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Excess costs of post-traumatic stress disorder related to child maltreatment in Germany.

BACKGROUND: Childhood maltreatment (CM) significantly increases the risk of developing post-traumatic stress disorder (PTSD) for which the prevalence in Europe is higher than initially assumed. While the high economic burden of PTSD is well-documented, little is known about the health care cost differences between individuals with PTSD-CM and those without PTSD in Germany. This study aimed to determine the excess health care and absenteeism costs associated with PTSD-CM in Germany. METHODS: Baseline data from a multi-center randomized controlled trial on individuals with PTSD-CM (n = 361) wer…

Re-emergence of Mycoplasma pneumoniae before and after COVID-19 pandemic in Germany.

BACKGROUND: Mycoplasma pneumoniae (M. pneumoniae) is a common pathogen of community-acquired pneumonia (CAP). Epidemics occur every 3-7 years especially in pediatric patients. We collected data from a large laboratory network in Germany to define the epidemiological dynamics in the pre- and post-COVID-19 pandemic period. METHODS: In this retrospective cohort study we included all patients that obtained targeted or multiplex PCR for M. pneumoniae from nasopharyngeal swabs, sputum or bronchoalveolar fluids from 2015 to 2024. Demographic data (age, sex, place of residence, in- or outpatient stat…

Cutaneous non-tuberculous mycobacterial infections: A retrospective study of 94 cases from Germany.

BACKGROUND: Cutaneous non-tuberculous mycobacterial infections (NTM) remain a diagnostic and therapeutic challenge. The aim of this study was to characterize cutaneous NTM infections in Germany over a 24-year-period. PATIENTS AND METHODS: 73 patients with cutaneous NTM infections diagnosed at 17 different German University Hospitals from 2000-2011 and 21 patients treated at the Department of Dermatology of the University Hospital Cologne, from 2010-2024. Retrospective analysis of patient, demographic, clinical information, and data on different diagnostic workups and therapeutic approaches/re…

От обычного к выборочному: каким образом обновленные руководящие принципы МРТ изменяют использование гадолиния в Германии.

Магнитный резонансный снимок (MRI) представляет собой критический диагностический инструмент и механизм мониторинга множественного склероза (MS), часто использующий контрастные агенты на основе гадолиния (Gd). Вместе с тем обеспокоенность по поводу накопления Гд побудила к принятию международных руководящих принципов (MAWDMS-CMSC-NAIMS, 2021) выступать за ограничение использования Gd. В этой связи мы провели оценку воздействия 2021 Руководящие принципы использования ГД в МРТ для пациентов, страдающих МЗ в Германии, путем проведения ретроспективного анализа данных МРТ, полученных от 12,833 Паци

Совпадение в аннотации оригинала
Magnetic resonance imaging (MRI) is a critical diagnostic tool and monitoring modality for multiple sclerosis (MS), frequently employing gad … quently, we assessed of the impact of the 2021 guidelines on the use of Gd in MRI in MS patients in Germany by conducting a retrospective analysis of MRI data from 12,833 MS patients in the German MS Register (2019-2024). Generalized additive models were employed to analyze Gd use trends over time by MRI type (cranial, spinal, combined). From 2020 to 2024 …

Family structure transitions and educational outcomes: Explaining heterogeneity by parental education in Germany.

Recent research has documented that the effect of parental separation on children's educational outcomes depends on socioeconomic background. Yet, parental separation could lead to a stable single-parent family or to a further transition to a stepfamily. Little is known about how the effect of family structure transitions on educational outcomes depends on the education of parents and stepparents, and there has been limited empirical research into the mechanisms that explain heterogeneity in the effects of family transitions. Using longitudinal data from the German Socio-Economic Panel and mod

Toxoplasma gondii in Wild Boars (Sus scrofa) in Germany: Serological Screening from Thuringia.

