Результаты поиска

Структура-ориентированное исследование ДНК-аптамера, целевого PTK7, выявляет сложную 3D-составляющую, направляющую оптимизацию функции.

DNA аптамеры вышли в качестве новых молекулярных инструментов в терапевтической и диагностической медицине благодаря своей высокой аффинности и специфичности к белковым целям, что определяется их способностью сворачиваться в отличительные трехмерные (3D) структуры. Однако при проектировании и моделировании аптамеров часто игнорируются тонкие атомные взаимодействия, формирующие 3D структуры, что приводит к неэффективной оптимизации функциональных свойств. Проблемы сохраняются при определении высокоразрешающих структур комплексов аптамер-белок. Кроме того, экспериментально определенные 3D структ

Совпадение в аннотации оригинала
DNA aptamers have emerged as novel molecular tools in disease theranostics owing to their high binding affinity and specificity for protein … hed structure-function relationship, we efficiently engineered two sgc8c variants by modifying the apical loop and introducing L-DNA base pairs to simultaneously enhance thermostability, biostability, and binding affinity for both protein and cell targets, a feat not previously attained despite extensive efforts. This work showcases a simplified NMR-ba …

Combined Immune Defect in B-Cell Lymphoproliferative Disorders Is Associated with Severe Infection and Cancer Progression.

B cell chronic lymphoproliferative diseases (B-CLPD) are associated with secondary antibody deficiency and other innate and adaptive immune … 12 patients (14%), due to prior history of infections, autoimmune and granulomatous conditions, atypical or variegated course and compatible biological data. This first proposed SID classification might have relevant clinical implications, in terms of predicting severe infections and cancer progression, and might be applied to different B-CLPD entitie …

Systemic AL Amyloidosis: Current Approaches to Diagnosis and Management.

AL amyloidosis is characterized by a low-level expansion of an indolent, small plasma cell clone that produces amyloidogenic light chains. Amyloid aggregates or preceding intermediaries cause direct cell damage through their proteotoxicity, and amyloid deposits distort tissue architecture, and, eventually, lead to organ impairment. It is a rare, underdiagnosed disease with a diverse clinical presentation depending on the organ tropism of the amyloid fibrils; cardiac and renal involvement is most common, but any organ can be affected, excluding the central nervous system. A high level of awaren

Совпадение в полном тексте источника
… Fontana M, Pica S, Reant P, et al. Prognostic value of late gadolinium enhancement cardiovascular magnetic resonance in cardiac amyloidosis. Circulation. 2015;132:1570–1579. 43. Banypersad SM, Fontana M, Maestrini V, et al. T1 mapping and survival in systemic light-chain amyloidosis. …

Дополнительные и смешанные мероприятия в связи с реальностью у людей с множественным склерозом: систематический обзор.

Справочная информация: В последние годы люди, страдающие множественным склерозом (МС), стали более зримыми в связи с тем, что они способны оказывать услуги в области лечения с учетом конкретных задач и многочувствительных методов лечения. Цель: В рамках этого систематического обзора изучается применение технологий " смешанной реальности " (MR) и " повышенной реальности " (AR) в нейрореабилитации для лиц, имеющих MS. Метод: в семи базах данных был проведен всеобъемлющий систематический обзор, и было выявлено семь приемлемых исследований, связанных с мероприятиями MR/AR, орие

Совпадение в полном тексте источника
… Pica A. Pascucci S. Serrao M. Marinozzi F. Bini F. A Proof of Concept Combined Using Mixed Reality for Personalized Neurorehabilitation of Cerebellar Ataxic Patients Sensors 2023 23 1680 10.3390/s23031680 36772721 PMC9920853 44. Franzo M. Marinozzi F. Finti A. Lattao M. Trabassi D. Castiglia S.F. …

Bortezomib and dexamethasone for multiple myeloma: higher AST and LDH levels associated with a worse prognosis on overall survival.

