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Prediction of cancer drugs by chemical-chemical interactions.

Cancer, which is a leading cause of death worldwide, places a big burden on health-care system. In this study, an order-prediction model was built to predict a series of cancer drug indications based on chemical-chemical interactions. According to the confidence scores of their interactions, the order from the most likely cancer to the least one was obtained for each query drug. The 1(st) order prediction accuracy of the training dataset was 55.93%, evaluated by Jackknife test, while it was 55.56% and 59.09% on a validation test dataset and an independent test dataset, respectively. The propos

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… Several drugs, such as thalidomide, sildenafil, bupropion and fluoxetine, have been successfully repositioned to new indications [13] , [14] . …

Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 5 million adults in the United States, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. In this article we focus on lower extremity PAD and specifically on the superficial femoral and proximal popliteal artery (SFPA), which are the most common anatomic locations of lower extremity atherosclerosis. We summarize current evidence and perform a systematic review on the diagnostic evaluation as well as the medical, endovascular and s

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… strong association with both PAD and cardiovascular disease, it is a class I recommendation in current guidelines that comprehensive smoking cessation interventions should be offered to all patients with lower extremity PAD, including behavior modification therapies, nicotine replacement therapy or bupropion …

The Multifaceted Nature of GLP-1: Molecular Mechanisms and Signaling Pathways in Metabolic and Neurodegenerative Diseases.

The aim of this article is to present the current state of knowledge regarding the use of GLP-1 agonists in the treatment of type 2 diabetes, obesity, and other potential clinical indications, including neurodegenerative conditions. The article describes the characteristics of the diseases discussed, with particular emphasis on the pathophysiological mechanisms and the impact of metabolic disorders on the course of the diseases. In addition, the specific role of GLP-1 receptor agonists and their mechanisms of action leading to improved clinical outcomes were discussed, including their impact o

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… These include phentermine–topiramate, orlistat, naltrexone–bupropion, tirzepatide, and the glucagon-like peptide type 1 receptor agonists (GLP-1 RA): liraglutide and semaglutide [ 47 , 56 ]. …

Endothelial dysfunction in congenital adrenal hyperplasia due to 21-hydroxylase deficiency: current knowledge and novel biomarkers.

Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is a complex endocrine disorder characterized by impaired cortisol synthesis and androgen excess. Beyond its hormonal and metabolic implications, CAH has been increasingly associated with an elevated risk of cardiovascular complications, including endothelial dysfunction, a critical precursor to atherosclerosis and a risk factor for cardiovascular and metabolic diseases. This review explores the current knowledge on endothelial function in patients with CAH, focusing on the interplay between chronic hormonal imbalanc

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… Newer antiobesity medications (liraglutide, semaglutide, tirzepatide, and naltrexone/bupropion) have not yet been studied in patients with CAH. …

Impact of physical exercise in cancer survivors during and after antineoplastic treatments.

Cancer patients experience symptoms and adverse effects of treatments that may last even after the end of treatments. Exercise is a safe, non-pharmacological and cost-effective therapy that can provide several health benefits in cancer patient and survivors, reducing cancer symptoms and cancer treatment side effects. The purpose of this review is to describe how the physical exercise is capable to reduce cancer symptoms and cancer treatment side effects. We realized a pragmatic classification of symptoms, dividing them into physical, psychological and psycho-physical aspects. For each symptom

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… Pharmacologic treatment for depression in cancer patients envisages tricyclic antidepressant (TCAs), monoamine oxidase inhibitors (MAOIs), SSRIs, SNRIs and other agents, such as mirtazapine and bupropion. …

The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction.

PURPOSE: Erectile dysfunction (ED) is one of the most prevalent male sexual dysfunctions. ED has been in the past mistakenly considered a purely psycho-sexological symptom by patients and doctors. However, an ever-growing body of evidence supporting the role of several organic factors in the pathophysiological mechanisms underlying ED has been recognized. METHODS: The Italian Society of Andrology and Sexual Medicine (SIAMS) commissioned an expert task force involving several other National Societies to provide an updated guideline on the diagnosis and management of ED. Derived recommendations

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… Among antidepressants, bupropion, a norepinephrine and dopamine reuptake inhibitor, has shown limited or no influence on sexual dysfunction, both when depressed population and healthy volunteers were considered [ 115 ]. …

Systemic Consequences of Inflammatory Bowel Disease Beyond Immune-Mediated Manifestations.

