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Osteochondral Autograft Transplantation for Capitellar Osteochondritis Dissecans.

BACKGROUND: The goal of the osteochondral autograft transplantation (OAT) procedure is to replace both the bone and cartilage that have been … ng cartilage fractures and eventually comes loose, often floating around the joint as a loose body. Fibrocartilage may form to fill the void left behind but cannot restore either the structural integrity of the bone or the gliding and compressive properties of hyaline cartilage. Replacement of both the bone and the cartilage requires an osteochondral transplant. …

Spatiotemperal Dynamics of Osteoarthritis: Преобразование значений от стенда до Бедсайда.

Остеоартрит (OA) представляет собой многогранное дегенеративное совместное расстройство, вызванное различными факторами риска, такими, как возраст, механический стресс, воспаление и метаболическое воздействие. Эти элементы способствуют его разнообразным фенотипам и эндотипам, что подчеркивает имманентную сложность болезни. Участие нескольких тканей и их взаимодействие еще больше осложняет расследование ОА. Нынешние ограничения в области технологий пространственного фенотификации в сочетании со сложной сетью многофакторных взаимодействий препятствуют обнаружению надежных ранних диагностических

Совпадение в полном тексте источника
… Prehypertrophic chondrocytes (preHTC), inflammatory chondrocytes (InfC), pre-inflammatory chondrocytes (preInfC), and fibrocartilage chondrocytes (FC) predominantly occupy the surface and superficial layers [ 144 ]. … Fibrocartilage chondrocytes (FCs) emerge in the articular surface and middle zone in early OA, contributing to increased fibrocartilage-specific markers and eventually dominating the middle zone and deep zone in advanced OA, resulting in increased matrix stiffness and maladaptive repair processes. …

[Study on the role of annexin A5 in temporomandibular joint osteoarthritis in rats].

Objective: To systematically explore the intervention efficacy of annexin A5 (AnxA5) on temporomandibular joint osteoarthritis (TMJOA) induc … the cartilage (TC), the thickness of the hypertrophic chondrocyte layer (HL), the thickness of the fibrocartilage layer (FL), as well as the thickness of the anterior band (A), Intermediate zone (In) and posterior bands (P) of the articular disc were measured.The changes in the content of glycosaminoglycans in the condylar cartilage matrix were observed by Alci …

Is There an Association of Patient Mindset and Physician Willingness to Acquiesce to Unhealthy Patient Preferences?

BACKGROUND: Patient requests for visits, tests, and treatment may diverge from what is healthy based on evidence and experience, in part rel … o moderately with operative treatment to address a common incidental finding on imaging (triangular fibrocartilage complex "tear" on MRI, -1.4 [-2.1 to -0.76]), and modestly with surgery for a pathophysiology that does not seem to account for the symptoms (ganglion cyst removal for diffuse arm pain, -0.90 [-1.6 to -0.18]). Surgeons were slightly more likely to a …

Skeletal stem cells, a new direction for the treatment of bone and joint diseases.

Skeletal stem cells (SSCs) are tissue-specific stem cells characterized by their capacity for self-renewal and their position at the apex of the differentiation hierarchy. They can generate mature bone cell types essential for bone development, maintenance, and repair. Lineage tracing experiments have demonstrated that SSCs reside in the bone marrow, periosteum, and the resting zone of the growth plate. These findings not only enhance our understanding of bone growth and development mechanisms but also offer novel therapeutic strategies for conditions such as epiphyseal injuries, fractures, os

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… Articular cartilage lacks intrinsic regenerative capacity and is typically replaced by mechanically inferior fibrocartilage following injury. Current interventions, such as subchondral bone drilling and osteochondral transplantation, offer only temporary relief[ 113 ]. … Cartilage injuries, encompassing conditions such as degenerative joint disease, traumatic cartilage damage, meniscus avascular zone repair, chondromalacia patellae, and intervertebral disc degeneration, involve the destruction of cartilage or fibrocartilage structures[ 117 - 119 ]. …

Rare Causes of Musculoskeletal Pain: Thinking beyond Common Rheumatologic Diseases.

OBJECTIVES: Rare metabolic bone diseases can present with symptoms mimicking more common rheumatological conditions including spondyloarthritis, osteoarthritis, and fibromyalgia. Increasing awareness of these rare diseases within the rheumatology community is vital to ensure that affected patients are diagnosed and appropriately treated. The literature includes several reports of tumour-induced osteomalacia initially diagnosed as rheumatic disease, but other rare diseases such as X-linked hypophosphatemia (XLH) and hypophosphatasia (HPP) also deserve attention. Here, we describe two cases of a

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… CPPD disease was present in both the knees and scapholunate ligament of our case; other commonly affected sites in patients with HPP include the triangular fibrocartilage of the wrist and less commonly the hips, shoulders, elbows, ankles, and hands [ 5 , 23 ]. …

Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders.