Game meat is an important source of meat borne parasitic infections. Due to its omnivorous diet, the wild boar is an important host of zoonotic parasites such as Toxoplasma gondii. T. gondii can cause severe to fatal disease in immunosuppressed patients, as well as congenital disorders in foetus and neonates. Consumption of undercooked infected meat is a main source of T. gondii infection. Information about the risk of toxoplasmosis through game meat is scarce. We collected serum samples from 42 wild boars from the federal state of Thuringia (Germany) between December 2017 and February 2018. I…

The other health care system in Germany: care for people without health insurance.

BACKGROUND: A large number of people in Germany have no health insurance. Their access to the official healthcare system is significantly more difficult or impossible. Charitable institutions try to provide medical care and create parallel healthcare structures. Their possibilities and limits are still unknown. METHODS: This study identified 128 institutions for people without health insurance. A data query was used to determine the status of medical care for uninsured patients. RESULTS: Sixty-eight of 128 identified institutions participated in the study. They provided care to 26,300 people…

Cancer Risk in Patients with Down Syndrome-A Retrospective Cohort Study from Germany.

BACKGROUND: Individuals with Down syndrome are thought to have a unique tumor profile. METHODS: Using the IQVIA Disease Analyzer database, patients aged ≥18 years diagnosed with Down syndrome in German general practices between 2005 and 2021 were compared with patients without Down syndrome for cancer incidence, adjusting for age, sex, average annual visit frequency, and comorbidity. The 5-year cumulative incidence of cancer overall and specific cancers was analyzed using Kaplan-Meier curves and compared using the log-rank test. In addition, univariable Cox regression analysis was performed.

Adverse Obstetric Outcomes after Breast Cancer Diagnosis: An Observational Database Study in Germany.

BACKGROUND/OBJECTIVES: Breast cancer may negatively affect later pregnancy and childbirth. We aimed to analyze the impact of previous breast cancer on obstetric outcomes in postdiagnosis pregnancies. METHODS: Insurance claims data in Southern Germany were used to identify breast cancer (BC) survivors with at least one subsequent delivery after cancer diagnosis between 2010 and 2020. In total, 74 BC survivors were compared to 222 age-matched controls with frequency matching on their age at their postdiagnosis delivery. RESULTS: Endocrine therapy was associated with a significantly lower proba…

Measles vaccination - An underestimated prevention measure: Analyzing a fatal case in Hildesheim, Germany.

Measles and rubella are targeted for elimination in the WHO region Europe. To reach the elimination goal, vaccination coverage of 95% must be achieved and sustained, the genotype information has to be provided for 80% of all outbreaks and transmission chains of a certain variant must not be detected for >12 months. The latter information is collected at Germany's National Reference Center Measles, Mumps, Rubella (NRC MMR). We describe here an outbreak of measles occurring in Hildesheim. The outbreak comprised 43 cases and lasted 14 weeks. Surprisingly, a high number of vaccination failures was…

Differences in characteristics between patients from Egypt and Germany presenting with lacunar stroke.

Despite the enormous health burden of lacunar stroke, data from low- and middle-income countries on lacunar stroke characteristics and its comparison with that of high-income countries are scarce. Thus, we aimed to investigate and compare the variable characteristics and vascular status in patients from Egypt and Germany suffering lacunar stroke. Two cohorts of lacunar stroke patients from Ain Shams University Hospital, Egypt and Goethe University Hospital Frankfurt, Germany were retrospectively collected between January 2019 and December 2020 and analyzed for demographics, risk factors, mode …

Antimicrobial resistance of clinical Enterobacterales isolates from urine samples, Germany, 2016 to 2021.

IntroductionEmpirical therapy for the treatment of urinary tract infections should be tailored to the current distribution and susceptibility of potential pathogens to ensure optimal treatment.AimWe aimed to provide an up-to-date overview of the epidemiology and susceptibility of Enterobacterales isolated from urine in Germany.MethodsWe retrospectively analysed antimicrobial susceptibility data from 201,152 urine specimens collected between January 2016 and June 2021 from in- and outpatients. Multiple logistic regression analysis was used to evaluate the association between year of investigati…

Dynamic evaluation of modeled ozone concentrations in Germany with four chemistry transport models.