Inflammatory bowel disease (IBD) management traditionally focuses on intestinal inflammation, yet extraintestinal manifestations can substantially impair patient quality of life. In this perspective, we emphasize the broad systemic impact of IBD-from highly prevalent conditions such as anemia, metabolic dysfunction-associated steatotic liver disease, or fatigue to rare but severe complications like interstitial lung disease and drug-induced glomerulonephritis. We review underlying mechanisms linking gut inflammation to distant organs, including immune dysregulation, microbial translocation, an

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… Antidepressants, particularly SSRIs commonly used to manage depression in IBD, are associated with sexual side effects, whereas alternatives like SNRIs, mirtazapine, or bupropion may have fewer adverse effects [ 110 ]. …

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance.

Chemotherapy is an effortless and frequently used approach in cancer therapy. However, in most cases, it can only prolong life expectancy and does not guarantee a complete cure. Furthermore, chemotherapy is associated with severe adverse effects, one of the major complications of effective cancer therapy. In addition, newly published research outputs show that cancer stem cells are involved in cancer disease progression, drug resistance, metastasis, and recurrence and that they are functional in the trans-differentiation capacity of cancer stem cells to cancer cells in response to treatments.

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… prostate cancer cells. 2 | Azithromycin 172 | An antibacterial antibiotic for bacterial infections | COVID-19 | Azithromycin influences intracellular mitogen-activated protein kinase (MAPK), in particular, extracellular signal-regulated kinases 1/2 (ERK1/2) and the NF-κB pathway downstream of ERK. 3 | Bupropion …

Psychosocial Determinants of Lifestyle Change after a Cancer Diagnosis: A Systematic Review of the Literature.

The aim of this study is to provide a systematic overview of the scientific literature on sociodemographic, psychological and social determinants that may facilitate or hamper lifestyle change after the diagnosis cancer. Four databases (PubMed, PsychINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science) were searched for relevant papers up to October 2021. Of the 9586 references yielded by the literature search, 123 papers were included: 71 quantitative and 52 qualitative papers. Findings showed a large variety of determinants influencing lifestyle change

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… A bupropion smoking cessation clinical trial for cancer patients Cancer Causes Control. 2010 21 811 820 10.1007/s10552-010-9507-8 20087643 58. Schnoll R.A. Rothman R.L. Wielt D.B. Lerman C. Pedri H. Wang H. Babb J. Miller S.M. Movasas B. Sherman E. …

Clinical Practice Guidelines for Menopause: An Executive Summary and Recommendations: Indian Menopause Society 2026.

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… Pharmacological options may include bupropion, flibanserin, or selected SSRIs/SNRIs as adjuncts (Grade B). [215-217] B ODY C OMPOSITION (BC), S KIN, AND M ETABOLIC C HANGES 133. …

Obesity as a Multifactorial Chronic Disease: Molecular Mechanisms, Systemic Impact, and Emerging Digital Interventions.

Obesity is a multifactorial chronic disease resulting from complex genetic, molecular, environmental, and behavioral interactions. Its prevalence rises worldwide, affecting cardiovascular, metabolic, oncological, hepatic, respiratory, and skeletal health. Beyond caloric excess, genetic predisposition, epigenetic modifications, gut microbiota dysbiosis, endocrine-disrupting agents, circadian misalignment, and intergenerational and prenatal influences are critical determinants of obesity risk. Core pathophysiological mechanisms include insulin resistance, dyslipidemia, chronic low-grade inflamma

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… Between 2012 and 2014, several centrally acting drugs, including GLP1RAs such as LIR and the combination of naltrexone and bupropion, were approved for long-term weight management. …

Emerging Role of GLP-1 Agonists in Obesity: A Comprehensive Review of Randomised Controlled Trials.

