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National Toxic Substances Incidents Program - Nine States, 2010-2014.

PROBLEM/CONDITION: Every year in the United States, thousands of toxic substance incidents harm workers, first responders, and the public wi … effort with a variety of stakeholders including industry and labor, responder groups, policymakers, academia, and citizen advocacy groups.

Clinical burden of dry eye disease in patients with ocular graft versus host disease.

BACKGROUND: Ocular graft-versus-host disease (oGVHD) is a frequent complication after hematopoietic stem cell transplant, with dry eye being the most common presentation. Patient experience with dry eye from oGVHD may negatively affect quality of life. The purpose of this study was to evaluate patients' perspectives on the symptoms, treatments, and care burdens associated with dry eye from oGVHD. MATERIALS AND METHODS: An electronic questionnaire was sent to patients with dry eye asking about their diagnoses, symptoms, treatments, and experiences associated with dry eye. RESULTS: Of the 639

Nirogacestat-the pathway to approval of the first treatment for desmoid tumors, a rare disease.

Drug development for rare diseases can be long, complex, and costly. Desmoid tumors (DT), a rare type of soft-tissue tumor, are associated with substantial and debilitating burden, including disease-specific symptoms (e.g., pain, impaired mobility), reduce functioning for daily activities, and worsen quality of life for patients with this condition. These tumors can be potentially life-threatening when they invade surrounding tissues, affect vital structures, or interfere with the body's functions. Until recently, there were no approved treatments specific to DT and little alignment on disease

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… In this review, we detail the real-world clinical development journey of nirogacestat, the first therapy specifically indicated to treat adults with progressing DT. 14 , 33 We highlight how collaborations among academia, industry, and patient advocacy groups overcame critical challenges, uncertainties … Ultimately, as awareness of these meetings spread, DT clinicians and researchers in academia voiced their support. …

Fluid intake in term and preterm infants exposed to maternal diabetes.

INTRODUCTION: Diabetes (DM) in pregnancy is associated with obesity and cardiometabolic abnormalities in childhood. Our prior work has shown that preterm infants exposed to DM in pregnancy have differences in early growth trajectory compared with preterm infants not exposed to DM. The influence of early nutrition on growth patterns in preterm infants exposed to DM in pregnancy is not known. The objective of this study was to examine the influence of DM in pregnancy on early total fluid intake (TFI) and weight change during newborn hospitalization. MATERIALS AND METHODS: In a prospective cohor

Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy.

High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and development have led to a growing interest in repurposing "old" drugs to treat both common and rare diseases, particularly cancer. Cancer, a complex and heterogeneous disease, often necessitates a combination of different treatment modalities to achieve optimal outcomes. The intrinsic polygenicity of cancer, intricate biological signalling networks, and feedback loops make the inhibition of a single target frequently insufficient for achieving the desired therapeutic impact. As a result, addressing these c

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… Collaborations between academia and pharmaceutical industry are therefore becoming increasingly attractive for drug repurposing projects, as they can help to ameliorate profit-driven limitations of pharmaceutical companies inbuilt into their business model, as well as offer academia expertise in the … In the USA, a collaboration between academia, the pharmaceutical industry, and national institutes of health made 58 failed compounds available to academia for repurposing [ 22 ]. …

Editorial: Towards continued and affordable accessibility of innovative drugs: sustainable development and efficient use of medicines.

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… Overall, academia-driven drug development could be instrumental in guiding novel public-private partnerships towards more affordable therapies. 6 Repurposing precision medicine in oncology Drug repurposing uses approved medicines for new indications, offering alternative treatments or addressing unmet … Advancing academia-driven treatment optimisation in oncology: launch of the EMA cancer medicines Forum. Eur. J. Cancer 168, 77–79. 10.1016/j.ejca.2022.03.025 Smale E. M., van den Bemt B. J. F., Heerdink E. R., Desar I. M. E., Egberts T. C. G., Bekker C. L., et al. (2023). …

Nanotherapeutics in the EU: an overview on current state and future directions.

The application of nanotechnology in areas of drug delivery and therapy (ie, nanotherapeutics) is envisioned to have a great impact on public health. The ability of nanotherapeutics to provide targeted drug delivery, improve drug solubility, extend drug half-life, improve a drug's therapeutic index, and reduce a drug's immunogenicity has resulted in the potential to revolutionize the treatment of many diseases. In this paper, we review the liposome-, nanocrystal-, virosome-, polymer therapeutic-, nanoemulsion-, and nanoparticle-based approaches to nanotherapeutics, which represent the most suc

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… Successful translation of research from academia to production lines has been identified as one of the major challenges in nanotherapeutic development. … The key to success is an interdisciplinary and open-minded approach complemented with the partnership and knowledge exchange between academia, industry, and regulatory agencies. …

Guía de práctica clínica mexicana para el diagnóstico y tratamiento de las dislipidemias y enfermedad cardiovascular aterosclerótica.

