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Сексуальные отношения с лицами, страдающими расстройством бдительности: обзор.

Целью этого обзора повествования является проведение синтетического обзора современных знаний о взаимосвязи между расстройством гиперактивности (АДХД) и сексуальным функционированием взрослых с уделением особого внимания нейробиологическим механизмам, коморбидным расстройствам и воздействию фармакотерапии. Шесть независимых исследователей провели всеобъемлющий обзор литературы с использованием баз данных PubMed, Scopus и Google Scientist, охватывающих публикации, имеющиеся по состоянию на май 2024 года. Были включены первоначальные исследовательские документы, обзоры и метаанализы на английско

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… One of the main representatives of this group is bupropion, a drug widely used in psychiatry, including in the treatment of depression and nicotine dependence. … At present, the literature does not contain unambiguous case descriptions regarding the influence of bupropion on sexual behaviors in patients treated with this medication. …

Cost-effectiveness of interventions for chronic obstructive pulmonary disease (COPD) using an Ontario policy model.

UNLABELLED: In July 2010, the Medical Advisory Secretariat (MAS) began work on a Chronic Obstructive Pulmonary Disease (COPD) evidentiary fr … ersus usual care (UC). – nicotine replacement therapy (NRT) versus UC. – IC + NRT versus placebo. – bupropion versus placebo; multidisciplinary care (MDC) teams versus UC in moderate to severe COPD in an outpatient setting; pulmonary rehabilitation (PR) versus UC following acute exacerbations in moderate to severe COPD; long-term oxygen therapy (LTOT) versu …

Clinical and Therapeutic Implications of Male Obesity.

The prevalence of obesity, a disorder linked to numerous comorbidities and metabolic complications, has recently increased dramatically worldwide and is highly prevalent in men, even at a young age. Compared to female patients, men with obesity more frequently have delayed diagnosis, higher severity of obesity, increased mortality rate, and only a minority of obese male patients are successfully treated, including with bariatric surgery. The aim of this review was to present the current state of knowledge about the clinical and therapeutic implications of obesity diagnosed in males.

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… Currently, five drugs are approved for weight-reduction therapy (orlistat, naltrexone/bupropion, 3 mg liraglutide, 2.4 mg semaglutide, phentermine/topiramate). … Naltrexone ER/bupropion ER is a combination drug. Bupropion is a neuronal dopamine and norepinephrine reuptake inhibitor and a nicotinic receptor antagonist. It is used alone (that is without naltrexone) in the treatment of depression and nicotine dependency. …

Second-generation antidepressants for treatment of seasonal affective disorder.

BACKGROUND: Seasonal affective disorder (SAD) is a seasonal pattern of recurrent depressive episodes that is often treated with second-gener … five non-randomised studies reported adverse event data on a total of 249 participants who received bupropion, fluoxetine, escitalopram, duloxetine, nefazodone, reboxetine, light therapy, or placebo. We were only able to obtain crude rates of adverse events, therefore caution is advised regarding interpretation of this information. Between 0% and 100% of pa …

Progressive multiple sclerosis: Evaluating current therapies and exploring future treatment strategies.

Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no relapses nor new activity on MRIs. Clinically, neurologic worsening in MS can occur in the relapsing-remitting (RRMS) phase of disease due to incomplete recovery from neuroinflammatory relapses. However, a progressive disease course is the dominant factor related to accumulating disability. There is persistent central nervous system (CNS) compa

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… Depression SSRIs (e.g. sertraline, fluoxetine, citalopram, etc), SNRIs, (e.g. duloxetine, venlafaxine) bupropion, mirtazapine, trazodone Antidepressants are commonly used in MS patients. Gait abnormality Dalfampridine Used to improve walking. … Depression SSRIs (e.g. sertraline, fluoxetine, citalopram, etc), SNRIs, (e.g. duloxetine, venlafaxine) bupropion, mirtazapine, trazodone Antidepressants are commonly used in MS patients. Gait abnormality Dalfampridine Used to improve walking. Drugs used for symptom management in progressive MS. …

Role of trazodone in treatment of major depressive disorder: an update.

