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Bridging the Gap: Pregnancy-And Lactation-Associated Osteoporosis.

Early diagnosis of pregnancy- and lactation-associated osteoporosis (PLO) is mandatory for a good outcome. Standard care is not a matter of conventional guidelines, rather it requires an individualized strategy while true overall incidence and pathogeny remain open issues. This is a narrative review based on full-length English articles, published between January 2021 and March 2023 and accessed via PubMed (no traumatic fractures or secondary osteoporosis are included). Our case-sample-based analysis included 836 females with PLO (the largest cohort based on published cases so far) through 12

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… Climacteric. 2022;25:11–21. doi: 10.1080/13697137.2021.2011197. 6. Nordin B., Roper A. Post-pregnancy osteoporosis; a syndrome? Lancet. 1955;268:431–434. doi: 10.1016/S0140-6736(55)90214-2. 7. Ofluoglu O., Ofluoglu D. … Climacteric. 2022;25:73–80. doi: 10.1080/13697137.2021.1926974. 37. Yang B., Kong L., Hao D. Challenges in the Management of Pregnancy and Lactation Associated Osteoporosis: Literature Review and Retrospective Study. Curr. Stem. …

The "Road" to Malignant Transformation from Endometriosis to Endometriosis-Associated Ovarian Cancers (EAOCs): An mTOR-Centred Review.

Ovarian cancer is an umbrella term covering a number of distinct subtypes. Endometrioid and clear-cell ovarian carcinoma are endometriosis-associated ovarian cancers (EAOCs) frequently arising from ectopic endometrium in the ovary. The mechanistic target of rapamycin (mTOR) is a crucial regulator of cellular homeostasis and is dysregulated in both endometriosis and endometriosis-associated ovarian cancer, potentially favouring carcinogenesis across a spectrum from benign disease with cancer-like characteristics, through an atypical phase, to frank malignancy. In this review, we focus on mTOR d

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… Climacteric. 2018;21:249–255. doi: 10.1080/13697137.2018.1450855. 160. Streuli I., Gaitzsch H., Wenger J.-M., Petignat P. Endometriosis after menopause: Physiopathology and management of an uncommon condition. Climacteric. 2017;20:138–143. doi: 10.1080/13697137.2017.1284781. 161. …

Что делают физиотерапевты в борьбе с недержанием мочи у женщин в системе первичной медико-санитарной помощи?

Недержание мочесодержания, определяемое как недобровольная потеря мочи, широко распространено среди женщин и оказывает значительное воздействие на физическое, эмоциональное и социальное благополучие. Несмотря на широкое признание того, что обучение мускулам тазового пола является первым направлением деятельности для легкого и умеренного УИ, роль физиотерапевтов в лечении этого заболевания в рамках системы первичной медико-санитарной помощи (ПМС) по-прежнему недостаточно изучена. Учитывая центральную роль ПМО в системах здравоохранения и преобладание общих и многопрофессиональных групп в этой с

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… Climacteric. (2019) 22(3):217–22. 10.1080/13697137.2019.1585401 7. Subak LL, Richter HE, Hunskaar S. Obesity and urinary incontinence: epidemiology and clinical research update. J Urol. (2009) 182(6 Suppl):S2–7. 10.1097/JU.0b013e3181b4c3e7 8. …

If It's Not One Thing, It's Another: An Inverse Relationship of Malignancy and Atherosclerotic Disease.

Atherosclerosis and malignancy are pervasive pathological conditions that account for the bulk of morbidity and mortality in developed countries. Our current understanding of the patholobiology of these fundamental disorders suggests that inflammatory processes may differentially affect them; thus, atherosclerosis can be largely driven by inflammation, where as cancer often flourishes as inflammatory responses are modulated. A corollary of this hypothesis is that cancer (or its treatment may significantly attenuate atherosclerotic disease by diminishing host inflammatory response, suggesting p

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… resorption of arterial atheromatous deposits in wasting disease , American Journal of Pathology , 23 ( 5 ): 793 – 804 ( 1947 ). 19970960 PMC1934310 21 Skeijima T , Tanabe A , Maruoka R , Fijishiro N , Yu S , Fujiwara S , et al , Impact of platinum-based chemotherapy on the progression of atherosclerosis , Climacteric …

Genomic Medicine: Lessons Learned From Monogenic and Complex Bone Disorders.

