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An Overview of Polymeric Nanoparticles-Based Drug Delivery System in Cancer Treatment.

Cancer is recognized as one of the world's deadliest diseases, with more than 10 million new cases each year. Over the past 2 decades, several studies have been performed on cancer to pursue solutions for effective treatment. One of the vital benefits of utilizing nanoparticles (NPs) in cancer treatment is their high adaptability for modification and amalgamation of different physicochemical properties to boost their anti-cancer activity. Various nanomaterials have been designed as nanocarriers attributing nontoxic and biocompatible drug delivery systems with improved bioactivity. The present

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… In this manner, a more reasonable translation of the “magic shot” idea is for a compound that communicates with its aim in a restrictive, profoundly explicit style. This cooperation requires the 2 components needed to be in closeness. … Since the magic projectile does not interface altogether with something besides the objective, the name “magic slug” can be supported. …

The future of NMR metabolomics in cancer therapy: towards personalizing treatment and developing targeted drugs?

There has been a recent shift in how cancers are defined, where tumors are no longer simply classified by their tissue origin, but also by their molecular characteristics. Furthermore, personalized medicine has become a popular term and it could start to play an important role in future medical care. However, today, a "one size fits all" approach is still the most common form of cancer treatment. In this mini-review paper, we report on the role of nuclear magnetic resonance (NMR) metabolomics in drug development and in personalized medicine. NMR spectroscopy has successfully been used to evalu

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… For studies of intact tissues (e.g., biopsy material), high-resolution magic angle spinning (HR-MAS) can be used to achieve spectra with a quality that is comparable to those of extracted molecules [ 41 ]. … As the name indicates, in HR-MAS the higher resolution is achieved by spinning the samples at a specific angle (“the magic angle”) [ 41 ]. …

Psychedelic-assisted therapy for treating anxiety, depression, and existential distress in people with life-threatening diseases.

BACKGROUND: Psychedelic-assisted therapy refers to a group of therapeutic practices involving psychedelics taken under therapeutic supervisi … two different interventions: psychedelic-assisted therapy with classical psychedelics (psilocybin ('magic mushrooms') and lysergic acid diethylamide (LSD)), and psychedelic-assisted therapy with 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy'). The studies randomised 149 participants with life-threatening diseases and analysed data for 140 of them. …

Targeted Drug Delivery and Theranostic Strategies in Malignant Lymphomas.

Malignant lymphomas represent the most common type of hematologic malignancies. The first clinically approved TDD modalities in lymphoma patients were anti-CD20 radioimmunoconjugates (RIT) 131I-tositumomab and 90Y-ibritumomab-tiuxetan. The later clinical success of the first approved antibody-drug conjugate (ADC) for the treatment of lymphomas, anti-CD30 brentuximab vedotin, paved the path for the preclinical development and clinical testing of several other ADCs, including polatuzumab vedotin and loncastuximab tesirine. Other modalities of TDD are based on new formulations of "old" cytostatic

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… Nanosystems for TDD: Structure, Passive and Active Targeting Thanks to huge progress in the field of biomedical polymer research, Ehrlich’s original idea of the magic bullet gave rise to a new scientific discipline called controlled drug delivery, or controlled drug release. … Paul Ehrlich’s magic bullets. N. Engl. J. Med. 2004;350:1079–1080. doi: 10.1056/NEJMp048021. 21. Maloney D.G., Grillo-Lopez A.J., Bodkin D.J., White C.A., Liles T.M., Royston I., Varns C., Rosenberg J., Levy R. …

Resuscitating Patient Rights during the Pandemic: COVID-19 and the Risk of Resurgent Paternalism.

The COVID-19 Pandemic a stress test for clinical medicine and medical ethics, with a confluence over questions of the proportionality of resuscitation. Drawing upon his experience as a clinical ethicist during the surge in New York City during the Spring of 2020, the author considers how attitudes regarding resuscitation have evolved since the inception of do-not-resuscitate (DNR) orders decades ago. Sharing a personal narrative about a DNR quandry he encountered as a medical intern, the author considers the balance of patient rights versus clinical discretion, warning about the risk of resurg

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… To think otherwise was to fall prey to what Joan Didion called magical thinking. 5 Of course, the complexity of resuscitation did not end with the narrow question of futility. … The Year of Magical Thinking. New York: Vintage; 2007. . Fins JJ, Miller FG. Proportionality, pandemics and medical ethics American Journal of Medicine 2020;Jul 9:S0002-9343(20)30555-6. doi: 10.1016/j.amjmed.2020.06.008. Online ahead of print. Red Nacional de Vigilancia Epidemiológica. …

Beyond Formulation: Contributions of Nanotechnology for Translation of Anticancer Natural Products into New Drugs.