Major depressive disorder (MDD) is the most common mood disorder and a leading cause of disability worldwide. Trazodone, a triazolopyridine serotonin receptor antagonist and reuptake inhibitor (SARI) antidepressant approved for major depressive disorder (MDD) in adults, has established efficacy that is comparable to other available antidepressants, and is effective for a range of depression symptoms, including insomnia, which is one of the most common and bothersome symptoms of depression. Also, trazodone's pharmacodynamic properties allow it to avoid the side effects of insomnia, anxiety and

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… classes of antidepressants, including selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, paroxetine, sertraline, citalopram, and escitalopram, serotonin-norepinephrine reuptake inhibitors (SNRIs) like venlafaxine and mirtazapine, inhibitors of norepinephrine and dopamine reuptake (bupropion … Comparison of bupropion and trazodone for the treatment of major depression. J Clin Psychopharmacol. 1994;14:170–179. 54. Sheehan DV, Rozova A, Gossen ER, Gibertini M. …

Sex- and Gender-Related Differences in Obesity: From Pathophysiological Mechanisms to Clinical Implications.

Obesity, primarily characterized by excessive fat accumulation, is a multifactorial chronic disease with an increasing global prevalence. Despite the well-documented epidemiology and significant advances in understanding its pathophysiology and clinical implications, the impact of sex is typically overlooked in obesity research. Worldwide, women have a higher likelihood to become obese compared to men. Although women are offered weight loss interventions more often and at earlier stages than men, they are more vulnerable to psychopathology. Men, on the other hand, are less likely to pursue wei

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… Specifically, 85.5% of naltrexone/bupropion, 82.2% of phentermine/topiramate, and 72.4% of liraglutide prescriptions were given to females [ 133 ]. … Preregistration clinical trials of the combination naltrexone/bupropion and phentermine/topiramate also showed a tendency of higher weight loss in females than males [ 142 ]. …

Оценка и лечение агрессивного сексуального поведения: нынешние ограничения и потенциальные стратегии.

Несмотря на то, что в МКБ-11 была введена соответствующая классификация и симптоматика расстройства сексуального поведения (CSBD) по-прежнему противоречива. В этом обзоре мы изучили историю, эпидемиологический статус-кво, коморбиды, теории нейрофизики, текущие диагнозы и рекомендации по лечению для CSBD. Кроме того, мы подчеркнули недостатки текущих исследований и перспективы будущей работы. Селективные ингибиторы серотонина и налтрексон обычно используются в качестве "немаркированных" наркотиков. Диагностика и лечение пациентов, проходящих курс лечения, должны включать в себя биологические, п

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… Naltrexone: 50–200 mg/d; 15 Patients concurrent use of SSRI or SNRI, two patients additionally bupropion, three patients additionally bupropion and SSRI. Seventeen patients showed significant improvement in CSB symptoms. …

Evaluation and Treatment of Obesity and Its Comorbidities: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity.

The goal of the 8th edition of the Clinical Practice Guidelines for Obesity is to help primary care physician provide safe, effective care to patients with obesity by offering evidence-based recommendations to improve the quality of treatment. The Committee for Clinical Practice Guidelines comprised individuals with multidisciplinary expertise in obesity management. A steering board of seven experts oversaw the entire project. Recommendations were developed as the answers to key questions formulated in patient/problem, intervention, comparison, outcomes (PICO) format. Guidelines underwent mult

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… Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (CORI): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2010;376:595–605. doi: 10.1016/S0140-6736(10)60888-4. 105. … Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes. Diabetes Care. 2013;36:4022–9. doi: 10.2337/dc13-0234. 110. …

Alternative Cancer Therapeutics: Unpatentable Compounds and Their Potential in Oncology.

Cancer remains a leading cause of death globally. Cancer patients often seek alternative therapies in addition to, or instead of, conventional treatments like chemotherapy, radiation, and surgery. The progress in medical advancements and early detection provides more treatment options; however, the development of cancer drugs requires a significant amount of time, demands substantial investments, and results in an overall low percent of regulatory approval. The complex relationship between patent protection and pharmaceutical innovation complicates cancer drug development and contributes to hi

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… Bupropion, a medication primarily known for its application in treating major depressive disorder and as an aid in smoking cessation, was demonstrated to have certain anticancer properties. … Antidepressants (e.g., Bupropion, Duloxetine) | These drugs impact cancer cell growth, death, and spread by affecting serotonin pathways, especially through the 5-HT1A and 5-HT2A/2C receptors. …

Contemporary treatment patterns of overweight and obesity: insights from the Mass General Brigham health care system.

