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The Effect of Bisphosphonates on Fracture Healing Time and Changes in Bone Mass Density: A Meta-Analysis.

BackgroundOsteoporosis is a common complication of acute fracture, which can lead to fracture delayed union or other complications and resulting in poor fracture healing. Bisphosphate is a common anti-osteoporosis drug, but its application in fracture patients is still controversial because of its inhibitory effect on bone resorption.MethodStudies were acquired from literature databases in accordance with established inclusion criteria. Standard mean difference (SMD) and 95% confidence intervals (Cls) were calculated to evaluate the effectiveness of the bisphosphonates treatment in fracture pa

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… Zoledronic Acid Combined With Percutaneous Kyphoplasty in the Treatment of Osteoporotic Compression Fracture in a Single T12 or L1 Vertebral Body in Postmenopausal Women. Osteoporos Int (2019) 30(7):1475–80. 10.1007/s00198-019-04896-w 40. … Clinical Efficacy Analysis of Percutaneous Kyphoplasty Combined With Zoledronic Acid in the Treatment and Prevention of Osteoporotic Vertebral Compression Fractures. J Invest Surg (2018) 31(5):425–30. 10.1080/08941939.2017.1339151 56. Li YT, Cai HF, Zhang ZL. …

Comparison of vertebroplasty using directional versus straight needle.

BACKGROUND: Percutaneous vertebroplasty is a minimally invasive procedure that can be performed to treat pain and immobility associated with vertebral compression fractures. Previous studies have shown that a single injection can achieve adequate fill across the midline of the vertebral body. PURPOSE: To compare the radiological outcomes of using a novel steerable needle with using a conventional, straight needle in unipedicular vertebroplasty. MATERIAL AND METHODS: Data were collected from 19 patients who were operated at our institute between 1 September 2010 and 31 March 2011. Outcomes we

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… Patients who underwent kyphoplasty or vertebroplasty using other types of needles were excluded from the study. The medical notes of patients who fitted the inclusion criteria were obtained from the Medical Records Department. … Int J Surg Oncol 2011 ; 2011 : 107969 – 107969 . 22312491 10.1155/2011/107969 PMC3265280 10 Chi JH Gokaslan ZL Vertebroplasty and kyphoplasty for spinal metastasis . …

A multidisciplinary bone metastases clinic at Toronto Sunnybrook Regional Cancer Centre - A review of the experience from 1999 to 2005.

Our objective in this study was to review the experience of a one-stop multidisciplinary bone metastases clinic (BMC) that offers a coordinated multidisciplinary approach to the care of cancer patients with bone metastases in a tertiary cancer centre. Patients with symptomatic bone metastases were referred to BMC and assessed by a team of specialists in various disciplines - interventional radiology, orthopedic surgery, palliative medicine, and radiation oncology. At initial consultation, patient demographics, reasons for referral, and case disposition were recorded. From January 1999 to Febru

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… Newer minimally invasive procedures such as percutaneous vertebroplasty and kyphoplasty are also highly effective in treating painful vertebral compressive fractures and preventing future vertebral collapse.” … bone metastases Radiother Oncol 75 64 9 15878102 10.1016/j.radonc.2004.12.016 Cleeland C Gonin R Hatfield A 1996 Pain and its treatment in outpatients with metastatic cancer N Engl J Med 330 592 6 7508092 10.1056/NEJM199403033300902 Fourney DR Schomer DF Nader R 2003 Percutaneous vertebroplasty and kyphoplasty …

Guidelines for the management of osteoporosis and fragility fractures.

The purpose of this document, a result of the harmonisation and revision of Guidelines published separately by the SIMFER, SIOMMMS/SIR, and SIOT associations, is to provide practical indications based on specific levels of evidence and various grades of recommendations, drawn from available literature, for the management of osteoporosis and for the diagnosis, prevention, and treatment of fragility fractures. These indications were discussed and formally approved by the delegates of the Italian Scientific Associations involved in the project (SIE, SIGG, SIMFER, SIMG, SIMI, SIOMMMS, SIR, and SIO

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… Vertebroplasty or kyphoplasty can only be recommended for patients with intractable pain for weeks, with due consideration of the potential risks associated with the procedures and the uncertain benefits in the long term. … Aparisi F Vertebroplasty and kyphoplasty in vertebral osteoporotic fractures Semin Musculoskelet Radiol 2016 20 382 391 10.1055/s-0036-1592431 27842431 …

Chronic Pain and Bone-Related Pathologies: A Narrative Review.

