Результаты поиска

Сипонимод поддерживает воспоминание в неподдерживающей среде.

Воспаление, характерное для множественных повреждений склероза (MS), приводит к функциональным повреждениям и постепенной потере аксона с течением времени. Хотя, как считается, ремилеляция защищает аксоны, внутренние регенерационные процессы часто являются неполными или полностью неэффективными у многих пациентов с синдромом MS. Хотя точные причины провала воспоминаний остаются неясными, неоднократное обезвоживание в ранее затронутых районах с белыми телами является признанным фактором, способствующим этому. В одном из предыдущих исследований мы продемонстрировали, что модификатор Siпонimod с

Uncovering the boundary conditions of the association between concerns about falling and physical activity in adult populations: a scoping review protocol.

IntroductionDespite evidence of variation in how concerns about falling influence physical activity, many of the currently available knowledge syntheses merely assume that this relation is uniform across populations and contexts. Therefore, we propose a scoping review protocol to guide a summary of the bodywork that has examined the association between concerns about falling and physical activity in adult populations, with an eye on the availability of empirical evidence of moderation.Methods and analysesStudies reporting on both the concepts of concerns about falling and physical activity amo

A Rebalancing of Financial Valuations and Expectations Moving Forward in the Telehealth Sector as the United States Moves Toward a Post-COVID-19 Reality.

The telehealth sector of health care delivery experienced significant growth at the start of the pandemic as web-based care quickly became essential for the ongoing safety of patients and health care providers, such as clinicians and other health care professionals. After vaccines were introduced, however, telehealth companies lost value as the need for web-based care appeared to lessen. Presently, both existing telehealth companies and new entrants to the space are seeking ways to innovate, gain investor and customer buy-in, and overcome competitors. New companies are hoping to be seen not as

A Canadian Perspective: Monoclonal Antibodies for Pre- and Post-Exposure Protection from COVID-19 in Vulnerable Patients with Hematological Malignancies.

Patients with hematological malignancies have an increased risk of serious outcomes following COVID-19 infection, suggesting broader protection is needed beyond vaccination. Monoclonal antibodies such as sotrovimab, casirivimab-imdevimab, and bamlanivimab have provided valuable options for the treatment of COVID-19 disease. More recently, monoclonal antibodies have been examined for the prevention of COVID-19 infection. The monoclonal antibody combination, tixagevimab-cilgavimab, was recently approved by Health Canada as pre-exposure prophylaxis against COVID-19 in individuals who are immunoco

Совпадение в полном тексте источника
… There is presently a lack of cost-effectiveness analyses for tixagevimab–cilgavimab, as for other COVID-19 therapies made available through the federal government to the provinces. …

Identifying and describing cancer survivors: Implications for cancer survivorship research and clinical care.

BackgroundGathering information directly from cancer survivors has advanced our understanding of the cancer survivorship experience. However, it is unknown whether surveys can distinguish important subgroups of cancer survivors. This study aimed to describe the current landscape of survey questions used to identify and describe cancer survivors in national cross-sectional studies.MethodsUsing publicly available databases, the authors identified national cross-sectional surveys used in the United States within the past 15 years that included a question on self-reported history of cancer. After

Совпадение в полном тексте источника
… Cancer.2022. 10.1002/cncr.33937 This article was prepared as part of some of the authors' official duties as employees of the US Federal Government (Michelle A. Mollica, Joanne W. Elena, Paul B. Jacobsen, and Emily S. Tonorezos). …

Репродуктивная автономия женщин, живущих с множественной миеломой, участвующих в программе профилактики беременности.