Nature is the largest pharmacy in the world. Doxorubicin (DOX) and paclitaxel (PTX) are two examples of natural-product-derived drugs employed as first-line treatment of various cancer types due to their broad mechanisms of action. These drugs are marketed as conventional and nanotechnology-based formulations, which is quite curious since the research and development (R&D) course of nanoformulations are even more expensive and prone to failure than the conventional ones. Nonetheless, nanosystems are cost-effective and represent both novel and safer dosage forms with fewer side effects due to m

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… Conclusions and Further Perspectives Perhaps we are still a long way from obtaining true “magic bullets”. Otherwise, nanotechnology properties have improved various outcomes compared to conventional formulations. … Paul Ehrlich’s magic bullet concept: 100 years of progress. Nat. Rev. Cancer. 2008;8:473–480. doi: 10.1038/nrc2394. 97. Gabizon A., Catane R., Uziely B., Kaufman B., Safra T., Cohen R., Martin F., Huang A., Barenholz Y. …

Uncovering potential targets for antibody-drug conjugates in the treatment of gynecologic malignancies.

BackgroundAntibody-drug conjugates (ADCs) play an important role in the targeted therapy of gynecological malignancies. The purpose of this study was to investigate the expression of targets in gynecologic malignancies in order to predict the selection of targets for the development of antibody-drug conjugates.MethodsIn this article, we identified existing ADCs and their targets through clinical trial databases and public genomic datasets, performed differential analysis of tumor antigen targets (TATs) expression between tumor and normal tissues, and evaluated the necessity of the targets for

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… In 1907, German Nobel laureate Paul Ehrlich proposed a compound that could selectively target pathogenic microorganisms such as bacteria while protecting normal cells, a concept known as the “magic bullet” ( Strebhardt and Ullrich, 2008 ). … Antibody-drug conjugates: advancing from magic bullet to biological missile . Clin. Cancer Res. 30 ( 8 ), 1434 – 1437 . 10.1158/1078-0432.Ccr-23-3414 38306232 Wahby S. Fashoyin-Aje L. Osgood C. L. Cheng J. Fiero M. H. Zhang L. ( 2021 ). …

Effectiveness of interventions for improving educational outcomes for people with disabilities in low- and middle-income countries: A systematic review.

BACKGROUND: People with disabilities are consistently falling behind in educational outcomes compared to their peers without disabilities, w … t school systems are not set up to teach children with different impairment types. There is no one 'magic bullet' intervention which can equalise health outcomes for this group. A twin-track approach is needed, which both addresses the specific needs of children with disabilities but also ensures that they are included in mainstream activities (e.g., th …

Использование реальных доказательств в США. Управление по контролю за продуктами питания и лекарственными препаратами и Европейское агентство по лекарственным препаратам утверждают онкологические продукты, поддерживаемые односторонними испытаниями (Advisory and Drug Argency and the European Medicals Agency (European Medicals Agency)2022-2025).

ВВЕДЕНИЕ: Усилился интерес регулирующих органов к реальным доказательствам (РВЭ) в дополнение к односторонним испытаниям (САТ) в области онкологии, однако по-прежнему отсутствует полное понимание того, как Управление по контролю за продуктами питания и лекарствами (ДПП) и Европейское агентство по медицине (ЕМА) оценивают такие доказательства. ЦЕЛЬ: Всеобъемлющая оценка недавних решений по онкологии, в которых СТА поддерживаются РВЭ, с описанием обратной связи по вопросам нормативного регулирования, методологических подходов, роли РВЭ в процессе принятия решений. Мы рассмотрели новые прикладные

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… DLBCL: diffuse large B-cell lymphoma; EBMT: European Society for Blood and Marrow Transplantation; EMA: European Medicines Agency; EMR: electronic medical record; FDA: Food and Drug Administration; FL: follicular lymphoma; GVHD: graft-versus-host disease; HSCT: hematopoietic stem cell transplantation; MAGIC … Descriptive Melphalan | Delcath registry population study | Retrospective RWD cohort | Product registry (European patient registry maintained by applicant for their product) | Patient level | Other (PRO) | Benchmark data of QoL post treatment initiation overtime in registry | Descriptive Remestemcel-L-rknd | MAGIC …

Opportunities and Challenges in Antibody-Drug Conjugates for Cancer Therapy: A New Era for Cancer Treatment.

