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Соблюдение основанных на фактах рекомендаций по лечению костного здоровья, боли и мобильности пациентов с множественной миеломой: смешанный метод в палестинской системе здравоохранения.

Были разработаны рекомендации по оценке, регулированию и мониторингу состояния здоровья, боли и мобильности костных костей у пациентов с множественной миеломой, основанные на принципе " консенсус/доказательства " . Это исследование было проведено с целью оценки соответствия гематологов-онкологов принятым на основе консенсуса/доказательств рекомендациям в отношении оценки, регулирования и мониторинга состояния здоровья костей, боли и мобильности у пациентов с множественной миеломой, которые получали медицинскую помощь в палестинской системе здравоохранения. Рекомендации, основанные на

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… Kyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma. J Clin Oncol. 2002;20(9):2382–7. doi: 10.1200/JCO.2002.09.097. 41. Hadjipavlou AG, Tzermiadianos MN, Katonis PG, Szpalski M. … Percutaneous vertebroplasty and balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures and osteolytic tumours. J Bone Joint Surg Br. 2005;87(12):1595–604. doi: 10.1302/0301-620X.87B12.16074. 42. Knips L, Bergenthal N, Streckmann F, Monsef I, Elter T, Skoetz N. …

Painful boney metastases.

Boney metastasis may lead to terrible suffering from debilitating pain. The most likely malignancies that spread to bone are prostate, breast, and lung. Painful osseous metastases are typically associated with multiple episodes of breakthrough pain which may occur with activities of daily living, weight bearing, lifting, coughing, and sneezing. Almost half of these breakthrough pain episodes are rapid in onset and short in duration and 44% of episodes are unpredictable. Treatment strategies include: analgesic approaches with "triple opioid therapy", bisphosphonates, chemotherapeutic agents, ho

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… Kyphoplasty Kyphoplasty has evolved from vertebroplasty and aims to offer the benefit of analgesia in vertebral fractures in combination with restoration of vertebral body height. … Qian and colleagues performed a retrospective review of clinical outcome data for 48 patients with multiple spinal metastases treated with kyphoplasty [ 84 ]. …

Current concepts in bone metastasis, contemporary therapeutic strategies and ongoing clinical trials.

BackgroundElucidation of mechanisms regulating bone metastasis has progressed significantly in recent years and this has translated to many new therapeutic options for patients with bone metastatic cancers. However, the rapid rate of progress in both the basic science literature and therapies undergoing clinical trials makes staying abreast with current developments challenging. This review seeks to provide an update on the current state of the science in bone metastasis research and give a snap shot of therapies in clinical trials for bone metastatic cancer.Main bodyBone metastasis represents

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… Other treatment modalities Percutaneous minimally invasive techniques Treatments such as percutaneous vertebroplasty, kyphoplasty, and radiofrequency ablation are often employed as a palliative measure in the treatment of patients with bone metastatic spinal tumors [ 121 ]. … Balloon kyphoplasty is like vertebroplasty but utilizes a balloon to control bone cement extravasation in the spine [ 122 ]. …

Surgical management of spinal multiple myeloma: insights from the National Inpatient Sample database.

BackgroundManagement of multiple myeloma (MM) of the spine includes a multimodal approach consisting of chemotherapy, bisphosphonates, radiation, and surgical intervention. This study aims to explore the trends in surgical treatment of MM including hospital costs, odds of complications, and the impact of patient comorbidities on the risk of complications using the National Inpatient Sample (NIS) database.MethodsThe NIS was queried for patients with MM and plasmacytoma of the spine who underwent surgical intervention between 2005 and 2014. Rates of spinal decompression, spinal stabilization wit

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… Cement augmentation via percutaneous vertebroplasty or balloon kyphoplasty are minimally invasive treatment options that strengthens the vertebrae and provides pain relief, mechanical stability, and improves quality of life ( 16 , 17 ). … Lastly, our analysis does not include outpatient surgical procedures and therefore likely underrepresents the overall incidence of procedures including vertebroplasty/kyphoplasty, which are commonly performed in the outpatient setting. …

Role of Decompressive Surgery in Neurologically Intact Patients with Low to Intermediate Intraspinal Metastatic Tumor Burden.