Множественная миелома — неизлечимый гематологический рак, который в первую очередь затрагивает пожилых людей. Женщины, имеющие фертильный потенциал, составляют небольшую, но уникальную долю населения, страдающего от многочисленных миелом. Иммуноводные агенты (талидомид, линалидомид и помалидомид) являются высокоэффективными средствами лечения для улучшения длительных периодов глубокой ремиссии и долгосрочного выживания в Множестве миеломы, которые осуществляются в рамках программ контролируемого распределения, требующих наблюдения за беременностью для женщин с потенциалом деторождения, с тем ч

ISEV2025 Резюме книги.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

A scoping review of the literature on the application and usefulness of the Problem Management Plus (PM+) intervention around the world.

BackgroundGiven the high rates of common mental disorders and limited resources, task-shifting psychosocial interventions are needed to provide adequate care. One such intervention developed by the World Health Organization is Problem Management Plus (PM+).AimsThis review maps the evidence regarding the extent of application and usefulness of the PM+ intervention, i.e. adaptability, feasibility, effectiveness and scalability, since it was introduced in 2016.MethodWe conducted a scoping review of seven literature databases and grey literature from January 2015 to February 2024, to identify peer

Нейрофармакология каннабиноидов: всеобъемлющий обзор доклинических и клинических данных о экстрактах гемп-деривных веществ и активных соединениях.

Каннабис сатива содержит более 120 фитоканнабиноидов, причем наиболее характерными из них являются Δ9-тетрагидроканнабинол (THC) и каннабидиол (CBD). В настоящем обзоре обобщаются доклинические и клинические данные об экстрактах гематома, каннабиноидах и активных соединениях. THC действует главным образом как частичный агонист каннабиноидного рецептора типа 1 (CB1) и типа 2 (CB2), приводящий к психоактивным, аппетитным, антиэметическим и анальгетическим эффектам. КБР не является опьяняющим и имеет мультимодальный профиль, включающий негативную аллостерическую модуляцию CB1, обратное агонизм CB

Cardiometabolic health in people with HIV: expert consensus review.

ObjectivesTo develop consensus data statements and clinical recommendations to provide guidance for improving cardiometabolic health outcomes in people with HIV based on the knowledge and experience of an international panel of experts.MethodsA targeted literature review including 281 conference presentations, peer-reviewed articles, and background references on cardiometabolic health in adults with HIV published between January 2016 and April 2022 was conducted and used to develop draft consensus data statements. Using a modified Delphi method, an international panel of 16 experts convened in

Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats.

The COVID-19 pandemic exposed a global deficiency of systematic, data-driven guidance to identify high-risk individuals. Here, we illustrate the utility of routinely recorded medical history to predict the risk for 1741 diseases across clinical specialties and support the rapid response to emerging health threats such as COVID-19. We developed a neural network to learn from health records of 502,489 UK Biobank participants. Importantly, we observed discriminative improvements over basic demographic predictors for 1546 (88.8%) endpoints. After transferring the unmodified risk models to the All

Detection of potential complications in cancer survivors after chemotherapy and development of a regional care network: the PASCA feasibility study.

Complications are often poorly identified and managed in cancer survivors after treatment and restoring their initial quality of life remains a challenge, particularly in a context of unequal access to care nationwide. The PASCA "Parcours de Santé au cours du Cancer [in English: healthcare pathways with cancer]" feasibility study was conducted in the Léon Bérard Comprehensive Cancer Center (Lyon, France) to assess the feasibility of a complications detection program, in cancer survivors who have received intensive chemotherapy. An initial network of physicians and healthcare professionals was

Genetically determined telomere length and multiple myeloma risk and outcome.

Telomeres are involved in processes like cellular growth, chromosomal stability, and proper segregation to daughter cells. Telomere length measured in leukocytes (LTL) has been investigated in different cancer types, including multiple myeloma (MM). However, LTL measurement is prone to heterogeneity due to sample handling and study design (retrospective vs. prospective). LTL is genetically determined; genome-wide association studies identified 11 SNPs that, combined in a score, can be used as a genetic instrument to measure LTL and evaluate its association with MM risk. This approach has been

Advances and Challenges in Cervical Cancer: From Molecular Mechanisms and Global Epidemiology to Innovative Therapies and Prevention Strategies.