BackgroundBortezomib offers a novel approach to the treatment of multiple myeloma producing rapid control. The aim of this study was to investigate the outcomes of bortezomib and dexamethasone-treated patients with multiple myeloma.MethodsWe conducted a retrospective study of 44 consecutively-treated multiple myeloma patients with bortezomib (1.3 mg/m(2) on days 1, 4, 8, and 11 of a 21-day cycle or 1.3 mg/m(2) intravenously 1, 8, 15, and 22 of every 35-day cycle) and dexamethasone.ResultsThe median time to progression, progression free survival time, and overall survival time in the treatment

Совпадение в полном тексте источника
… Corso A, Varettoni M, Mangiacavalli S, Zappasodi P, Pica GM, Algarotti A, Pascutto C, Lazzarino M. Bortezomib plus dexamethasone is highly effective in relapsed and refractory myeloma patients but responses are short-lived. Eur J Haematol. 2009;83(5):449–454. doi: 10.1111/j.1600-0609.2009.01295.x. …

Расследование нарушений питания среди лиц, страдающих неевродегенеративными заболеваниями: обзор.

АИМ: Нейродегенеративные заболевания и неправильное питание стали быстро расширяющимися областями исследований. Вместе с тем исследования, посвященные взаимосвязи между two не хватает. МЕТОДЫ: Был завершен обзор аналитического исследования на основе методологической основы Института Джоанны Бриггс для обобщения данных, касающихся беспорядочного поведения в области питания среди лиц, страдающих нейродегенеративными заболеваниями. Стратегия систематического поиска применялась во всех областях four - научные базы данных. Был проведен описательный описательный анализ в целях выявления ключевых мод

Совпадение в полном тексте источника
… Ceschin L., Giannunzio V., Favaro A., and Santonastaso P., “Pica in an Eating Disordered Woman With Multiple Sclerosis: Impulse Dyscontrol, Compulsive Symptom or Self‐Medication Attempt?,” Eating and Weight Disorders‐Studies on Anorexia, Bulimia and Obesity 15 (2010): e116–e118. 44. …

State of the Art of Cardiac Amyloidosis.

Cardiac amyloidosis is defined by extracellular deposition of misfolded proteins in the heart. The most frequent cases of cardiac amyloidosis are caused by transthyretin and light chain amyloidosis. This condition is underdiagnosed, and its incidence has been continuously rising in recent studies because of the aging of the population and the development of noninvasive multimodal diagnostic tools. Amyloid infiltration affects all cardiac tunics and causes heart failure with preserved ejection fraction, aortic stenosis, arrythmia, and conductive disorder. Innovative, specific therapeutic approa

Совпадение в полном тексте источника
… Fontana M., Banypersad S.M., Treibel T.A., Maestrini V., Sado D.M., White S.K., Pica S., Castelletti S., Piechnik S.K., Robson M.D., et al. Native T1 mapping in transthyretin amyloidosis. JACC Cardiovasc. Imaging. 2014;7:157–165. doi: 10.1016/j.jcmg.2013.10.008. 28. …

Parasites' immunomodulators: a breakthrough in immunotherapeutics displaying antineoplastic activity against human colorectal and hepatocellular carcinoma cells.

The complex interplay between parasites and cancer is yielding promising advances in the field of cancer therapeutics. This study explored the in vitro anti-cancer potential of parasite immunomodulators (antigens and antibodies) of Schistosoma mansoni, Trichinella spiralis, and Toxoplasma gondii on human HT-29 colorectal and HepG2 hepatocellular carcinoma cells using the MTT assay. Results revealed that those parasites' immunomodulators exhibited antineoplastic activity and demonstrated a statistically significant inhibition of both cancer cell lines' proliferation (P ˂0.05). Notably, Trichine

Совпадение в полном тексте источника
… Pica-Mattoccia L Cioli D Sex-and stage-related sensitivity of schistosoma mansoni to in vivo and in vitro praziquantel treatment Int J Parasitol 2004 34 4 527 33 10.1016/j.ijpara.2003.12.003 15013742 Pica-Mattoccia L, Cioli D. …

Проблемы с многократной терапией миеломы у пациентов постарше и посторонних.

