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Bone health in cancer: perspective on the use of osteoanabolic agents.

Cancer negatively impacts bone health through various mechanisms, including treatment-induced bone loss and malignant bone lesions, often leading to increased fracture risk and higher morbidity and mortality. Antiresorptive agents (bisphosphonates and denosumab) are the current standard of care to reduce the risk of skeletal-related events and prevent treatment-related fragility fractures in patients with cancer. While there is strong evidence to support their benefits in cancer, there is potential room for further reduction in the risk of pathologic and fragility fractures. This narrative rev

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… Climacteric 2015 ; 18 ( 4 ): 483 – 491 . 25845383 10.3109/13697137.2015.1020484 PMC4581591 3 Shahinian VB Kuo YF Freeman JL , et al . Risk of fracture after androgen deprivation for prostate cancer . …

The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms.

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail. The in

European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

UnlabelledGuidance is provided in a European setting on the assessment and treatment of postmenopausal women with or at risk from osteoporosis.IntroductionThe European Foundation for Osteoporosis and Bone disease (subsequently the International Osteoporosis Foundation) published guidelines for the diagnosis and management of osteoporosis in 1997. This manuscript updates these in a European setting.MethodsThe following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fracture risk; general and pharmacological management of oste

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… If low doses of hormone replacement treatment (HRT) are used for a limited period of time for the management of climacteric symptoms, concomitant use of bisphosphonates may provide an appropriate reduction in bone turnover that may not be achieved with low doses of HRT alone. … In most countries, HRT is only recommended for climacteric symptoms, at a dose as small as possible and for a limited period of time. Thus, HRT is no longer recommended as a first-line treatment for the prevention and treatment of osteoporosis. …

Symptom Clusters and Symptom Burden in Cancer Survivors.

ContextLimited information is available on the symptom burden and symptom clusters in cancer survivors.ObjectivesDescribe the occurrence, severity, and distress of 44 symptoms; determine risk factors associated with a higher symptom burden; and evaluate for symptom clusters using symptom occurrence rates.MethodsSurvivors (n = 1147) were recruited using an online survey. Symptom burden and symptom clusters were assessed using the Memorial Symptom Assessment Scale that included 44 symptoms and evaluated occurrence, severity, and distress. Simultaneous multivariable linear regression analysis was

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… R., “Sexual Quality of Life in Men and Women After Cancer,” Climacteric 22, no. 6 (2019): 553–557, 10.1080/13697137.2018.1526893. 59. Rossi A., Leone A. …

Global research trends of acupuncture therapy on cancer pain: A bibliometric and visualized study.

BackgroundThe number of publications on acupuncture for cancer pain is increasing rapidly with an upward tendency. Considering that no bibliometric articles related to this topic have been published yet. It is necessary to evaluate the global scientific output of research in this field, and shed light on the direction of clinical cancer pain management in the future.MethodsResearch publications regarding acupuncture on cancer pain from inception to 2022 were downloaded from the Web of Science Core Collection. Bibliometric analyses were performed using CiteSpace software, the bibliometrix R pac

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… Climacteric (2020) 23(2):130–9. doi: 10.1080/13697137.2019.1664460 30. Lyman GH, Greenlee H, Bohlke K, Bao T, DeMichele AM, Deng GE, et al. Integrative therapies during and after breast cancer treatment: ASCO endorsement of the SIO clinical practice guideline. …

Sexual health in patients with malignant hematological disease: a Danish cross-sectional study.

BackgroundPatients who undergo treatment for hematologic malignancies may experience a decline in sexual health, alterations in sexual functioning, and reproductive capacity during survivorship.AimThis study investigated the prevalence of sexual dysfunction and factors influencing sexual activity and functioning in patients with hematologic malignancies, to identify potential targets for interventions in clinical practice.MethodsThis nationwide cross-sectional study included adult patients diagnosed with a hematologic malignant disease in Denmark in the period from January 20, 2013, to August

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… Climacteric. 2019;22(6):553–557. https://doi.org/ 10.1080/13697137.2018.1526893 7. Sears CS, Robinson JW, Walker LM. A comprehensive review of sexual health concerns after cancer treatment and the biopsychosocial treatment options available to female patients. …

Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer.

The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medicines (CHMs) have long been used as such synergistic combinations. Therefore, we summarized the synergistic combinations of CHMs used in the treatment of cancer and their roles in chemotherapy in terms

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… Black cohosh (Cimicifuga racemosa) in tamoxifen-treated breast cancer patients with climacteric complaints - a prospective observational study. Gynecol. Endocrinol. 2011;27(10):844–848. doi: 10.3109/09513590.2010.538097. 112. Mori K., Kondo T., Kamiyama Y., Kano Y., Tominaga K. …

Воздействие предварительной терапии по замене эстрогена на клинические результаты после хирургической операции со скачком люмбара.