BackgroundIn the global scenario of public health, cervical cancer poses a major threat with high mortality rates, especially in women. New incidence cases and prevalence vary across different regions, as recently shown by GLOBOCAN data. The development of cervical cancer is primarily due to persistent infection by high-risk genotypes of human papillomavirus (HPV), which is a multifaceted process that is influenced by genetic, environmental, and lifestyle factors.PurposeThe goal of this study is to thoroughly investigate cervical cancer, including its etiology, molecular mechanisms, progressio

Астроглиальная модуляция синаптической функции в недемилинированной коре головного мозга зависит от сигнала MyD88 в модели токсичного обезвоживания.

Прогрессивный неврологический спад в множественном склерозе связан с аксонной потерей и синаптической дисфункцией в недемилинированном нормальном сером веществе (NAGM) и занимает видное место в мозжечке. В отличие от ранних стадий заболеваний, когда синаптическая и нейро-аксональная патология коррелирует с масштабами инфильтрации клеток Т, для прогрессивных MS была предложена важная роль врожденной иммунной системы. Вместе с тем конкретный вклад микроглии и астроцитов в синаптическую патологию мозгового мозга в НГММ - независимо от адаптивной реакции Т клеток - по-прежнему в значительной степе

Euthanasia and physician-assisted suicide not meeting due care criteria in the Netherlands: a qualitative review of review committee judgements.

UNLABELLED: ObjectivesTo assess how Dutch regional euthanasia review committees (RTE) apply the euthanasia and physician-assisted suicide (EAS) due care criteria in cases where the criteria are judged not to have been met ('due care not met' (DCNM)) and to evaluate how the criteria function to set limits in Dutch EAS practice. DESIGN: A qualitative review using directed content analysis of DCNM cases in the Netherlands from 2012 to 2016 published on the RTE website (https://www.euthanasiecommissie.nl/) as of 31 January 2017. RESULTS: Of 33 DCNM cases identified (occurring 2012-2016), 32 case

Revolutionizing hematological disorder diagnosis: unraveling the role of artificial intelligence.

The integration of artificial intelligence (AI) into medical diagnostics is transforming the landscape of healthcare, particularly in hematology. AI technologies, leveraging advanced machine learning algorithms and big data analytics, are revolutionizing the diagnosis of hematological disorders such as anemia, leukemia, and lymphoma. This review explores how AI enhances diagnostic accuracy, efficiency, and patient outcomes by processing complex datasets and identifying patterns beyond human capability. AI-driven advancements in hematology include innovations in image analysis, genomic data int

ISEV2018 абстрактная книга

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Oncology biosimilars: New developments and future directions.

Biologicals have become an integral part of cancer treatment both as therapeutic agents and as supportive care agents. It is important to know that biologics are large, complex molecular entities requiring extensive immunogenicity testing and pharmacovigilance strategies to ensure no immune response is evoked in the body. Oncology's pharmacological market is dominated by biologics; however, their high development and manufacturing costs are burdensome to health care systems. Biologics being the most expensive prescription drugs on the market limit the accessibility for necessary treatment in t

Лупин (Lupinus angustifolius) Протеин гидролизат уменьшает остроту экспериментального аутоиммунного энцефаломелита: предварительное исследование.

Множественный склероз (MS) — нейродегенеративное заболевание, основным источником которого является воспаление и окислительный стресс в центральной нервной системе. Существует много лекарств, которые уменьшают клинические признаки MS, но ни один из них не лечит болезнь. Было доказано, что пищевые белки содержат зашифрованные пептиды, которые могут высвобождаться после гидролиза и осуществлять многочисленные биологические виды деятельности. Недавно мы продемонстрировали антивоспалительные и антиоксидантные действия волчьего белка гидролизата (LPH) как in vitro, так и in vivo. Поэтому цель этого