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Quantitative effects of tumescent infiltration and bupivicaine injection in decreasing postoperative pain in submuscular breast augmentation.

BACKGROUND: In submuscular breast augmentation, the muscle is transected along its inferior and medial border to allow the implant to rest beneath the breast mound and supply adequate cleavage. This leads to significant pain in the postoperative period. OBJECTIVE: This study was undertaken to quantitatively document the effectiveness of tumescent infiltration and bupivicaine with epinephrine injection in controlling postoperative pain in primary submuscular breast augmentation and its effect on operating time, narcotic use, and complications. METHODS: A retrospective chart review of 150 prim

ITGA11 regulates lens epithelial-mesenchymal transition by modulating PTGS2-mediated lipid metabolism.

PURPOSE: Anterior subcapsular cataract (ASC) is driven by lens epithelial cell (LEC) epithelial-mesenchymal transition (EMT), yet the upstre … was silenced in LECs using siRNA, and PTGS2(COX-2) activity was inhibited using the COX-2 inhibitor celecoxib. RNA sequencing of ITGA11-silenced cells was performed to identify downstream pathways. EMT markers, cell migration, and signaling changes were assessed by RT-qPCR, Western blotting, immunofluorescence, and scratch assays. RESULTS: ASC lenses exhib …

Pathological and therapeutic implications of Notch overexpression in claudin-low breast cancers.

Claudin-low breast cancers (BCs), representing approximately 1.5-14% of all BCs, are characterized by high aggressiveness, enriched cancer s … upporting its potential as a biomarker for identification of aggressive BC. Combined treatment with celecoxib (10 µM) and doxorubicin (1 µM) in claudin-low cells not only significantly inhibited Notch signaling and claudin expression, but also suppressed viability, proliferation, migration, and BCSC populations. Since Notch signalling may be an essential fa …

Efficacy of Superficial Acupuncture Stimulation with Dynamic Mobilization in Chronic Neck Pain: A Multicenter Randomized Controlled Trial.

INTRODUCTION: This multicenter randomized controlled trial investigated the clinical efficacy and durability of shallow acupuncture (SA; superficial needling with concurrent active mobilization) for chronic neck pain (CNP). METHODS: A total of 252 participants were randomized into SA, celecoxib, or wait-list groups. The SA intervention involved standardized superficial stimulation at biomechanically sensitized points coupled with active neck mobilization. Clinical outcomes, including Overall Clinical Efficacy, Visual Analog Scale (VAS), Neck Disability Index (NDI), Self-Rating Anxiety Scale (…

Anti-Inflammatory Treatment and Active Physical Therapy Have Differing Effects on Functional, Mechanical, and Histological Properties in a Rat Model of Post-Traumatic Elbow Contracture.

Post-traumatic joint contracture (PTJC) frequently occurs in the elbow after injury, decreasing range of motion (ROM) and causing dysfunctio … uced in rats followed by joint immobilization (IM). Animals received either anti-inflammatory drug (celecoxib or CEL) treatment, active physical therapy (wheel activity or WA), or both (CELWA). An untreated cage activity (CA) group served as control. Functional evaluation, joint mechanical testing, and histological analysis were used to compare groups. All …

Integrating Drug Target Information in Deep Learning Models to Predict the Risk of Adverse Events in Patients with Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder.

Background/Objectives: Comorbid post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) patients are at a significantly higher … in PTSD + AUD patients. Several medications, including OnabotulinumtoxinA, Dronabinol, Acamprosate, Celecoxib, Exenatide, Melatonin, and Semaglutide, were identified as potentially reducing the risk of adverse events by targeting significant proteins. Conclusions: T-DeepBiomarker demonstrates high accuracy in predicting adverse outcomes in PTSD + AUD patien …

Morphological, Biochemical and Molecular Docking Evaluation of the Anti-inflammatory Effects of Methanolic Extract of Bridelia ferruginea stem bark on Acetic acid-induced Ulcerative Colitis in Rats.

Ulcerative colitis (UC) is a chronic disorder that involves inflammation. This study was carried out to examine the anti-inflammatory effect … its remarkable binding affinity for IL-6, iNOS, IL1-β,TNF-α and COX-2 relative to prednisolone and celecoxib. This study suggests that the extract attenuated acetic acid-induced colitis via antioxidative and anti-inflammatory mechanisms. .

Opioid-sparing Effects of SoluMatrix Indomethacin in a Phase 3 Study in Patients With Acute Postoperative Pain.

