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Augmented Reality-Assisted Training Tool for Mental Health Task-Sharers: Pilot Mixed Methods Usability Study.

BACKGROUND: The growing global mental health (MH) burden, especially in underresourced communities, calls for innovative, scalable, and cult … ility testing protocol included a semistructured prestudy interview, orientation to the AR headset (Magic Leap 2), a think-aloud user testing session, and a poststudy quantitative questionnaire and qualitative interview. Usability was assessed using a modified Post-Study System Usability Questionnaire (PSSUQ), which measures system usefulness, informati …

Impact of transforming growth factor-β2 enriched food for special medical purposes on nutritional status, microbiota and clinical outcomes after allogeneic hematopoietic stem cell transplantation: prospective analysis of 192 consecutive patients.

BACKGROUND AND AIMS: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents an essential treatment for various diseases d … up A exhibited a lower incidence of clinically significant acute graft-versus-host disease (aGVHD) (MAGIC II-IV) (18.4 % in Group A vs. 45.4 % in Group B, p < 0.001), particularly gastrointestinal aGVHD (12.8 % in Group A vs. 42.3 % in Group B, p < 0.001), and a reduced incidence of pneumonia (24.1 % in Group A, vs. 48.1 % in Group B, p < 0.001). Moreov …

Three alkali-metal-gold-gallium systems. Ternary tunnel structures and some problems with poorly ordered cations.

Six new intermetallic compounds have been characterized in the alkali metal (A = Na, Rb, Cs)-gold-gallium systems. Three isostructural compo … e valence electron counts of known representatives of this structure type and, thereby, reveal some magic numbers to guide the search for new isotypic compounds. Theoretical calculation of total energies vs volumes obtained by VASP (Vienna Ab initio Simulation Package) calculations for KAu(3)Ga(2) and RbAu(3)Ga(2) suggest a possible transformation from …

Structural and spectroscopic studies on mercury(II) tribenzylphosphine complexes.

The tribenzylphosphine (PBz3) complexes of mercury(II), [Hg(PBz3)2](BF4)2, [Hg(PBz3)2(NO3)2] and [HgX(NO3)(PBz3)](X = Cl, Br, I and SCN), ha … solid-state NMR spectra of the six tribenzylphosphine mercury(II)-complexes, obtained by combining magic-angle spinning, proton dipolar decoupling and proton-phosphorus cross-polarization (CP-MAS), have been recorded. The spectra of [Hg(PBz3)2](BF4)2 and [HgX(NO3)(PBz3)](X = Cl, Br, I and SCN) exhibit a single line, due to species that contain non-magn …

Sexual Health Determinants During the Life Course and Migration of Haitian-Origin People in French Guiana: Protocol for the Parcours d'Haïti Biographical and Transdisciplinary Study.

BACKGROUND: French Guiana, an overseas territory located in the Guiana Shield in South America, faces unique social and demographic challeng … guage, and financial and mobility issues. The anthropological results are expected to emphasize the magical-religious origins of HIV and the use of plants and traditional medicine for its treatment. Phylogenetic results are anticipated to show a high prevalence of Caribbean B HIV subtypes. CONCLUSIONS: The Parcours d'Haïti study aims to provide valuabl …

Risk. Impact of having a first-degree relative with affective disorder: a 7-year follow-up study.

This study investigated a high-risk sample in order to elucidate risk factors for affective disorder. Healthy monozygotic (MZ) and dizygotic … order to have an impact on prevention. Furthermore, there is a need to move beyond the notion of ''magic bullets'', instead developing an integrated paradigm encompassing clusters of biomarkers related to behavioural measures of developmental psychopathology. Finally, as most psychiatric treatment developed to date target end-state disorders, the ident …

Genetically engineered monoclonal antibodies for direct anti-neoplastic treatment and cancer cell specific delivery of chemotherapeutic agents.

Classical therapeutic modalities such as surgery, radiation, and chemotherapy not only fail to cure the great majority of malignant tumors, but their employment often leads to severe and debilitating side effects. The severe cancer related morbidity is also in direct correlation with the use of x-radiation and chemotherapy, making them less than ideal forms of therapy. The development of hybridoma technology and the advances in monoclonal antibody (MoAB) production have revitalized the initial concept of Ehrlich concerning the existence of cancer cell-targeted, specific "magic bullets". Entire…

Incidence and Impact of Endothelial Dysfunction Events and Veno-Occlusive Disease in Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide: A Retrospective Analysis From the Argentinian Group of Marrow Transplant and Cellular Therapy (GATMO-TC).

