secondary analysis of cross-sectional data from the 2023 National Health Interview Survey. METHODS: Survey weights and variance estimation variables were employed. Pain duration over the past 3 months was used to determine whether individuals with CFS/ME were experiencing chronic pain. Rao-Scott chi-square test examined group-based differences …

Differential Characteristics and Comparison Between Long-COVID Syndrome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Long-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome are disabling diseases characterised by ongoing fatigue, post-exertional malaise, cognitive impairment, and autonomic dysfunction. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome typically follows viral infections, whereas Long-COVID exclusively follows SARS-CoV-2 infection, with overlapping but distinct features. This review uses comprehensive searches of online databases to compare their clinical presentations, pathophysiologies, and treatments. Both Long-COVID and ME/CFS appear to involve multifactorial mechanisms, includi…

Understanding concussion in myalgic encephalomyelitis/chronic fatigue syndrome: Findings from the 2023 National Health Interview study.

BACKGROUND: Although myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) symptoms (dysautonomia, dizziness, balance impairments) may theoretically contribute to an association with concussion, the nature of this association has not been determined. This study explored the association between ME/CFS and concussion, as well as risk factors for concussion, history of recent falls, and feelings of being dizzy or off balance. METHOD: 2023 National Health Interview Survey data were utilized. United States adults (unweighted N = 29,373) responded to items regarding sociodemographic factors, …

Does Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Represent a Poly-Herpesvirus Post-Virus Infectious Disease?

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem illness with unknown etiology. An estimated 17-24 million people representing approximately 1% of the population are afflicted worldwide. In over half of cases, ME/CFS onset is associated with acute "flu-like" symptoms, suggesting a role for viruses. However, no single virus has been identified as the only etiological agent. This may reflect the approach employed or more strongly the central dogma associated with herpesviruses replication, which states that a herpesvirus exists in two states, either lytic…

HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions.

Viral infections have been widely implicated in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) pathogenesis. Recent evidence has also identified certain Human Leukocyte Antigen (HLA) alleles that are significantly associated with ME/CFS risk/protection. Here we tested the hypothesis that ME/CFS risk or protection conferred from those HLA alleles is associated with binding affinity to antigens of HHV viruses, a critical step in initiating the adaptive immune system response to foreign antigens. Specifically, we determined in silico the predicted binding affinity of two susceptibili…

Морронисайд улучшает экспериментальный аутоиммунный энцефаломиэлит, регулируя кишечную микроокружающую среду, иммунный баланс и нейронно-воспалительный путь NF.

Множественный склероз (MS) — хроническое заболевание, характеризующееся обезвоживанием и нейроинфламмацией в центральной нервной системе. Экспериментальный аутоиммунный энцефаломиелит (EAE) — классическая модель животных для MS. Существующие терапевтические препараты для MS имеют такие ограничения, как высокая стоимость, значительные побочные эффекты и неспособность обратить вспять повреждения нервной системы. Морронисайд, как естественный иридоидный гликосид, осуществляет деятельность по борьбе с воспалением и антиоксидантами, однако его терапевтический механизм в MS остается неясным. Моррони

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic disease characterized by demyelination and neuroinflammation in the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is a classic animal model for MS. Existing therapeutic drugs for MS have limitations such as high cost, significant side effects, and the inability to reverse nerve damage. Morronisid…

Фолликулярная регуляционная Т-клетки стимулирует экспериментальный аутоиммунный энцефаломиэлит, поддерживая эгрессию клеток B из микробных центров.

Фолликулярные регуляционные Т клетки (Тфр-клетки) представляют собой поднабор регуляторных Т клеток, имеющих ключевое значение для иммунной реакции в микробных центрах (ГЦ), которые сдерживают производство автоантиорганизмов. Однако их роль в аутоиммунных болезнях, таких, как множественный склероз (MS) и его мусриновая модель, экспериментальный аутоиммунный энцефаломиелит (EAE), который представляет собой нейро-воспалительные заболевания, вызываемые Т и В клетками. Здесь мы оценили периферийные иммунные субпопуляции в двух группах пациентов с MS и обнаружили более высокую частоту циркулировани

Совпадение в аннотации оригинала
Follicular regulatory T cells (Tfr cells) constitute a subset of regulatory T cells pivotal to the immune response in germinal centers (GCs) that inhibit autoantibody production. Their role, however, remains ill-defined in autoimmune diseases like multiple sclerosis (MS) and its murine model, experimental autoimmune encephalomyelitis (EAE), which are neuroin…

Immunomodulatory and neuroprotective effects of miR-146a-enriched MSC-derived extracellular vesicles in experimental autoimmune encephalomyelitis.

BACKGROUND: Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as promising cell-free therapeutics due to their immunomodulatory and reparative properties, especially through microRNAs (miRNAs). This study investigates the therapeutic potential of EVs enriched with miR-146a-EVs, a key regulator of inflammatory signaling, in experimental autoimmune encephalomyelitis (EAE), a murine model of MS. METHODS: Human adipose-derived MSCs (hADSCs) were transfected with miR-146a mimics or miR-control, and their EVs were isolated. After EAE induction in C57BL/6 mice, they were tr…

Терапевтические эффекты пептида, полученного из теломеразы, GV1001 в экспериментальном аутоиммунном энцефаломиэлите: ингибирование нейроинфламмации и поощрение ремиилизации.

GV1001, пептид, полученный из человеческой теломеразы обратной транскрипции, демонстрирует антираковые и антивоспалительные действия, однако его воздействие на экспериментальный аутоиммунный энцефаломиелит (EAE) - установленную мышь модель множественных склероз-резервей неизвестна. В этом исследовании была проведена оценка терапевтического потенциала и механизма GV1001 в EAE. Подкожное управление GV1001 сократило клинические оценки, подстрекательские стенограммы цитокина и патология спинного мозга в мышах EAE. Spinal шнур RNA-seq показал, что GV1001 подавлял иммунный и нейронно-воспалительный

Совпадение в аннотации оригинала
GV1001, a peptide derived from human telomerase reverse transcriptase, exhibits anti-cancer and anti-inflammatory actions, yet its impact on experimental autoimmune encephalomyelitis (EAE)-an established mouse model of multiple sclerosis-remains unknown. This study assessed the therapeutic potential and mechanism of GV1001 in EAE. Subcutaneous administration…