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Pedicled myofascial temporalis flap for closure of large maxillary defects after medication-related osteonecrosis of the jaws. A case series.

BACKGROUND: Medication-related osteonecrosis of the jaws (MRONJ) located in the maxilla may lead to challenging oro-antral and oro-nasal defects too extensive to be predictably closed with local soft tissue flaps. The use of a pedicled myofascial temporalis flap (PMTF) is, however, well-established for closing large maxillary defects following ablative craniomaxillofacial surgery. OBJECTIVES: The purpose of the present study was to evaluate the use of PMTF for maxillary defect closure in patients with stage 3 MRONJ. METHODS: A retrospective cohort study was conducted based on data from the C

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… No cases of trismus, permanent facial nerve dysfunction, or clinically significant temporal hollowing were observed. Minimal alopecia along the incision line was noted. … published a case series on complications after 366 PMTF, divided into periods 1978–1993 (195 patients) and 1994–2012 (171 patients), describing total flap necrosis in 1.5% and 1.7%, intraoral dehiscence in 12.8% and 12.2%, permanent paralysis of the frontal branch of the facial nerve in 12.8% and 12.2%, trismus …

Adverse drug reactions and drug-related problems with supportive care medications among the oncological population.

AimThe current study emphasizes the impact of adverse drug reactions (ADRs) and Drug-Related Problems (DRPs) caused by supportive care medications administered with chemotherapy.MethodThis is a longitudinal observational study carried out at the Ramaiah Medical College Hospital in Bengaluru, Karnataka, India, at the Department of Oncology. The data was recorded using a specifically created data collecting form. Based on the PCNE (Pharmaceutical Care Network Europe), DRPs are identified. The WHO probability scale, Modified Hartwig and Siegel for ADR severity assessment, Naranjo's algorithm for

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… Morais-Faria K Palmier NR de Lima CJ Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus Support Care Cancer 2020 28 9 4345 4352 10.1007/s00520-019-05241-x 31912359 Morais-Faria K, Palmier NR, de Lima CJ, et al. … Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus. Support Care Cancer. 2020;28(9):4345–52. 31912359 10.1007/s00520-019-05241-x 16. …

Bromelain has significant clinical benefits after extraction of the third molar during chemotherapy in patients with hematologic tumor.

The purpose of this study was to investigate the application of bromelain in the treatment of pain, swelling, and limited mouth opening in patients with hematologic tumor after extraction of the third molar during chemotherapy. We recruited 72 patients with hematologic tumor who were treated by oral and maxillofacial surgery in our hospital, and third molar extraction was performed under local anesthesia. After extraction, patients in the control group were treated with cold - hot compress and patients in the experimental group were treated by oral administration of bromelain. One, three, and

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… Pre-emptive effect of dexamethasone and methylprednisolone on pain, swelling, and trismus after third molar surgery: A split-mouth randomized triple-blind clinical trial. Int J Oral Maxillofac Surg. 2014;43:93–98. doi: 10.1016/j.ijom.2013.05.016. 4. …

Incidence of oral manifestations in hematological malignancy patients undergoing chemotherapy: prospective cohort study.

BackgroundOral manifestations are frequent in patients with hematological malignancies undergoing chemotherapy and may be directly or indirectly related to drug toxicity. Few studies have assessed the chemotherapy and oral manifestations that patients might develop. Therefore, this study aimed to evaluate the incidence of oral manifestations in patients with hematologic neoplasms during hospitalization and chemotherapy.Material and methodsA Prospective Cohort Study, in which adult patients diagnosed with hematological malignancies undergoing chemotherapy were followed up daily to observe the p

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… Oral mucositis, fungal and viral infections, xerostomia, vascular disturbance such as haemorrhagia, haematoma, petechiae; trismus and abscess can be observed in patients under chemotherapy ( 7 , 10 ). …

Surgical techniques for the removal of mandibular wisdom teeth.

BACKGROUND: The surgical removal of mandibular wisdom teeth is one of the most common operations undertaken in oral and maxillofacial surger … ntial consequences. However, surgery is frequently associated with postoperative pain, swelling and trismus. Less commonly complications include infection, including dry socket, trigeminal nerve injuries and rarely fracture of the mandible. OBJECTIVES: To compare the relative benefits and risks of different techniques for undertaking various aspects or s …

Routes of administration, reasons for use, and approved indications of medical cannabis in oncology: a scoping review.