Endothelial dysfunction events (EDE) and veno-occlusive disease (VOD) are clinically relevant early complications after hematopoietic stem c … nd posterior reversible encephalopathy syndrome (PRES); acute GvHD (aGvHD) was analyzed separately (MAGIC criteria). VOD cases were re-adjudicated using EBMT criteria as the standard. Disease risk was categorized using the disease risk index (DRI). All patients received ursodeoxycholic acid prophylaxis and PTCy-based GvHD prophylaxis. Cumulative inciden …

Incidence and Role of Recipient-Specific Antibodies in Allogeneic Hematopoietic Cell Transplantation from Mismatched Related Donors.

High titer of donor-specific antibodies (DSAs) increases the risk of graft rejection after mismatched related hematopoietic cell transplanta … nsplantation. We used modified Jodele criteria for TA-TMA diagnosis, and based aGVHD grading on the MAGIC criteria. VOD was assessed using the European Society for Blood and Marrow Transplantation. Anti-HLA antibodies were detected in 12 donors (43%) and in 9 recipients (32%). There were no significant differences between donors and recipients according …

Interventions for treating oral mucositis for patients with cancer receiving treatment.

BACKGROUND: Treatment of cancer is increasingly effective but associated with short and long-term side effects. Oral side effects, including … re not found to be effective: benzydamine HCl, sucralfate, tetrachlorodecaoxide, chlorhexidine and 'magic' (lidocaine solution, diphenhydramine hydrochloride and aluminum hydroxide suspension). Six trials compared the time to heal and mucositis was found to heal more quickly with two interventions: Granulocyte Macrophage-Colony Stimulating Factor when c …

Human cancer detection and immunotherapy with conjugated and non-conjugated monoclonal antibodies.

Classical therapeutic modalities such as surgery, radiation and chemotherapy not only fail to cure the majority of neoplastic disease, but t … production have revitalized the concept concerning the existence of cancer cell-targeted, specific "magic bullets". In addition, a variety of different agents (e.g. toxins, radionuclides, chemotherapeutic drugs) have been conjugated to mouse and human MoABs for selective delivery to cancer cells. Preclinical observations in athymic, nude mice using xeno …

Concluding remarks: Achievements, challenges, and trajectories for high-entropy alloy nanoparticles.

The field of high-entropy alloy nanoparticles (HEA-NPs) had to move and indeed has moved beyond the early enthusiasm of simply "mixing five or more elements and hoping the configurational entropy will do some magic" in terms of chemical and physical properties. What the 2025 Faraday Discussion made clear is that, at the nanoscale, entropy is often a minor player. Phase stability, structure, and functional properties are instead dominated by kinetics, surface reconstruction, defects, segregation, decomposition, and - more often than we like to admit - (unnoticed) interstitial contamination (C, …

Interventions for treating oral mucositis for patients with cancer receiving treatment.

BACKGROUND: Treatment of cancer is increasingly effective but associated with short and long term side effects. Oral side effects, including … re not found to be effective: benzydamine HCl, sucralfate, tetrachlorodecaoxide, chlorhexidine and 'magic' (lidocaine solution, diphenhydramine hydrochloride and aluminum hydroxide suspension). Six trials compared the time to heal and mucositis was found to heal more quickly with two interventions: granulocyte macrophage-colony stimulating factor when c …

Computer aided detection and diagnosis of polyps in adult patients undergoing colonoscopy: a living clinical practice guideline.

CLINICAL QUESTION: In adult patients undergoing colonoscopy for any indication (screening, surveillance, follow-up of positive faecal immuno … nel, including three patient partners, 11 healthcare providers, and seven methodologists, deemed by MAGIC and The BMJ to have no relevant competing interests, developed this recommendation. For this guideline the panel took an individual patient approach. The panel started by defining the clinical question in PICO format, and prioritised outcomes includ …

[Symptoms of DSM IV borderline personality disorder in a nonclinical population of adolescents: study of a series of 35 patients].

1,363 high school students were solicited to complete a personality disorder questionnaire and were encouraged to continue in the study by s … ty disorder were also frequent in this group: 68.6% of the borderline group reported odd beliefs or magical thinking, in particular beliefs in clairvoyance or telepathy and 88.6% reported unusual perceptual experiences, in particular sensing the presence of a force or person and bodily illusions. Moreover, 31.4% of the borderline group reported transien …

Maintenance of Clinical Endpoints After Discharge from a Pharmacist-Managed Risk Reduction Clinic at a Veterans Affairs Medical Center.

