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Multiple functional therapeutic effects of DL-3-n-butylphthalide in the cuprizone model of demyelination.

AIMS: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). The disease mechanisms driving progressive MS remain unresolved. Without this information, current therapeutic strategies are unsatisfactory in preventing disease progression. Our previous work revealed that DL-3-n-butylphthalide (NBP) treatment reduced demyelination in an ethidium bromide mouse model of demyelination. Here, we examine the effect of NBP in the cuprizone model of demyelination by evaluating the pathologic, functional, and behavioral consequences of treatment with N…

Behind the wheel safety in palliative care: a literature review.

BACKGROUND: Driving is a complex activity that requires physical abilities and adequate executive and cognitive functioning. There is concer … cles were screened. 14 articles satisfied the search criteria. Six studies focused on patients with multiple sclerosis (MS). Four studies investigated driving ability in patients with Huntington's disease. The remaining four articles studied heart failure, chronic obstructive pulmonary disease (COPD), interstitial lung disease and patients with cancer. In the road t …

Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model.

BACKGROUND: In multiple sclerosis (MS), neurodegeneration is the main reason for chronic disability. Alpha-lipoic acid (LA) is a naturally occurring antioxidant which has recently been demonstrated to reduce the rate of brain atrophy in progressive MS. However, it remains uncertain if it is also beneficial in the early, more inflammatory-driven phases. As clinical studies are costly and time consuming, optic neuritis (ON) is often used for investigating neuroprotective or regenerative therapeutics. We aimed to investigate the prospect for success of a clinical ON trial using an experimental au…

Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis.

Angiogenesis, the formation of new vessels, is found in Multiple Sclerosis (MS) demyelinating lesions following Vascular Endothelial Growth Factor (VEGF) release and the production of several other angiogenic molecules. The increased energy demand of inflammatory cuffs and damaged neural cells explains the strong angiogenic response in plaques and surrounding white matter. An angiogenic response has also been documented in an experimental model of MS, experimental allergic encephalomyelitis (EAE), where blood-brain barrier disruption and vascular remodelling appeared in a pre-symptomatic disea…

Chlamydia pneumoniae seropositivity in Iranian patients with multiple sclerosis: a pilot study.

BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. Genetic and environmental factors could not completely explain the pathogenesis of the disease. Among environmental factors, infectious agents are of more interest than other candidates, so Chlamydia pneumoniae (C. pneumoniae) may have a role in MS development or progression. This study aimed to evaluate C. pneumoniae seropositivity in MS patients. MATERIAL AND METHODS: Serum samples obtained from a cohort of 85 patients with MS and from 50 age- and sex-matched controls …

No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset.

OBJECTIVE: An impaired cerebrospinal venous drainage, defined as chronic cerebrospinal venous insufficiency (CCSVI), has been recently hypothesized to be the possible cause of multiple sclerosis (MS). We investigated this hypothesis by studying the occurrence of CCSVI in clinically isolated syndromes (CISs) suggestive of MS. METHODS: Fifty consecutive patients presenting with a CIS and evidence of dissemination in space of the inflammatory lesions (ie, possible MS [pMS]) underwent a detailed diagnostic workup, including extracranial and transcranial venous echo-color Doppler sonography (ECDS-…

Evidence for acute neurotoxicity after chemotherapy.

OBJECTIVE: Chronic neurotoxicity is a recognized long-term complication following chemotherapy in a range of diseases. Neurotoxicity adversely affects patients' quality of life. The objective of this study is to examine whether there is evidence of acute neurotoxicity. METHODS: This prospective study included patients with secondary progressive multiple sclerosis (SPMS-BMT, n = 14) and hematological malignancies (HM-BMT, n = 17) receiving chemotherapy as preconditioning for bone marrow transplant. The control groups included SPMS patients matched for demographic and clinical data (SPMS-PL, n …

Weak electromagnetic fields improve body image perception in patients with multiple sclerosis.

Neuropsychological studies have demonstrated that multiple sclerosis (MS) is associated with various cognitive deficits and it has been suggested that it be considered a form of subcortical dementia. It is now recognized that visuoperceptive and visuomotor deficits commonly occur in MS patients particularly in those with chronic progressive course of the disease. The Human Figure Drawing Test has been employed in the assessment of generalized intellectual deterioration and specifically in the evaluation of visuoperceptive, visuospatial and visuoconstructional abilities in brain injured patient…

Mesenchymal stromal cells and neuroinflammation: a multimodal approach to neuroprotection and future therapeutic horizons.

