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A Complex Presentation of Multiple Myeloma With Renal Complications in a Young Female: Diagnostic Challenges and Treatment Approach.

A previously healthy 30-year-old woman experienced worsening back pain, fatigue, weakness, loss of appetite, and facial puffiness. After 18 months of these symptoms, she was diagnosed with multiple myeloma, which was also damaging her kidneys. The treatment involved a combination of medications and blood transfusions, leading to improved kidney function. Despite the challenges of managing her condition as a mother of young children, she remains hopeful. This case emphasizes the need for awareness of multiple myeloma in younger patients and the importance of early diagnosis and multidisciplinar

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… Parameters | Result | Ref. range Color | Pale yellow | pH | 7.0 | Specific gravity | 1.013 | 1.005–1.030 Protien | 2 (+) (Rechecked by SSA method) | Nil Glucose | Nil | Nil Ketones | Nil | Nil Bilirubin | Nil | Nil Occult blood | 1 (+) | Nil Leucocytes | Nil | Nil White (pus) cells | Occasional / hpf …

Воздействие упражнений на движение в сочетании с методами дыхания на торакический угл кифоза у лиц с торакическим гиперкифозом: систематический обзор и мета-анализ.

Теоретический гиперкифоз (THK) — посттуральная деформация, связанная с болью, расстройством дыхательных путей, снижением качества жизни, повреждением лопаточного ритма, биомеханическими изменениями плеча и повышенным риском падения. Хотя упражнения по исправлению положения широко используются, дополнительная ценность интеграции конкретных методов дыхания остается неясной. Цель этого систематического обзора и метаанализа состояла в том, чтобы оценить воздействие двигающихся упражнений в сочетании с дыхательными методами на угол торакического кифоза (TKA) у отдельных лиц с помощью THK.MetodsA си

Экулизумаб для связанной с АТКР тромботической микроангиопатии в китайском реципиенте трансплантации почек с типом 2 диабет: отчет по делу.

ЦЕЛЬ: Данное исследование было направлено на изучение эффективности экулизумаба в лечении недавно разработанной тромботической микроангиопатии (TMA), связанной с острым отторжением с помощью Т-клеток (ATCR) у пациентов с типом 2 диабет после трансплантации почек. МЕТОДЫ: Новая тромботическая микроангиопатия после трансплантации почек является относительно редким, но серьезным осложнением, которое клинически трудно уладить и требует своевременного вмешательства для предотвращения пересадки или ранней потери трансплантатата. В настоящее время в клинической практике отсутствует консенсус в отноше

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… Finally, continuous monitoring of renal tubular function and urine output during 24-h urine output withinTMA treatment revealed persistently normal parameters (urine specific gravity 1.010; the normal range), obviating the need for venous catheter placement and high-efficiency hemodialysis based on renal …

Prolonged recovery time from zoledronic Acid induced acute tubular necrosis: a case report and review of the literature.

Acute tubular necrosis (ATN) due to bisphosphonates has been reported with Zoledronic acid but the time to recovery (if any) has been usually less than 4 months. Possible recovery time from ATN of any cause is usually less than 6 months. In this paper, we present the case of a 59-year-old Caucasian female with metastatic breast cancer who had received 16 monthly injections of Zoledronic acid for treatment of tumor induced hypercalcemia and developed several episodes of mild acute kidney injury which resolved by withholding treatment. Unfortunately, after the sixteenth injection, the patient ex

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… Urinalysis showed 2+ protein, specific gravity of 1.020, and 1+ leukocyte esterase, with no blood, nitrites, or bacteria. …

Multiple myeloma presenting as acute tubulointerstitial nephritis.

BACKGROUND: Acute tubulointerstitial nephritis (ATIN) is a very rare paraneoplastic manifestation in patients with multiple myeloma (MM). It is an uncommon pattern of renal disease in such patients. CASE PRESENTATION: We report a case of an 82-year-old male who was admitted with acute kidney injury. Renal biopsy showed typical findings of light chain-associated ATIN with scattered inflammatory cells in the interstitium and associated active tubulitis. No other common manifestations of MM were present at the time of presentation, including hypercalcemia, hyperuricemia, proteinuria, bone pain o

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… Spot urinalysis revealed clear light-yellow urine with a specific gravity of 1.010 without any protein. The urine did not show significant white blood cells, red blood cells and was also negative for nitrites and leukocyte esterase. No urine casts were identified, and no eosinophils were noted. …

Where Is the 'Oma' in Multiple Myeloma? Origins and Limitations of some Myeloma-Related Terminology.

