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Свободный свет о взаимодействии между неврологическими симптомами и психиатрическими эпзодами в множестве склерозов: Новел Гипотез и терапевтические авеню.

Множественный склероз — это хроническое нервно-воспалительное расстройство, при этом различные повреждения центральной нервной системы вызываются в разные моменты времени. Тревожные расстройства и серьезные депрессивные расстройства являются обычным коморбидом множественного склероза. В таких случаях очевидна корреляция между остротой психиатрических приступов и неврологическими симптомами, однако детализированная причинно-следственная связь является неясной. Данные свидетельствуют о том, что дисрегулированные и/или миелин антигенно-реактивные лимфоциты проникают в мозговую ткань, стимулируя п

Совпадение в аннотации оригинала
Multiple sclerosis is a chronic neuroinflammatory disorder, with different central nervous system lesions being induced at distinct time poi … oting inflammatory macrophages/microglia and astrocytes, which induce axonal damage, demyelination, remyelination failure, neuroinflammation, and atrophy of the thalamus, insula, cingulate cortex, hippocampus, amygdala, and dorsolateral prefrontal cortex, accompanied by impaired dorsolateral prefrontal cortex regulation of the related brain regions, at the earl …

S-ketamine facilitates motor function recovery after brachial plexus root avulsion and reimplantation in mice.

BACKGROUND: Brachial plexus root avulsion (BPRA) often occurs in high-speed traffic accidents or shoulder dystocia, resulting in motor dysfu … uron survival, enhanced central and peripheral nervous connectivity, promoted axon regeneration and remyelination, improved the neuromuscular junction integrity, and prevented muscle atrophy. As a result, motor function recovery was significantly improved, which was attributed to increased BDNF production via ERK-CREB phosphorylation. The BDNF receptor antagoni …

Effectiveness of sesame oil and melatonin on P53 level in spinal cord injury of rat menopausal model.

OBJECTIVE: Identifying mechanisms that prevent neuronal inflammation and apoptosis can offer promising approaches to prevent and treat neuro … ly (SC) for 3 weeks. The p53 level was studied by western blotting and real-time PCR. Moreover, the remyelination process was studied using luxol fast blue staining. RESULTS: The animals receiving sesame oil and Mel showed significantly less demyelination and higher GPx-1 levels than the OVX-SCI groups (p < 0.01 and p < 0.05). Additionally, the level of p53 in …

Engineered Extracellular Vesicles Modified by Angiopep-2 Peptide Promote Targeted Repair of Spinal Cord Injury and Brain Inflammation.

Engineered extracellular vesicles play an increasingly important role in the treatment of spinal cord injury. In order to prepare more effec … iments that M-Ang2-EVs can promote microglia/macrophages to phagocytose sphingomyelin, promote axon remyelination and axon elongation, and maintain the integrity of the blood-spinal barrier. Since Ang2 can also target the blood-brain barrier, we found that M-Ang2-EVs can also reduce brain inflammation that results from spinal cord injury. Our study applied the …

Neurotropin alleviates Alzheimer's disease pathology by inhibiting FUS-mediated Calhm2 transcription, blocking the Calhm2/EFhd2 interaction, to improve mitochondrial dysfunction-associated microglia polarization.

Neurotropin, a non-protein extract widely used for the treatment of neuropathic pain, has recently been reported to protect against ischemic brain injury, enhance remyelination in demyelinating diseases, and ameliorate neuroinflammation and memory deficits. However, its role in microglial polarization and mitochondrial dysfunction in Alzheimer's disease (AD) remains poorly understood. In this study, we investigated the therapeutic potential of Neurotropin in the 5xFAD mouse model of AD. Neurotropin administration alleviated cognitive decline, reduced amyloid-β (Aβ) deposition, suppressed neuro…

GLP-1 and the Degenerating Brain: Exploring Mechanistic Insights and Therapeutic Potential.

Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and depression, are marked by progressive … s, inhibit apoptosis, and modulate neuroinflammation. These agents also regulate autophagy, promote remyelination, and reprogram microglial phenotypes toward anti-inflammatory states. Preclinical models have shown that GLP-1RAs reduce amyloid-β and tau pathology in AD, preserve dopaminergic neurons in PD, protect astrocytes and neural progenitors after ischemic …

Paroxetine ameliorates corticosterone-induced myelin damage by promoting the proliferation and differentiation of oligodendrocyte precursor cells.

