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New bacterial species associated with chronic periodontitis.

Recent investigations of the human subgingival oral flora based on ribosomal 16S cloning and sequencing have shown many of the bacterial spe … om the OP11 phylum, and clone I025 from the TM7 phylum, and the named species Eubacterium saphenum, Porphyromonas endodontalis, Prevotella denticola, and Cryptobacterium curtum. Species or phylotypes more prevalent in periodontal health included two uncultivated phylotypes, clone W090 from the Deferribacteres phylum and clone BU063 from the Bacteroidetes, and n …

Curcumin as an adjunct in periodontal therapy: local effects, delivery systems, and clinical perspectives.

Curcumin, the active polyphenol in turmeric (Curcuma longa), is well-known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a promising therapeutic agent for a range of diseases, including neuroinflammatory conditions and periodontal disease. Periodontitis, a prevalent oral disease, is associated with chronic inflammation and bacterial infection. Curcumin has demonstrated antibacterial effects against periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia when applied locally as a sub-gingival gel i…

Metronidazole-Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis.

In this study, a methacrylamide β-cyclodextrin-based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. The developed MACD nGel is synthesized by free radical polymerization and successfully loaded with MNZ. The nGel/MNZ system is shown to be effective against the main causative organisms of periodontitis, Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum), and shows significant bacteriostatic effects and good cytocompatibility. In animal studies, the topical application o…

Time-Responsive Activity of Engineered Bacteria for Local Sterilization and Biofilm Removal in Periodontitis.

Periodontitis is a highly prevalent and common condition in people of all ages, however, existing drugs to treat periodontitis have difficulty penetrating complex biofilms. Here, we report a biofilm-penetrating probiotic hybrid strategy for the treatment of periodontitis. It consists of therapeutic probiotics of E. coli Nissle 1917, which can produce antimicrobial peptides and hydrogen, and is coated with D-amino acids that can penetrate biofilms. After the fusion of D-amino acids with the biofilm, EcN entered the plaque biofilm and produced antimicrobial peptides to kill porphyromonas gingiva…

Gut Microbiota and Polycystic Ovary Syndrome (PCOS): Understanding the Pathogenesis and the Role of Probiotics as a Therapeutic Strategy.

Polycystic ovary syndrome (PCOS) is one of the most common disorders among women in modern societies. A variety of factors can contribute to the development of PCOS. These women often exhibit high insulin resistance (IR), hyperandrogenism, irregular periods, and infertility. Dysbiosis of the gut microbiota (GMB) in women with PCOS has attracted the attention of many researchers. Porphyromonas spp., B. coprophilus, and F. prausnitzii are found in higher numbers in the gut of women with PCOS. Short-chain fatty acids (SCFAs), produced by the intestinal microbiota through fermentation, play an ess…

Microbiome in Hidradenitis Suppurativa-What We Know and Where We Are Heading.

Recently, interest in the microbiome of cutaneous diseases has increased tremendously. Of particular interest is the gut-brain-skin axis proposed by Stokes and Pillsbury in 1930. The microbiome has been suggested in the pathogenesis of hidradenitis suppurativa, however the link between the commensals and the host is yet to be established. Across all studies, the increased abundance of Porphyromonas, Peptoniphilus, and Prevotella spp., and a loss of skin commensal species, such as Cutibacterium in HS lesions, is a consistent finding. The role of gut and blood microbiome in hidradenitis suppurat…

[Research progress in the relationship between Veillonella and oral diseases].

Veillonella species, known as the early colonizer of oral biofilm, are prevalent in oral microbiota. Seven Veillonella species have been isolated from oral cavity. Their distribution varies not only with different people but also with different sites in the oral cavity. Oral Veillonella are associated with oral diseases. They contribute to the adhesion of Streptococcus mutans and consume the lactate generated by streptococci. Veillonella species play an important role in the occurrence and development of periodontal diseases by providing adhesion sites for Porphyromonas gingivalis and boosting…

The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease.