Каждый год больше, чем 150,000 во всем мире диагностируются случаи множественной миеломы (ММ) и более 100,000 Зарегистрированы случаи смерти в результате этого злонамеренного поведения. Уровень заболеваемости ММ растет во всем мире, особенно в странах с высоким уровнем дохода и среди мужского населения в возрасте ≥ 50. Хотя прогресс в осуществлении стратегий лечения привел к повышению уровня выживания за последние десятилетия, ММ остается неизлечимым во многих случаях. Важно то, что one- треть пациентов с диагнозом MM - >75 возраст и характеризуется относительно низкой трудоспособностью или сл

Совпадение в полном тексте источника
… Manier S., Corre J., Hulin C., Laribi K., Araujo C., Pica G.-M., Touzeau C., Godmer P., Slama B., Karlin L., et al. …

Education, Employment, and Financial Outcomes in Adolescent and Young Adult Cancer Survivors-A Systematic Review.

Adolescents and young adults (AYAs) with cancer face unique challenges. We aimed to describe (i) education, employment, and financial outcomes and (ii) determinants for adverse outcomes in AYA cancer survivors. We performed a systematic literature search. We included original research articles on AYA (15-39 years of age) cancer survivors (≥2 years after diagnosis) and our outcomes of interest. We narratively synthesized the results of the included articles. We included 35 articles (24 quantitative and 11 qualitative studies). Patients in education had to interrupt their education during cancer

Совпадение в полном тексте источника
… Pica A. Hrbacek J. Bachtiary B. Walser M. Leiser D. Lomax A.J. Weber D.C. Outcomes of adolescents and young adults treated for brain and skull base tumors with pencil beam scanning proton therapy Pediatr. Blood Cancer 2020 67 e28664 10.1002/pbc.28664 32881313 38. Lu A.D. Zheng Z. Han X. Qi R. …

AL Amyloidosis for Cardiologists: Awareness, Diagnosis, and Future Prospects: JACC: CardioOncology State-of-the-Art Review.

Amyloid light chain (AL) amyloidosis is a rare, debilitating, often fatal disease. Symptoms of cardiomyopathy are common presenting features, and patients often are referred to cardiologists. Cardiac amyloid infiltration is the leading predictor of death. However, the variable presentation and perceived rarity of the disease frequently lead to delay in suspecting amyloidosis as a cause of heart failure, leading to misdiagnoses and a marked delay in diagnosis, with devastating consequences for the patient. A median time from symptom onset to correct diagnosis of about 2 years is often too long

Совпадение в полном тексте источника
… Fontana M., Pica S., Reant P., et al. Prognostic value of late gadolinium enhancement cardiovascular magnetic resonance in cardiac amyloidosis. Circulation. 2015;132:1570–1579. doi: 10.1161/CIRCULATIONAHA.115.016567. 62. Banypersad S.M., Fontana M., Maestrini V., et al. …

Diagnostic and prognostic value of cardiac imaging in amyloidosis.

Amyloidosis is an infiltrative disease caused by extracellular protein deposition that has accumulated a lot of scientific production in recent years. Different types of amyloidosis can affect the heart. Transthyretin amyloidosis and light chain amyloidosis are the two most common types of cardiac amyloidosis. These entities have a poor prognosis, so accurate diagnostic techniques are imperative for determining an early therapeutic approach. Recent advances in cardiac imaging and diagnostic strategies show that these tools are safe and can avoid the use of invasive diagnostic techniques to his

Совпадение в полном тексте источника
… Fontana M, Pica S, Reant P, Abdel-Gadir A, Treibel TA, Banypersad SM, Maestrini V, Barcella W, Rosmini S, Bulluck H, Sayed RH, Patel K, Mamhood S, Bucciarelli-Ducci C, Whelan CJ, Herrey AS, Lachmann HJ, Wechalekar AD, Manisty CH, Schelbert EB, Kellman P, Gillmore JD, Hawkins PN, Moon JC. …

Paraskeletal and extramedullary plasmacytomas in multiple myeloma at diagnosis and at first relapse: 50-years of experience from an academic institution.