BackgroundMultiple myeloma, often simply called 'myeloma', is a clonal plasma cell malignancy that constitutes about one-tenth of all cancers managed by haematologists. Although the disease was first clearly described in the first half of the 19th century, it was only called multiple myeloma several decades later.AimsThis review summarizes myeloma-related terminology.ContentSeveral terms are commonly used in myeloma clinics, including paraprotein, immunoglobulins, kappa and lambda chains and plasma cells; other terms, such as dysproteinemia, are now less commonly used.SummaryIn this review, we

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… The patient's urine had stiffened his body linen despite the absence of urethral discharge and was of very high specific gravity [ 4 ]. …

Development of a Hybrid Simulated Patient Experience to Practice Care of the Dying Older Adult.

IntroductionCare of the dying older adult includes critical skills that emerging physicians should master but are not consistently taught. Simulation has been shown to be an excellent tool for teaching these skills in a standardized fashion. Simulation allows direct observation to assess and provide learner feedback. Our goal was to develop a learning activity to practice skills caring for the older adult at the end of life and identify areas in need of improvement.MethodsWe developed a hybrid simulation in which fourth-year medical students and internal medicine (IM) residents cared for a 70-

Case Report: Surgical treatment of stage 3 medication-related osteonecrosis of the maxilla using the "FTT Split" surgical protocol: a report of 14 cases.

Most severe presentation of medication-related osteonecrosis of the jaw (MRONJ) is classified as stage 3 for which there are still no standard surgical therapy guideline. Our aim was to describe "Five Times Three (FTT) Split" protocol as surgical treatment of stage 3 maxillary MRONJ. The present case series included a total of 14 patients diagnosed with stage 3 MRONJ of the upper jaw who were treated from February 2022 to September 2024 with mucoperiosteal flap and "FTT Split" protocol. The patients were followed up both clinically and radiologically for a period ranging from 9 months to 3 yea

Caregiver strain among patients of palliative care in Sri Lanka: validation of modified caregiver strain index - Sinhala version.

BackgroundCare givers of Palliated patients are at risk of adverse physical, psychosocial and emotional sequelae in varied nature. Efficient and valid assessment tools facilitate early detection to take corrective measures. The Modified Caregiver Strain Index (MCSI), composed of domains associated with caregiver strain is a simple and brief tool that can be used in both clinical and field settings. This study aimed to adapt and validate this in order to cater effective palliative care services in Sri Lanka.MethodsAfter cross-cultural adaptation, 200 primary caregivers in 3 teaching hospitals w

Adult-Onset Cerebral Adrenoleukodystrophy Without Adrenal Gland Involvement.

X-linked adrenoleukodystrophy (X-ALD) is a metabolic disorder characterized by endocrine and neurological degeneration. A rare and variegated entity in adults, diagnosis is often a significant challenge and can lead to extensive testing, including invasive procedures if clinical suspicion is not high. We present the case of a 46-year-old-male with neurological dysfunction that is uncommon in X-ALD with preserved adrenocortical function. Initially misdiagnosed with multiple sclerosis, the patient faced a significant neurological and cognitive decline in a short follow-up time frame, ultimately

A 16-week progressive exercise training intervention in treatment-naïve chronic lymphocytic leukaemia: a randomised-controlled pilot study.

BackgroundChronic lymphocytic leukaemia (CLL) typically presents with asymptomatic, early-stage disease that is monitored until disease progression ('treatment-naïve' CLL). The objective of this pilot study was to assess the feasibility and preliminary safety of an exercise program in treatment-naïve CLL. We also sought to preliminarily assess the impact of the exercise program on disease activity, as it has been proposed that exercise training may reduce disease outgrowth in treatment-naïve CLL.MethodsA total of 40 treatment-naïve CLL patients were recruited into this randomised-controlled pi

Cryoglobulinemia Associated With Multiple Myeloma in a Dog Presenting With Epistaxis and Skin Lesions.

A 10-year-old female neutered Labrador Retriever presented with epistaxis, discoloration and crusting of the nose and a necrotic lesion on the lip. Bloodwork revealed pancytopenia, azotemia, hypoalbuminemia and hyperglobulinemia. Aggregates of amorphous basophilic material were seen in a room-temperature blood smear which were not present in the sample after warming to 37°C, and grossly a cryoprecipitate was noted in the patient's serum at 4°C. This was interpreted as cryoglobulin. Computed tomography showed multiple heterogeneous lesions in the spleen. Cytology of the splenic lesions revealed

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… Urinalysis revealed proteinuria with urine protein–creatinine (UPC) ratio of 1.44 (normal: <0.2) with adequate specific gravity at 1.036, and an inactive sediment. …

Улучшают ли упражнения на ногах функции рук и рук для лиц с нееврологическими расстройствами? Обзор.

