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Outbreak of yellow fever in central and southwestern Uganda, February-may 2016.

BACKGROUND: On 28 March, 2016, the Ministry of Health received a report on three deaths from an unknown disease characterized by fever, jaun … r liver function abnormalities. A confirmed case was a probable case with IgM or PCR positivity for yellow fever. We reviewed medical records and conducted active community case-finding. In a case-control study, we compared risk factors between case-patients and asymptomatic control-persons, frequency-matched by age, sex, and village. We used multivariate cond …

Molecular epidemiology of dengue, yellow fever, Zika and Chikungunya arboviruses: An update.

Arboviruses are a group of viruses transmitted by arthropods. They are characterized by a wide geographic distribution, which is associated … ely to occur. Therefore, this review is focused on untangling the molecular epidemiology of Dengue, Yellow fever, Zika and Chikungunya due to their recent epidemics in Latinamerica but provides an update on the geographical distribution globally of these viral variants, and outlines the need for further understanding of the genotypes/lineages assignment.

The risk of urban yellow fever resurgence in Aedes-infested American cities.

Aedes aegypti, historically known as yellow fever (YF) mosquito, transmits a great number of other viruses such as Dengue, West Nile, Chikungunya, Zika, Mayaro and perhaps Oropouche, among others. Well established in Africa and Asia, Aedes mosquitoes are now increasingly invading large parts of the American continent, and hence the risk of urban YF resurgence in the American cities should because of great concern to public health authorities. Although no new urban cycle of YF was reported in the Americas since the end of an Aedes eradication programme in the late 1950s, the high number of non-…

Functional characterization of aquaporins and aquaglyceroporins of the yellow fever mosquito, Aedes aegypti.

After taking vertebrate blood, female mosquitoes quickly shed excess water and ions while retaining and concentrating the mostly proteinaceous nutrients. Aquaporins (AQPs) are an evolutionary conserved family of membrane transporter proteins that regulate the flow of water and in some cases glycerol and other small molecules across cellular membranes. In a previous study, we found six putative AQP genes in the genome of the yellow fever mosquito, Ae. aegypti, and demonstrated the involvement of three of them in the blood meal-induced diuresis. Here we characterized AQP expression in different …

Risk assessment for yellow Fever in Western and north-Western provinces of zambia.

BACKGROUND: North-Western and Western provinces of Zambia were reclassified as low-risk areas for yellow fever (YF). However, the current potential for YF transmission in these areas is unclear. AIMS: To determine the current potential risk of YF infection. SETTING AND DESIGN: A cross sectional study was conducted in North-Western and Western provinces of Zambia. MATERIALS AND METHODS: Samples were tested for both YF virus-specific IgG and IgM antibodies by the ELISA and YF virus confirmation was done using Plaque Reduction Neutralization Test. The samples were also tested for IgG and IgM a…

В Нидерландах подозревается в болезни вицертропика, связанной с желтой лихорадкой.

Желтая лихорадка (YF) 17D вакцина является одной из самых успешных вакцин, когда-либо разработанных. С 2001 года в рецензируемой литературе было опубликовано 56 случаев заболевания вицертропиком желтой лихорадки (YEL-AVD). В этой связи мы сообщаем о новом деле, подозреваемом в совершении преступления ЙЕЛ-АВД в Нидерландах. Необходимо провести дополнительные исследования для определения реальной распространенности ЕИЖ-АВД и уточнения факторов, связанных с носителями и вакцинами, в патогенезе ЙЕЛ-АВД. В связи с возможными неблагоприятными явлениями медицинские работники должны тщательно рассматр

Совпадение в аннотации оригинала
Yellow fever (YF) 17D vaccine is one of the most successful vaccines ever developed. Since 2001, 56 cases of yellow fever vaccine-associated viscerotropic disease (YEL-AVD) have been published in the peer-reviewed literature. Here, we report a new case suspected for YEL-AVD in the Netherlands. Further research is needed to determine the true incidence of YEL…

Mutagenesis analysis of T380R mutation in the envelope protein of yellow fever virus.

BACKGROUND: The RGD motif in the mosquito-borne flaviviruses envelope protein domain III (EDIII) FG loop was shown to bind negatively charged cellular molecules and mediate virus entry in mammals. However, its importance in virus entry in the mosquito has not yet been defined. The sequences of RGD motifs are conserved in JEV-serocomplex members primarily transmitted by Culex mosquitoes but absent from members of the DENV serocomplex, which utilize Aedes mosquitoes as vectors. Interestingly, the RGD sequence is present in the attenuated 17D strain of yellow fever virus as a result of the T380R …

Demographic profile of sylvatic yellow fever in Brazil from 1973 to 2008.