Current genetic studies of monogenic and complex bone diseases have broadened our understanding of disease pathophysiology, highlighting the need for medical interventions and treatments tailored to the characteristics of patients. As genomic research progresses, novel insights into the molecular mechanisms are starting to provide support to clinical decision-making; now offering ample opportunities for disease screening, diagnosis, prognosis and treatment. Drug targets holding mechanisms with genetic support are more likely to be successful. Therefore, implementing genetic information to the

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… Climacteric. ( 2005 ) 8 : 251 – 62 . 10.1080/13697130500118126 16390757 114. Nakamura T Fukunaga M Nakano T Kishimoto H Ito M Hagino H . … Climacteric. ( 2018 ) 21 : 189 – 95 . 10.1080/13697137.2018.1433655 29424257 141. Roux C Briot K The crisis of inadequate treatment in osteoporosis . Lancet Rhumatol . ( 2020 ) 2 : 110 – 9 . 10.1016/S2665-9913(19)30136-5 38263657 142. Arrowsmith J Miller P . …

Molecular-Based Treatment Strategies for Osteoporosis: A Literature Review.

Osteoporosis is an unavoidable public health problem in an aging or aged society. Anti-resorptive agents (calcitonin, estrogen, and selective estrogen-receptor modulators, bisphosphonates, anti-receptor activator of nuclear factor κB ligand antibody along with calcium and vitamin D supplementations) and anabolic agents (parathyroid hormone and related peptide analogs, sclerostin inhibitors) have major roles in current treatment regimens and are used alone or in combination based on the pathological condition. Recent advancements in the molecular understanding of bone metabolism and in bioengin

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… Climacteric. 2015;18:22–31. doi: 10.3109/13697137.2015.1098266. 69. Holick M.F. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin. Proc. 2006;81:353–373. doi: 10.4065/81.3.353. 70. Lips P. … Climacteric. 2018:1–7. doi: 10.1080/13697137.2018.1433655. 138. McClung M.R. Sclerostin antibodies in osteoporosis: Latest evidence and therapeutic potential. Ther. Adv. Musculoskelet. Dis. 2017;9:263–270. doi: 10.1177/1759720X17726744. 139. …

Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper.

IntroductionHormone replacement therapy (HRT) can help women experiencing menopausal symptoms, but usage has declined due to uncertainty around risks of cancer and some cardiovascular diseases (CVD). Moreover, improved cancer survival rates mean that more women who survive cancer go on to experience menopausal symptoms. Understanding these relationships is important so that women and their clinicians can make informed decisions around the risks and benefits of HRT. This study's primary aim is to determine the association between HRT use after cancer diagnosis and the risk of cancer-specific mo

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… Climacteric 2017 ; 20 : 268 – 73 . 10.1080/13697137.2017.1309382 28399661 40 Ganti AK . Another nail in the coffin for hormone-replacement therapy? Lancet 2009 ; 374 : 1217 – 8 . 10.1016/S0140-6736(09)61571-3 19767095 41 Biglia N , Gadducci A , Ponzone R , et al . …

Post-traumatic growth and cancer survivorship: experiences of living with treatment-related impairment.

PurposeIncreased distress has been associated with impairment related to cancer treatment and with post-traumatic growth (PTG), but the influence of treatment-related impairment on PTG has not been explored. This study aimed to understand the lived experience of PTG for cancer survivors living with treatment-related impairment.MethodsHermeneutic phenomenology was used to develop a deep understanding of the lived experience of adult cancer survivors living with ongoing treatment-related impairment who had experienced self-perceived PTG following their cancer experience. Semi-structured individu

Identification of iron metabolism-related predictive markers of endometriosis and endometriosis-relevant ovarian cancer.

Endometriosis is associated with ovarian cancers, mainly endometrioid and clear-cell carcinomas. Iron metabolism has been shown to play a role in endometriosis. Therefore, it is vital to explore the relationship between iron metabolism and ovarian cancer and to identify novel markers for diagnostics and therapeutics. The endometriosis dataset GSE51981 and the ovarian cancer dataset GSE26712 were obtained from the gene expression omnibus database, and differentially expressed genes were identified. Iron metabolism genes were obtained from molecular signatures database, and hub genes from the 3

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… Climacteric. 2021;24:587–92. [11] Kobayashi H, Yamashita Y, Iwase A, et al. The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis. Fertil Steril. 2012;98:415–22.e1. [12] Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7–30. …

Effects of exercise training on circulating levels of Dickkpof-1 and secreted frizzled-related protein-1 in breast cancer survivors: A pilot single-blind randomized controlled trial.