BackgroundSurgical decompression (SD) followed by radiotherapy (RT) is superior to RT alone in patients with metastatic spinal disease with epidural spinal cord compression (ESCC) and neurological deficit. For patients without neurological deficit and low- to intermediate-grade intraspinal tumor burden, data on whether SD is beneficial are scarce. This study aims to investigate the neurological outcome of patients without neurological deficit, with a low- to intermediate-ESCC, who were treated with or without SD.MethodsThis single-center, multidepartment retrospective analysis includes patient

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… In patients with intractable pain due to spinal metastasis who are too sick to undergo extensive surgery, kyphoplasty is a valid treatment option [ 30 , 31 ]. … Due to an increased release of circulating tumor cells after kyphoplasty, this approach should be weighed carefully in patients with oligometastatic disease [ 32 ]. …

The Burden of Metastatic Cancer-Induced Bone Pain: A Narrative Review.

Bone pain is one of the most common forms of pain reported by cancer patients with metastatic disease. We conducted a review of oncology literature to further understand the epidemiology of and treatment approaches for metastatic cancer-induced bone pain and the effect of treatment of painful bone metastases on the patient's quality of life. Two-thirds of patients with advanced, metastatic, or terminal cancer worldwide experience pain. Cancer pain due to bone metastases is the most common form of pain in patients with advanced disease and has been shown to significantly reduce patients' qualit

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… Minimally invasive therapies (eg, epidural or intrathecal anesthesia, nerve blocks, ablative procedures, kyphoplasty, cementoplasty, and vertebroplasty) are an option when oral or injectable pharmacological therapies are not effective for persistent pain relief. … Long-term evaluation of pain reduction after vertebroplasty and kyphoplasty. Acta Radiol Open . 2021;10(7):20584601211028994. doi: 10.1177/20584601211028994 73. Sadeghi-Naini M, Aarabi S, Shokraneh F, et al. Vertebroplasty and kyphoplasty for metastatic spinal lesions: a systematic review. …

Percutaneous vertebroplasty for osteoporotic vertebral compression fracture.

BACKGROUND: Percutaneous vertebroplasty remains widely used to treat osteoporotic vertebral fractures although our 2015 Cochrane review did … ebo (541 randomised participants), eight with usual care (1136 randomised participants), seven with kyphoplasty (968 randomised participants) and one compared vertebroplasty with facet joint glucocorticoid injection (217 randomised participants). Trial size varied from 46 to 404 participants, most participants were female, mean age ranged between 62.6 and 81 …

Minimally invasive interventional therapy for pain.

Pain interventional therapy, known as the most promising medical technology in the 21st century, refers to clinical treatment technology based on neuroanatomy, neuroimaging, and nerve block technology to treat pain diseases. Compared with traditional destructive surgery, interventional pain therapy is considered a better and more economical choice of treatment. In recent years, a variety of minimally invasive pain interventional therapy techniques, such as neuroregulation, spinal cord electrical stimulation, intervertebral disc ablation, and intrasheath drug infusion systems, have provided eff

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… Percutaneous vertebroplasty and kyphoplasty: current status, new developments and old controversies Cardiovasc Intervent Radiol 40 2017 1815 1823 28856402 10.1007/s00270-017-1779-x 49 Premat K. Clarençon F. Cormier É. … New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures Spine 26 2001 1511 1515 11462078 10.1097/00007632-200107150-00002 54 Clark W. Bird P. Gonski P. …

Treatment Outcomes in Spinal Tumors According to Patients' Perspectives: A Focus on Indeterminate Spinal Instability.