PurposePain related to bone may occur as a result of trauma, bone fracture, genetic disease, arthritis, benign or malignant primary bone tumors and bone cancer metastases. We discuss the pathophysiology of chronic bone-related pain, treatment options and therapeutic perspectives.MethodsUsing predefined terms, we searched PubMed, MEDLINE, and Google Scholar for meta-analyses, evidence-based reviews, and clinical practice guidelines. This narrative article reviews pathologies linked to chronic bone pain and discusses the preventive and therapeutic strategies for better bone pain management.Resul

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… A recent meta analysis 71 showed kyphoplasty to be superior to vertebroplasty in terms of reducing cement leakage and of increasing postoperative vertebral body height; but this is more costly and has a longer operative time. … Vertebroplasty versus kyphoplasty in the treatment of osteoporotic vertebral compression fractures: a meta-analysis. World Neurosurg . 2023;171:65–71. PMID: 36455843. doi: 10.1016/j.wneu.2022.11.123 72. Krishnamurthy N, Grimshaw AA, Axson SA, et al. …

Radiofrequency sacroplasty as a pain treatment for symptomatic sacral destruction due to prostate metastasis: a case report and a review of the literature.

In progressive malignant diseases such as prostate cancer, metastatic bone destruction is a frequent cause of chronic, debilitating pain. Pathological fractures of the sacrum can lead to complete immobility in patients. Cement augmentation of the sacrum has proven effective in treating sacral insufficiency fractures, resulting in significant pain reduction and improved mobility. In recent years, this technique has also been applied to pathological fractures of the sacrum. We present a case of successful treatment of prostate cancer-induced sacral bone infiltration and destruction using advance

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… Sacral kyphoplasty for relieving pain caused by sacral hemangioma. Spinal Cord 2006;44:196–9. 10.1038/sj.sc.3101829. 18. Valencia-Anguita J, Juliá-Narváez M, Rodríguez-Burgos F, et al. Ponce de León a. [Percutaneus sacroplasty for relieving pain caused by sacral metastases]. … Sacral kyphoplasty for the treatment of painful sacral insufficiency fractures and metastases. Spine J 2012;12:113–20. 10.1016/j.spinee.2012.01.019. 26. Sun G, Jin P, Li M, et al. …

Effects of Percutaneous Sacroplasty on Pain and Mobility in Sacral Insufficiency Fracture.

ObjectiveSacral insufficiency fracture (SIF) contributes to severe low back pain. Prolonged immobilization resulting from SIF can cause significant complications in the elderly. Sacroplasty, a treatment similar to vertebroplasty, has recently been introduced for providing pain relief in SIF. The purpose of this study is to investigate the clinical short-term effects of percutaneous sacroplasty on pain and mobility in SIF.MethodsThis study is conducted prospectively with data collection. Sixteen patients (3 men and 13 women) with a mean age of 77.5 years (58 to 91) underwent sacroplasty. Patien

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… Balloon-assisted sacroplasty may prevent polymethylmethacrylate (PMMA) migration, as kyphoplasty does for vertebral compression fracture 11) . In metastasis, multiple myeloma, and pelvic radiation necrosis as well, sacroplasty can provide pain relief 4 , 10 , 25) . … Balloon kyphoplasty for treatment of sacral insufficiency fractures. Report of three cases. Neurosurg Focus. 2005;18:e7. 12. Denis F, Davis S, Comfort T. Sacral fractures: an important problem. Retrospective analysis of 236 cases. Clin Orthop Relat Res. 1988;227:67–81. 13. …

Pain Management in Patients with Multiple Myeloma: An Update.

Most patients with multiple myeloma (MM) suffer from chronic pain at every stage of the natural disease process. This review focuses on the most common causes of chronic pain in MM patients: (1) pain from myeloma bone disease (MBD); (2) chemotherapy-induced peripheral neuropathy as a possible consequence of proteasome inhibitor therapy (i.e., bortezomib-induced); (3) post-herpetic neuralgia as a possible complication of varicella zoster virus reactivation because of post-transplantation immunodepression; and (4) pain in cancer survivors, with increasing numbers due to the success of antiblasti

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… Kyphoplasty is a similar procedure where an inflatable balloon is placed into the vertebral body before the injection of bone cement. … Back-specific functional status at one month was significantly improved in the kyphoplasty group, with the report of a rapid onset of pain relief [ 38 ]. …

Incidence and risk factors of medical complications and direct medical costs after osteoporotic fracture among patients in China.