The antibody, linker, and payload moieties all play a significant role in giving the ADC its unique therapeutic potential. The antibody subclass employed in ADCs is determined based on relative individual receptor affinities and pharmacokinetics. Meanwhile, the linker used in an ADC can either be cleavable or non-cleavable. ADC therapy comprises antibody-dependent mechanisms in addition to the direct cytotoxic effects of the payload. These include antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, and antibody-dependent cellular phagocytosis, as well as the "bystander

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… Discussion and Future Perspective Regarded as “magic bullets”, ADCs have started to revolutionize oncology research with their dual nature, resulting in many success stories. … Paul Ehrlich’s magic bullet concept: 100 Years of Progress. Nat. Rev. Cancer. 2008;8:473–480. doi: 10.1038/nrc2394. 4. The Nobel Prize in Physiology or Medicine 1908 NobelPrize.org. [(accessed on 10 February 2024)]. …

Using virtual reality hypnosis during stem cell transplant for patients in hematology: A protocol for a feasibility randomized study.

BackgroundStem cell transplantation is a highly stressful treatment for hematological cancer patients, negatively impacting their quality of life. Hypnosis has proven effective in managing symptoms like pain, fatigue, and anxiety, and improving quality of life. Virtual reality (VR) is used in cancer treatments to distract from pain, and combining VR with hypnosis (VRH) could enhance the hypnotic experience. However, methodological limitations in current studies prevent clear evaluation of its effectiveness, particularly for individualized care and psychosocial interventions.Aims1) To evaluate

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… With the application, participants will have access to four hypnosis recordings (i.e., beach, forest, magic hand, and security protection) as well as a bank of 200 landscapes they can visit. Participants will have a first VRH session with the investigator (i.e., beach). … During the two weeks, three other accompanied VRH sessions are scheduled with the patient by phone or on their own to do the remaining hypnosis recordings (i.e., forest, magic hand, and security protection). …

Adapted physical activity for hematology inpatients: focus on lean mass gain.

Adapted physical activity (APA) has become an essential asset in the care of patients with cancer. Although its positive impact has mainly been studied regarding quality of life, few studies have focused on changes in lean mass (LM) and its determinants. This study reports the results of an APA program for inpatients in the hematology department of Nice University Hospital (France). Body composition analyses and physical tests were performed at admission and discharge. A total of 123 patients were analyzed with relative LM gain as the primary outcome. Over a median hospitalization duration of

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… well as clinical malnutrition according to the Global Leadership Initiative on Malnutrition criteria. 25 For patients undergoing allogeneic HSCT, presence and grade of acute graft-versus-host disease (GVHD) and disease status at the time of transplant (remission or not) were also reported, using the MAGIC … International, multi-center standardization of acute graft-versus-host disease clinical data collection: a report from the MAGIC consortium. Biol Blood Marrow Transplant. 2015;22(1):4–10. doi: 10.1016/j.bbmt.2015.09.001. 27. Koeppel M, Mathis K, Schmitz KH, Wiskemann J. …

Arsenic Sulfide Induces Apoptosis in Myelodysplastic Neoplasm Cells Through the Suppression of ABI2.

BackgroundMyelodysplastic neoplasms (MDS) are a category of myeloid malignancies that can progress to acute myeloid leukemia (AML). Arsenic sulfide (As₂S₂) has demonstrated efficacy in the treatment of MDS. However, further investigation is required to elucidate its specific therapeutic targets.ObjectiveTo examine the influence of ABI2 on MDS and clarify the regulatory role of As₂S₂ on ABI2 within the therapeutic framework of MDS.MethodsTo explore ABI2's role in the expression and prognosis of patients with hematological malignancies, RNA interference was used to reduce ABI2 expression in SKM-

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… Chen S-J Zhou G-B Zhang X-W Mao J-H de Thé H Chen Z From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia Blood 2011 117 6425 37 10.1182/blood-2010-11-283598 21422471 PMC3123014 Chen S-J, Zhou G-B, Zhang X-W, Mao J-H, de Thé H, Chen … From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia. Blood. 2011;117:6425–37. 21422471 10.1182/blood-2010-11-283598 PMC3123014 17. …

Safety and Efficacy of Extracorporeal Photopheresis for Acute and Chronic Graft-versus-Host Disease.