From January 1970 to December 2018, 1304 patients were diagnosed with multiple myeloma (MM) at our institution and 256 (19.6%) had plasmacytomas (Ps) (paraskeletal -PPs- 17.6%, extramedullary -EMPs-1.9%). Patients with Ps had lower serum M-protein and less advanced ISS stage than those without. At first relapse, 192 out of 967 patients (19.8%) developed Ps (PPs 14.6%, EMPs 5.1%). The only factor associated with Ps at relapse was the presence of Ps at diagnosis (46% vs 13%, p < 0.00001) with no impact with exposure to novel drugs or previous autologous stem-cell transplantation (ASCT). The medi

Совпадение в полном тексте источника
… Varettoni M Corso A Pica G Mangiacavalli S Pascutto C Lazzarino M Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients Ann Oncol 2010 21 325 30 10.1093/annonc/mdp329 19633044 3. …

Molecular Impact of the Tumor Microenvironment on Multiple Myeloma Dissemination and Extramedullary Disease.

Multiple myeloma (MM) is the most common malignant monoclonal disease of plasma cells. Aside from classical chemotherapy and glucocorticoids, proteasome inhibitors, immunomodulatory agents and monoclonal antibodies are used in the current treatment scheme of MM. The tumor microenvironment (TME) plays a fundamental role in the development and progression of numerous solid and non-solid cancer entities. In MM, the survival and expansion of malignant plasma cell clones heavily depends on various direct and indirect signaling pathways provided by the surrounding bone marrow (BM) niche. In a number

Совпадение в полном тексте источника
… Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, Presenting Features and Outcome of Extramedullary Disease in Multiple Myeloma: A Longitudinal Study on 1003 Consecutive Patients. Ann Oncol Off J Eur Soc Med Oncol (2010) 21(2):325–30. doi: 10.1093/annonc/mdp329 16. …

Can 18F-NaF PET/CT before Autologous Stem Cell Transplantation Predict Survival in Multiple Myeloma?

There is an unmet need for positron emission tomography (PET) radiotracers that can image bone disease in multiple myeloma (MM) in a more sensitive and specific way than the widely used 18F-fluorodeoxyglucose (18F-FDG). Sodium fluoride (18F-NaF) is a highly sensitive tracer of bone reconstruction, evolving as an important imaging agent for the assessment of malignant bone diseases. We attempted to investigate for the first time the prognostic significance of 18F-NaF PET/CT in newly diagnosed, symptomatic MM patients planned for autologous stem cell transplantation (ASCT). Forty-seven patients

Совпадение в полном тексте источника
… Pica G. Mangiacavalli S. Pascutto C. Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: A longitudinal study on 1003 consecutive patients Ann. Oncol. 2010 21 325 330 10.1093/annonc/mdp329 19633044 46. Hall M.N. Jagannathan J.P. Ramaiya N.H. …

Bridging the Gap in Secondary Antibody Deficiencies: Current Evidence and Unmet Needs in Diagnosis and Management with Immunoglobulin Replacement.

Secondary antibody deficiency (SAD) represents a substantial yet under-recognised global healthcare burden. It is more prevalent than primary antibody deficiency, but frequently under-diagnosed and variably managed worldwide. Prompt diagnosis is often hindered by insufficient awareness among clinicians, lack of global consensus on screening/monitoring for SAD among at-risk patients, inadequate clinical immunology services and lack of standardised referral pathways/protocols. Management practices vary widely, with little international agreement, particularly regarding threshold to initiate immu

Non-relapse mortality with bispecific antibodies: A systematic review and meta-analysis in lymphoma and multiple myeloma.