UNLABELLED: We analyzed the incidence of medical complications after osteoporotic fractures and estimated its risk factors and cost impacts. Osteoporotic fractures can result in lots of serious medical complications, which is associated with patients' baseline characteristics such as patients' disease history and significantly increased patients' direct medical costs. PURPOSE: The purpose of the study is to investigate the incidence and identify the risk factors of medical complications after osteoporotic fracture, and quantify patients' economic burden. METHODS: Data were obtained from the

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… Hu YC Hart DJ Complications of vertebroplasty and kyphoplasty Tech Reg Anesth Pain Manag 2007 11 164 170 10.1053/j.trap.2007.05.010 9. … Zampini JM White AP McGuire KJ Comparison of 5766 vertebral compression fractures treated with or without kyphoplasty Clin Orthop Relat Res 2010 468 1773 1780 10.1007/s11999-010-1279-7 20177836 PMC2882011 10. …

Percutaneous vertebroplasty for osteoporotic vertebral compression fracture.

BACKGROUND: Percutaneous vertebroplasty remains widely used to treat osteoporotic vertebral fractures although our 2015 Cochrane review did … ebo (541 randomised participants), eight with usual care (1136 randomised participants), seven with kyphoplasty (968 randomised participants) and one compared vertebroplasty with facet joint glucocorticoid injection (217 randomised participants). Trial size varied from 46 to 404 participants, most participants were female, mean age ranged between 62.6 and 81 …

Percutaneous vertebroplasty for osteoporotic vertebral compression fracture.

BACKGROUND: Percutaneous vertebroplasty is widely used to treat acute and subacute painful osteoporotic vertebral fractures although recent … vertebroplasty with usual care (566 randomised participants) and four compared vertebroplasty with kyphoplasty (545 randomised participants). Trial size varied from 34 to 404 participants, most participants were female, mean age ranged between 63.3 and 80 years, and mean symptom duration varied from a week to more than six months.Both placebo-controlled tria …

Борьба с травматической деформацией подбородка на чехле в недавно диагностированном миеломе: пример.

Обычно фонопатенты с множественной миеломой (ММ) управляются многодисциплинарными командами по онкологии в соответствии с неврологической, онкологической, механической и систематической системой принятия решений. Хирургия указывается на механическую нестабильность и/или неврологические недостатки. В неврологических и механически стабильных пациентах химиотерапия и радиотерапия часто являются основным лечением. 66-year-old Пациент мужского пола получил кифотическое повреждение подбородка на чехле из-за недиагностированной спинной мышцы ММ. Он испытывал постепенную боль в шее и трудности в повсе

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… Percutaneous vertebroplasty and kyphoplasty . In: StatPearls . StatPearls Publishing ; 2023 . Accessed July 20, 2023. http://www.ncbi.nlm.nih.gov/books/NBK525963/ 30247838 20. Evangelisti G Pesce E Gala R , et al. Surgical management of multiple myeloma and plasmocytoma of the spine . … Percutaneous balloon kyphoplasty in the treatment of pathological vertebral body fracture and deformity in multiple myeloma: a one-year follow-up . Acta Radiol . 2006 ; 47 ( 4 ): 369 - 376 . 16739696 10.1080/02841850600570425 25. Houten JK Weinstein GR Collins MJ Komlos D . …

Percutaneous osteoplasty for extraspinal metastases.

As an extension of percutaneous vertebroplasty (PVP), percutaneous osteoplasty (POP) refers broadly to percutaneous bone cement injected into various parts of the body and narrowly to cement injected into extraspinal bone lesions. POP mainly includes such surgeries as percutaneous sacroplasty, percutaneous acetabuloplasty, percutaneous femoral osteoplasty, and percutaneous iliac osteoplasty (Figure 1). Currently, POP is a positive and an effective treatment for extraspinal bone lesions in that it can rapidly relieve pain, effectively prevent pathological fractures, and partially inactivate tum