Proteinase-activated receptors 1 (PAR1) and 2 (PAR2) are the most highly expressed members of the PAR family in the periodontium. These receptors regulate periodontal inflammatory and repair processes through their activation by endogenous and bacterial enzymes. PAR1 is expressed by the periodontal cells such as human gingival fibroblasts, gingival epithelial cells, periodontal ligament cells, osteoblasts, and monocytic cells and can be activated by thrombin, matrix metalloproteinase 1 (MMP-1), MMP-13, fibrin, and gingipains from Porphyromonas gingivalis. PAR2 is expressed by neutrophils, oste…

Diagnosis and anti-infective therapy of periodontitis.

Periodontal diseases (gingivitis and periodontitis) are chronic bacterial infections with a remarkably high prevalence and morbidity. Periodontitis, in contrast to gingivitis, is not reversible, is associated with certain bacterial species and affects all of the soft tissue and bone that support teeth. Among the periodontal pathogens, species, such as Aggregatibacter (Actinobacillus) actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythensis, and several forms of uncultivable spirochetes play the major role in the pathogenesis. In severe chronic, recurrent …

Early-onset periodontitis.

The group of periodontal diseases known as the early-onset periodontal diseases are defined by the age of onset of periodontal destruction, … rresponsiveness. Bacterial colonization by Actinobacillus actinomycetemcomitans (serotype b) and/or Porphyromonas gingivalis appears to be the primary initiator of disease. Evidence suggests that lesion distribution may be a function of the nature of the infecting agent and the characteristics of the immune response.

Effect of periodontal therapy on the oral microbiome and lung function: an intervention study.

INTRODUCTION: The oral cavity harbors over 700 bacterial species, and disruption of this balance can lead to periodontitis, which has been l … tance. Microbiome analysis showed a shift from periodontitis-associated taxa, including Prevotella, Porphyromonas, and Tannerella, toward health-associated species such as Actinomyces oris, and Rothia dentocariosa. Higher airway resistance was associated with a greater relative abundance of periodontitis-associated bacteria. DISCUSSION: Together, findings sugg …

A synergistic strategy of AIE and electron asymmetry anchored in covalent organic frameworks for enhanced periodontitis photodynamic therapy.

Periodontitis, a widespread inflammatory disease, is difficult to treat effectively due to incomplete mechanical cleaning and increasing ant … mics, and reactive oxygen species (ROS) generation. It showed strong antibacterial activity against Porphyromonas gingivalis and Fusobacterium nucleatum in vitro and demonstrated effective periodontitis treatment with decreased inflammatory responses in vivo. This work pioneered the integration of AIE and LAED in COFs, providing a promising antibiotic-free stra …

Influence of magnesium oxide nanoparticles on in vitro mechanical and antibacterial performance of self-curing dental polymethyl-methacrylate.

Self-curing polymethyl methacrylate is widely used for provisional restorations, retainers and denture repairs, but its lack of antibacterial activity favors bacterial colonization. Magnesium oxide nanoparticles exhibit broad antibacterial effects through the generation of reactive oxygen species. This study evaluated the influence of mechanochemically synthesized magnesium oxide nanoparticles on the mechanical properties of self-curing polymethyl methacrylate and on its antibacterial activity against Actinomyces israelii, Porphyromonas gingivalis, Capnocytophaga gingivalis, Prevotella interme…

Oral microbiota dysbiosis in pediatric patients undergoing treatment for acute lymphoid leukemia a preliminary study.

Acute lymphoblastic leukemia (ALL) stands out as the most prevalent neoplasm during childhood, characterized by the rapid production of abno … s identified key taxa during this phase, namely Neisseria flavescens, Prevotella melaninogenica and Porphyromonas. The findings underscore the substantial impact of ALL treatment on the oral microbiota composition, indicating diminished bacterial diversity and an elevated prevalence of oral mucositis.

Glycosylation orchestrates virulence and pathogenicity of periodontal keystone pathogens.