BackgroundWingless and integration site growth factor (Wnt) signaling is a tumorigenesis-related signaling pathway. Dickkpof-1 (DKK1) and secreted frizzled-related protein-1 (SFRP1) are endogenous negative regulators of Wnt/β-catenin signaling. Accumulating evidence indicates that higher serum levels of DKK1 are correlated with poor prognosis of various types of cancer. Here, we investigated whether exercise training causes changes in the serum levels of DKK1 and SFRP1 in patients with breast cancer.MethodsTwenty-four breast cancer survivors, after chemo- or radiotherapy, participated in this

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… Climacteric. 2015;18: 852–858. 10.3109/13697137.2015.1071346 50. Bhandari R, Kelley GA, Hartley TA, Rockett IR. Metabolic syndrome is associated with increased breast cancer risk: a systematic review with meta-analysis. Int J Breast Cancer. 2014;2014: 189384 10.1155/2014/189384 51. …

The Treatment Gap in Osteoporosis.

Worldwide, there are millions of people who have been diagnosed with osteoporosis, a bone disease that increases the risk of fracture due to low bone mineral density and deterioration of bone architecture. In the US alone, there are approximately ten million men and women diagnosed with osteoporosis and this number is still growing. Diagnosis is made by measuring bone mineral density. Medications used for the treatment of osteoporosis are bisphosphonates, denosumab, raloxifene, and teriparatide. Recently, romosozumab has been added as well. In recent years, a number of advances have been made

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… Raloxifene effects on vasomotor and other climacteric symptoms in postmenopausal women. Prim. Care Updat. OB/GYNS. 1998;5:166. doi: 10.1016/S1068-607X(98)00066-3. 44. Cuzick J., Sestak I., Bonanni B., Costantino J.P., Cummings S., DeCensi A., Dowsett M., Forbes J.F., Ford L., LaCroix A.Z., et al. …

Advances in the Study of Denosumab Treatment for Osteoporosis and Sarcopenia in the Chinese Middle-Aged and Elderly Population.

Osteosarcopenia (OS) is a geriatric syndrome characterized by the concurrent presence of osteoporosis and sarcopenia, predominantly affecting the elderly population. Osteoporosis (OP) is a systemic skeletal disorder characterized by decreased bone mass, compromised bone microarchitecture, and heightened bone fragility, substantially elevating fracture risk. Sarcopenia (SP) is defined by decreased muscle mass, strength, and/or functional capacity. Both conditions are age-related degenerative diseases with overlapping pathophysiological mechanisms, commonly co-occurring in elderly individuals an

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… Climacteric . 2022 ; 25 ( 1 ): 88 – 95 . doi: 10.1080/13697137.2021.1951204 34308725 40. Kirk B , Al Saedi A , Duque G . Osteosarcopenia: a case of geroscience . Aging Med . 2019 ; 2 ( 3 ): 147 – 156 . doi: 10.1002/agm2.12080 PMC6880711 31942528 41. Kirk B , Zanker J , Duq G. …

Medication-Related Osteonecrosis of the Jaw (MRONJ): A Review of Pathophysiology, Risk Factors, Preventive Measures and Treatment Strategies.

Medication-related osteonecrosis of the jaw (MRONJ) is a major problem that can occur in people taking certain medications such bisphosphonates and denosumab. It can be used to treat osteoporosis or cancer. Bisphosphonate exposure, dental diseases and procedures, age, sex, anatomical factors, medical issues, and hereditary factors are all variables that enhance the risk of MRONJ. Even though MRONJ and antiresorptive medications have a close association, the pathophysiology of MRONJ is unknown. Careful dental preparation and oral hygiene instructions significantly minimize the risk of osteonecr

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… Climacteric. 2015;18:32–38. doi: 10.3109/13697137.2015.1099092. Bagán J., Blade J., Cozar J.M., Constela M., García Sanz R., Gómez Veiga F., Lahuerta J.J., Lluch A., Massuti B., Morote J. …

Pharmacological Interventions for the Management of Cancer-Related Fatigue Among Cancer Survivors: Systematic Review and Meta-Analysis.

ObjectiveCurrent guidelines have different recommendations on applying pharmacological interventions for managing cancer-related fatigue (CRF) among cancer survivors. This systematic review aims to synthesize clinical evidence on pharmacological interventions for managing CRF.MethodsFive databases were searched for potential randomized controlled trials (RCTs) from their inception until October 2020. RCTs assessing the effect of pharmacological treatments for CRF among cancer survivors were considered eligible. Clinical significance was determined by comparing the estimated effect with that of

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… Climacteric. 2011;14:164-170. 38. Salehifar E, Azimi S, Janbabai G, et al. Efficacy and safety of bupropion in cancer-related fatigue, a randomized double blind placebo controlled clinical trial. BMC Cancer. 2020;20:158. 39. Lawrence JA, Griffin L, Balcueva EP, et al. …

Нейроатомные корреляции пузырьков наполняют: активация симметрии оценки мета-анализа функциональных исследований в области нейронизации.