Исследование " Ретроспективное когортное исследование дизайна " . Мы предположили, что ЭРТ будет ассоциироваться с более низкими показателями псевдоартроза после синтеза поясничного позвоночника. >50 годами проходят одноуровневые и многоуровневые операции по синтезу поясничного позвоночника. Совпадение показателей доходности1::1) привели к равномерному распределению ГЭР и групп, не относящихся к ГЭР. К числу критериев исключения относятся предыдущие операции на поясничном позвоночнике, новообразования позвоночника, травмы, провокационные или инфекционные заболевания костей. Были пров

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… Climacteric . 2012 ; 16 ( 1 ): 154 - 160 . 22642912 10.3109/13697137.2012.672496 12 Maddalozzo GF Widrick JJ Cardinal BJ Winters-Stone KM Hoffman MA Snow CM . The effects of hormone replacement therapy and resistance training on spine bone mineral density in early postmenopausal women . …

Forecasting drug utilization and expenditure in a metropolitan health region.

BackgroundNew pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm, Sweden, a model has been developed including early warning (horizon scanning), forecasting of drug utilization and expenditure, critical drug evaluation as well as structured programs for the introduction and follow-up of new drugs. The aim of this

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… Genito-urinary tract and sex hormones (ATC G) This group is dominated by sex hormones for contraception and hormone therapy for climacteric symptoms. The prescribing of hormone therapy decreased substantially after publication of the randomized studies HERS and WHI in 2002 [ 34 , 35 ]. …

Understanding and Managing Fracture Risk in Patients With Cancer: A Literature Review.

One of the most important complications of cancer and its treatments is the increased fracture risk. Fractures can have a significant impact on the patient's quality of life and may be associated with morbidity, mortality, and reduced functional status. The present study aims to investigate the mechanisms underlying the increased risk of fractures in cancer patients, the effect of cancer treatments on fracture risk, and strategies to prevent fractures in this population. This is a literature review using the PubMed - National Center for Biotechnology Information (NCBI), Web of Science, Cochran

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… .2021.652979 PMC8378175 67 Negative impact of aromatase inhibitors on proximal femoral bone mass and geometry in postmenopausal women with breast cancer Calcif Tissue Int Lee SJ Kim KM Brown JK 551 559 97 2015 26232103 10.1007/s00223-015-0046-x 68 Selective estrogen receptor modulators and bone health Climacteric …

New Generation of Meso and Antiprogestins (SPRMs) into the Osteoporosis Approach.

Receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) play key roles in bone metabolism and the immune system. The RANK/RANKL complex has also been shown to be critical in the formation of mammary epithelia cells. The female hormones estradiol and progesterone closely control the action of RANKL with RANK. Blood concentration of these sex hormones in the postmenopausal period leads to an increase in RANK/RANKL signaling and are a major cause of women's osteoporosis, characterized by altered bone mineralization. Knowledge of the biochemical relationships between hormones and RAN

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… Climacteric. 2020;23:404–409. doi: 10.1080/13697137.2020.1758057. 24. Manokawinchoke J., Ritprajak P., Osathanon T., Pavasant P. Estradiol induces osteoprotegerin expression by human dental pulp cells. Odontology. 2014;104:10–18. doi: 10.1007/s10266-014-0178-x. 25. …

Bone Health for Gynaecologists.

Osteoporosis, the most common bone disorder, profoundly impacts women's health, especially during postmenopausal phases. Characterised by diminished bone mineral density (BMD), it increases the risk of fractures, affecting mobility, quality of life, and potentially mortality. The present review analyses the intricate interactions among physiological alterations, diseases, and medications that lead to bone mineral density reduction in women. It underscores the importance of gynaecologists in the prevention, diagnosis, and management of osteoporosis via early risk assessment, suitable hormone tr

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… The application of HRT and SERM for preserving bone health in relatively younger women should be limited in duration, and HRT should not be administered to asymptomatic women (lacking climacteric symptoms) as a treatment for osteoporosis. …

Medication for bone loss in female patients with anorexia nervosa: a systematic review and management algorithm.

PURPOSE: Anorexia Nervosa can have a major impact on bone health through low bone mass and bone loss. Considering the lack of consensual guidelines for the prevention and treatment of bone loss in this condition, a systematic review was performed to provide practical treatment guidance for clinicians. METHODS: We systematically searched Medline, Cochrane, Psychinfo, and the Web of Science for anorexia nervosa AND (osteopenia OR osteoporosis OR bone density OR bone loss) AND (prevention OR treatment OR medication OR therapeutic) in clinical studies from March 1st, 2017, to October 31st, 2024,

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… Climacteric [Internet]. 2022 Jan 2 [cited 2024 Jul 22]; Available from: https://www.tandfonline.com/doi/abs/10.1080/13697137.2021.1926974 74. …

Bone loss induced by cancer treatments in breast and prostate cancer patients.

Cancer and cancer therapies are a major factor risk for osteoporosis due to bone loss and deterioration of bone microarchitecture. Both factors contribute to a decrease in bone strength and, consequently, increased bone fragility and risk of fracture. Cancer-associated bone loss is a multifactorial process, and optimal interdisciplinary management of skeletal health, accurate assessment of bone density, and early diagnosis are essential when making decisions aimed at reducing bone loss and fracture risk in patients who have received or are receiving treatment for cancer. In this document, a mu

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… All these drugs carry a slight increase in the risk of thromboembolic events due to their estrogenic agonist activity at the cardiovascular level, as well as climacteric symptoms. …

Clinical approaches to osteoporosis in patients with chronic kidney disease: A comprehensive review.