BACKGROUND: Yellow fever is an acute, frequently fatal, febrile arbovirosis that in Brazil occurs only in the sylvatic form. Sylvatic yellow fever (SYF) appears in sporadic outbreaks over a large area of Brazil. In this paper, we analyze the demographic profile of 831 SYF cases that occurred between 1973 and 2008, to determine which segments of the exposed population are at greater risk. METHODS: Data were statistically analyzed and were also geo-referenced in order to observe their spatial pattern. The basic reproductive number of infections, R0, was estimated by the ratio between average li…

Lack of interference by zoster vaccine with the immune response to yellow fever vaccine.

Concerns exist about the serologic response to yellow fever (YF) vaccine when given within 28 days of another live virus vaccine. We report the case of a healthy adult who received 17D YF vaccine 21 days following administration of another live viral vaccine, and developed a protective level of immunity against YF virus.

Evaluation of two molecular methods for the detection of Yellow fever virus genome.

Yellow fever virus (YFV), a member of the family Flaviviridae, genus Flavivirus is endemic to tropical areas of Africa and South America and is among the arboviruses that pose a threat to public health. Recent outbreaks in Brazil, Bolivia, and Paraguay and the observation that vectors capable of transmitting YFV are presenting in urban areas underscore the urgency of improving surveillance and diagnostic methods. Two novel methods (RT-hemi-nested-PCR and SYBR(®) Green qRT-PCR) for efficient detection of YFV strains circulating in South America have been developed. The methods were validated us…

Yellow fever vaccination and increased relapse rate in travelers with multiple sclerosis.

OBJECTIVE: To investigate the effect of yellow fever (YF) immunization on the subsequent multiple sclerosis (MS) relapse risk. DESIGN: Self-controlled case series study. SETTING: An MS outpatient clinic. PATIENTS: Seven patients with clinical relapsing-remitting MS traveling to endemic YF areas who received the YF 17D-204 vaccine were studied. INTERVENTION: The YF 17D-204 vaccine. MAIN OUTCOME MEASURE: Number of relapses. Secondary outcomes included the number of new lesions on magnetic resonance imaging and peripheral mononuclear cell cytokine and chemokine production. RESULTS: The annu…

Description of a prospective 17DD yellow fever vaccine cohort in Recife, Brazil.

From September 2005 to March 2007, 238 individuals being vaccinated for the first time with the yellow fever (YF) -17DD vaccine were enrolled in a cohort established in Recife, Brazil. A prospective study indicated that, after immunization, anti-YF immunoglobulin M (IgM) and anti-YF IgG were present in 70.6% (IgM) and 98.3% (IgG) of the vaccinated subjects. All vaccinees developed protective immunity, which was detected by the plaque reduction neutralization test (PRNT) with a geometric mean titer of 892. Of the 238 individuals, 86.6% had IgG antibodies to dengue virus; however, the presence o…

[Epidemiological situation of yellow fever in Burkina Faso from 2003 to 2008].

Despite the existence of antiamaril vaccine in the routine Expanded Program of Immunization (EPI) in Burkina Faso, yellow fever cases still occur in the country. In collaboration with WHO, the national health authorities set up a surveillance system through the national reference laboratory in Centre Muraz (Bobo-Dioulasso). All samples of feverish icterus cases of the 63 health districts of the country were analysed in this lab for M Immunoglobulin using Enzyme Linked Immunosorbent Assay (Elisa). Positive Elisa samples were sent to Pasteur Institute of Dakar (Senegal) for confirmation using a …

Yellow fever in Brazil: thoughts and hypotheses on the emergence in previously free areas.

This article describes and discusses factors associated to the reemergence of yellow fever and its transmission dynamics in the states of São Paulo (Southeastern Brazil) and Rio Grande do Sul (Southern) during 2008 and 2009. The following factors have played a pivotal role for the reemergence of yellow fever in these areas: large susceptible human population; high prevalence of vectors and primary hosts (non-human primates); favorable climate conditions, especially increased rainfall; emergence of a new genetic lineage; and circulation of people and/or monkeys infected by virus. There is a nee…

[Serological, molecular and virological analyses associated with yellow fever surveillance in Colombia].

INTRODUCTION: Yellow fever is an immunopreventable viral hemorrhagic fever that causes high morbidity and mortality in tropical and sub-tropical regions. In Colombia, approximately 5 million persons are at risk of becoming infected with yellow fever virus. OBJECTIVE: The serological, molecular and virological analyses on the yellow fever surveillance samples were summarized in order to indicate the importance of appropriate and timely sampling in the process of case confirmation. MATERIALS AND METHODS: The survey was based on samples received at the Arbovirus Laboratory, Virology Group, Inst…