Obesity is a chronic disease with high prevalence and associated comorbidities, making it a growing global concern. These comorbidities include type 2 diabetes, hypertension, ventilatory dysfunction, arthrosis, venous and lymphatic circulation diseases, depression, and others, which have a negative impact on health and increase morbidity and mortality. GLP-1 agonists, used to treat type 2 diabetes, have been shown to be effective in promoting weight loss in preclinical and clinical studies. This review summarizes numerous studies conducted on the main drugs in the GLP-1 agonists class, outlini

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… However, between 2012 and 2014, three centrally acting medications—extended-release phentermine/topiramate (ER), an opioid receptor antagonist combined with a dopamine/norepinephrine reuptake inhibitor used for depression, liraglutide 3 mg/day, and naltrexone ER/bupropion (ER)—were approved for chronic …

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management.

Chronic pain is one of the most prevalent health problems. The establishment of chronic pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants, tricyclic antidepressants and opioidergic drugs. However, they have limited therapeutic efficacy, and some even with severe side effects. We turned our interest into alkaloids separated from traditional Chinese medicine (TCM), that usually act on multiple drug targets. In this article, we introduced the best-studied analgesic alkaloids derived from TCM, including tetrahydropalmatine, aloperine, oxysophocarpine, matrine

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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… drugs classification related to SJS/TEN and comparison with US FDA label Anti-epileptic drugs/antipsychotics US FDA n (%) Carbamazepine Labeled 268 26.07 Phenytoin Labeled 137 13.33 Lamotrigine Labeled 104 10.12 Phenobarbital Labeled 21 2.04 Oxcarbazepine Labeled 18 1.75 Valproic acid Labeled 2 0.19 Bupropion … comparison with US FDA label Anti-epileptic drugs/antipsychotics | US FDA | n | (%) Carbamazepine | Labeled | 268 | 26.07 Phenytoin | Labeled | 137 | 13.33 Lamotrigine | Labeled | 104 | 10.12 Phenobarbital | Labeled | 21 | 2.04 Oxcarbazepine | Labeled | 18 | 1.75 Valproic acid | Labeled | 2 | 0.19 Bupropion …

Strategies to overcome myeloid cell induced immune suppression in the tumor microenvironment.

Cancer progression and metastasis due to tumor immune evasion and drug resistance is strongly associated with immune suppressive cellular responses, particularly in the case of metastatic tumors. The myeloid cell component plays a key role within the tumor microenvironment (TME) and disrupts both adaptive and innate immune cell responses leading to loss of tumor control. Therefore, strategies to eliminate or modulate the myeloid cell compartment of the TME are increasingly attractive to non-specifically increase anti-tumoral immunity and enhance existing immunotherapies. This review covers cur

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… Binimetinib on Probe Drugs in Patients With BRAF V600-mutant Melanoma or Other Advanced Solid Tumors | Active, not recruiting | No Results Available | Advanced Solid Tumors|Metastatic Melanoma | Drug: losartan|Drug: dextromethorphan|Drug: caffeine|Drug: omeprazole|Drug: midazolam|Drug: rosuvastatin|Drug: bupropion …

Inpatient Medicine

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Резюме докладов 2017 Ежегодное совещание Общества общей внутренней медицины.

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15th Конгресс Европейской ассоциации клинической фармакологии и терапии (ЕАКПТ)

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… Methods: In a 5-phase randomized controlled trial of 16 healthy volunteers a 0.05 mg dose of repaglinide was administered alone and together with the Geneva cocktail, containing oral probe substrates for six CYP enzymes (50 mg caffeine/CYP1A2, 20 mg bupropion/CYP2B6, 10 mg flurbiprofen/CYP2C9, 10 mg …

Methods to increase response to postal and electronic questionnaires.

BackgroundSelf-administered questionnaires are widely used to collect data in epidemiological research, but non-response reduces the effective sample size and can introduce bias. Finding ways to increase response to postal and electronic questionnaires would improve the quality of epidemiological research.ObjectivesTo identify effective strategies to increase response to postal and electronic questionnaires.Search methodsWe searched 14 electronic databases up to December 2021 and manually searched the reference lists of relevant trials and reviews. We contacted the authors of all trials or rev

Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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