As the global population ages, neurodegenerative and neuroinflammatory diseases are becoming a rapidly growing public health challenge, with … d neuroinflammatory disorders of the CNS, particularly Alzheimer's disease, Parkinson's disease and multiple sclerosis, a primary autoimmune demyelinating disorder.

Manual federated simulation for multiple sclerosis integrating XGBoost algorithm with SHAP explanation.

Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system, underscoring the importance of early and accurate diagnosis. In this study investigates the predictive modelling of MS progression in patients with Clinically Isolated Syndrome (CIS), privacy-preserving for a federated and explainable Machine Learning (ML) framework. To address missing data while preserving inter-feature dependencies, Multivariate Imputation by Chained Equations (MICE) with iterative imputers was employed. Classification was performed using the Extreme Gradient Boosting (XGBoost) algorithm.…

Глубокое обучение и сетчатка: новая граница в многоклерозном диагностике.

Множественный склероз (MS) — хроническое аутоиммунное заболевание центральной нервной системы, которое приводит к нейродегенерации и функциональным расстройствам. Поскольку последние достижения в области сетчатки сетчатки показали, что сетчатка является неинвазивным окном в мозг, предлагающим ценные биомаркеры для диагностирования и отслеживания прогресса MS, мы изучили интеграцию искусственного интеллекта (AI), особенно глубокого обучения (DL), в анализ таких основанных на фондах методов снимков, как оптическая гармония (OCT), фотография фонда и сканирующая лазерная офтальмоскопия (SLO). Эти

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that leads to neurodegeneration and functional disability. Because recent advances in retinal imaging have revealed that the retina is a non-invasive window into the brain, offering valuable biomarkers for MS diagnosis and progression tracking, we explored the integration o…

Применяемые на основе хлороиндазола эстрогенные рецепторы β лиганды с благоприятными фармакокинетиками способствуют функциональному восстановлению и визуальному восстановлению.

Множественный склероз (MS) — хроническая аутоиммунная, демиелинационная и нейродегенеративная болезнь, приводящая к моторным, визуальным и когнитивным недостаткам. Хотя существующие методы лечения могут замедлить прогресс в области заболеваний, они редко восстанавливают утраченную неврологическую функцию или значительно повышают качество жизни. Эстроген рецептор β (ERβ) стал многообещающей терапевтической целью, поскольку он способен активировать неклассические каналы сигнала, связанные с нейрозащитой, иммунной модуляцией и ремиэлированием. В этом исследовании были выявлены два ERβ-селективных

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune, demyelinating, and neurodegenerative disease that results in motor, visual, and cognitive deficits. While existing treatments can slow disease progression, they rarely restore lost neurological function or significantly enhance quality of life. Estrogen receptor β (ERβ) has emerged as a promising therapeutic t…

У пациентов с множественным склерозом, у которых прогресс не зависит от обратной активности.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Прогресс, не зависящий от рецидива (ИПРА), связан с худшими результатами у людей с множественным склерозом (pwMS). Хотя в ходе предыдущих исследований ПИРА увязывалась с ускоренной атрофией мозга и спинного мозга и разрозненной хронической воспалением, роль дегенерации тракта белых веществ (ВМ) остается неясной. Цель этого исследования заключалась в изучении взаимосвязи между ПИРА и целостностью основных трактов WM с использованием диффузных настольных изображений (DTI). МЕТОДЫ: КРУГ ВИДОВ ДЕЯТЕЛЬНОСТИ 258 ПМС была стратифицирована на основе наличия или отсутствия

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: Progression independent of relapse activity (PIRA) is associated with worse outcomes in people with multiple sclerosis (pwMS). Although previous research has linked PIRA to accelerated brain and spinal cord atrophy and compartmentalized chronic inflammation, the role of white matter (WM) tract degeneration remains unclear. This stu…

Paeoniflorin непосредственно ставит ENO1 перед инхибитом M1 поляризацию микроглий/макропатических и смягчающих болезнь EAE.