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… 18779931 10.1007/s11547-008-0314-1 39 Gangi A Guth S Imbert JP Percutaneous vertebroplasty: Indications, technique, and results Radiographics 23 2003 e10 12889460 10.1148/rg.e10 40 Gao CX Liu HL Luo ZP Modification of calcium phosphate cement with poly (γ-glutamic acid) and its strontium salt for kyphoplasty … 2017 352 361 10.1016/j.msec.2017.05.070 28866174 41 Klein R Tetzlaff R Weiss C Osteointegration and resorption of intravertebral and extravertebral calcium phosphate cement Clin Spine Surg 30 2017 e291 e296 28323714 10.1097/BSD.0b013e3182aab2df 42 Lieberman IH Togawa D Kayanja MM Vertebroplasty and kyphoplasty …

Percutaneous-Reinforced Osteoplasty: A Review of Emerging Treatment Strategies for Bone Interventions.

Percutaneous-reinforced osteoplasty is currently being investigated as a possible therapeutic procedure for fracture stabilization in high-risk patients, primarily in patients with bone metastases or osteoporosis. For these patients, a percutaneous approach, if structurally sound, can provide a viable method for treating bone fractures without the physiologic stress of anesthesia and open surgery. However, the low strength of fixation is a common limitation that requires further refinement in scaffold design and selection of materials, and may potentially benefit from tissue-engineering-based

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… Percutaneous osteoplasty, a procedure similar to vertebroplasty or kyphoplasty in the spine, is an effective radiological procedure used widely for the treatment of benign or malignant (extraspinal) bone lesions [ 18 ]. … Prevention and treatment of bone cement-related complications in patients receiving percutaneous kyphoplasty. Int. J. Clin. Exp. Med. 2015;8:2371–2377. Associated Data Data Availability Statement Not applicable. …

Complications After Percutaneous Pedicle Screw Fixation for the Treatment of Unstable Spinal Metastases.

BackgroundComplications after surgical stabilization for the treatment of unstable spinal metastases are common. Less invasive surgical (LIS) procedures are potentially associated with a lower risk of complications; however, little is known regarding the complications after LIS procedures for the treatment of spinal metastases. Our primary objective was to determine the characteristics and rate of complications after percutaneous pedicle screw fixation (PPSF) for the treatment of mechanically unstable spinal metastases. The secondary objective was to identify factors associated with the occurr

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… Vertebroplasty was performed in six patients (6 %), kyphoplasty in 10 patients (10 %), and vertebral body stenting in 19 patients (19 %). Cement augmentation of pedicle screws was performed in three patients (3 %). … Zairi F Court C Tropiano P Minimally invasive management of thoraco-lumbar fractures: combined percutaneous fixation and balloon kyphoplasty Orthop Traumatol Surg Res. 2012 98 S105 S111 10.1016/j.otsr.2012.06.004 22901522 13. …

Efficacy and safety of C-arm computed tomography-guided microwave ablation with percutaneous osteoplasty for flat bone metastases.

BACKGROUND: Flat bone metastases are common in patients with advanced cancers, often resulting in severe pain, limited mobility, and reduced quality of life (QOL). Traditional treatment options, such as radiotherapy or systemic therapies, often fail to provide sufficient pain relief or improve functional outcomes in these patients. Microwave ablation (MWA) offers advantages, such as shorter procedure times and larger ablation zones, while percutaneous osteoplasty (PO) enhances bone stability and prevents pathological fractures. Despite these benefits, the combination of these techniques for tr

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… Kanika K Murphy K Eminefendic H Masala S Regge D Temperature measurement during polymerization of bone cement in percutaneous vertebroplasty: an in vivo study in humans Intervent Radiol 2009 32 491 498 10.1007/s00270-009-9509-7 19280257 13 Yang HL Sun ZY Wu GZ Chen KW Gu Y Qian ZL Do vertebroplasty and kyphoplasty … Med Hypotheses 2011 76 145 146 10.1016/j.mehy.2010.09.018 20961693 14 Masala S Lunardi P Fiori R Liccardo G Massari F Ursone A Simonetti G Vertebroplasty and kyphoplasty in the treatment of malignant vertebral fractures J Chemother 2004 16 Suppl 5 30 33 10.1080/1120009x.2004.11782379 15675473 15 Halpin …

Essential Concepts for the Management of Metastatic Spine Disease: What the Surgeon Should Know and Practice.