Background/Objectives: Despite novel biological agents, steroid-dependent or -refractory graft-versus-host disease (GvHD) remains a severe complication of allogeneic hematopoietic cell transplantation (allo-HCT). Extracorporeal photopheresis (ECP) is an alternative, non-immunosuppressive treatment for patients with acute (aGvHD) or chronic (cGvHD) GvHD. The aim of this study was to investigate the safety and efficacy of ECP in the treatment of acute and chronic GvHD; Methods: We prospectively studied 112 patients with cGvHD who received one or more previous lines of treatment and 28 patients w

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… Another limitation that has to be recognized is that our work started before the establishment of the National Institutes of Health (NIH) 2015 response criteria for cGVHD and Magic criteria for aGVHD, and therefore, we did not perform retrospective evaluations against them [ 48 , 49 , 50 ]. 4. … The MAGIC Algorithm Probability Is a Validated Response Biomarker of Treatment of Acute Graft-versus-Host Disease Blood Adv. 2019 3 4034 4042 10.1182/bloodadvances.2019000791 31816061 PMC6963240 51. The EBMT/EHA CAR-T Cell Handbook Springer New York City, NY, USA 2022 9783030943523 36121969 52. …

The importance of systemic inflammatory response measurements as pretransplant risk factors for outcome after allogeneic haematopoietic cell transplantation.

Systemic inflammatory response (SIR) measures are known prognostic values in patients with solid tumours. Little is known about their impact in haematological diseases or allogeneic haematopoietic cell transplantation (alloHCT). Therefore, we evaluate the association of pretransplant inflammatory markers with the clinical outcome in a prospective analysis of alloHCT. We included 2201 consecutive patients undergoing their first alloHCT. At admission, C-reactive protein (CRP), serum albumin (sALB), a composite inflammatory score (modified Glasgow prognostic score, mGPS) and the body mass index (

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… outcomes. 23 , 24 Of the established HCT scores, none includes inflammation markers or nutritional status, except BMI >35 kg/m 2 entailing one point in the HCT‐CI. 1 For example, the combination of clinical symptoms and biomarkers has recently been established for the outcome of aGvHD in the novel MAGIC … Novel MAGIC composite scores using both clinical symptoms and biomarkers best predict treatment outcomes of acute GVHD. Blood. 2024;144:1010–1021. 26. Urbain P, Birlinger J, Lambert C, Finke J, Bertz H, Biesalski HK. …

Oral mucosal injury caused by mammalian target of rapamycin inhibitors: emerging perspectives on pathobiology and impact on clinical practice.

In recent years oral mucosal injury has been increasingly recognized as an important toxicity associated with mammalian target of rapamycin (mTOR) inhibitors, including in patients with breast cancer who are receiving everolimus. This review addresses the state-of-the-science regarding mTOR inhibitor-associated stomatitis (mIAS), and delineates its clinical characteristics and management. Given the clinically impactful pain associated with mIAS, this review also specifically highlights new research focusing on the study of the molecular basis of pain. The incidence of mIAS varies widely (2-78%

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… In addition, the steroid mouth rinses and “magic” mouthwashes, often used for the palliative management of chemotherapy‐induced stomatitis, have been suggested for the prevention and treatment of mIAS 17 , 46 . … A case report of a patient with mIAS for whom treatment included topical dexamethasone, intralesional injections of the corticosteroid triamcinolone, and magic mouthwash oral rinse demonstrated significant improvement in the signs and symptoms of mIAS lesions 47 . …

Delivery of Drugs into Cancer Cells Using Antibody-Drug Conjugates Based on Receptor-Mediated Endocytosis and the Enhanced Permeability and Retention Effect.