Depression is frequently associated with demyelination in the prefrontal cortex (PFC), and promoting remyelination can improve neuronal signaling and alleviate depressive symptoms. Paroxetine, a classic selective serotonin reuptake inhibitor (SSRI), is known to exert its antidepressant effects by increasing serotonin levels. However, its potential to alleviate myelin damage in depression remains unclear. A corticosterone (CORT)-induced mouse model of depression was used in this study. Myelin staining and transmission electron microscopy (TEM) were employed to assess myelin damage in the PFC, w…

Amniotic membrane hydrogel as novel injectable platform in combination with metformin for treatment of sciatic nerve injury.

Peripheral nerve tissue engineering is a field that uses cells, growth factors and biological scaffold material to provide a nutritional and … studies, and histological evaluations were performed 14 days after injury. SFI, SSI, latency time, remyelination rate and the expression of NF-200 and S-100β improved in hydrogel group. Response to mechanical stimulus, myelin density, axonal regeneration, and myelin sheath reconstruction improved in the mix group. The gastrocnemius muscle index was significant …

Tomato (Solanum lycopersicum) extract promotes myelin restoration and reduces oxidative stress in cuprizone-induced demyelination in C57BL/6 mice.

This study investigated the neuroprotective potential of tomato extract against cuprizone-induced demyelination. Forty-two C57BL/6 male mice … he CC and reduced neuronal necrosis in the cerebral cortex (p < 0.05). No significant demyelination/remyelination was observed in the LFB-stained spinal cord (p > 0.05). Biochemically, Cup elevated malondialdehyde and protein carbonyl levels while reducing total antioxidant capacity and glutathione levels (p < 0.05). Tomato extract, particularly at 400 mg/kg, s …

Нацеливание на прорастающую микроглию в прогрессивном множественном склерозе: подход, основанный на геронаучной информации.

Множественный склероз (MS) — нервно-воспалительное и нейродегенеративное расстройство центральной нервной системы (КНС). Возраст является самым сильным прогнозом фенотипа заболеваний, при этом большинство пожилых людей переходят к прогрессивной форме, характеризующейся необратимым неврологическим спадом. Эта клиническая прогрессия связана с охлаждением, отсеиванием CNS воспаления и нейродегенерацией, для которых в настоящее время не существует эффективных методов лечения, позволяющих регулировать заболевания. Клеточная сенесцензия, характеризующаяся секрецией посредников, выступающих за воспла

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disorder of the central nervous system (CNS). Age is the strongest pred … of damage. Senescent microglia have been identified within MS lesions, where their SASP may impair remyelination and exacerbate neurodegeneration. Senolytic agents selectively target and eliminate senescent cells by disrupting anti-apoptotic pathways. In experimental autoimmune encephalomyelitis (EAE), a widely used model of MS, senolytic treatment reduces sen …

Guiding Multiple Sclerosis Care: An Update to the 2013 Consensus Statement from the MS in the 21st Century Steering Group.

INTRODUCTION: In 2013, the "MS in the 21st Century" (MS21) initiative established a consensus statement for multiple sclerosis (MS) standard … mes including unmet care needs in ageing PwMS, MS prevention, and treatments for progressive MS and remyelination. The top priority for both HCPs and PwMS/PAG representatives was "access to quick and decisive treatment after diagnosis." CONCLUSION: For PwMS to be unburdened by symptoms, professionals and stakeholders within the MS community should work togethe …

Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: A systematic review.

OBJECTIVE: This systematic review evaluates the therapeutic potential of quercetin (QUE) and resveratrol (RSV) in Alzheimer's disease (AD), … al M1 markers, increased M2/Arg‑1 and astrocytic homeostatic markers), alongside neuronal survival, remyelination markers, and synaptic proteins. Nanoparticle/liposomal formulations of QUE/RSV increased BBB penetration and brain concentrations relative to free compounds. CONCLUSION: QUE and RSV demonstrate significant potential as adjunctive therapies for miti …

Потенциальный потенциал визуального видения, вызывающий запоздалость и амплитуду, является субклиническим прогнозом клинического прогноза в множестве склерозов.

