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Right atrial thrombus as a complication of total parenteral nutrition in pregnancy.

BACKGROUND: Right atrial thrombus, a rare but potentially fatal complication of central venous catheter use in total parenteral nutrition, has not been reported during pregnancy. CASE: A pregnant woman with persistent hyperemesis gravidarum developed a right atrial thrombus related to central venous catheter use for total parenteral nutrition. CONCLUSION: Right atrial thrombus can be treated successfully with heparin, leading to its resolution and a normal pregnancy outcome.

Fatal septic complication of transcatheter chemoembolization for hepatocellular carcinoma.

A patient with hepatocellular carcinoma, associated segmental portal vein thrombosis, and accompanying pneumobilia, developed a liver abscess and sepsis following transcatheter chemoembolization (TCE). It was believed that the combination of bile duct necrosis after arterial occlusion and pneumobilia led to ascending enteric infection and seeding of the necrotic tumor, which ultimately led to fatal outcome. We conclude that TCE is contraindicated in such cases.

Spontaneous reduction of growth rate of a large intracranial meningioma. Case report.

A relatively young patient with a large intracranial meningioma producing a paucity of neurological signs and symptoms showed no progression of symptomatology over 14 years. This may represent a spontaneous growth arrest in an otherwise early expected fatal outcome. The location of the tumor with its benign course producing no demonstrable increase in visual loss over 14 years in such a young patient is quite unusual.

Энцефалит кори иммунодефицита.

Описан первый случай энцефалита кори у взрослого человека с поздним началом первичной гипогаммаглобулиной. Этот диагноз был подтвержден исследованием теменной коры при вскрытии электронным микроскопом. Поскольку смертельный исход этого дела мог быть предотвращен с помощью иммуноглобулиновой терапии, мы предлагаем начать такую терапию после диагностики, даже если у пациента были лишь незначительные приступы инфекции.

Совпадение в аннотации оригинала
The first case of measles encephalitis occurring in an adult with late onset primary hypogammaglobulinaemia is described. This diagnosis was confirmed by examination of the parietal cortex at autopsy with the electron microscope. As the fatal outcome of this case might have been prevented with immunoglobulin replacement therapy, we suggest that such therapy …

New forms of neonatal death dwarfism. Report of 3 cases.

The term Lethal Neonatal Dwarfism (Death Dwarfism) denotes bone dysplasias which always have a fatal outcome. Three different cases of "new" forms of death dwarfism are reported. A babygram should be a routine examination in all the cases of stillborn babies or those who die soon after the birth. If then the diagnosis cannot be established microscopic investigations of the growth cartilage should be performed.

[Acute ulcerative colitis associated with cytomegalic inclusion virus in a non-immunodepressed patient (author's transl)].

A new case of acute ulcerative colitis associated with cytomegalic inclusion virus within the colonic wall is reported. Some unusual features are discussed, such as the absent defect in cellular or humoral immunity, the location of the lesion which were limited to the sigmoid colon, and the fatal outcome of the disease. The possible pathogenic relationship between cytomegalic infection and acute a chronic ulcerative colitis are reviewed.

Eczema herpeticum. Treatment with methylene blue and light.

Kaposi varicelliform eruption due to herpes simplex virus (eczema herpeticum) is a serious disease in infants, with occasional fatal outcome. Photoinactivation therapy consisting of local application of methylene blue followed by light exposure resulted in rapid improvement both clinically and virologically. Methylene blue, at a concentration of 10(-5)M was found to be viricidal to herpesvirus in the light but not in the dark.

A critical appraisal of the CURE trial: role of clopidogrel in non-ST-segment elevation acute coronary syndromes.

BACKGROUND: A clinical study, the CURE trial, compared the use of clopidogrel/acetylsalicylic acid (ASA) to ASA alone in 12,562 patients with non-ST-segment elevation acute coronary syndromes (ACS). Results of the trial suggested a possible first-line role for the more expensive combination of clopidogrel/ASA. OBJECTIVE: To perform a critical appraisal of the CURE trial, to determine the efficacy and safety of the clopidogrel/ASA combination in the management of ACS patients and to describe the population most likely to benefit from this combination. METHODS: A critical appraisal of the CURE

Non-fatal Overdose and Associated Factors Among People Who Use Opioids: Findings From a Cross-sectional Study.

People who use opioids (PWUO) face a higher risk of overdose, often resulting in significant morbidity and mortality within this population. Understanding the factors that contribute to non-fatal overdose among PWUO is essential for developing effective prevention strategies. Thus, the present study aimed to report on the history of and factors associated with non-fatal opioid overdose among PWUO. From April to June 2024, 199 adults with a recent history of opioid use were enrolled in a cross-sectional study to evaluate past experiences of non-fatal overdose. Participants self-reported their s

MEDICAL AND SOCIAL ANALYSIS OF PATIENTS WHO DIED OF SARS-COV-2 IN THE SPECIALIZED INFECTIOUS DEPARTMENT OF THE CITY OF SUMY DURING THE FIRST WAVE OF THE EPIDEMIC.

OBJECTIVE: The aim of the article is to analyze demographic indicators, clinical symptoms, concomitant pathology, and the course of acute respiratory viral infection (ARVI) caused by SARS-CoV-2 in patients with a fatal outcome of the disease. PATIENTS AND METHODS: Materials and methods: To achieve the goal, a statistical method, an analytical method, and a method of retrospective analysis of the medical histories of patients with fatal cases who were hospitalized with a diagnosis of ARVI caused by SARS-CoV-2 were used. RESULTS: Results: Mortality among patients who were hospitalized with a d…

Post-stroke cognitive impairment and the risk of stroke recurrence and death in patients with insulin resistance.