The objective of this study was to analyze treatment approaches and outcomes according to patients' perspectives for patients with indeterminate spinal instability caused by neoplastic lesions. Data were collected from 31 patients with a total of 147 spinal neoplastic lesions, 29 of whom had lesions classified as indeterminate. These lesions were divided into two groups: the low indeterminate group (SINS 7-9) and the high indeterminate group (SINS 10-12). Conservative treatment was the primary approach (93%), resulting in improvement in 59% of cases, stability in 22%, and asymptomatic outcomes

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… | 1 (50.0) None | 1 (20.0) | 0 (0.0) SINS—posterolateral involvement = None (n (%)) | 4 (100.0) | 1 (50.0) Description surgery (%) | | Dorsal Instrumentation T10–L2 | 0 (0.0) | 1 (50.0) Dorsal Instrumentation T10–L2 | 1 (20.0) | 0 (0.0) Corpectomy with dorsal instrumentation | 1 (20.0) | 0 (0.0) Kyphoplasty … L3 | 1 (20.0) | 0 (0.0) Kyphoplasty T12–L2 | 1 (20.0) | 0 (0.0) Operation terminated due to complications | 0 (0.0) | 1 (50.0) Kyphoplasty L4 | 1 (20.0) | 0 (0.0) Of all patients within the indeterminate group, 23 (79.3%) received radiotherapy and 27 (93.1%) received chemotherapy. 3.2. …

Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients.

OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patient

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… This questionnaire has been adapted and validated in Portuguese since 1999. 2 We found only one previous report that described the use of the SF-36 questionnaire in MM patients to compare QoL pre- and post-kyphoplasty. 6 Recently, the EORTC validated a disease-specific questionnaire module (QLQ-MY20) … Interpretation of quality of life scores in multiple myeloma by comparison with a reference population and assessment of the clinical importance of score differences Eur J Haematol 2004 72 172 80 10.1046/j.0902-4441.2003.00195.x 14962235 10.1046/j.0902-4441.2003.00195.x 6 Dudeney S Lieberman IH Reinhardt MK Kyphoplasty …

Rapid Fire

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Current Advancements in the Diagnosis and Treatment of Metastatic Spinal Cord Compression and Its Postintervention Care: A Comprehensive Review.

Malignant spinal cord compression (MSCC) is a serious oncological emergency that can result in neurological impairment and significant pain. It is associated with high morbidity, mortality, and a decrease in quality of life. This review reviews the current literature concerning diagnosis, guidelines, timely intervention, and management options in oncology patients with MSCC. A literature search of PubMed using relevant keywords and MeSH terms yielded 604 articles. Of these, 31 studies met the predefined inclusion criteria and were selected for detailed data extraction and synthesis into a narr

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… Surgical advancements, including minimally invasive spine surgery and kyphoplasty, have provided additional solutions for mechanical instability and painful vertebral compression fractures [ 12 ]. … In addition, minimally invasive techniques, such as kyphoplasty, vertebroplasty and percutaneous fixation with pedicle screws, have also been shown to be effective in reducing pain, stabilizing the spine, and preserving neurological function. [ 12 , 14 , 25 ] Pharmacological Interventions High-dose …

Outcomes in Patients with Spinal Metastases Managed with Surgical Intervention.

BackgroundSpinal metastases are a significant cause of morbidity in patients with advanced cancer, and management often requires surgical intervention. Although prior studies have identified factors that influence outcomes with surgery, the ability of these factors to predict outcomes remains unclear in the era of contemporary therapies, and there is a need to better identify patients who are likely to benefit from surgery.MethodsWe performed a single-center, retrospective analysis to evaluate risk factors for poor outcomes in patients with spinal metastases treated with surgery. The primary o

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… Broadly, patients can be treated with radiation therapy (RT), systemic therapy, interventional techniques such as kyphoplasty, or surgery, including en bloc metastases resection, debulking, or stabilization procedures [ 4 , 5 , 6 , 7 , 8 ]. … Balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: A multicentre, randomised controlled trial Lancet Oncol. 2011 12 225 235 10.1016/S1470-2045(11)70008-0 21333599 8. …

Percutaneous vertebroplasty combined with chemotherapy in the treatment of multiple myeloma patients with vertebral compression fractures.

