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The value of ultrasound with ultrasound-guided fine-needle aspiration biopsy compared to computed tomography in the detection of regional metastases in the clinically negative neck.

PURPOSE: Head and neck oncologists have not reached consensus regarding the role of contemporary imaging techniques in the evaluation of the clinically negative neck in patients with head and neck squamous cell carcinoma (HNSCC). The purpose of the present study was to compare the accuracy of ultrasound with guided fine-needle aspiration biopsy (UGFNAB) and computed tomography (CT) in detecting lymph node metastasis in the clinically negative neck. METHODS AND MATERIALS: Sixty-four neck sides of patients with HNSCC were examined preoperatively by ultrasound/UGFNAB and CT at one of five partic…

Side Effects of Cancer Immunotherapies: Dermatologic and Rheumatologic Toxicities.

Dermatologic and rheumatologic toxicities are frequent adverse events during treatment with immune checkpoint inhibitors in oncology. Timely identification of these events and the referral to the oncologist or dermatologist are important in daily practice, such an organ damage involvements can be severe and sometimes life-threatening. The diagnosis and management of cutaneous toxicities, such as maculopapular rash and bullous dermatitis in particular, must be based on the body surface affected by skin lesions. Corticosteroids are basic treatment in moderate to severe cases. Rheumatologic toxic

Central Hepatectomy in a 6-Month-Old Child with Hepatoblastoma following Chemotherapy.

A hepatoblastoma in a 6-month-old child was initially considered unresectable because of diffuse liver involvement. The patient received 4 courses of cisplatin with an interval time of 2 weeks. A computed tomography scan after 4 courses of chemotherapy showed shrinking of the tumor, which made it resectable, and the tumor was removed by central hepatectomy. The patient was able to eat a regular diet on the fourth day and was sent home on the seventh day, after the operation. The pediatric oncologist followed the patient with liver ultrasonography and alpha-fetoprotein and administered 2 more c

[Cardiovascular, broncho-parenchimal and neoplastic anomalies related to pulmonary sequestration: a critical review.].

The main aim of this critical review on the pulmonary sequestration is to focus the attention of pneumologists, thoracic surgeons and oncologists on some features concerning the heart, vessels, lungs, pleura, diaphragm as well as unusual infections and neoplasms, closely related to such rare disease. The Author emphasizes the importance of these aforementioned peculiarities with reference to the diagnosis timelines as well as to treatment appropriateness. He believes that the new advanced tools to day available makes to achieve this target: it is a must to take in more greater account the rare…

The anesthetic, critical care and surgical challenges in the management of craniopharyngioma.

Among the childhood brain neoplasms, craniopharyngioma constitutes about 2-6% of all primary intracranial tumors. Craniopharyngioma poses a multitude of challenges to the neurosurgeon, endocrinologist, oncologist, intensivist and the anesthesiologist. The morbidity and mortality due to radical surgical treatment is quite high, to the extent of 40-50%. The conservative approach with limited surgical intervention and radiotherapy assistance is taken by some neurosurgeons, but its usefulness is very doubtful. We are reporting a case of craniopharyngioma in an 18-year-old female who had progressiv

Advanced hidradenitis suppurativa presenting with bilateral vulvar masses.

Hidradenitis suppurativa is a chronic suppurative inflammatory disease of the apocrine sweat glands. It is more common in women and involves the genital region in half of all affected patients. An advanced case of hidradenitis suppurativa with bilateral vulvar masses is presented. Possible etiologies of the disease are discussed, as well as strategies for definitive therapy. Because the disease frequently affects the female external genitalia and therapy can require extensive surgical resection and reconstruction, the services of a gynecologic oncologist may be required. Adequate therapy based

Access to Guideline-Concordant Oncology Genomic Testing: A Qualitative Study of Black Cancer Patients and Oncology Providers.

Genomic testing is a key component of precision oncology; however, Black patients receive genomic testing at lower rates. The purpose of thi … d within last 10 years (2014-2023), at least 18 years old, and English-speaking. Providers included oncologists and oncology patient navigators. Topics included motivators, barriers, and knowledge of genomic testing and factors influencing decision-making. The Penchansky and Thomas theoretical framework of healthcare access (e.g., availability, accessibility, …

Normalization of CEA, CA15-3, and CA27-29 Tumor Markers Following Single Lung Transplant in a Patient With a History of Early-Stage Breast Cancer and Idiopathic Pulmonary Fibrosis: A Case Report.

