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Compulsory and voluntary admissions in comparison: A 9-year long observational study.

BACKGROUND: Few studies, so far, have been specifically designed to highlight the features related to Compulsory Admissions (CA) and Voluntary Admissions (VA) in Italian psychiatric emergency wards. AIMS: The main purpose of this observational study was to compare the sociodemographic and clinical characteristics of VA and CA and to explore possible predictors of re-admissions. METHODS: During a 6-month Index Period (February, the 1st-July, the 31st 2008) all psychiatric admissions were documented and then followed-up through all available informatic systems for the next 9 years. RESULTS: O

Identification and Classification of Rare Variants in NPC1 and NPC2 in Quebec.

Niemann-Pick disease type C (NPC) is a treatable autosomal recessive neurodegenerative condition which leads to a variety of progressive manifestations. Despite most cases being diagnosed at a young age, disease prevalence may be underestimated, especially in adults, and interpretation of NPC1 and NPC2 variants can be difficult. This study aims to identify potential pathogenic variants in a large cohort of healthy individuals and classify their risk of pathogenicity to assist with future interpretation of variants. The CARTaGENE (CaG) cohort was used to identify possible variants of NPC1 and N

Prevalence of Clonal Hematopoiesis Mutations in Tumor-Only Clinical Genomic Profiling of Solid Tumors.

IMPORTANCE: Although clonal hematopoiesis (CH) is well described in aging healthy populations, few studies have addressed the practical clinical implications of these alterations in solid-tumor sequencing. OBJECTIVE: To identify and quantify CH-related mutations in patients with solid tumors using matched tumor-blood sequencing, and to establish the proportion that would be misattributed to the tumor based on tumor-only sequencing (unmatched analysis). DESIGN, SETTING, AND PARTICIPANTS: Retrospective analysis of samples from 17 469 patients with solid cancers who underwent prospective clinic

[Hygienic assessment of intraschool environment in rural and urban secondary school institutions].

The purpose of the research is to assess the intra-environment indices in urban and rural secondary schools. In the course of special studie … below the normative values and varied in the range of 0.32-1.3%. It is noted that in the offices of informatics natural light indices are significantly lower than in the classrooms for core subjects. The artificial lighting in urban schools was found to be lower than hygienic standards on the desks by 1.9 times, 2.2 times - at the board. There were obtained s …

Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis.

BACKGROUND: Despite great efforts to improve diagnosis and treatment, tuberculosis (TB) remains a major health problem worldwide, especially in developing countries. Lack of concrete immune markers is still the obstacle to properly evaluate active TB. Therefore, identification of more validated biomarkers and phenotypic signatures is imperative. In particular, T cell-related biomarkers are more significant. METHODOLOGY: To understand the nature of CD4(+) T cell-derived signatures involved in infection and disease development, we examined and analyzed whole genome expression profiles of purifi

Metabolomics tools for identifying biomarkers for neuropsychiatric diseases.

The repertoire of biochemicals (or small molecules) present in cells, tissue, and body fluids is known as the metabolome. Today, clinicians … ication side effects (pharmachometabolomics). State of the art metabolomic analytical platforms and informatics tools are being used to map potential biomarkers for a multitude of disorders including those of the central nervous system (CNS). Indeed, CNS disorders are linked to disturbances in metabolic pathways related to neurotransmitter systems (dopamine, …

Rational Design of Single-Phase High-Entropy Oxides via Large Language Model Data Mining and Explainable Machine Learning.

The rational design of high-entropy oxides (HEOs) is currently hindered by the scarcity of structured property data in the scientific literature. In this work, we present an end-to-end materials informatics framework that couples large language model (LLM) data mining with interpretable machine learning to predict single-phase stability in HEOs. We deployed agents based on gpt-oss-120b to extract compositions, phases, and synthesis methods from unstructured scientific abstracts. Combined with regular-expression routines, the LLM-based agent achieved an accuracy of 96% in database generation de…

Research on fire scenario analysis and emergency response strategies for L-shaped buildings using FDS.