ObjectiveThe objective of this study was to describe the prevalence of obesity, obesity-related conditions (ORCs), and antiobesity medication (AOM) eligibility and prescribing practice among eligible patients in a large health care system.MethodsIn this cross-sectional analysis of the multicenter Mass General Brigham health care system (Boston, Massachusetts) spanning 2018 to 2022, adults eligible for AOMs (BMI ≥ 30 kg/m2 or BMI 27-29.9 kg/m2 with ≥1 ORC) were identified. Among those AOM-eligible, the prevalence of prescriptions for AOMs approved for long-term weight management was evaluated.R

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… Overall, liraglutide 3.0 mg was the most frequently prescribed (45.8%), followed by semaglutide 2.4 mg (34.2%), naltrexone‐bupropion (10.7%), phentermine‐topiramate (6.3%), and orlistat (3.1%) (Table 4 ). … The proportion of naltrexone‐bupropion, phentermine‐topiramate, and orlistat prescriptions was generally similar across BMI categories. …

Multidisciplinary Progress in Obesity Research.

Obesity is a chronic disease that endangers human health. In recent years, the phenomenon of obesity has become more and more common, and it has become a global epidemic. Obesity is closely associated with many adverse metabolic changes and diseases, such as insulin resistance, type 2 diabetes mellitus, coronary heart disease, nervous system diseases and some malignant tumors, which have caused a huge burden on the country's medical finance. In most countries of the world, the incidence of cancer caused by obesity is increasing year on year. Diabetes associated with obesity can lead to seconda

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… There was no difference in the rates of treatment discontinuation due to drug-related adverse events in patients treated with Phentermine/Topiramate, Liraglutide, and Naltrexone-Bupropion. … The combination of Naltrexone-Bupropion may cause chronic drug dependence [ 121 ]. Historically, concerns about the long-term safety of drug therapy for weight loss have limited the clinical use of drugs with significant adrenergic effects or drugs with central appetite-suppressive effects [ 122 ]. …

In Vivo and In Vitro Pharmacokinetic Studies of a Dual Topoisomerase I/II Inhibitor.

Due to high mortality rates, new and more effective drugs are urgently needed in cancer therapy. The novel dual topoisomerase inhibitor P8-D6, a dimethylaminoethyl-substituted pyridophenanthroline, showed in vitro impressive induction of apoptosis in tumors such as ovarian cancer or multiple myeloma compared to the current standard therapy. The purpose of this study was to investigate its in vitro and in vivo pharmacokinetics and to discover further potential drug candidates. Samples of plasma, various tissues, urine, feces, and cell culture supernatants were examined by HPLC. In addition, the

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… However, as some conversions were catalyzed by several enzymes, the conversion rates in HLM increased (e.g., bupropion and diclofenac). 1 IC 50 Values of the CYP Inhibition by P8-D6 a = no inhibition detected. … | (IC 50 in μM) CYP | HLM | CYP isoenzyme Phenacetin (CYP1A2) | 912.5 | 503.1 Bupropion (CYP2B6) | | Amodiaquine (CYP2C8) | 245.5 | 282.1 Diclofenac (CYP2C9) | 162.1 | 71.44 Amitriptyline (CYP2C19) | 148.7 | 792.8 Dextromethorphan (CYP2D6) | 285.0 | 166.1 Testosterone (CYP3A4) | 164.8 | 94.03 Synthesis …

Clinical and Demographic Correlates of Pornography Addiction: A Cross-sectional Study from India.

BACKGROUND: Pornography addiction is a growing public health concern worldwide, with increasing recognition of its prevalence and consequences in India. This study explores the onset, manifestation, and impact of pornography addiction within the Indian context, addressing the need for culturally relevant research. METHOD: A retrospective, observational, cross-sectional study was conducted using data from 589 individuals who sought treatment for pornography addiction through online and offline healthcare platforms. Patients aged 18 and older were included based on the International Classificat

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… Patients were Provided Individualized Treatment Plans Pharmacological treatment, such as selective serotonin reuptake inhibitors (SSRIs: paroxetine, sertraline, fluoxetine) or bupropion, is used to address compulsivity and co-occurring affective symptoms. 15 , 16 Psychotherapy, delivered by qualified … Pharmacological treatment, particularly SSRIs and bupropion, was commonly used and is consistent with prior research on their utility in reducing compulsive sexual behavior and co-occurring affective symptoms. 15 , 16 Psychotherapy was more frequently recommended for younger individuals. …

Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose.

INTRODUCTION: The Clinical Toxicology Recommendations Collaborative was established by three international clinical toxicology societies and … tion of antidysrhythmics (types I and III not discussed specifically), beta-adrenergic antagonists, bupropion, calcium-channel blockers, carbamazepine, cardiac glycosides, chloroquine, cocaine, colchicine, cyanide, dapsone, diphenhydramine, disopyramide, factor Xa inhibitors, ibuprofen, isoniazid, lamotrigine, methotrexate, moclobemide, opioids, organophosp …

[Neurobiology and pharmacotherapy of social phobia].