Simulating the ozone variability at regional scales using chemistry transport models (CTMs) remains a challenge. We designed a multi-model intercomparison to evaluate, for the first time, four regional CTMs on a national scale for Germany. Simulations were conducted with LOTOS-EUROS, REM-CALGRID, COSMO-MUSCAT and WRF-Chem for January 1st to December 31st, 2019, using prescribed emission information. In general, all models show good performance in the operational evaluation with average temporal correlations of MDA8 O3 in the range of 0.77-0.87 and RMSE values between 16.3 μg m-3 and 20.6 μg m-…

Hospital intervention volume affects outcomes of emergency transcatheter aortic valve implantations in Germany.

The literature has shown an inverse volume-outcome relationship for transcatheter aortic valve implantation (TAVI). However, little is known about emergency admissions in Germany. Using German national electronic health records, we identified all isolated balloon-expandable and self-expanding transfemoral TAVI in 2018. The focus was on those patients with emergency admission. 17,295 patients were treated with TAVI, including 1682 emergency cases. 49.2% of the emergency admissions were female, the mean age was 81.2 years and the logistic EuroSCORE was 23.3%. The percentage of emergency cases wa…

Leclercia pneumoniae sp. nov., a bacterium isolated from clinical specimen in Leipzig, Germany.

Strain 49125T was isolated from an infant with pneumonia and septicaemia at the Leipzig University Hospital. Phenotypic and genomic traits were investigated. The strain's biochemical profile and its MALDI-TOF spectrogram did not differ from comparative samples of Leclercia adecarboxylata, thus far the sole member of the Leclercia species. A circular genome with a size of 4.4 Mbp and a G+C content of 55.0 mol% was reconstructed using hybrid Illumina and Nanopore sequencing. Phylogenetic analysis was based on 172 marker genes and validated using a k-mer-based search against a large genome collec

Quality assessment, inclusive community development, and collective learning: An institutional perspective from Germany.

This article reviews the German discourse on quality of life, quality assurance, and outcome measurement in services for persons with intellectual disabilities. Following institutional assumptions of path dependencies in organizational development, it is argued that concepts such as quality assurance must be understood in the context of the national support system development. For the Federal Republic of Germany, it can be noted that previous approaches to quality assurance of services based on measurement and evaluation tools have not been the drivers of innovation for inclusion. The driving …

Genomic Analysis of ESBL-Producing E. coli in Wildlife from North-Eastern Germany.

Antimicrobial resistance (AMR) is a serious global health threat and extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales are a major contributor. This study aimed to gain a deeper insight into the AMR burden of wild animals. In total, 1595 fecal samples were collected by two systematic searches in Mecklenburg-Western Pomerania, north-east Germany. Samples were screened for ESBL-carrying Escherichia (E.) coli and isolates found were further analyzed using antimicrobial susceptibility testing and whole-genome sequencing. We found an estimated prevalence of 1.2% ESBL-producing E. c…

Predictors of Loneliness among Homeless Individuals in Germany during the COVID-19 Pandemic.

PURPOSE: The aim of the study was to identify the frequency of loneliness and to examine the factors associated with loneliness among homeless individuals in Germany during the COVID-19 pandemic. METHODS: Data were taken from the 'national survey on the psychiatric and somatic health of homeless individuals during the COVID-19 pandemic'. The data collection took place from 26th July to 17th September 2021 (the analytical sample included n = 491 observations). The well-established UCLA-3 tool was used to quantify loneliness. Independent variables included sex, age, marital status, the existenc…

Web content mining analysis of e-scooter crash causes and implications in Germany.

In Germany, police reports published via press are neither uniformly written nor accessible to the public. There is a lack of comprehensive and factual data-based analyses of e-scooter crashes and their causes. We collected 1936 crash-related reports over two years via the German press portal based on a systematic web content mining process. Sentiment analysis results revealed that the police reports' coverage is predominantly factual and neutral and, therefore, useful for keyword-based analyses. After identifying the 46 most relevant keywords in the reports, we generated an adjacency matrix t…