BACKGROUND: The use of serum tumor markers can provide additional information about a patient's response to treatment, but their use has been controversial in the management of breast cancer (BC) because of a lack of standardization. CEA, CA15-3, and CA27-29 are used to monitor disease activity in metastatic BC (MBC), but they have poor sensitivity and specificity in early-stage BC. Some oncologists or lung transplant centers may test these tumor markers to detect potential occult existing malignancy in patients who are eligible for transplant. However, these tests may provide inaccurate resul…

Autonomous motivation and adherence intention in long-term breast cancer treatment: a self-determination theory model.

BACKGROUND: Non-adherence to long-term oral therapies in breast cancer, adjuvant endocrine therapy and oral targeted therapies in metastatic disease, affects 30-50% of patients and is associated with increased recurrence risk or poorer disease control. Socio-economic and clinical determinants are well documented, but the motivational mechanisms linking them to adherence remain insufficiently modelled. METHODS: Cross-sectional observational study in two phases. Adult women with breast cancer treated for ≥6 months were recruited via Seintinelles (France). Phase 1 (n = 89) validated an SDT instr

CTRIAL-IE (ICORG) 15-34: The impact of the 21 gene breast recurrence score® assay on chemotherapy prescribing in oestrogen receptor positive, lymph node positive early stage breast cancer in Ireland.

BACKGROUND: The 21-gene Breast Recurrence Score® (Oncotype DX®) assay has improved the selection of patients for chemotherapy in early breast cancer. Internationally, this test is used in lymph node positive disease, but at the time this study was conducted, it was not reimbursed for this indication in Ireland. AIMS: Determine how access to the Recurrence Score® testing reduces chemotherapy use and quantifies the impact on oncologists' treatment recommendations. METHODS: Between March and September 2017, 75 patients were enrolled in a prospective study across ten hospitals. Eligible patients…

Current Status and Challenges in Pediatric Radiation Therapy in China: A Nationwide Survey.

PURPOSE: This study aims to provide a comprehensive evaluation of the current state of pediatric radiation therapy (RT) in China, identifying key challenges in infrastructure, workforce, and access to advanced technologies while exploring opportunities for improving care delivery. METHODS AND MATERIALS: A 29-item online questionnaire was distributed to radiation oncologists and clinical teams across China, with 123 responses from 103 hospitals. The survey explored six domains: hospital characteristics, radiotherapy equipment and techniques, pediatric oncology staffing, patient admission and t…

Prostate Cancer Patients' Perceptions Regarding the Relevance of a Digital Rectal Examination During Their Follow-Up After Radiation Therapy.

BACKGROUND: Prostate cancer is an example of the undervaluation of clinical examinations in care of patients. After external radiotherapy, cancer recurrence is primarily determined biologically by measuring prostate-specific antigen concentration. Consequently, there is no systematic requirement for the digital rectal examination (DRE). Nevertheless, research has shown that patients attach both practical and symbolic significance to being examined by their physicians. This study aimed to assess how patients perceive DRE omission after prostate cancer radiation therapy. MATERIALS AND METHODS:

Segmental Renal Infarction Associated with Accessory Renal Arteries After Para-Aortic Lymphadenectomy in Gynecologic Malignancies.

Background and Objectives: The causes and clinical outcomes of renal perfusion abnormalities occurring after para-aortic lymphadenectomy (PA … nary function may be limited. Awareness of this potential complication is essential for gynecologic oncologists performing PANDx.

Dizziness and impaired walking balance in aging patients during chemotherapy.

INTRODUCTION: Older adults are at risk of adverse effects during chemotherapy including nausea and fatigue, but many also suffer from dizziness and peripheral neuropathy. This may lead to balance and walking impairments and increased risk of falls and affect health-related quality of life. Moreover, these symptoms are often underreported with inadequate awareness among health professionals leading to deficient focus on the need for targeted assessment and rehabilitation. We aimed to examine the prevalence of dizziness, impaired walking balance, and neuropathy and falls in older adults ≥65 year

Current gaps in emergency medicine core content education for oncologic emergencies: A targeted needs assessment.