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… Patients with MM-associated VCFs without neurological involvement can undergo vertebral augmentation, including percutaneous kyphoplasty (PKP) and percutaneous vertebroplasty (PVP). [ 2 ] In recent years, preliminary studies have demonstrated the effectiveness of PVP or PKP in controlling the pain and … Vertebroplasty or kyphoplasty as palliative treatment for cancer-related vertebral compression fractures: a systematic review . Spine J 2019 ; 19 : 1067 – 1075 . doi: 10.1016/j.spinee.2019.02.012 . 30822527 10.1016/j.spinee.2019.02.012 3. Chen X . …

Effects of Osteoporosis Medication Use on Reprocedure Rates Following Vertebral Augmentation: A Nationwide Cohort Study.

BACKGROUD: In this study, we aimed to investigate the effects of osteoporosis medication use and prescription duration on the rates of reprocedures for re-fractures in patients who underwent vertebral augmentation (VA). METHODS: This retrospective cohort study was conducted using data collected from the National Health Insurance Service database of South Korea. Patients aged 50 years or older who underwent VA in 2012 were included in this study. A reprocedure was defined as an additional VA performed for re-fractures during a follow-up period of up to 5 years. Patients were categorized based

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… Comparison of percutaneous vertebroplasty and balloon kyphoplasty for the treatment of single level vertebral compression fractures: a metaanalysis of the literature. Pain Physician. 2015;18(3):209–222. 3. Nie M, Chen Z, Shi L, Cao H, Xu L. … Risk factor analysis for re-collapse of cemented vertebrae after percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP) Int Orthop. 2018;42(9):2131–2139. doi: 10.1007/s00264-018-3838-6. 8. Lee DG, Park CK, Park CJ, Lee DC, Hwang JH. …

Patient-Reported Outcomes with Peripheral Nerve Stimulation for Low Back Pain from Vertebral Plana Deformities: A Case Series.

Objectives: This study evaluated peripheral nerve stimulation (PNS) as a treatment for vertebra plana fractures, focusing on its impact on pain intensity, physical function, anxiety, depression, fatigue, social role participation, and pain interference. The goal was to assess whether PNS could serve as a minimally invasive alternative for managing pain in patients with severe vertebral fractures. Methods: Four patients with lumbar vertebra plana fractures received PNS implants for 60 days. Pain scores and PROMIS-29 domains (physical function, anxiety, depression, fatigue, social participation,

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… Advanced procedures, such as vertebroplasty and kyphoplasty, are also available. Spine surgery is typically reserved for cases with neurologic compromise [ 7 , 8 , 9 , 10 ]. … Vertebroplasty and kyphoplasty for the treatment of osteoporotic vertebral compression fractures J. Am. Acad. Orthop. Surg. 2014 22 653 664 10.5435/JAAOS-22-10-653 25281260 10. Anderson P.A. Froyshteter A.B. Tontz W.L. Jr. …

Chemotherapy May Obviate Prophylactic Femoral Nail Surgery for Multiple Myeloma Patients With High Mirels' Score Lesions and Impending Pathological Hip Fracture.