Periodontal diseases, chronic inflammatory conditions initiated by dysbiotic microbial communities, are predominantly driven by the "red complex" pathogens. This review explores how glycosylation on surface molecules of Tannerella forsythia, Porphyromonas gingivalis, and Treponema denticola modulate their pathogenesis. Research reveal glycosylation profoundly impacts synthesis, stability and functionality of major virulence factors like gingipains, fimbriae and surface layer proteins in these keystone pathogens. Distinct glycan motifs facilitate immune evasion by masking antigenic epitopes, su…

A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights.

The oral microbiome is increasingly linked to human health. To further examine this microbial community, we present the human reference oral … Patescibacteria. Additionally, an oral CPR subclade is associated with periodontitis, complementing Porphyromonas gingivalis in predicting disease. Finally, comparing HROM with reference genomes of the gut microbiome reveals taxonomic and functional divergence between these microbiomes. HROM contains 42 ectopic oral species, and their relative abundance in gut …

Множественные пациенты, страдающие склерозом, имеют оральный дисбиоз с уменьшением числа колонизаторов и более низким уровнем гипотаурина.

Хотя дисбиоз кишечного микробиома связан с патобиологией множественного склероза (MS), роль перорального микробиома (OM), второго по величине микробиома, по-прежнему недостаточно понятна. Кроме того, в то время как слюнный метаболом связан с другими нейродегенеративными заболеваниями, его роль в людях с релапсирующими-излучающими MS (pwRRMS), наиболее распространенной формой MS, неизвестна. Комбинируя метагеномику дробовика с нецелевой метаболомией, мы выявили уменьшение изобилия нескольких ранних колонизирующих видов, включая Стрептококококку и Актиномику в ПВИРМС, и обогащение бактерий с пат

Совпадение в аннотации оригинала
Although gut microbiome dysbiosis is implicated in the pathobiology of multiple sclerosis (MS), the role of the oral microbiome (OM), the se … n pwRRMS and an enrichment of bacteria with pathogenic potential including Fusobacterium nucleatum, Porphyromonas gingivalis, and several Prevotella species. pwRRMS had an altered metabolite profile including a decreased hypotaurine compared to healthy controls. Thus we report altered oral microbiome and metabolome in pwRRMS which might contribute to MS pathobi …

Symptomatic and asymptomatic apical periodontitis associated with red complex bacteria: clinical and microbiological evaluation.

In this study, the association of red complex (RC) bacteria that include Treponema denticola, Tannerella forsythia and Porphyromonas gingivalis with acute, exacerbated or chronic apical periodontitis was evaluated. Seventy-one patients with periapical disease were evaluated by clinical examination and microbiological samples obtained from the root canals were analyzed by a polymerase chain reaction assay. Twenty-one (29.6%) samples were positive for RC bacteria, with T. denticola, T. forsythia and P. gingivalis being detected in 14 (19.7%), 10 (14.1%) and 6 (8.5%) samples, respectively. RC bac…

Local and systemic antibody response to putative periodontopathogens in patients with chronic periodontitis: correlation with clinical indices.

Specific immunoglobulin G (IgG), IgA and IgM antibody titres to Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans were measured by enzyme-linked immunosorbent assay in serum and gingival crevicular fluid at 5 sites in each of 20 chronic periodontitis patients. Specific serum antibody titres correlated with mean gingival crevicular fluid titres. The 3 immunoglobulin subclass responses (IgA, IgG and IgM) to P. gingivalis correlated. A comparison of sites with probing depth < 4 mm and > or = 4 mm showed that the latter group had significantly lower gingival crevicular fluid IgG ti…

Dental Pulp Stem Cells for the Management of Plaque Biofilm-Associated Infections : A Review.

This structured narrative review synthesises current evidence (2000-2025) on the antimicrobial, immunomodulatory, and regenerative propertie … strategy: (1) direct microbial control through the secretion of antimicrobial peptides that disrupt Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans and (2) resolution of inflammation via macrophage M2 polarisation, suppression of IL-1β/TNF-α (Interleukin-1β and Tumor Necrosis Factor-α), and microbiome rebalancing. Additionally, DPSCs support …