BACKGROUND: Diabetes, dyslipidemia, and hypertension are complex chronic disease states that often require close monitoring and frequent fol … y clinic related to the RRC, including the Diabetes PharmD, Diabetes MD, MIDAS (group diabetes), or MAGIC (group dyslipidemia) clinics. Data collection included patient demographics; date of and indication for consultation to the RRC; date of first RRC visit; date of discharge from the RRC; number of visits to the RRC; A1c, LDL, SBP, and weight at consu …

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

BACKGROUND: Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma predispos … ncer Genome Consortium [ICGC] PedBrain, Medulloblastoma Advanced Genomics International Consortium [MAGIC], and the CEFALO series) and from prospective cohorts from four clinical studies (SJMB03, SJMB12, SJYC07, and I-HIT-MED). Whole-genome sequences and exome sequences from blood and tumour samples were analysed for rare damaging germline mutations in …

Ruxolitinib for the treatment of acute graft-versus-host disease: a retrospective analysis.

Steroid-refractory acute graft-versus-host disease (aGvHD) is a serious complication after allogeneic hematopoietic stem cell transplantation, associated with significant mortality. Ruxolitinib was the first drug approved for aGvHD, based on results of the REACH2 trial; however, real-world data are limited. We retrospectively analyzed the safety and efficacy of ruxolitinib for treatment of aGvHD at our center from March 2016 to August 2022 and assessed biomarkers of risk. We identified 49 patients receiving ruxolitinib as second- (33/49), third- (11/49), fourth- (3/49), or fifth-line (2/49) tr

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… The aGvHD grading, recently updated by the MAGIC consortium, and the intensity of immunosuppression (IS) were assessed at the start of ruxolitinib treatment and repeated after 1 week, 1 month, 3 months, and 6 months. … FFS = failure free survival; MAP = MAGIC Algorithm Probability Discussion With an incidence of 30–60% and a mortality rate of 15–30%, aGvHD is a major complication after allo-HSCT [ 3 , 30 , 31 ]. …

Biomarkers for Early Complications of Endothelial Origin After Allogeneic Hematopoietic Stem Cell Transplantation: Do They Have a Potential Clinical Role?

Endothelial cell (EC) dysfunction causes a number of early and life-threatening post hematopoietic stem cell transplant (HCT) complications that result in a rapid clinical decline. The main early complications are graft-vs.-host disease (GVHD), transplant associated thrombotic microangiopathy (TA-TMA), and sinusoidal obstruction syndrome (SOS). Post-HCT endothelial dysfunction occurs as a result of chemotherapy, infections, and allogeneic reactivity. Despite major advances in transplant immunology and improvements in supportive care medicine, these complications represent a major obstacle for

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… Moreover, MAGIC predictive algorithm not only is prognostic for NMR and overall survival, but it can be used as response biomarker for acute GVHD treatment ( 108 ). … At the moment, among the proposed GVHD biomarker panels, MAGIC is the closest to clinical application, as it has been validated and some clinical centers have recently started to use it. …

Recent advances in antiemetics: new formulations of 5HT3-receptor antagonists.

PurposeTo discuss new therapeutic strategies for chemotherapy-induced nausea and vomiting (CINV) involving 5-hydroxytryptamine type 3 (5HT3)-receptor antagonists (RAs).SummaryCINV remains poorly controlled in patients receiving moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC); nausea and delayed-phase CINV (24-120 hours after chemotherapy) are the most difficult to control. National Comprehensive Cancer Network (NCCN) and American Society of Clinical Oncology (ASCO) antiemesis-guideline recommendations for HEC include a four-drug regimen (5HT3 RA, neurokinin 1 [

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… In IV and oral formulations of 5HT 3 RAs, headache is reported more frequently than constipation, but in the MAGIC trial of GERSC, this finding was reversed. … The most common ISR in both trials was bruising, which was higher in the MAGIC trial (GERSC arm 41.9%, ondansetron arm 33.6%) than in the previous Phase III trial (GERSC 10 mg, related 15.6%, unrelated 4.3%; palonosetron 0.25 mg IV, related 6.5%, unrelated 2.6%). 54 , 59 However, if ISRs in the MAGIC …