INTRODUCTION: Some patients diagnosed with cancer use medical cannabis to self-manage undesirable symptoms, including nausea and pain. To improve patient safety and oncological care quality, the routes of administration for use of medical cannabis, patients' reasons, and prescribed indications must be better understood. METHODS: Based on the Joanna Briggs Institute guidelines, a scoping review was conducted to map the current evidence regarding the use of medical cannabis in oncological settings based on the experiences of patients diagnosed with cancer and their healthcare providers. A searc

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… activities 23/163 (14.1%) •Boost energy and reduce fatigue •Facilitate daytime activities •Improve concentration and memory •Increase activity tolerance Alleviating musculoskeletal symptoms 10/163 (6.1%) •Combat muscle tension •Reduce spasticity •Treat arthritis •Decrease spasm and tremors •Control trismus … 23/163 (14.1%) | | •Boost energy and reduce fatigue •Facilitate daytime activities •Improve concentration and memory •Increase activity tolerance Alleviating musculoskeletal symptoms | 10/163 (6.1%) | | •Combat muscle tension •Reduce spasticity •Treat arthritis •Decrease spasm and tremors •Control trismus …

Ретроспективная оценка снижения симптомов с групповой акупукцией в Центре комплексного раковых заболеваний НКИ.

Иглоукалывание все чаще включается в онкологическую помощь в качестве нефармакологической стратегии борьбы с симптомами рака и лечения. Вместе с тем конкретные меры реагирования на симптомы по-прежнему являются неполными. В этом исследовании ретроспективно оценивались изменения в индивидуальных симптомах после завершения структурированного группового режима иглоукалывания в определенном NCI комплексном онкологическом центре. Пациенты, проходящие лечение в рамках программы интеграции онкологии и выживших пациентов 2023 и 2025 которые закончили ≥8 В него были включены инкубационные сеансы и вопр

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… The largest median reductions were noted in upper and lower gastrointestinal symptoms, depression, ENT-related concerns, and urinary incontinence, with additional improvements in pain, fatigue, insomnia, anxiety–stress, peripheral neuropathy, hot flashes, and radiation-related changes (e.g., trismus) …

Oral Side Effects in Patients with Metastatic Renal Cell Carcinoma Receiving the Antiangiogenic Agent Pazopanib-Report of Three Cases.

Pazopanib is a potent multi-kinase inhibitor that hinders angiogenesis and blocks tumor growth. It has been approved for the treatment of metastatic renal cell carcinoma (mRCC) and advanced soft tissue sarcoma. There is emerging evidence that bleeding is a common adverse effect of pazopanib and other targeted therapies in patients with mRCC. In addition, jaw osteonecrosis related to pazopanib was recently described in the literature. We report three cases of patients with mRCC who developed adverse oral events related to pazopanib. The first patient, treated with pazopanib as monotherapy, pres

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… Pain, incapability of receiving food, paresthesia and trismus are complications arising due to jaw necrosis [ 13 , 14 , 15 ]. …

Could kinesiology taping help mitigate pain, breathlessness and abdominal-related symptoms in cancer?

We present the case of a woman who was an amateur athlete diagnosed with primary breast cancer, and 10 years later with terminal metastatic cancer. This case report was prepared posthumously in co-operation with her next of kin (husband). The patient first presented to a sports physiotherapist (AR) for her pain-management and to help maintain physical fitness so that she could continue with sports and an active lifestyle. The patient continued with physiotherapy for several months to enable her to be active. However, when her health deteriorated significantly due to advancing cancer, the treat

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… *KT has no/negligible effects on muscle strength | Williams et al 26 n=10; MSK pain, ROM, proprioception, muscle strength *small beneficial effect on strength, force sense error and active ROM; insufficient evidence for pain, ankle proprioception and muscle activity | Ristow et al §, 33 n=3; pain, trismus …

Oral health status of patients with multiple myeloma.

ObjectiveTo describe the oral health status of patients with multiple myeloma and compare to a control group.Materials and methodsThe medical history of the studied subjects was obtained from the medical records and through interviews. Trained examiners evaluated the oral mucosa, teeth, periodontium and imaging aspects. The dental status was evaluated by the decayed, missing and filled teeth index. The presence of bone lesions was investigated with cone beam computer tomography images of the jaws.ResultsThe most common oral mucosa features were paleness (31%) and coated tongue (14.3%) in the m

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… This is a morbid condition characterized by exposed bone in the mouth, which is mainly triggered by tooth extraction. 10 Other oral manifestations like amyloidosis, 16 trismus, 6 root resorption, 3 gingival hyperplasia, 2 , 7 dental abscess 3 and burning mouth syndrome, 26 have been reported in patients …

Early and late oral features of chronic graft-versus-host disease.

BackgroundChronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites.ObjectiveThe aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation.MethodsThis was a cross-sectional multicenter study that enrolled patients submitted to transplantation. Oral evaluations used the National Institutes of Health criteria, salivary flow rates, and the range of mouth opening. Pain and xerostomia were evaluated through a visual analogue scale. Patients were divided i

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… Criteria for trismus in head and neck oncology. Int J Oral Maxillofac Surg. 2006;35(4):337–342. doi: 10.1016/j.ijom.2005.08.001. 18. Allen J.L., Fore M.S., Wooten J., Roehrs P.A., Bhuiya N.S., Hoffert T. …

Effect of Perioperative Oral Management on Hospital Stay in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Retrospective Case-Control Study.

Background Prolonged hospitalization in patients with hematologic and collagen diseases presents significant challenges for patient recovery and healthcare resource utilization. Perioperative oral management (POM) has been suggested to reduce systemic complications; however, its impact on length of hospital stay remains unclear. Methods This retrospective case-control study analyzed 278 patients admitted to the Department of Hematology and Rheumatology at Kagoshima University Hospital between November 2009 and January 2025. Patients who received POM during hospitalization were compared with th

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… For patients unable to tolerate conventional instrumentation (e.g., due to trismus or severe oral mucositis), mechanical cleaning was performed using sponge brushes and oral moisturizing gels to gently manage biofilm and debris. …

A retrospective study on the incidence of medication-related osteonecrosis of the jaws (MRONJ) associated with different preventive dental care modalities.

PURPOSE: To assess the efficacy of different preventive dental visits and treatments in reducing the risk of medication-related osteonecrosis of the jaws (MRONJ). METHODS: In this retrospective study, patients diagnosed with MRONJ were divided into 5 groups based on available data: no preventive dental visits (group 0); dental visits and compliance with recommended treatments, at the university hospital's dental clinic (group 1) or maxillofacial surgery unit (group 2), or at a private dentist's (group 3); dental visits at one of the above and noncompliance with proposed treatments (group 4);

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… but no clinical evidence of exposed bone | Stage 1 | Exposed/necrotic bone in patients who are asymptomatic, with evidence of infection | Focal ONJ Clinical signs and symptoms: bone exposure, sudden dental mobility, non-healing post-extraction socket, mucosal fistula, swelling, abscess formation, trismus …

The "CROMa" Project: A Care Pathway for Clinical Management of Patients with Bisphosphonate Exposure.

Aim. To describe 7 years of activity of "CROMa" (Coordination of Research on Osteonecrosis of the Jaws) project of "Sapienza" University of Rome. Materials and Methods. A preventive and therapeutic care pathway was created for patients with bisphosphonates (BPs) exposure. Demographic, social, behavioural, pharmacological, and clinical variables were registered in a dedicated database. Results. In the project, 502 patients, 403 females and 99 males, were observed. Bone pathologies were 79% osteometabolic diseases (OMD) and 21% metastatic cancer (CA). Females were 90% in OMD group and 41% in CA.

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… and symptoms : halitosis, odontogenic abscess, mandibular asymmetry, pain of dental and/or boned origin, bone exposure, mucosal fistula, postextractive mucosal healing failure, rapid onset tooth mobility, paresthesia/dysesthesia of the lips, purulent leakage, spontaneous seizure of bone fragments, trismus …

Should oral foci of infection be removed before the onset of radiotherapy or chemotherapy?

Pretreatment dental screening aims to locate and eliminate oral foci of infection in order to eliminate local, loco-regional, or systemic complications during and after oncologic treatment. An oral focus of infection is a pathologic process in the oral cavity that does not cause major infectious problems in healthy individuals, but may lead to severe local or systemic inflammation in patients subjected to oncologic treatment. As head and neck radiotherapy patients bear a lifelong risk on oral sequelae resulting from this therapy, the effects of chemotherapy on healthy oral tissues are essentia

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… HEAD AND NECK CANCER Radiotherapy to the head and neck region involving the oral cavity and salivary glands results in multiple acute and late side effects such as oral mucositis, a reduced salivary flow (hyposalivation), a sensation of oral dryness (xerostomia), loss of taste, trismus, skin fibrosis …

Longitudinal Swallowing and Salivary Changes With CLR 131 and Re-Irradiation in Recurrent Head and Neck Cancer.