Chronic kidney disease (CKD) induces secondary osteoporosis, characterized by an imbalance between bone formation and resorption due to kidney dysfunction; the result is a reduction in both bone mineral density and quality. This condition is compounded by disruption of bone metabolic turnover, abnormalities in bone microstructure and collagen cross-linking, and compromised bone quality, all of which contribute to increased bone fragility. Reduced kidney function is complicated by secondary hyperparathyroidism, which exacerbates bone fragility. Managing osteoporosis in patients with CKD is chal

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… Climacteric 17: 273–284. 71. Ishani A, Blackwell T, Jamal SA, Cummings SR, Ensrud KE (2008) The effect of raloxifene treatment in postmenopausal women with CKD. J Am Soc Nephrol 19: 1430–1438. 72. …

Unveiling the Link Between Breast Cancer Treatment and Osteoporosis: Implications for Anticancer Therapy and Bone Health.

Background: The interplay between breast cancer treatment and osteoporosis has important consequences for anticancer therapy and patient bone health. Many breast cancer therapies involve hormonal treatments that lower estrogen levels, which can lead to an increased risk of osteoporosis due to reduced bone mineral density. Aromatase inhibitors, chemotherapy, and surgeries such as oophorectomy can further aggravate bone loss, highlighting the necessity of prioritizing bone health during cancer treatment. Objective: This review is aimed at investigating the complex relationship between breast can

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… Climacteric . 2022;25(1):1–3. doi: 10.1080/13697137.2021.1965408. 13. Shapiro C. L. Osteoporosis: a long-term and late-effect of breast cancer treatments. Cancers . 2020;12(11):p. 3094. doi: 10.3390/cancers12113094. 14. Taxel P., Faircloth E., Idrees S., Van Poznak C. …

Guidelines for the management of osteoporosis and fragility fractures.

The purpose of this document, a result of the harmonisation and revision of Guidelines published separately by the SIMFER, SIOMMMS/SIR, and SIOT associations, is to provide practical indications based on specific levels of evidence and various grades of recommendations, drawn from available literature, for the management of osteoporosis and for the diagnosis, prevention, and treatment of fragility fractures. These indications were discussed and formally approved by the delegates of the Italian Scientific Associations involved in the project (SIE, SIGG, SIMFER, SIMG, SIMI, SIOMMMS, SIR, and SIO

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… For women suffering from the climacteric syndrome, especially if still within the 50–55 age-range, temporary administration of oestrogen or oestrogen plus progestin (depending on whether or not there is an intact uterus) may be considered in some way to be physiological and be proposed, it is also effective …

Thai Osteoporosis Foundation (TOPF) position statements on management of osteoporosis.

The adjusted incidence rate of hip fracture in Thailand has increased more than 31% from 1997 to 2006. Mortality and morbidity after hip fracture are also high. One year mortality after a hip fracture has increased from 18% in 1999 to 21% in 2007. The Thai Osteoporosis Foundation (TOPF) developed the first Clinical Practice Guideline (CPG) in 2002 and keeps updating the CPG since then. This latest version of the CPG is our attempt to provide comprehensive positional statement on the diagnosis, prevention and treatment of osteoporosis in Thailand. The study group who revised this position state

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… Global consensus statement on menopausal hormone therapy Climacteric 16 2013 203 204 23488524 10.3109/13697137.2013.771520 40 Writing Group for the Women’s Health Initiative Investigators Risks and benefits of estrogen plus progestin in healthy postmenopausal women JAMA 288 2002 321 333 12117397 10.1001 …

Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases.

Bone and joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), and bone tumors, pose significant health challenges due to their debilitating effects on the musculoskeletal system. 14-3-3 proteins, a family of conserved regulatory molecules, play a critical role in the pathology of these diseases. This review discusses the intricate structure and multifunctionality of 14-3-3 proteins, their regulation of signaling pathways, and their interactions with other proteins. We underscore the significance of 14-3-3 proteins in the regulation of osteoblasts, osteoclasts, chon

Primary hyperhidrosis: an updated review.

BACKGROUND: Hyperhidrosis (HH) is a condition characterized by excessive sweating beyond the physiological needs of thermoregulation. HH can be classified as primary (idiopathic) hyperhidrosis (PHH) or secondary hyperhidrosis (SHH), which is associated with underlying medical conditions, medications or systemic disorders. This narrative review provides an updated overview of PHH, with a focus on epidemiology, aetiopathogenesis, clinical manifestations, diagnostic approaches and current management strategies, particularly highlighting pharmacological and procedural treatment options. METHODS:

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… Climacteric. 2016;19(4):406–408. doi: 10.1080/13697137.2016.1191461. 80. Drummond PD. Mechanisms of physiological gustatory sweating and flushing in the face. J Auton Nerv Syst. 1995;52(2–3):117–124. doi: 10.1016/0165-1838(94)00151-9. 81. Geraghty LN, Pomeranz MK. …