Ужасная континуальность зависит от сложного взаимодействия между хранением мочи и дезертирством с участием как спинных рефлексов, так и сверхспинных участков мозга для координации добровольного контроля за опорожнением. Несмотря на большое число исследований в области патофизиологии нейрогенного мочевого пузыря и его недержание, меньше известно о центральных корреляциях заполнения мочевого пузыря. Metods ALE (оценка вероятности активации) метаанализа, включая общее число 14 исследования 243 Участники в различных условиях заполнения мочевого пузыря в ходе функционального нейроимации были продем

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… Climacteric. 2019;22:217–222. doi: 10.1080/13697137.2018.1543263. 6. Mahony D.T., Laferte R.O., Blais D.J. Integral storage and voiding reflexes. Neurophysiologic concept of continence and micturition. Urology. 1977;9:95–106. doi: 10.1016/0090-4295(77)90297-7. 7. …

Approach to the Patient With Bone Fracture: Making the First Fracture the Last.

The global burden of osteoporosis and osteoporotic fractures will increase significantly as we enter a rapidly aging population. Osteoporotic fractures lead to increased morbidity, mortality, and risk of subsequent fractures if left untreated. However, studies have shown that the majority of patients who suffer an osteoporotic fracture are not investigated or treated for osteoporosis, leading to an inexcusable "osteoporosis care gap." Systematic and coordinated models of care in secondary fracture prevention known as fracture liaison services (FLS) have been established to streamline and impro

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… Climacteric . 2015 ; 18 ( 6 ): 805 ‐ 812 . 26029985 10.3109/13697137.2015.1045484 20 Lyles KW , Colón-Emeric CS , Magaziner JS , et al; HORIZON Recurrent Fracture Trial . Zoledronic acid and clinical fractures and mortality after hip fracture . …

Oral care and the use of bone-targeted agents in patients with metastatic cancers: A practical guide for dental surgeons and oncologists.

BackgroundBone-targeted agents such as bisphosphonates and the RANKL antibody have revolutionised the care of patients with bone metastases. There has, however been increasing concern about the oral health of these patients and in particular osteonecrosis of the jaw (ONJ), especially with the increasing use of these agents at higher potencies for greater periods of time.MethodsA review of the published data in PubMed and meeting abstracts was performed to examine incidence, risk factors, pathogenesis, clinical course and management of osteonecrosis of the jaw with focus on cancer patients trea

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… Managing bone health with zoledronic acid: a review of randomized clinical study results Climacteric: The Journal of the International Menopause Society 14 2011 321 332 21182431 10.3109/13697137.2010.529966 3 Hegarty A. Georgakopolou E. Porter S. …

Intravenous zoledronic acid for the treatment of osteoporosis: The evidence of its therapeutic effect.

INTRODUCTION: Osteoporosis is a disease characterized by low bone mineral density and poor bone quality resulting in reduced bone strength and increased risk of fracture. Oral bisphosphonates, first-line therapy for most patients with osteoporosis, are associated with suboptimal adherence to therapy due to factors that include a complex dosing regimen and gastrointestinal intolerance in some patients. Intravenous bisphosphonates address these limitations through infrequent injectable dosing that assures 100% bioavailability. Intravenous zoledronic acid is the newest bisphosphonate to be approv

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… MacLennan A Lester S Moore V Oral estrogen replacement therapy versus placebo for hot flushes: a systematic review Climacteric 2001 4 58 74 11379379 25. …

European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

UnlabelledGuidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis.IntroductionThe International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2008. This manuscript updates these in a European setting.MethodsSystematic literature reviews.ResultsThe following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fr

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… In most countries, HRT is only recommended for climacteric symptoms, at a dose as small as possible and for a limited period of time. …

'Bone Health-Across a Woman's Lifespan'.

Despite a high burden of osteoporosis and minimal trauma fractures worldwide, there is still a treatment gap in timely diagnosis and optimal treatment. There is also a lack of international consensus and guidelines on the management of bone fragility in premenopausal women. This review article provides an overview of the current understanding of factors impacting women's bone health across the adult lifespan, as well as dilemmas in the diagnosis, assessment and management of osteoporosis in premenopausal and postmenopausal women, premature ovarian insufficiency and bone health following breast

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… Keshavarz , “ The Global Prevalence of Primary Ovarian Insufficiency and Early Menopause: A Meta‐Analysis ,” Climacteric 22 , no. 4 ( 2019 ): 403 – 411 , 10.1080/13697137.2019.1574738 . 30829083 40 J. S. Finkelstein , S. E. Brockwell , V. …