With the rapid development of information and communication technologies, modern fire rescue models are evolving towards informatization, proactivity, and spatialization. Existing fire simulation models primarily focus on the impact of individual building parameters, lacking a systematic analysis of the multi-factor coupling effects on fire spread. As a result, it is difficult to accurately predict the trend of fire spread and meet the demands of dynamic escape routes for three-dimensional rescue systems. In this study, a typical L-shaped building was used as the research object, and a paramet

Computed tomography description of abdominal complications due to fishbone ingestion.

PURPOSE: Inadvertent ingestion of fishbone can lead to bowel perforation. Numerous cases reports have been published; therefore, we aimed to describe the localization and type of complication in a dedicated cohort. MATERIAL AND METHODS: From 2009 to 2023, we queried our local informatic department (Cayenne Hospital, French Guiana) to search electronic patient records (ICD-10 code T18: Foreign body in alimentary tract) and we reviewed each case to identify abdominal complication caused by fishbone ingestion. Patients with complication occurring above the stomach without a computed tomography a

Longitudinal Reliability of Rheumatology Patient Safety Measures and Implications for CMS Case Minimums.

BACKGROUND: Metrics with acceptable reliability are necessary to ensure that quality measures reward performance. Low metric reliability may … inator counts on practice-specific reliability estimates. METHODS: Data came from the Rheumatology Informatics System for Effectiveness (RISE) registry, which passively collects electronic health record (EHR) data. Practice-specific metric reliability was calculated on two safety measures-QPP176 (tuberculosis screening) and ACR10 (hepatitis B screening)-in t …

Приоритизация терапевтических целей воспаления с использованием протеомики, биоинформатики и интерэктомики силикоцитов.

Взаимодействие между протеином и протеином играет ключевую роль в процессе экстравазации лейкоцитов в мозг и является привлекательной терапевтической целью для предотвращения воспаления мозга с помощью блокировки (или нейтрализации) антител. Эти цели включают белково-протеиновое взаимодействие между цитокинами (или хемокинами) и их рецепторами на лейкоцитах и между молекулами сцепления лейкоцита и эндотелием мозга. Хотя в настоящее время в клинике для лечения аутоиммунных и подстрекательских расстройств головного мозга (например, множественный склероз) используется ряд терапевтических средств,

Совпадение в аннотации оригинала
Protein-protein interactions play key roles in leukocyte extravasation process into the brain and have been attractive therapeutic targets f … ions between activated leukocytes and brain endothelial cells using a combination of proteomics, bioinformatics, and in silico interactomics. The result is a prioritized list of protein-protein interactions in a network consisting of leukocyte-brain endothelial cell communication and contacts. These interactions can be further pursued for development of thera …

Artificial intelligence in obstructive sleep apnea: A bibliometric analysis.

OBJECTIVE: To conduct a bibliometric analysis using VOSviewer and Citespace to explore the current applications, trends, and future directio … two most prolific authors. Universidad de Valladolid and the IEEE Journal of Biomedical and Health Informatics were the most productive institution and journal, respectively. The top three authors in terms of co-citation frequency are Hassan, Ar, Young, T, and Vicini, C. "Estimation of the global prevalence and burden of obstructive sleep apnoea: a literatur …

Data-driven hierarchical causal modeling of risk propagation in bridge operations: evidence from 132 accidents in China.

Aging bridges worldwide face growing safety challenges due to extended service life and environmental stressors. However, most existing studies lack a systemic perspective and mainly rely on fragmented, expert-driven assessments. Such approaches fail to capture the interplay of risk factors. This gap in understanding the interactions and propagation of risks limits the development of effective safety strategies for bridge operation. To address this gap, this study aims to identify and structure key risk factors affecting bridge safety in operational contexts by adopting a data-driven hierarchi

Counting the Carbon: Quantifying Financial and Environmental Implications of Wasted Inhaler Doses in the Hospital Setting.