ANTECEDENTES: Las enfermedades cardiovasculares son la principal causa mundial de mortalidad y México no es la excepción. Los datos epidemio … Cirugía Vascular y Endovenosa, A.C., Instituto Mexicano de Investigaciones Nefrológicas, A.C. y la Academia Mexicana de Neurología, A.C.; con el apoyo metodológico de la Agencia Iberoamericana de Desarrollo y Evaluación de Tecnologías en Salud, con la finalidad de establecer recomendaciones basadas en la mejor evidencia disponible y consensuadas por un gr …

Precision Oncology Clinical Trials: A Systematic Review of Phase II Clinical Trials with Biomarker-Driven, Adaptive Design.

Novel clinical trial designs are conducted in the precision medicine era. This study aimed to evaluate biomarker-driven, adaptive phase II trials in precision oncology, focusing on infrastructure, efficacy, and safety. We systematically reviewed and analyzed the target studies. EMBASE and PubMed searches from 2015 to 2023 generated 29 eligible trials. Data extraction included infrastructure, biomarker screening methodologies, efficacy, and safety profiles. Government agencies, cancer hospitals, and academic societies with accumulated experiences led investigator-initiated precision oncology cl

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… The novel clinical trial designs, such as umbrella, basket, and platform trials, were initially commenced by cancer centers and/or research centers, such as MDACC, and quickly gained traction with government, academia, and pharmaceutical companies. … Our analysis demonstrates that governmental agencies and/or academia/cancer clinical study groups have taken a leading role in the initiation of POCTs since the early 2010s in the form of IIT with the support of experimental drugs from pharmaceutical companies. …

Адаптация эукариот-подобных PRS к прокариот-подобным tRNAPro.

Синтеты Проли-ТРНА (ПРОРС) уникальны среди аминоачил-тРНК (ААРС) two различные структурные архитектуры различных организмов: прокариота-подобные (П-тип) и эукариоте/археон-подобные (Е-тип). Интересно, что Бакиллус Тюрингьенси гавань обоих типов, сосуществует P-тип (BtProRS1) и E-тип PRS (BtProRS2). Несмотря на свои различия, оба фермента формально выражаются и функционируют в vivo. По аналогии с BtProRS1, BtPRS2 выборочно заряжает TRNAPro типа P и демонстрирует более высокий допуск к галоугинону, чем каноническая PRS. Однако эти two Изозимы признают основные идентификационные элементы типа P t

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… Supplementary Material Acknowledgements We thank See-Yeun Ting of Academia Sinica and Nguyen Viet Khang of NCU for technical assistance. … Mass spectrometry data were acquired at the Academia Sinica Common Mass Spectrometry Facilities for Proteomics and Protein Modification Analysis located at the Institute of Biological Chemistry, Academia Sinica, supported by Academia Sinica Core Facility and Innovative Instrument Project (AS-CFII-111 …

FUNCTIONAL DISORDERS OF THE TEMPOROMANDIBULAR JOINTS AS A FACTOR RESPONSIBLE FOR SLEEP APNOEA.

INTRODUCTION: Functional disorders of the temporomandibular joints (TMJ) in the contemporary population are considered by World Health Organization to be the third most frequent dental disease after caries and periodontitis. It is thought to affect 84% of the adult population. In patients aged 65 years and older these disorders become more severe and may affect up to 100% of this age group. MATERIAL AND METHOD: We examined 150 patients aged 35-70 years (mean age 46.5 years). All patients were diagnosed in 2006-2010 at the Department of Dental Prosthetics of the Pomeranian Medical University i

A COMPARISON OF EFECTIVENESS, AND AN ASSESSMENT OF THE QUALITY OF LIFE OF PATIENTS AFTER LAPAROSCOPIC SLEEVE GASTRECTOMY AND ROUX-EN-Y GASTRIC BYPASS.

INTRODUCTION: Morbid obesity is nowadays one of the major problems of well developed countries. Treatment of this disease comprises many modalities, but the most successful are surgical ones. With the advent of laparoscopic operations it became clear that these are particularly useful for operation in obese patients due to their minimal invasiveness. The aim of the study was to compare the effectiveness and quality of life of patients operated on for morbid obesity by laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric by-pass (LRYGB) by one surgeon in one surgical centre.