Study designLiterature review.ObjectiveTo provide an overview of the recent advances in spinal oncology, emphasizing the key role of the surgeon in the treatment of patients with spinal metastatic tumors.MethodsLiterature review.ResultsTherapeutic advances led to longer survival times among cancer patients, placing significant emphasis on durable local control, optimization of quality of life, and daily function for patients with spinal metastatic tumors. Recent integration of modern diagnostic tools, precision oncologic treatment, and widespread use of new technologies has transformed the tre

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… VCFs following SSRS have been described in up to 40% of treatments compared with a less than 5% risk following cEBRT. 64 - 66 The majority of post-SBRT VCF are asymptomatic radiographic findings, with interventions such as kyphoplasty required for a small proportion of these fractures. 67 The International … Safety and utility of kyphoplasty prior to spine stereotactic radiosurgery for metastatic tumors: a clinical and dosimetric analysis. J Neurosurg Spine. 2018;28:72–78. doi:10.3171/2017.5.SPINE1746 …

Impact of Cytogenetic Abnormalities, Induction and Maintenance Regimens on Outcomes After High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Patients With Newly Diagnosed Multiple Myeloma: A Decade-Long Real-World Experience.

BackgroundHigh-dose chemotherapy and autologous stem cell transplant (HDT-ASCT) has become a standard of care for transplant eligible newly diagnosed multiple myeloma (NDMM) patients. While cytogenetic abnormalities have been shown to affect outcomes after HDT-ASCT in clinical trials, these trials often exclude or underrepresent elderly patients with comorbidities and those belonging to ethnic minorities. We describe our institutional experience highlighting the impact of high-risk cytogenetic abnormalities (HRCAs) on outcomes after HDT-ASCT for NDMM patients.MethodsA total of 449 patients wit

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… Pulmonary embolism of polymethyl methacrylate during percutaneous vertebroplasty and kyphoplasty. AJR Am J Roentgenol. 2004;183(4):1097–1102. doi: 10.2214/ajr.183.4.1831097. 14. Patel Z, Sangani R, Lombard C. … Cement pulmonary embolism after percutaneous kyphoplasty: An unusual culprit for non-thrombotic pulmonary embolism. Radiol Case Rep. 2021;16(11):3520–3525. doi: 10.1016/j.radcr.2021.08.047. 15. Debbie Jiang MD, Alfred Ian Lee MD. Thrombotic risk from chemotherapy and other cancer therapies. …

Use of bone-modifying agents and clinical outcomes in older adults with multiple myeloma.

BACKGROUND: Guidelines recommend bone-modifying agents (BMAs) for all patients initiating treatment for myeloma. We examined adherence to this recommendation, and BMA effectiveness in the era of bortezomib/lenalidomide-based therapy among Medicare beneficiaries. METHODS: From the linked Surveillance, Epidemiology, and End Results-Medicare registry, we selected beneficiaries receiving anti-myeloma chemotherapy in 2007-2013. We matched BMA recipients (within 90 days of first chemotherapy) to nonrecipients using a propensity score, balancing patient-, disease-, and therapy-related confounders. C

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… The cumulative incidence function (CIF) of a SRE was defined as time from start of therapy to first fracture of vertebrae, hip, pelvis, femur, performance of kyphoplasty or vertebroplasty, or a hospital admission with spinal cord compression. … The most common SRE was vertebral fracture (42.1%), followed by hip fracture (23.3%), kyphoplasty (19.7%), spinal cord compression (8.5%), and pelvis fracture (6.4%). Osteonecrosis of the jaw occurred in 116 patients, more often among BMA recipients (4% vs 1%). …

Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study.

BACKGROUND: Pain is a common symptom in patients with multiple myeloma (MM). Many patients are dependent on analgesics and in particular opioids, but there is limited information on the impact of these drugs and their side effects on health-related quality of life (HRQoL). METHOD: In a cross-sectional study, semi-structured interviews were performed in 21 patients attending the hospital with symptomatic MM on pain medications. HRQoL was measured using items 29 and 30 of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30. RESULTS: Patients were able to recall a med

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… In addition, local pain control may be achieved using vertebroplasty or balloon kyphoplasty for vertebral fractures and surgical fixation for unstable long bones or spine [ 5 , 6 ]. … Changes in pain and other symptoms in patients with painful multiple myeloma-related vertebral fracture treated with kyphoplasty or vertebroplasty. J Pain : Off J Am Pain Soc. 2012;13:564–570. doi: 10.1016/j.jpain.2012.03.003. 6. Wedin R. Surgical treatment for pathologic fracture. …