BACKGROUND: Inhalers contribute to health care-related environmental impacts, particularly through greenhouse gas emissions. They are dispen … inhalers remaining unused. METHODS: For this multicentre, retrospective chart review, the pharmacy informatics team generated a report of adult inpatients for whom one or more inhalers were dispensed from the pharmacy to the respiratory and general medicine wards at a 500-bed tertiary hospital or to the medicine-surgery ward at a 48-bed community hospital ov …

Refining a Machine Learning Model for Predicting Infant Sepsis: A Multidisciplinary Team Supported by Human-Centered Design Methods.

Human-centered design (HCD) methods in machine learning generally focus on workflow, user interfaces, and data visualizations, but there is … iew process was conducted by a multidisciplinary team with members having expertise in neonatology, informatics, data science, and human computer interaction (HCI). Anomalies identified via the mockups and interview analysis were further analyzed by inspections of patient charts and model features and code.The HCD-facilitated review revealed anomalies in thre …

Prenatal PM2.5 exposure and hypertensive disorders of pregnancy: a systematic review and meta-analysis.

PURPOSE: This study endeavors to unravel the association between PM2.5 exposure and hypertensive disorders of pregnancy (HDP) via a comprehensive review of epidemiological studies. METHODS: Pertinent studies investigating the association between PM2.5 exposure and HDP were retrieved from PubMed, Embase, Web of Science, and the Cochrane Library until June 20, 2024. In addition, one article was identified through an updated search on September 1, 2025. Our study utilized the Newcastle-Ottawa Scale (NOS) and the Journal of Biomedical Informatics (JBI) scale for eligible study quality assessment.…

Sex Differences in Cystoscopic Findings Among Veterans With Interstitial Cystitis.

PURPOSE: Previous studies have found significant sex differences in symptoms among patients with interstitial cystitis/bladder pain syndrome … al System between October 2004 and July 2016. Patients with IC/BPS were identified from the Veteran Informatics and Computing Infrastructure (VINCI) system using appropriate ICD codes. Patients older than 18 years of age with a confirmed diagnosis of IC/BPS who underwent cystoscopy were included. Rates of cystoscopic findings of ulceration, glomerulation, inf …

Treatment trends after hip fracture of veterans with osteoporosis.

INTRODUCTION: Osteoporosis is the most common metabolic bone disease in the United States. It is often underdiagnosed and undertreated resul … ans aged 65 and older. METHODS: Utilizing the national Department of Veterans Affairs database, VA Informatics and Computing Infrastructure or VINCI, a cohort of patients aged 65 and older with a prior diagnosis of osteoporosis taking bisphosphonates who subsequently had a hip fracture was collected and analyzed. This created a cohort of 46,004 patients. Thi …

Trends in Congenital Syphilis Incidence and Mortality in Brazil's Southeast Region: A Time-Series Analysis (2008-2022).

Congenital syphilis (CS) is an important infectious cause of miscarriage, stillbirth, and neonatal morbidity and mortality. Despite the adva … inas Gerais, Rio de Janeiro, and São Paulo. The data was extracted from the Brazilian Health System Informatics Department. Incidence and mortality rates were calculated per 100,000 live births. Joinpoint regression models were employed to identify trends in annual percentage change and average annual percentage change with 95% confidence intervals. The tempo …

Multi-proteomic analyses of 5xFAD mice reveal new molecular signatures of early-stage Alzheimer's disease.

An early diagnosis of Alzheimer's disease is crucial as treatment efficacy is limited to the early stages. However, the current diagnostic m … esicles of 3- and 6-month-old 5xFAD mice were analyzed using quantitative proteomics. Subsequent bioinformatics and biochemical analyses were performed to compare the molecular signatures between wild type and 5xFAD mice across different brain regions and age groups to elucidate disease pathology. There was a unique signature of significantly altered proteins …