OBJECTIVES: To report the opioid-sparing effects of SoluMatrix indomethacin, developed using SoluMatrix Fine Particle Technology, in a phase 3 study in patients with acute pain following bunionectomy. METHODS: This phase 3, placebo-controlled study randomized 462 patients with moderate-to-severe pain following bunionectomy surgery to receive SoluMatrix indomethacin 40 mg 3 times daily, SoluMatrix indomethacin 40 mg twice daily, SoluMatrix indomethacin 20 mg 3 times daily, celecoxib 400-mg loading dose followed by 200 mg twice daily, or placebo. Patients were permitted to receive opioid-contai…

Human intermittent hypoxia-induced respiratory plasticity is not caused by inflammation.

Ventilatory instability, reflected by enhanced acute hypoxic (AHVR) and hypercapnic (AHCVR) ventilatory responses is a fundamental component … nonsteroidal anti-inflammatory drugs indomethacin (nonselective cyclooxygenase (COX) inhibitor) and celecoxib (selective COX-2 inhibitor). Pre- and post-intermittent hypoxia resting ventilation, AHVR, AHCVR and serum concentration of the pro-inflammatory cytokine tumour necrosis factor (TNF)-α were assessed.Pre-intermittent hypoxia resting ventilation, AHVR …

Randomized and controlled prospective trials of Ultrasound-guided spinal nerve posterior ramus pulsed radiofrequency treatment for lower back post-herpetic neuralgia.

OBJECTIVE: To evaluate the efficacy of ultrasound-guided spinal nerve posterior ramus pulsed radiofrequency treatment for lower back post-herpetic neuralgia. MATERIALS AND METHODS: 128 cases of lower back or anterior abdominal wall acute post-herpetic neuralgia patients were selected. They were randomly divided into two groups. Group A: oral treatment only with gabapentin + celecoxib + amitriptyline. Group B: while taking these drugs, patients were treated with radiofrequency (RF) pulses using a portable ultrasound device using the paravertebral puncture technique. In both groups, sudden outb…

Leflunomide increases the risk of silent liver fibrosis in patients with rheumatoid arthritis receiving methotrexate.

INTRODUCTION: We identified silent liver fibrosis in patients with rheumatoid arthritis (RA) using transient elastography, and investigated … ncluding methotrexate, leflunomide, sulfasalazine, hydroxychloroquine, prednisolone, meloxicam, and celecoxib were calculated. RESULTS: The median age of patients (20 men and 85 women) was 52.4 years. The median LSM value was 4.7 kPa and 24 (22.9%) patients had abnormal LSM values. Gamma-glutamyltranspeptidase levels and the cumulative doses of leflunomide …

The effect of analgesic agents on the healing rat medial collateral ligament.

BACKGROUND: Studies have suggested that some nonselective nonsteroidal anti-inflammatory drugs, including piroxicam, may improve ligament healing, whereas other nonsteroidal anti-inflammatory drugs, including ibuprofen and the cyclooxygenase-2 inhibitor celecoxib, may have no effect on the mechanical properties or may even deter the healing process. These results might reflect variations in cyclooxygenase enzyme selectivity by different drugs or, alternatively, may be related to their analgesic properties because it is generally accepted that early activity improves ligament healing. HYPOTHES…

Inhibition of proinflammatory mediators by coumaroyl lupendioic acid, a new lupane-type triterpene from Careya arborea, on inflammation-induced animal model.

ETHNOPHARMACOLOGICAL RELEVANCE: Careya arborea Roxb. (Lecythidaceae) is a large tree found throughout India in deciduous forests and grassla … also compared with betulinic acid (BA) at the doses of 10 and 20mgkg-1, p.o. using indomethacin and celecoxib (10 and 20mgkg-1, p.o., respectively) as reference drugs. The effect of CLA on the production of NO, MPO, PGE2, TNF-α, IL-1β and IL-6 were assessed. In addition, the histopathology and immunohistochemistry (NF-ҡB, COX-2 and TNF-α protein expression) …

Management of Postoperative Pain After Arthroscopic Elbow Surgery with Oral Analgesics and Local Anesthesia.