Bone involvement presents in >80% of patients with multiple myeloma. This causes lytic lesions for which prophylactic surgery is indicated to prevent pathological fractures if the lesion is graded ≥9/12 on Mirels' score. Although successful, these surgeries have risks and extended recovery periods. We present a case indicating myeloma chemotherapy may obviate prophylactic femoral nailing for high Mirels' score lesions in the femoral head with impending pathological hip fracture. A 72-year-old woman presented in December 2017 with back pain. A plain X-ray indicated degenerative anterolisthesis

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… Prophylactic orthopaedic surgery e.g. vertebroplasty, kyphoplasty and stabilisation for spinal lesions and nailing for long bone stabilisation [ 2 ], is indicated to prevent pathological fractures if the lesion is graded ≥9/12 on Mirels’ score [ 3 ]. … recently been a shift from managing myeloma patients, especially elderly patients experiencing their first relapse, with osteolytic lesions via instrumented surgical intervention to the aforementioned combination of steroids and chemotherapy as well as the use of minimally invasive surgery such as kyphoplasty …

A Comprehensive Review of the Role of the Latest Minimally Invasive Neurosurgery Techniques and Outcomes for Brain and Spinal Surgeries.

Minimally invasive neurosurgical techniques offer reduced surgical trauma, lower complication rates, and faster recovery compared to traditional open procedures. Approaches such as keyhole craniotomy, endoscopic skull base surgery, endovascular neurosurgery, and percutaneous spinal techniques have advanced the management of cranial and spinal pathologies. These methods aim to minimize tissue disruption, blood loss, and hospital stay while maintaining surgical efficacy. This narrative review explores their evolution, applications, and advantages in modern neurosurgery.

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… Percutaneous Vertebroplasty and Kyphoplasty for Osteoporotic Vertebral Fractures Vertebral fractures caused by osteoporosis are one of the most frequent and debilitating complications of osteopenia. … To summarize, PVP and kyphoplasty represent two highly effective and safe therapeutic options for treating osteoporotic vertebral fractures. …

Какие факторы связаны с неблагоприятным прогнозом у нескольких пациентов с миеломой после операции?

Для изучения прогнозов пациентов с множественной миеломой (ММ) после операции, анализа факторов риска, ведущих к неблагоприятным результатам послеоперационного лечения, и создания номограммы. МЕТОДЫ: Клинические данные 154 пациентов с MM, которые прошли операцию в нашем учреждении между 2007 и 2019 был ретроспективно проанализирован. Оценка и сопоставление уровней боли, качества жизни и функционального состояния пациентов до и после операции (Р) < 0.05) были признаны статистически значимыми. Кривая выживания Каплана-Мейера использовалась для оценки средней продолжительности выживаемости. Отриц

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… Results General information Among the 154 patients, 45 (29.2%) underwent vertebral percutaneous kyphoplasty (PKP) surgery, 41 (26.6%) underwent spinal decompression and internal fixation surgery. … Acute versus chronic vertebral compression fractures treated with kyphoplasty: early results. Spine Journal: Official J North Am Spine Soc. 2004;4:418–24. doi: 10.1016/j.spinee.2004.01.003. 31. Öztürk R, Amer K, Gençoğlu AT, Öztürk FG, Kasali K, Aytekin MN. …

Newly Diagnosed Multiple Myeloma Patients with Skeletal-Related Events and Abnormal MRI Pattern Have Poor Survival Outcomes: A Prospective Study on 370 Patients.

Contemporary information is sparse on the frequency of skeletal-related events (SREs) in multiple myeloma (MM) patients at a population-based level in the era of novel agents. In this context, we conducted this single-center, prospective, observational study to determine the incidence of SREs among newly diagnosed MMs (NDMM) and to explore the possible correlations with disease characteristics, imaging finding, and patient prognosis. A total of 370 patients with available baseline MRIs were included. Among them, 208 (56%) presented with at least one SRE at diagnosis. Fractures were the most co

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… Main surgical interventions included vertebroplasty, balloon kyphoplasty, and laminectomy. Those minimally invasive procedures have shown to be effective regarding pain relief and restoration of function in the patients who do not respond to conservative measures [ 36 ]. … Surgical management included mainly kyphoplasty and laminectomy. A thorough description of SREs loci at diagnosis is presented in Table 4 . The most common sites of fractures at MM diagnosis were the lower thoracic spine, the upper lumbar spine and the ribs. …