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Pulfrich pendulum phenomenon in patients with a history of acute optic neuritis.

The Pulfrich phenomenon is a stereoillusion in which a pendulum swinging at right angles to the line of gaze appears to be describing an elliptical path when absorbing filters are placed in front of one eye. We used two sets of polaroid glasses as adjustable filters. A spot on a modified oscilloscope served at a pendulum bob. Twenty-nine former patients with a history of optic neuritis and visual acuities of greater than or equal to 6/6 in both eyes and twenty-two normal subjects underwent examinations. The patients showed pathological recordings which separated them from the control subjects.…

Baseline Features of Optic Neuritis in South Korea: A Retrospective Multicenter Study.

BACKGROUND: To investigate the clinical features and serologic test results of optic neuritis through a multi-institutional study in Korea. METHODS: The is a retrospective cohort study from multicenters (21 centers) in Korea. A cohort consists of 181 Korean patients diagnosed with noninfectious optic neuritis from January 2022 to December 2023. The types of optic neuritis were classified and analyzed based on serologic and imaging tests. The positive rate of serologic tests was analyzed. In addition, demographics, visual function tests including visual acuity and visual field, and anatomical …

Anti-NMDA-receptor encephalitis and MOGAD associated optic neuritis: a case series.

INTRODUCTION: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a well-recognized autoimmune condition that often presents with neuropsychiatric symptoms and seizures. Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) often manifests as optic neuritis and, less frequently, as acute demyelinating encephalomyelitis or transverse myelitis. The co-occurrence of anti-NMDAR encephalitis and MOGAD is becoming increasingly recognized, but clinical series remain limited. DESCRIPTION OF CASES: We present three patients with anti-NMDAR encephalitis and MOGAD optic neuritis…

Case Report: Concurrent retinal vasculitis and optic neuritis in systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can affect the ocular system, with retinal vasculitis and optic neuritis being rare but serious manifestations. We present a case of a 26-year-old female with newly diagnosed SLE who developed both retinal vasculitis and optic neuritis, leading to progressive visual impairment. She was successfully treated with methylprednisolone and rituximab, achieving significant visual recovery. A review of existing literature highlights the diagnostic challenges, pathophysiology, and optimal treatment strategies for such cases. Ou…

Acute Chlamydia pneumoniae infection in a child, complicated by retrobulbar optic neuritis.

INTRODUCTION: This case highlights a rare and significant complication of Chlamydia pneumoniae infection: optic neuritis (ON). Acute Chlamydia pneumoniae infection in children typically presents with respiratory tract symptoms and may occasionally lead to complications or sequelae. ON is a condition most commonly associated with viral infections or other demyelinating diseases. CASE REPORT: The patient, a 10-year-old girl, initially presented with the typical systemic symptoms of Chlamydia pneumoniae infection, including fever, chills, and headache, in addition to an atypical symptom-chromati…

Клинические прогнозы по острому оптическому невриту: анализ на основе данных клинических испытаний.

ЦЕЛЬ: Определение исходных клинических прогнозов визуальных результатов через 6 месяцев после острого оптического невраита с использованием данных, полученных в ходе нашего завершенного клинического испытания на нейрозащиту: Лечение оптического неретита эритропоэтином (ТОНЕ). DESIGN: Вторичный анализ данных, полученных в рамках исследования TONE (NCT01962571). УЧАСТНИКИ: В общей сложности 103 пациента, представляющие в течение 10 дней после первого эпизода острого одностороннего оптического неврита в качестве клинически изолированного синдрома с исходной высокой контрастной визуальной акустией

Совпадение в аннотации оригинала
PURPOSE: To identify baseline clinical predictors of visual outcomes 6 months after acute optic neuritis using data from our completed clinical neuroprotection trial: Treatment of Optic Neuritis with Erythropoietin (TONE). DESIGN: Secondary analysis of data from the TONE study cohort (NCT01962571). PARTICIPANTS: A total of 103 patients presenting within 10…

Radiologic Predictors of Visual Outcome in Myelin Oligodendrocyte Glycoprotein-Related Optic Neuritis.

PURPOSE: This study aimed to determine whether magnetic resonance imaging (MRI) biomarkers are associated with visual prognosis in myelin oligodendrocyte protein (MOG)-associated optic neuritis (ON). DESIGN: Cross-sectional analysis. PARTICIPANTS: Patients meeting 2023 international diagnostic criteria for MOG antibody-associated disease who were seen for first episodes of MOG-associated ON at 3 tertiary neuro-ophthalmology practices between January 2017 and July 2023 were enrolled. Patients who received < 3 months of neuro-ophthalmic follow-up and did not demonstrate visual recovery (visual…

Optic Neuritis and Vertebral Osteomyelitis: An Uncommon Presentation of Cat-Scratch Disease.