Bispecific antibodies (BsAb) are associated with distinct immune-related toxicities that impact morbidity and mortality. This systematic review and meta-analysis examined non-relapse mortality (NRM) with BsAb therapy in B-cell non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). A PubMed and Embase search up to October 2024 identified 29 studies (21 NHL, 8 MM) involving 2,535 patients. The overall NRM point estimate was 4.7% (95% confidence interval [CI] 3.4%-6.4%), with a median follow-up of 12.0 months. We noted no significant difference in NRM across disease entities (NHL: 4.2%, MM: 6.2%,

Совпадение в полном тексте источника
… Lebreton P., Lachenal F., Bouillie S., Pica G.M., Aftisse H., Pascal L., Montes L., Macro M., Johnson N., Harel S., et al. Teclistamab for relapsed refractory multiple myeloma patients on dialysis. Br. J. Haematol. 2024;205:2077–2079. doi: 10.1111/bjh.19772. 49. Crowther M., Lim W., Crowther M.A. …

Whole-body magnetic resonance imaging (WBMRI) versus whole-body computed tomography (WBCT) for myeloma imaging and staging.

Myeloma-associated bone disease (MBD) develops in about 80-90% of patients and severely affects their quality of life, as it accounts for the majority of mortality and morbidity. Imaging in multiple myeloma (MM) and MBD is of utmost importance in order to detect bone and bone marrow lesions as well as extraosseous soft-tissue masses and complications before the initiation of treatment. It is required for determination of the stage of disease and aids in the assessment of treatment response. Whole-body low-dose computed tomography (WBLDCT) is the key modality to establish the initial diagnosis

Совпадение в полном тексте источника
… Varettoni M, Corso A, Pica G, Mangiacavalli S, Pascutto C, Lazzarino M. Incidence, presenting features and outcome of extramedullary disease in multiple myeloma: a longitudinal study on 1003 consecutive patients. Ann Oncol. 2010;21(2):325–330. doi: 10.1093/annonc/mdp329. 32. …

Mediterranean Diet Food Components as Possible Adjuvant Therapies to Counteract Breast and Prostate Cancer Progression to Bone Metastasis.

Bone metastasis is a serious and often lethal complication of particularly frequent carcinomas, such as breast and prostate cancers, which not only reduces survival but also worsens the patients' quality of life. Therefore, it is important to find new and/or additional therapeutic possibilities that can counteract the colonization of bone tissue. High adherence to the Mediterranean diet (MD) is effective in the prevention of cancer and improves cancer patients' health, thus, here, we considered its impact on bone metastasis. We highlighted some molecular events relevant for the development of

Совпадение в полном тексте источника
… Porciello G., Montagnese C., Crispo A., Grimaldi M., Libra M., Vitale S., Palumbo E., Pica R., Calabrese I., Cubisino S., et al. Mediterranean diet and quality of life in women treated for breast cancer: A baseline analysis of DEDiCa multicentre trial. …

Amyloidosis with Cardiac Involvement: Identification, Characterization, and Management.

Purpose of reviewAmyloidosis is a protein deposition disease whereby a variety of precursor proteins form insoluble fibrils that deposit in tissues, causing organ dysfunction and, many times, death. Accurate characterization of the disease based on the nature of the precursor protein, organ involvement, and extent of disease is paramount to guide management. Cardiac amyloidosis is critical to understand because of its impact on prognosis and new treatment options available.Recent findingsNew imaging methods have proven to be considerably valuable in the identification of cardiac amyloid infilt

Совпадение в полном тексте источника
… Fontana M, Pica S, Reant P, Abdel-Gadir A, Treibel TA, Banypersad SM, Maestrini V, Barcella W, Rosmini S, Bulluck H, Sayed RH, Patel K, Mamhood S, Bucciarelli-Ducci C, Whelan CJ, Herrey AS, Lachmann HJ, Wechalekar AD, Manisty CH, Schelbert EB, Kellman P, Gillmore JD, Hawkins PN, Moon JC. …