В настоящее время хронические аутоиммунные заболевания, связанные с множественным склерозом (MS), остаются неизлечимыми. Паеонифлорин (PF), который представляет собой монотерпеновый глюкосид, полученный из Paeonia lactiflora Pall, признается за нейрозащитные и антивоспалительные свойства. Однако точный механизм, с помощью которого ПФ регулирует НР, является неясным. Эта работа направлена на разъяснение основополагающих механизмов PF в EAE, хорошо зарекомендовавшей себя животной модели MS, и на выявление целевых белков, которые PF действует непосредственно. Наши результаты показали, что управле

Совпадение в аннотации оригинала
The chronic autoimmune disease multiple sclerosis (MS) now remains incurable. Paeoniflorin (PF), which is a monoterpene glucoside obtained from Paeonia lactiflora Pall, is recognized for neuroprotective and anti-inflammatory properties. However, the precise mechanism by which PF regulates MS is unclear. This work aims to elucidate the underlying mechanisms o…

От ожирения до митохондриальной дисфункции в периферальных тканях и в центральной нервной системе.

Ожирение - это состояние хронического низкосортного воспаления, затрагивающего периферийные органы тела, а также центральную нервную систему. Дефункция жировой ткани, возникающая в условиях ожирения, является ключевым фактором возникновения и развития различных заболеваний, включая нейродегенеративные расстройства. Митохондрия, ключевые органеллы в производстве клеточной энергии, играет важную роль в этой дисфункции тканей. В многочисленных исследованиях подчеркивается тесная связь между ожирением и дисфункцией митохондриалов адипоцита, что приводит к чрезмерному производству ROS и воспалению

Совпадение в аннотации оригинала
Obesity is a condition of chronic low-grade inflammation affecting peripheral organs of the body, as well as the central nervous system. The … e development of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, emphasizing the central role played by mitochondria, the main actors in the cross-talk between adipose tissue and the central nervous system.

Parakinesia Brachialis Oscitans in a Patient With a First Manifestation of Multiple Sclerosis.

OBJECTIVES: Parakinesia brachialis oscitans (PBO) is the involuntary movement of an otherwise paretic upper limb triggered by yawning. We describe the first case of PBO in a patient with a first manifestation of tumefactive multiple sclerosis (MS). METHODS: A 35-year-old man presented to the emergency department with a first episode of generalized seizure. Neurologic examination revealed left-sided spastic hemiparesis, predominantly affecting his upper limb. Brain MRI showed a tumefactive right hemisphere lesion consistent with demyelination. CSF did not document unmatched oligoclonal bands. …

Hepatitis C: A Rare Cause of Subacute Paralysis.

The effects of the hepatitis C virus (HCV) on the nervous system have been primarily reported with a pathology of the peripheral nervous sys … ine revealed an intramedullary T2 hyperintense signal at the lower thoracic cord concerning for TM, multiple sclerosis, ischemia, or neoplasm. MRI of the brain was unremarkable. Lumbar puncture results also displayed no abnormalities. HCV screening should be considered in all patients who develop acute neurological deficits that are not otherwise explained, such as …

Involvement of midkine in autoimmune and autoinflammatory diseases.

Midkine (MK) is a heparin-binding growth factor that markedly expressed during embryogenesis but downregulated to inconsiderable levels in h … emic lupus erythematosus (SLE), and Sjögren's syndrome (SS) and other autoimmune conditions such as multiple sclerosis (MS). Additionally, it has been shown that MK is overexpressed in two major clinically defined forms of inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), which are classified as autoinflammatory diseases. Taken tog …

Meningeal and choroid plexus cells--novel drug targets for CNS disorders.

The meninges and choroid plexus perform many functions in the developing and adult human central nervous system (CNS) and are composed of a … in injuries (TBI), brain inflammation following infections, and neurodegenerative disorders such as Multiple Sclerosis (MS) and Alzheimer's disease (AD) and other brain disorders. The choroid plexus regulates the composition of the cerebrospinal fluid (CSF) as well as brain entry of inflammatory cells under basal conditions and after injuries. The meninges and choro …

Preventing and curing multiple sclerosis by controlling Epstein-Barr virus infection.

It has been noted since 1981 that late primary infection with the Epstein-Barr virus (EBV) in adolescence or young adulthood can account for the epidemiology of multiple sclerosis (MS), including the association with higher socio-economic status, the latitudinal variation in prevalence, the effects of migration on the risk of acquiring MS, and the occurrence of clusters and epidemics. Virtually all (>99%) people with MS are EBV seropositive, suggesting that EBV infection is essential for the development of MS. The EBV-infected autoreactive B-cell hypothesis of autoimmunity published in 2003 pr…