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[Effect of a long-acting analgesic, buprenorphine on cancer pain--a single-blind crossover comparison with pentazocine].

The therapeutic value of buprenorphine was investigated in 31 patients suffering from moderate to severe cancer pain by intramuscular administration at the single doses of 0.2 mg and 0.3 mg in comparison with pentazocine 30 mg. Analgesic effect of buprenorphine 0.3 mg was significantly superior to buprenorphine 0.2 mg and pentazocine 30 mg. The duration of analgesia with buprenorphine was 9 hours at 0.2 mg and 11 hours at 0.3 mg, which were markedly longer than pentazocine's 6 hours. Side effects most commonly observed in the three groups were nausea, vertigo, oral dryness, urinary retention, …

Comparative Effectiveness of Mind-Body Exercise Modalities on Pain Intensity and Fatigue in Patients with Non-Neuropathic Cancer-Related Pain: A Systematic Review and Network Meta-Analysis.

PURPOSE: Cancer-related pain (CRP) is a prevalent issue among cancer survivors, especially during extended periods of survivorship. Existing therapeutic approaches for CRP present certain limitations. To investigate safe and accessible non-pharmacological interventions that may reduce both pain and fatigue, we performed a network meta-analysis (NMA) to compare various Mind-Body Exercises (MBEs) in cancer survivors experiencing CRP, excluding cases of neuropathic pain. PATIENTS AND METHODS: We systematically searched eight databases for randomized controlled trials (RCTs) assessing MBEs in adu

Psychosocial interventions for reducing pain and pain-related distress in infants, children, and adolescents undergoing cancer treatment: a systematic review and meta-analysis of randomized control trials.

CRD42022343066.

Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study.

OBJECTIVES: To explore the effect of breakthrough cancer pain (BTcP) treatment on quality of sleep and other aspects of the health-related quality of life (HRQoL) in patients with cancer pain. METHODS: In an observational, multicenter, cohort study, cancer patients from palliative care units, oncology departments, and pain clinics and affected by BTcP were included. Enrolled patients were assessed at the four visits: T0 (baseline), T7, T14, and T28. Stable chronic background pain (numeric rating scale, NRS ≤ 4) during the whole study period was mandatory. BTcP was treated through transmucosal…

Persistent Breast Pain Among Women With Histories of Breast-conserving Surgery for Breast Cancer Compared With Women Without Histories of Breast Surgery or Cancer.

OBJECTIVES: This study compared persistent breast pain among women who received breast-conserving surgery for breast cancer and women without a history of breast cancer. METHODS: Breast cancer survivors (n=200) were recruited at their first postsurgical surveillance mammogram (6 to 15 mo postsurgery). Women without a breast cancer history (n=150) were recruited at the time of a routine screening mammogram. All women completed measures of breast pain, pain interference with daily activities and intimacy, worry about breast pain, anxiety symptoms, and depression symptoms. Demographic and medica

A Prospective, Single-Cohort, Open, Multi-center, Observational Study of Sublingual Fentanyl for Breakthrough Cancer Pain: Effectiveness, Safety, and Tolerability in Korean Cancer Patients.

PURPOSE: Fentanyl, a highly lipophilic opioid, was developed as a sublingual fentanyl tablet (SFT) for the management of breakthrough cancer pain (BTcP), and its efficacy and safety were confirmed in a randomized, controlled study. We investigated the effectiveness and safety of SFT administered to alleviate BTcP in a real-world setting. MATERIALS AND METHODS: In this prospective, open, single-cohort study, conducted in 13 referral hospitals in South Korea, opioid-tolerant cancer patients receiving around-the-clock opioids for persistent cancer pain were enrolled if the individual had BTcP ≥ …

Cancer-Related Neuropathic Pain, Chemotherapy-Induced Peripheral Neuropathy and Cognitive Decline in a 5-Year Prospective Study of Patients with Breast Cancer-NEON-BC.