Цель проведения аналитического обзора, содержащего резюме существующей литературы об использовании упражнений на ногах для улучшения функции руки для лиц, страдающих неврологическими условиями. 5 базы данных (PubMed, Empase, Cumulative Index to Medrsing and Alimate Health Licture, Scopus, Cochrane Central), вторичные ссылки и 9 Серые литературные базы данных с января 1, 1947, по октябрь 28, 2025Студенты по отбору исследователей включали взрослых, живущих в неврологических условиях и осуществляющих программы тренировки с ориентацией на ногу, которые включали в себя конкретные результаты по рука

Skin manifestations associated with systemic diseases - Part I.

The skin demonstrates what is happening in the body in many diseases, as it reflects some internal processes on the surface. In this sense, skin as an organ, goes beyond its protective and barrier functions, as it provides clues for the identification of some systemic diseases. The dermatologist then raises diagnostic hypotheses for conditions related to all systems and refers them to the appropriate specialty. With easy access to examination by trained eyes and biopsies, the skin can present specific or non specific alterations on histopathology. In the first case this combination establishes

Влияние инженерного распределения твердых частиц обычного портовых цемента на дополнительный цемент: сравнительный анализ эффективности с коммерческим портландским цементом.

В этом исследовании рассматривается критическая взаимосвязь между распределением частиц по размеру (PSD) и соединениями Бога, при этом подчеркивается их важнейшая роль в повышении прочности цемента на раннем этапе при одновременном обеспечении устойчивости. В ходе исследования изучаются экспериментальные процедуры, в результате чего коммерческий обычный портленд цемент (К-ОПК) подвергается измельчению, что приводит к специфическому изысканию. 5390 см2/г, именуемый "стимулятором (S)". Преобразование этого стимулятора в стандарт C-OPC при точно калиброванном 45% Соотношение веса (именуемое "S45"

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… | C-OPC | S | GGBFS Physical properties Specific gravity | 3.15 | 3.15 | 2.90 Blaine fineness, m 2 /kg | 365 | 539 | 440 Chemical properties Calcium oxide, CaO (%) | 57.5 | 59.1 | 37.6 Silicon dioxide, SiO 2 (%) | 20.5 | 20.7 | 34.8 Aluminum oxide, Al 2 O 3 (%) | 6.1 | 5.7 | 17.9 Ferric oxide, Fe 2 …

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential.

Single-cell sequencing (SCS) techniques have the potential to offer precise insights into cellular diversity by revealing unique genetic and transcriptomic profiles at the single-cell level. This advanced technology has been used extensively in research, but it has still not translated to clinical diagnostics, despite its potential. SCS provides more accurate granular information about heterogeneous cell populations and the creation of personalized treatment strategies. However, the integration of SCS into clinical practice is challenging. This review discusses the potential of SCS technologie

Перевозка и сдерживание движения sphingosine-1-phosphate Экспортеры SPNS2.

Sphingosine-1-phosphate (S1P) — сигнал лизолипида, имеющий решающее значение для развития сердца, иммунитета и слуха. Соответственно, мутации в переносчике S1P SPNS2 связаны с уменьшением числа белых клеток и нарушениями слуха. СПНС2 также экспортирует S1P-mimicking FTY720-P (Финголимод) и, таким образом, является центральным элементом фармакокинетики этого препарата при лечении множественного склероза. Здесь мы используем комбинацию крио-электронной микроскопии, иммунофлюоресценции, связывания in vitro и в vivo S1P-оценки экспорта, а также молекулярное моделирование динамики для исследования

Prognostic understanding, quality of life and mood in patients undergoing hematopoietic stem cell transplantation.

Little is known about how patients undergoing hematopoietic stem cell transplantation (HCT) and their family caregivers (FC) perceive their prognosis. We examined prognostic understanding in patients undergoing HCT and their FC and its relationship with quality of life (QOL) and mood. We conducted a longitudinal study of patients (and FC) hospitalized for HCT. We used a questionnaire to measure participants' prognostic understanding and asked the oncologists to estimate patients' prognosis prior to HCT. We assessed QOL and mood weekly and evaluated the relationship between prognostic understan

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management.

Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders. Types II and III are known as mixed CG (MC): Type II consists of polyclonal IgG and monoclonal IgM with rheumatoid factor (RF) activity, whereas Type III includes polyclonal IgG and polyclonal IgM with RF activity. MC is predominantly associated with hepatitis C virus (HCV) infection and involve

(Поли) фенолы и множественный склероз: результаты межсекционного исследования наблюдений.

(Поли) фенолы представляют собой широкий и разнородный класс веществ с рядом потенциальных преимуществ для здоровья. Их роль в нейрозащите и когниции по-прежнему вызывает сомнения. Цель этого исследования заключается в изучении возможной взаимосвязи между общим и индивидуальным (поли)поглощением фенола, основными источниками питания и остротой множественного склероза (МС) в группе пациентов, страдающих НР. Были собраны демографические данные, данные о физической активности участников, данные о курении и рационе питания наряду с клиническими параметрами, включая Расширенный цикл оценки инвалидн