[Cellulite - causes, prevention, treatment ].

Cellulite is a multifactorial etiology ailment. It changes the skin topography by the formation of the skin surface's appearance, changes described as "orange peel". This prob- lem concerns 85-98% of women, and for them it is one of the most intolerable aesthetic imperfections. In the past few years the interest of scientists in this problem has clearly increased. Several theories on the pathophysiology of cel- lulite have been produced A number of different thera- peutic regimens have been developed using modern tech- nology. However, despite the many treatment options for cellulite, it is ex

[ACNE VULGARIS--AETIOLOGY, CLASSIFICATION, TREATMENT].

A spotless skin is a rarity. Both women and men have different problems related to the complexion. One of the most common problems is acne, which affects an increasing number of people of all ages. Seborrhea skin areas rich in sebaceous glands, the formation of comedones, inflammation, and scars are characteristic for this disease. The aim of the study was to discuss the causes of acne vulgaris, methods of treatment, and proper care of the skin affected by this problem.

[Transverse abdominal plane - anatomical and clinical aspects].

In medicine spectacular progress can be observed at many stages, which sometimes requires the redefinition of already known anatomical structures. One of them is the transverse abdominal plane, which was the focus of anaesthetists. It was observed that anaesthetics introduced locally into this plane have similar power to a traditional epidural procedure or spinal anaesthesia. The concept of the trans- verse abdominal plane is a relatively new anatomical term which was introduced into clinical medicine by anaesthetists. Because of the potential performance of anaesthetic pro- cedures through ac

[ASSOCIATION OF ANTERIOR AND POSTERIOR URETHRAL VALVES. IS IT POSSIBLE TO RECOGNIZE THIS ASSOCIATION IN CLINICAL SIGNS AND RADIOLOGICAL EXAMINATIONS?].

We present a rare association of anterior and posterior urethral valves. A 5 days-old boy was admitted because of clinical presenation of lower urinary tract obstruction. A renal ultrasound and voiding cysto-urethrography revealed obstructive pathology in anterior urethra. On endoscopy an association of anterior and posterior urethral valves was recognized, and the valves were incised. Follow-up demonstrated improvement of preoperative signs. We try to recognize an association of anterior and posterior urethral valves in radiological examinations.

[Pregnancy in a rudimentary horn of the uterus].

Pregnancy in a rudimentary horn of the uterus, a rare form of ectopic pregnancy, develops in women affected by developmental abnormalities of the growth and fusion of the Müllerian paramesonephric ducts. In the Polish population, this problem affects 4-8 women per year. The paper analyzes the problems that are associated with pregnancy developing in the rudimentary horn. Due to the continuous progress in medical sciences, maternal mortality has been almost completely eliminated in this form of ectopic pregnancy, while neonatal survival has risen to about 20%. Further devel- opments in medicine

[AN ANALYSIS OF THE INDICATIONS FOR, AND ASSESSMENT OF THE OUTCOMES OF SECONDARY SURGERY AFTER PRIMARY REPAIR OF INJURIES WITHIN THE UPPER LIMB].

INTRODUCTION: The objective of the study was the analysis of the indications for, and assessment of the outcomes of secondary interventions after primary repair of injuries within the upper limb in the authors' institution--Department of General and Hand Surgery of the Pomeranian Medical University in Szczecin (a tertiary care unit). MATERIAL AND METHODS: Answers on questionnaires (including DASH) mailed to 33 patients were the subject of the analysis. The group consisted of 27 men and 6 women, mean age 36 years, in whom secondary interventions were performed at a mean of 8 months after prima

[Blastocystis hominis- parasites or commensals? ].

Blastocystis hominis (B. hominis) is a cosmopolitan pro- tozoa which parasitizes the human large intestine. This parasite had been considered to be commensal of the large intestine for a long time, because even an intense invasion may be asymptomatic. However, this species is now being regarded as a parasitic organism. In this paper the latest data concerning the epidemiology, diagnostics and treatment of B. hominis invasion have been cited and discussed.

[Evaluation of physical fitness in children of pre-school age including postural problems].

BACKGROUND: Pre-school age is a period of intensive development when children shape their posture, habits and motor memory. In recent years an increased incidence of postural problems has been observed among children and adolescents. This process results from civilisation progress and sedentary life style. Most of the early-detected abnormalities are of a functional nature and are relatively easy to correct. However, if no preventive measures are taken, deformities of bones and joints may develop which are difficult to treat and result in serious health disorders. The aim of our study was to e