Множественный склероз (MS) является хроническим воспалительным заболеванием центральной нервной системы, характеризующимся поражением мозга, аксонной дисфункцией/дегенерацией и глиозом, что может привести к различным клиническим расстройствам. Визуальный потенциал (ВЭП) представляет собой чувствительные и повторяющиеся методы, способные отслеживать значительные краткосрочные изменения в нейроаксональной целостности и изменения в нервном проводе, вызываемые острым оптическим невритом. АИМ: Цель данного исследования состоит в том, чтобы оценить, могут ли ПВП запоздалость и амплитуда служить в ка

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by focal demyelinating les … valuable candidates for early treatment adjustments and evaluating future pharmacotherapy-supported remyelination.

2-Bromo-1,4-Naphthalenedione promotes CD8+ T cell expansion and limits Th1/Th17 to mitigate experimental autoimmune encephalomyelitis.

Treating Multiple sclerosis (MS), a well-known immune-mediated disease characterized by axonal demyelination, is challenging due to its comp … lination in central nervous system. Furthermore, it was noted that BrQ does not directly affect the remyelination process. Through cell-chat analysis based on bulk RNA-seq data, coupled with validation of flow analysis, we discovered that BrQ significantly promotes the expansion of CD8+ T cells and their interactions with other immune cells in peripheral immune …

Differentiated mesenchymal stem cells-derived exosomes immobilized in decellularized sciatic nerve hydrogels for peripheral nerve repair.

Peripheral nerve injury (PNI) and the limitations of current treatments often result in incomplete sensory and motor function recovery, whic … the dExo-loaded pDNH group significantly improved sensory and motor function recovery and enhanced remyelination compared to dExo and pDNH only groups, highlighting the synergistic regenerative effects. Interestingly, we observed a negative correlation between the number of colony-stimulating factor-1 receptor (CSF-1R) positive cells and the extent of PNI rege …

Increased White Matter Aerobic Glycolysis in Multiple Sclerosis.

OBJECTIVE: Despite treatments which reduce relapses in multiple sclerosis (MS), many patients continue to experience progressive disability accumulation. MS is associated with metabolic disruptions and cerebral metabolic stress predisposes to tissue injury and possibly impaired remyelination. Additionally, myelin homeostasis is metabolically expensive and reliant on glycolysis. We investigated cerebral metabolic changes in MS and when in the disease course they occurred, and assessed their relationship with microstructural changes. METHODS: This study used combined fluorodeoxyglucose (FDG) po…

Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis.

Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by inflammation, demyelination, and neurodegeneration. The ideal MS therapy would both specifically inhibit the underlying autoimmune response and promote repair/regeneration of myelin as well as maintenance of axonal integrity. Currently approved MS therapies consist of non-specific immunosuppressive molecules/antibodies which block activation or CNS homing of autoreactive T cells, but there are no approved therapies for stimulation of remyelination nor maintenance of axonal integrity. In an effort to r…

Forskolin, an Adenylcyclase/cAMP/CREB Signaling Activator Restoring Myelin-Associated Oligodendrocyte Destruction in Experimental Ethidium Bromide Model of Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic neurodegenerative disease marked by oligodendrocyte loss, which results in central neuronal demyelinati … otor deficits and memory and cognitive abnormalities. Following pharmacological treatments improved remyelination by enhancing myelin basic protein and increasing AC, cAMP, and CREB levels in brain homogenates. Furthermore, FSK therapy restored brain mitochondrial-ETC complex enzymes and neurotransmitter levels while decreasing inflammatory cytokines and oxidat …

Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders.

The visual system offers unparalleled precision in the assessment of neuroaxonal damage. With the majority of patients with multiple scleros … visual outcomes over more expensive MRI outcomes. With the next frontier of therapeutics focused on remyelination and neuroprotection, visual outcomes are likely to take center stage. As an international community of collaborative, committed, vision scientists, this review by the International MS Visual System Consortium (IMSVISUAL) outlines the quality standar …

White matter injury in the neonatal hypoxic-ischemic brain and potential therapies targeting microglia.

Neonatal hypoxic-ischemic (H-I) injury, which mainly causes neuronal damage and white matter injury (WMI), is among the predominant causes o … ses. Finally, we discuss current knowledge of strategies aiming to improve microglia modulation and remyelination following neonatal H-I injury. Overall, microglia-targeted therapy might provide novel and valuable insights into the treatment of neonatal H-I insult.