Innumerable people worldwide die of cancer every year, although pharmaceutical therapy has actualized many benefits in human health. For background, anti-cancer drug development is difficult due to the multifactorial pathogenesis and complicated pathology of cancers. Cancer cells excrete hydrophobic low-molecular anti-cancer drugs by overexpressed efflux transporters such as multiple drug resistance 1 (MDR1) at the apical membrane. Mutation-driven drug resistance is also developed in cancer. Moreover, the poor distribution of drug to cancer cells is a serious problem, because patients suffer f

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… The concept of the “magic bullet” proselytized by Dr. Paul Ehrlich in 1900 is possible by mAbs against cancer antigens [ 52 ]. It is known that highly selective molecules as cancer antigens are expressed on the surface of cancer cells. … Magic bullet: Paul Ehrlich, Salvarsan and the birth of venereology. Sex. Transm. Infect. 2015;91:68–69. doi: 10.1136/sextrans-2014-051779. 53. Yamaguchi T. Current situations and the future prospect of monoclonal antibody products. [(accessed on 1 August 2022)];Bull. Natl. Inst. …

The next frontier in antibody-drug conjugates: challenges and opportunities in cancer and autoimmune therapy.

Antibody-Drug Conjugates (ADCs) have achieved significant success in cancer therapy by combining the targeting specificity of monoclonal antibodies with cytotoxic payloads. However, the concomitant issue of drug resistance has become increasingly prominent, with primary mechanisms including alterations in target antigen expression, impaired drug transport, and inhibition of cell death pathways. ADCs have also shown emerging therapeutic potential in the treatment of autoimmune diseases; for instance, ABBV-3373 has achieved initial success in this area, yet it also faces unique challenges such a

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… INTRODUCTION By combining the precise tumor-targeting properties of antibodies with the powerful cytotoxic effects of their drug payloads, antibody-drug conjugates (ADCs) hold great promise in cancer treatment and are often conceptualized as the “magic bullets” of cancer therapy [ 1 ] . … Paul Ehrlich’s magic bullet concept: 100 years of progress. Nat Rev Cancer. 2008;8:473–80. doi: 10.1038/nrc2394. 2. Huang Z, Braunstein Z, Chen J, et al. Precision medicine in rheumatic diseases: unlocking the potential of antibody-drug conjugates. …

Пациенты испытывают на себе воздействие множественных склерозов и корректирующих болезни терапии.

ЦЕЛЬ: Для регулирования множественных склерозов (MS) жизненно важное значение имеют методы лечения, корректирующие заболевания (DMT), однако исследования, проводимые с использованием административных данных, часто исключают предпочтения пациентов и факторы, которые врачи учитывают при принятии решений о лечении. Данные об опыте пациентов имеют важнейшее значение для понимания и улучшения инициирования, соблюдения и результатов лечения НР. МЕТОДЫ: С декабря в Интернете было проведено перекрестное обследование взрослых в США, имеющих MS или клинически изолированный синдром. 2022 по январь 2023 К

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… It’s not as if my tolerance for generic will improve or as if my MS will magically disappear.” – A person with PPMS “There is an extremely high level of anxiety created when insurers ‘arbitrarily’ remove specific DMTs from formulary.” – A person with CIS “It is frustrating to have to deal with insurance … It’s not as if my tolerance for generic will improve or as if my MS will magically disappear.” – A person with PPMS “There is an extremely high level of anxiety created when insurers ‘arbitrarily’ remove specific DMTs from formulary.” – A person with CIS “It is frustrating to have to deal with insurance …

Decreased Plasma Level of Cytokeratin 20 (KRT20) Is Indicative of the Emergence and Severity of Acute GvHD Irrespective to the Type of Organ Involvement.

Accurate risk prediction of acute graft versus host disease (aGvHD) is currently an unmet clinical need. This study sought to analyze whether three plasma proteins expressed in a largely skin- and gut-restricted manner would be affected by the development of acute cutaneous and gastrointestinal aGvHD. The diagnostic sensitivity, specificity, and prognostic value of plasma cytokeratin-15 (KRT15) cytokeratin-20 (KRT20), and occludin (OCLN) were evaluated in a discovery and a validation cohort using ELISA in comparison with elafin (PI3) and regenerating family member 3 alpha (REG3A), two establis

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… The viability of such a “liquid biopsy” approach (i.e., an assessment of gut damage based on plasma protein analysis) has been convincingly demonstrated by the MAGIC algorithm and the example of REG3A, ST2, and TNFR1 in aGvHD [ 16 ]. … The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease Blood Adv. 2019 3 4034 4042 10.1182/bloodadvances.2019000791 31816061 PMC6963240 17. Ferrara J.L. Harris A.C. Greenson J.K. Braun T.M. Holler E. Teshima T. Levine J.E. Choi S.W. …