UNLABELLED: Pain after arthroscopic elbow surgery seriously impairs patients' quality of life, and its clinical management remains a signifi … d local anaesthesia alone, while the LC group was administered local anaesthesia combined with oral Celecoxib capsules. The treatment cycle was 3-5 days. The main assessments were pain level (VAS score), Ramsay sedation score, elbow function (MEPS score), and clinical efficacy in both groups. Secondary outcomes included stress factor levels [malondialdehyde …

Terpenoids in Euphorbia milii Ch. des Moulins and their anti-rheumatic potential.

Seven previously undescribed terpenoids (1-7) and sixteen known terpenoids (8-23) were isolated from Euphorbia milii Ch. des Moulins. Among … bitory effects on the production of the inflammatory cytokine NO at 50 μM than the positive control celecoxib. Furthermore, both compounds inhibited the proliferation of MH7A cells, which are synovial fibroblasts derived from rheumatoid arthritis patients. Preliminary observations indicated that compound 2 could induce apoptosis in MH7A cells, arrest the ce …

Exploring the Anti-Inflammatory Potential of Saudi Propolis Through Phytochemical Characterization, Molecular Docking, and Dynamic Simulation.

Background/Objectives: Propolis is a resinous natural product rich in phenolic acids and flavonoids, recognized in ethnopharmacology for its … also exhibited potent and selective COX-2 inhibition with an IC50 of 6.19 ± 0.21 µg/mL (relative to celecoxib, IC50 0.681 ± 0.02 as positive control). LC-MS analysis identified 26 secondary metabolites. Computational studies ranked kaempferol as forming the most conformationally stable COX-2 complex among the ligands examined, including the reference inhibi …

Individualizing NSAID therapy in axial spondyloarthritis: N-of-1 trials with Bayesian analysis.

OBJECTIVE: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease predominantly affecting the spine and sacroiliac joints. NSAIDs are first-line therapy, but individual responses vary widely. We evaluated the efficacy and patient preference of three NSAIDs (celecoxib, meloxicam and naproxen) through Bayesian N-of-1 clinical trials to optimize axSpA management. METHODS: We conducted N-of-1 trials with 42 patients meeting ASAS criteria for axSpA. Each patient was asked to complete two cycles of randomized double-blind crossover comparisons of the three NSAIDs, each for 4 weeks. The p…

Deciphering the molecular connections between polycystic ovarian syndrome and autism spectrum disorder using bioinformatic analysis.

Epidemiological studies show a positive association between polycystic ovarian syndrome (PCOS) and autism spectrum disorder (ASD), potential … via DSigDB identified candidate small molecules through hypothesis generating prediction, including celecoxib, N-acetylcysteine and other drug molecules. Elevated maternal androgens are proposed as a shared environmental factor that may interact with molecularly regulated pathways, contributing to the observed molecular convergence. While the study integrat …

Drug repositioning as a promising approach for the eradication of emerging and re-emerging viral agents.

The global impact of emerging and re-emerging viral agents during epidemics and pandemics leads to serious health and economic burdens. Amon … ZMapp (pharming), Artesunate, imiquimod, saquinavir, capmatinib, naldemedine, Trametinib, statins, celecoxib, naproxen, metformin, ruxolitinib, nitazoxanide, gemcitabine, Dorzolamide, Midodrine, Diltiazem, zinc acetate, suramin, 5-fluorouracil, quinine, minocycline, trifluoperazine, paracetamol, berbamine, Nifedipine, and chlorpromazine. This succinct revi …

Конвергенты и дивергенты Митохондриалы в качестве драйверов и терапевтических целей в неврологических расстройствах.

Митохондриальная дисфункция затрагивает весь спектр неврологических заболеваний, однако ее причинно-следственная роль и механистическая специфичность остаются неясными. Для устранения этих пробелов в этом исследовании использовался многомерный комплексный анализ митохондриального генного экспрессии в болезни Альцгеймера (AD), амиотропическом боковом склерозе (ALS), множественном склерозе (MS) и болезни Паркинсона (PD). Мы комбинировали машинное обучение для прогнозирования моделирования с методами генетической причинно-следственной диагностики (Mendelian Randomization, Coлокализация, FheWAS),

Совпадение в аннотации оригинала
Mitochondrial dysfunction is implicated across a spectrum of neurological diseases, yet its causal role and mechanistic specificity remain u … ationship between red blood cell indices and MS risk. Finally, drug enrichment analysis highlighted Celecoxib, and subsequent molecular docking predicted a strong binding affinity to PDK1 (docking score S = -6.522 kcal/mol), generating hypotheses for potential metabolic modulation. Taken together, this study provides a computational hypothesis framework sug …