This study aims to estimate the prevalence and to identify the determinants of cancer-related neuropathic pain (CRNP), chemotherapy-induced peripheral neuropathy (CIPN) and cognitive decline among patients with breast cancer over five years after diagnosis. Women with an incident breast cancer (n = 462) and proposed for surgery were recruited at the Portuguese Institute of Oncology-Porto in 2012 and underwent systematic neurological examinations and evaluations with the Montreal Cognitive Assessment (MoCA) before treatment and after one, three, and five years. Multivariate logistic regression

No association between breast pain and breast cancer: a prospective cohort study of 10 830 symptomatic women presenting to a breast cancer diagnostic clinic.

BACKGROUND: Women with breast pain constitute >20% of breast clinic attendees. AIM: To investigate breast cancer incidence in women presenting with breast pain and establish the health economics of referring women with breast pain to secondary care. DESIGN AND SETTING: A prospective cohort study of all consecutive women referred to a breast diagnostic clinic over 12 months. METHOD: Women were categorised by presentation into four distinct clinical groups and cancer incidence investigated. RESULTS: Of 10 830 women, 1972 (18%) were referred with breast pain, 6708 (62%) with lumps, 480 (4%) w

Colored body images reveal the perceived intensity and distribution of pain in women with breast cancer treated with adjuvant taxanes: a prospective multi-method study of pain experiences.

Background and aims Breast cancer is the most prevalent adult cancer worldwide. A broader use of screening for early detection and adjuvant systemic therapy with chemotherapy has resulted in improved survival rates. Taxane-containing chemotherapy is one of the cornerstones of the treatment. However, taxane-containing chemotherapy may result in acute chemotherapy-induced nociceptive and neuropathic pain. Since this pain may be an additional burden for the patient both during and after taxane chemotherapy, it is important to rapidly discover and treat it. There is yet no gold standard for assess

A Multifaceted Approach to Improve the Availability and Accessibility of Opioids for the Treatment of Cancer Pain in Serbia: Results From the International Pain Policy Fellowship (2006-2012) and Recommendations for Action.

Cancer is the second leading cause of death in Serbia, and at least 14,000-16,000 patients experience moderate-to-severe cancer pain every year. Cancer pain relief has been impeded by inadequate availability of opioid analgesics and barriers to their accessibility. In 2006, a Serbian oncologist was selected as an International Pain Policy Fellow. The fellow identified barriers to opioid availability in Serbia and implemented an action plan to address the unavailability of oral morphine, attitudinal and knowledge barriers about opioids, and barriers in the national opioid control policy, in col…

The efficacy and safety profile of methadone for intractable cancer pain in advanced lung cancer patients: a single-center retrospective analysis of 37 Japanese patients.

BACKGROUND: For patients suffering from intractable cancer pain, which cannot be sufficiently relieved even with strong opioid analgesics, methadone is recommended in Japan. However, the real-world data on the efficacy and safety of methadone for intractable pain in patients with lung cancer remain scarce in clinical setting. The aim of this clinical study was to investigate the efficacy and safety of methadone for intractable pain in advanced lung cancer patients. METHODS: All the cases of advanced lung cancer patients who were administered methadone for intractable pain at the Shizuoka Canc…

Prevalence, patterns, and impact of myofascial pain in patients with head and neck cancer after cancer treatment - a single-center cross-sectional study in India.

PURPOSE: Head and neck cancer is the seventh most prevalent cancer, with over 660,000 new cases and 325,000 annual fatalities, accounting for 30% of all cancer cases. Chronic cancer-related pain affects 15-75% of patients, with myofascial pain being especially common in those with head and neck cancers, ranging from 11.9 to 44.8%. Surgery and radiotherapy, the primary treatments for these cancers, contribute to myofascial pain development. Additionally, head and neck cancer patients face higher psychological distress, with rates up to 50%. This study estimates the prevalence, topography of the

Validation of the Malayalam Version of Leeds Assessment of Neuropathic Symptoms and Signs Pain Scale in Cancer Patients in the Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