Social phobia (also known as social anxiety disorder) is still not clearly understood. It was not established as an authentic psychiatric en … c alternatives seem helpful for the management of social phobia, including venlafaxine, gabapentin, bupropion, nefazodone or augmentation with buspirone. Preliminary studies point to promising effects of these agents. Larger controlled clinical trials are now needed to confirm their potential role in the treatment of social phobia.

A geriatrician's approach to managing the complex older adult with obesity.

The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight-loss attempts during the middle years of life. Therefore, weight-loss intervention needs a personalized approach, taking into consideration weight-loss attempts, relapse, and life events, including bariatric surgery, functional limitations, psychosocial status, and current residential environment. Raci

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… Studies have been limited on older adults on naltrexone‐bupropion use, which raises concern on the use of this medication. … glyburide, glipizide, glimepiride, tolbutamide, nateglinide, repaglinide | Metformin, GLP‐1 agonists, GIP/GLP‐1 agonists β‐blockers | Propranolol, metoprolol, atenolol | Carvedilol Antidepressants/antimanic agents | Amitriptyline, mirtazapine, paroxetine, sertraline, citalopram, fluoxetine, lithium | Bupropion …

Neuropathic cancer pain: What we are dealing with? How to manage it?

Cancer pain is a serious health problem, and imposes a great burden on the lives of patients and their families. Pain can be associated with delay in treatment, denial of treatment, or failure of treatment. If the pain is not treated properly it may impair the quality of life. Neuropathic cancer pain (NCP) is one of the most complex phenomena among cancer pain syndromes. NCP may result from direct damage to nerves due to acute diagnostic/therapeutic interventions. Chronic NCP is the result of treatment complications or malignancy itself. Although the reason for pain is different in NCP and non

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… It acts both centrally and peripherally. 119 Bupropion is distinguished from other antidepressants in its efficacy for stimulation in the CNS. It can be used as a first-line drug in patients who are suffering from fatigue or somnolence in addition to NCP. … Double-blind, randomized trial of bupropion SR for the treatment of neuropathic pain. Neurology. 2001;57(9):1583–1588. doi: 10.1212/wnl.57.9.1583. 124. Vadalouca A, Raptis E, Moka E, Zis P, Sykioti P, Siafaka I. …

Interferon-Related Depression: A Primer on Mechanisms, Treatment, and Prevention of a Common Clinical Problem.

BACKGROUND: Depression is among the commonest of psychiatric disorders, and inflammatory mechanisms have been suggested to play a role in its pathophysiology. Interferons are a superfamily of proinflammatory cytokines that play a role in host defence mechanisms. Interferons are used in the treatment of a variety of autoimmune (e.g. multiple sclerosis), viral (e.g. chronic hepatitis B and C), and malignant (e.g. malignant melanoma, hairy cell leukemia) disorders; depression, however, is a notable and clinically troublesome adverse effect. OBJECTIVE: This article seeks to present a simple expla

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… In contrast, some data suggest that bupropion and modafinil may successfully treat neurovegetative symptoms such as insomnia, loss of appetite, and fatigue in the absence of mood and cognitive symptoms [ 28 , 57 ]. … Bupropion for interferon-alpha-induced depression in patients with hepatitis C viral infection: an open-label study. Psychiatry Investig. 2015;12(1):142–145. doi: 10.4306/pi.2015.12.1.142. [http://dx.doi.org/10.4306/pi.2015.12.1.142]. [PMID: 25670957]. 58. …

Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management.

BackgroundObesity or excess body fat is a major global health challenge that has not only been associated with diabetes mellitus and cardiovascular disease but is also a major risk factor for the development of and mortality related to a subgroup of cancer. This review focuses on epidemiology, the relationship between obesity and the risk associated with the development and recurrence of cancer and the management of obesity.MethodsA literature search using PubMed and Google Scholar was performed and the keywords 'obesity' and cancer' were used. The search was limited to research papers publish

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… Other drugs that have shown efficacy in weight reduction include orlistat, the phentermine–topiramine combination, the bupropion–naltrexone combination, benzphetamine, phendimetrazine, and diethylpropion [ 28 ] ( Table 4 ). … nausea, vomiting, and pancreatitis (rare) Liraglutide | GLP1R agonists, decreases appetite and delays gastric emptying and gut motility | 3.0 mg per day subcutaneous injection | 2.6% to 8% | diarrhea, nausea, vomiting, constipation, dyspepsia, abdominal pain, pancreatitis, and gallstones Naltrexone SR/bupropion …