In cat-scratch disease (CSD), hematogenous spread may result in atypical presentations. Ocular manifestations develop in a minority of patients, with treatment being important in reducing long-term visual sequelae. Bone infection is rare. We present the case of a 52-year-old woman, with close contact with cats, reporting acute unilateral blurred vision and presenting papilledema, optic disc pallor, and peripapillary hemorrhage. Etiologic study of optic neuritis revealed an elevated positive Bartonella IgG; hence, treatment for CSD with doxycycline plus rifampin and corticosteroids was started.…

Accuracy of International Classification of Diseases Codes for Identifying Acute Optic Neuritis.

BACKGROUND: The accuracy of International Classification of Diseases (ICD) codes for identifying cases of acute optic neuritis (aON) is not known. A prior study reported 61% accuracy for ICD code plus MRI consistent with aON within 2 months. This study determined accuracy for ICD code plus MRI within 2 months regardless of results. METHODS: Retrospective chart review was conducted using a medical record research repository of a tertiary care institution from 1998 to 2019. Subjects with ICD-9/10 codes for ON and an MRI brain and/or orbits within 2 months of earliest (initial) ICD code were inc…

Treatment With Erythropoietin for Patients With Optic Neuritis: Long-term Follow-up.

BACKGROUND AND OBJECTIVE: Erythropoietin (EPO) is a candidate neuroprotective drug. We assessed its long-term safety and efficacy as an adjunct to methylprednisolone in patients with optic neuritis and focused on conversions to multiple sclerosis (MS). METHODS: The TONE trial randomized 108 patients with acute optic neuritis but without previously known MS to either 33,000 IU EPO or placebo in conjunction with 1,000 mg methylprednisolone daily for 3 days. After reaching the primary end point at 6 months, we conducted an open-label follow-up 2 years after randomization. RESULTS: The follow-up…

Acute-Onset Retinal Conditions Mimicking Acute Optic Neuritis: Overview and Differential Diagnosis.

Acute optic neuritis (AON) is a common cause of sudden visual loss in young patients. Because of the risk of demyelinating disease, patients affected by unilateral or bilateral optic neuritis should be evaluated and treated accordingly. Despite advancements in imaging of the brain and retina, misdiagnosis of AON is not uncommon. Indeed, some acute disorders of the retina have the potential to mimic AON and their prompt diagnosis may avoid unnecessary neurologic investigation, psychological stress to the patient, and delays in treatment. This review describes uncommon retinal disorders presenti…

Delayed oculomotor response associates with optic neuritis in youth with demyelinating disorders.

INTRODUCTION: Impairment in visual and cognitive functions occur in youth with demyelinating disorders such as multiple sclerosis, neuromyel … neralized Estimating Equations were used to examine the association of eye-tracking parameters with optic neuritis history, structural metrics, and visual and cognitive scores. RESULTS: The study included 36 demyelinating disorders patients, aged 8-18 yrs. (75% F; median = 15.22 yrs., SD = 2.8) and 34 age-matched controls (65% F; median = 15.26 yrs., SD = 2.3). …

Sudden Vision Loss Due to Optic Neuritis-An Uncommon Presentation of Neurosarcoidosis.

Sarcoidosis is a systemic, granulomatous disease of unknown etiology, most often manifested by mediastinal and hilar lymph node enlargement … two cases demonstrate that sarcoidosis should be considered as a differential diagnosis in cases of optic neuritis.

Neuroprotective Effects of Novel Treatments on Acute Optic Neuritis-A Meta-Analysis.

Optic neuritis, inflammation of the optic nerve, can cause visual impairment through retinal nerve fiber layer (RNFL) degeneration. Optical coherence tomography could serve as a sensitive noninvasive tool for measuring RNFL thickness and evaluating the neuroprotective effects of treatment. We conducted a meta-analysis to compare RNFL loss between novel add-on treatments and corticosteroid therapy at least 3 months after acute optic neuritis. The outcome measures were mean differences (MDs) in (1) RNFL thickness compared with the baseline in the affected and unaffected eye and (2) LogMAR visual…

Unilateral optic neuritis after vaccination against the coronavirus disease: two case reports.

BACKGROUND: Due to the emergence of COVID-19, many countries have started mass immunization programs. To date, no cases of optic neuritis following COVID-19 vaccination have been reported in the literature. CASE PRESENTATION: Objective: Here, we report 2 cases of unilateral optic neuritis after vaccination against COVID-19 using the Sinopharm vaccine (Sinopharm Group Co. Ltd, China). DESIGN: The clinical history, examination, and test findings of two individuals with unilateral optic neuritis associated with the timing of COVID-19 vaccination were described and further analyzed. SETTING: Tw…