ObjectiveThe Self-administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) is a 7-item self-report scale developed to identify pain which is of predominantly neuropathic origin. The aim of this study was to develop a Malayalam version of the LANSS and to test its validity and reliability in chronic pain patients.MethodologyWe enrolled 101 Malayalam-speaking chronic pain patients who visited the Division of Palliative Medicine, Regional Cancer Centre, Thiruvananthapuram, Kerala, India. The translated version of S- LANSS was constructed by standard means. Fifty-one neuropathic p

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… O BSERVATION AND R ESULTS A variety of pain were analyzed ranging from cancer pain, radiation mucositis, postamputation pain, arthritis, vertebral metastasis, chronic cerebral palsy, postcoronary artery bypass grafting, multiple myeloma pain, soft tissue sarcoma, and so on [ Table 1 ]. …

NIR-II-triggered hollow mesoporous polydopamine nano-depot for integrated photothermal therapy and sustained cancer pain relief.

The short duration of action of ropivacaine (ROP) substantially limits its efficacy in cancer pain management. In this study, we developed a hollow mesoporous polydopamine nano-depot (HMP) for efficient ROP loading and externally controlled release. The resulting HMPR platform achieved a high ROP loading capacity of 42.82%. Upon irradiation with deep-tissue-penetrating NIR-II light at 1064 nm, HMPR enabled rapid on-demand ROP release followed by sustained diffusion. In a murine model of sciatic nerve tumor-induced cancer pain, a single HMPR injection combined with brief NIR-II irradiation prol…

Spinal cord stimulation for cancer pain: a narrative review of mechanistic rationale, clinical integration, and emerging applications.

BACKGROUND AND OBJECTIVE: Pain remains one of the most prevalent symptoms among patients with advanced cancer, with a substantial subset experiencing persistent pain despite optimized pharmacologic management. Although spinal cord stimulation (SCS) has emerged as a potential neuromodulatory option for refractory cancer-related pain, its role within contemporary multidisciplinary cancer pain management remains incompletely defined. This narrative review examines the mechanistic rationale, clinical applications, guideline positioning, and practical implementation of SCS across cancer pain phenot…

From tumor metabolism to brain circuits: METTL14 as a SAM sensor driving pain-depression in pancreatic cancer.

Our knowledge gaps regarding the mechanisms driving the varied signs and symptoms associated with malignancies are quickly being filled. In this edition, Yang et al. discover a critical connection linking pancreatic cancer and its associated comorbidities-pain and depression.

Preoperative Health Belief Model-Based Nursing Intervention on Anxiety and Pain-Related Stress in Lung Cancer Patients.

To explore the intervention effect of preoperative visit nursing based on the Health Belief Model (HBM) on the perception of preoperative anxiety and pain-related stress in patients with lung cancer (LC). This retrospective study included 110 LC patients who underwent surgery at our hospital from June 2022 to June 2024. Based on the preoperative nursing protocol received, patients were assigned to a control group (routine preoperative care, n = 55) or a study group (HBM-based preoperative visit nursing, n = 55). Primary outcomes were preoperative anxiety (Amsterdam Anxiety and Information Scal

Chronic Cancer-Related Pain in Children: A Narrative Review of Multimodal and Family-Centered Palliative Care Approach.

Background: Chronic pain in children with cancer is a major challenge in pediatric palliative care. It results from the interaction of disease-related and treatment-related factors, psychological distress, and the child's family and social environment. When poorly controlled, it can impair quality of life, emotional development, social functioning, and family well-being. This narrative review examines the challenges and management strategies for chronic pain in children with cancer from a pediatric palliative care perspective, with attention to pain mechanisms, assessment difficulties, and psy

Persistent Chemotherapy-Induced Peripheral Neuropathy as a Chronic Cancer Pain Syndrome: Mechanisms, Therapeutic Limitations, and Future Directions.

Background/Objectives: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, dose-limiting complication of cancer therapy and a major contributor to chronic neuropathic pain among cancer survivors. Although traditionally managed as a treatment-related toxicity, persistent CIPN frequently persists long after chemotherapy completion and is increasingly recognized as a major survivorship and palliative care challenge. This review synthesizes current mechanistic, clinical, and translational evidence and reframes persistent CIPN as a chronic neuropathic cancer pain syndrome. Methods: A nar…