OBJECTIVE: Post-stroke cognitive impairment (PSCI) is associated with etiology, severity, and functional outcome of stroke. The risks of recurrent stroke and death in patients with PSCI and insulin resistance (IR) is unknown. The goal of this study was to determine whether global and domain-specific cognitive impairment after stroke in patients with IR was associated with recurrent stroke and death. MATERIALS AND METHODS: We studied patients with recent stroke or transient ischemic attack (TIA) and IR with a baseline Modified Mini-Mental State Examination (3MS) cognitive exam at median of 79

Prognostic value of home blood pressure monitoring in patients under antihypertensive treatment.

The prognostic value of home blood pressure monitoring (HBPM) has been investigated in several studies in the general population, demonstrating its independent association with cardiovascular events. However, in the case of treated hypertensive subjects, evidence is controversial. Our purpose was to evaluate the prognostic value of HBPM in this population. Medicated hypertensive patients who performed a 4-day HBPM (Omron® HEM-705CP-II) between 2008 and 2015 were followed up for a median of 5.9 years, registering the occurrence of a composite primary outcome of fatal and non-fatal cardiovascula

Risk factors for fatal drowning in a Greek region: a retrospective case-control study.

BACKGROUND: Fatal drowning is one of the leading causes of unintentional injury mortality worldwide and a persistent public health concern i … e been previously associated with QT prolongation and other adverse effects which may contribute to fatal outcomes in a seawater environment. In contrast, there was a decreased risk of exposure to dependence-inducing drugs and paracetamol. CONCLUSIONS: Male sex, older age, foreign nationality and cardiovascular disease predisposed individuals to an elevated ri …

Noise as an explanatory factor in work-related fatality reports.

Noise exposure in the workplace is a common reality in Québec, Canada as it is elsewhere. However, the extent to which noise acts as a causa … ive (number and percentages). Noise was explicitly stated as one of the explanatory factors for the fatal outcome in 2.2% (17/788) of the fatal accidents, particularly when the work involved vehicular movement or the need to communicate between workers. Noise was not typically considered a unique cause in the accident, notably because the investigators consider …

A meta-analysis of complications and mortality of extracorporeal membrane oxygenation.

OBJECTIVE: To comprehensively assess published peer-reviewed studies related to extracorporeal membrane oxygenation (ECMO), focusing on outcomes and complications of ECMO in adult patients. DESIGN: Systematic review and meta-analysis. DATA SOURCES: MEDLINE/PubMed was searched for articles on complications and mortality occurring during or after ECMO. DATA EXTRACTION: Included studies had more than 100 patients receiving ECMO and reported in detail fatal or nonfatal complications occurring during or after ECMO. Primary outcome was mortality at the longest follow-up available; secondary outco

Circumstances and witness characteristics associated with overdose fatality.

STUDY OBJECTIVE: Emergency physicians have an opportunity to provide overdose fatality prevention interventions to individuals at risk for experiencing or witnessing an overdose to reduce fatality. The present study uses data about the most recent overdose observed by a sample of inner-city drug users to determine the circumstances of overdose that are associated with overdose fatality. METHODS: Participants (n=690) aged 18 years or older were recruited with targeted street outreach. All participants had used heroin or cocaine in the previous 2 months and had witnessed at least 1 overdose. Su

Metabolic syndrome and left ventricular hypertrophy in the prediction of cardiovascular events: the Strong Heart Study.

BACKGROUND AND AIMS: Metabolic syndrome (MetS) is associated with increased prevalence of echocardiographic LV hypertrophy (LVH), a potent predictor of cardiovascular (CV) outcome. Whether MetS increases risk of CV events independently of presence of LVH has never been investigated. It is also unclear whether LVH predicts CV risk both in the presence and absence of MetS. METHODS AND RESULTS: Participants in the 2nd Strong Heart Study examination without prevalent coronary heart disease, congestive heart failure or renal insufficiency (plasma creatinine >2.5mg/dL) were studied (n=2758; 1746 wo

Temporal trends of case-fatality in patients undergoing dual-injection coronary chronic total occlusion recanalization.

AIMS: Recently, interventional techniques and material to treat chronic total occlusion (CTO) with percutaneous coronary intervention (PCI) have evolved significantly. Nevertheless, it is still unknown whether this progress improved treatment success and patients' outcome. In a nationwide sample, we sought to analyze trends of patients' characteristics, complications and in-hospital case-fatality of patients undergoing CTO revascularization in Germany. METHODS AND RESULTS: We analyzed data on characteristics, treatments, and in-hospital outcomes for all coronary artery disease (CAD) patients

Neglected emergency: Autopsy case report on fatal delirium tremens.

Delirium tremens (DT) is one of the most severe and potentially fatal manifestations of alcohol withdrawal syndrome most often found in individuals with a history of prolonged and heavy alcohol use who suddenly stop. Without prompt intervention, DT may lead to life-threatening complications such as seizures, cardiovascular collapse and autonomic dysfunctions. The importance of understanding DT extends beyond its acute neurological and psychiatric symptoms. From a forensic perspective, autopsy findings can reveal a cascade of underlying physiological derangements. We present an autopsy case rep

Micafungin-induced hemolytic anemia: a case report and investigation of anti-micafungin antibody prevalence.

Micafungin and other echinocandins are commonly used for the prophylaxis and empirical treatment of invasive fungal infections in neutropenic patients due to their broad-spectrum activity and favorable safety profile. Drug-induced hemolytic anemia (DIHA) is a rare condition, and micafungin-related cases are exceptionally uncommon. We describe a fatal case of intravascular hemolysis triggered by re-administration of micafungin in a patient receiving chemotherapy for peripheral T cell lymphoma. The patient experienced convulsions and shock within minutes of infusion of the drug, followed by seve