ObjectiveThe core content of emergency medicine (EM) residency training includes the management of oncologic emergencies; however, documented knowledge gaps continue to exist in this subtopic. This study represents a targeted needs assessment as indicated by Step 2 of Kern's curriculum design to determine the specific training gaps to be addressed within the oncologic EM curriculum.MethodsA multi-institutional cross-sectional survey of oncologists (surgical and medical) and emergency physicians (attendings and residents) was conducted during 2023 at five institutions. The voluntary survey cons…

Quality of life, psychological distress, and prognostic perceptions in caregivers of patients with multiple myeloma.

Although caregivers of patients with multiple myeloma (MM) play a critical role in supporting their loved ones throughout the illness course, studies examining caregiver quality of life (QOL), psychological distress, and prognostic awareness are lacking. We conducted a cross-sectional, multisite study of patients undergoing treatment with MM and their caregivers. Eligible caregivers were enrolled to 1 of 3 cohorts based on lines of therapy. Caregivers completed validated questionnaires to assess their QOL, psychological distress, and perceptions of prognosis. We enrolled 127 caregivers of pati

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… Caregiver perceptions of patient’s goals of treatment and oncologist’s goals of treatment . … Beliefs about advanced cancer curability in older patients, their caregivers, and oncologists . Oncologist. 2019 ; 24 ( 6 ): e292 - e302 . 31015317 10.1634/theoncologist.2018-0890 PMC6656513 11. Dionne-Odom JN , Ejem D , Wells R , . …

Metastatic Recurrent Breast Cancer Identified in the Chiropractic Office: Case Report and Literature Review.

BACKGROUND Breast cancer is the most common cancer in women and the most common cause of spinal metastasis, and it may recur months to years after treatment. CASE REPORT A 41-year-old woman, recovered from breast cancer, presented to a chiropractor with acute-on-chronic 3-week history of low back pain radiating to the right leg. She had seen 2 providers previously; lumbar spondylosis had been diagnosed via radiography. Given her recent symptom progression and cancer history, the chiropractor ordered lumbar magnetic resonance imaging, revealing L5 vertebral marrow replacement, suggestive of met

Survivorship and the chronic cancer patient: Patterns in treatment-related effects, follow-up care, and use of survivorship care plans.

BACKGROUND: The survivorship needs of patients living with chronic cancer (CC) and their use of survivorship care plans (SCPs) have been overlooked and underappreciated. METHODS: A convenience sample of 39,088 SCPs completed for cancer survivors with an Internet-based SCP tool was examined; it included 5847 CC survivors (15%; CC was defined as chronic leukemia and/or recurrent/metastatic cancer of another nature). Patient-reported treatment effects and follow-up care patterns were compared between CC survivors and survivors treated with curative intent (CI). Responses from a follow-up survey

Symptom Management for Patients With Esophageal Cancer After Esophagectomy.

CASE STUDY KD is a 67-year-old man with a medical history of hypertension, asthma, and a 20-pack/year smoking history who developed progressive dysphagia 8 months ago. Upon consultation with his primary care provider, he underwent an esophagogastroduodenoscopy (EGD) for evaluation. A friable mass was visualized at the gastroesophageal junction, and biopsies confirmed adenocarcinoma of the esophagus. KD completed a staging evaluation with positron-emission tomography/computed tomography (PET/CT), which did not reveal distant metastatic disease. He also had an endoscopic ultrasound (EUS), which

Association of the U.S. Food and Drug Administration Morcellation Warning With Rates of Minimally Invasive Hysterectomy and Myomectomy.

OBJECTIVE: To evaluate whether there was a change in surgical practice immediately after the U.S. Food and Drug Administration (FDA) warning … -gynecologists (ob-gyns) and minimally invasive gynecologic specialists but not urogynecologists or oncologists and a significant decrease in minimally invasive myomectomies by reproductive endocrinologists and minimally invasive gynecologic specialists but not ob-gyns. CONCLUSION: There was a significant decrease in the proportion of minimally invasive hyst …