BACKGROUND: Patients with recurrent head and neck cancer (HNC) often present with severe, persistent dysphagia and xerostomia following prior chemoradiation. Although swallowing impairments and salivary dysfunction have been reported in this population, prior longitudinal studies have not examined changes in salivary composition or how these changes relate to swallowing physiology. PURPOSE: This study characterized longitudinal changes in swallowing and salivary function-including composition-following treatment with CLR 131, a novel tumor-selective radiotherapeutic, combined with external be

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… While modern conformal techniques have improved tumor control and reduced certain toxicities [ 4 – 7 ], late radiation-associated dysphagia (late-RAD) and other adverse effects, including mucositis, xerostomia, fibrosis, and trismus remain prevalent [ 8 – 10 ]. …

A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for denosumab.

BACKGROUND: Denosumab is authorized to treat several diseases, including cancer and bone disorders. Nevertheless, its use in clinical practice has been affected by safety concerns. The work retrospectively investigated adverse events (AEs) of denosumab to better understand toxicities. METHODS: The FAERS data base data from Q1 of 2010 to Q3 of 2023 was chosen. The definition of Medical Dictionary for Regulatory Activities (MedDRA) was dependent on preferred terms (PTs) and system organ class (SOCs). Following the removal of duplicate reports, a disproportionality analysis was conducted to iden

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… Hyperparathyroidism | 120 | 12.97496972 | 10.76332411 | 15.64106381 | 1215.703845 Bursitis | 119 | 2.357525514 | 1.966849386 | 2.825801809 | 91.48128931 Tetany | 119 | 15.62405869 | 12.93023641 | 18.87909874 | 1468.242186 Blood phosphorus decreased | 117 | 7.030223446 | 5.839191944 | 8.464191994 | 576.6684022 Trismus …

Oral Surgical Management of Bone and Soft Tissues in MRONJ Treatment: A Decisional Tree.

BACKGROUND: The aim of the present work was to analyze a 10-year retrospective series of surgically treated medication-related osteonecrosis of the jaws (MRONJ) cases, reporting the clinical outcome and success rate for each adopted procedure in order to draw a treatment algorithm that is able to standardize clinical decision making and maximize the success of oral surgical treatment of MRONJ. METHODS: Different surgical approaches were categorized taking into consideration two variables a) hard tissue management (defined as debridement, saucerization or marginal resective surgery of maxillar

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… According to the SICMF-SIPMO definition, the minor clinical signs and symptoms are represented by the following: bone exposure; sudden dental mobility; nonhealing postextraction sockets; mucosal fistula; swelling; abscess formation; trismus; gross mandibular deformity and/or hypoesthesia/paranesthesia …

New dimensional staging of bisphosphonate-related osteonecrosis of the jaw allowing a guided surgical treatment protocol: long-term follow-up of 266 lesions in neoplastic and osteoporotic patients from the university of bari.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is the most serious side effect in patients receiving bisphosphonates (BPs) for neoplastic disease and osteoporosis. The aim of this study is to propose a new dimensional stage classification, guiding the surgical treatment of BRONJ patients, and to evaluate the success rate of this new management. From 2004 to 2013, 203 neoplastic and osteoporotic patients with 266 BRONJ lesions were referred to the Odontostomatology Unit of the University of Bari. All patients underwent surgery after suspension of BPs therapy and antibiotic treatment. T

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… bone <1 cm B: painless exposed bone >1 cm | Exposed/necrotic bone in patients who are asymptomatic and who have no evidence of infection | Focal BRONJ Clinical signs and symptoms: bone exposure; sudden dental mobility; nonhealing postextraction socket; mucosal fistula; swelling; abscess formation; trismus …

Cancer cachexia--pathophysiology and management.

About half of all cancer patients show a syndrome of cachexia, characterized by anorexia and loss of adipose tissue and skeletal muscle mass. Cachexia can have a profound impact on quality of life, symptom burden, and a patient's sense of dignity. It is a very serious complication, as weight loss during cancer treatment is associated with more chemotherapy-related side effects, fewer completed cycles of chemotherapy, and decreased survival rates. Numerous cytokines have been postulated to play a role in the etiology of cancer cachexia. Cytokines can elicit effects that mimic leptin signaling a

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… diabetes Liver Transient hypoalbuminaemia Source: [ 81 ] Table 3 Nutritional complications associated with radiotherapy Region irradiated Early effects Late effects Head and neck Odynophagia, xerostomia, mucositis, anorexia, dysosmia, hypogeusia Ulceration, xerostomia, dental caries, osteoradionecrosis, trismus … Transient hypoalbuminaemia Table 3 Nutritional complications associated with radiotherapy Source: [ 81 ] Region irradiated | Early effects | Late effects Head and neck | Odynophagia, xerostomia, mucositis, anorexia, dysosmia, hypogeusia | Ulceration, xerostomia, dental caries, osteoradionecrosis, trismus …