Precision medicine has become a cornerstone in modern therapeutic strategies, with nucleic acid aptamers emerging as pivotal tools due to their unique properties. These oligonucleotide fragments, selected through the Systematic Evolution of Ligands by Exponential Enrichment process, exhibit high affinity and specificity toward their targets, such as DNA, RNA, proteins, and other biomolecules. Nucleic acid aptamers offer significant advantages over traditional therapeutic agents, including superior biological stability, minimal immunogenicity, and the capacity for universal chemical modificatio

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… Based on Apt19S, a DNA aptamer targeting pluripotent stem cells, 220 Hao et al. 221 proposed a meniscus regeneration strategy combining endogenous stem/progenitor cell (ESPC) recruitment with fibrocartilage formation. … This scaffold can sequentially activate the homing of ESPCs and the differentiation of fibrocartilage, achieving superior meniscus regeneration and protection of articular cartilage. …

Insights Into Late-Onset Rheumatoid Arthritis (LORA): Characteristics (Clinical and Imaging), Comorbidities, and Therapeutic Targets.

Late-onset rheumatoid arthritis (LORA) is defined as rheumatoid arthritis (RA) manifesting after the age of 65 years, although the terminology remains somewhat ambiguous. With the advent of a super-aging society and extended life expectancies, a significant increase in the incidence of LORA is anticipated. In comparison to young-onset RA (YORA), LORA is predominantly characterized by a higher incidence of acute onset, augmented disease activity and constitutional symptoms, a propensity for systemic manifestations, increased erythrocyte sedimentation rate at disease onset, reduced seropositivit

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… (A, B) Radiographic images of the wrists reveal the presence of calcification of the triangular fibrocartilage complex. (C, D) Radiographic images of the knees show meniscal chondrocalcinosis. …

Integrating imaging and biomarker assessment to better define psoriatic arthritis and predict response to biologic therapy.

The treatment options for PsA have substantially expanded over the last decade. Approximately 40% of patients will not respond to first-line anti-TNF-α therapies. There is limited data to help clinicians select the most appropriate biologic therapy for PsA patients, including guidance for decisions on biologic therapy switching. In this review we will examine the current understanding of predictors of response to treatment. Imaging technology has evolved to allow us to better study psoriatic disease and define disease activity, including synovitis and enthesitis. Enthesitis is implicated in th

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… Given that large entheses in the peripheral and axial skeleton have relatively abundant fibrocartilage present, we believe that a focus on such markers may be of particular interest to enthesitis-related pathology. …

The advancement and utility of multimodal imaging in the diagnosis of degenerative disc disease.

Degenerative disc disease (DDD) is a common spinal condition characterized by the deterioration of intervertebral discs, leading to chronic back pain and reduced mobility. While magnetic resonance imaging (MRI) has long been the standard for late-stage DDD diagnosis, its limitations in early-stage detection prompt the exploration of advanced imaging methods. Positron emission tomography/computed tomography (PET/CT) using 18F- fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) has shown promise in identifying metabolic imbalances and age-related spinal degeneration, thereby complementing CT

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… Introduction Intervertebral discs serve as cushions of fibrocartilage located between each vertebral body of the spine. …

Disorders of the Spinal Cord

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… FCEM is characterized by acute spinal cord infarction from embolization of fibrocartilage identical to that of the nucleus pulposus. A. Many theories exist as to the pathophysiology of the embolization, but none are proven. B. …

How the mechanical microenvironment of stem cell growth affects their differentiation: a review.

Stem cell differentiation is of great interest in medical research; however, specifically and effectively regulating stem cell differentiation is still a challenge. In addition to chemical factors, physical signals are an important component of the stem cell ecotone. The mechanical microenvironment of stem cells has a huge role in stem cell differentiation. Herein, we describe the knowledge accumulated to date on the mechanical environment in which stem cells exist, which consists of various factors, including the extracellular matrix and topology, substrate stiffness, shear stress, hydrostati

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… Su X Effects of dynamic radial tensile stress on fibrocartilage differentiation of bone marrow mesenchymal stem cells Biomed Eng Online 2020 19 1 8 10.1186/s12938-020-0751-1 32024525 PMC7003351 70. …

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… as repair is completed (provisional callus), and ultimately replaced by true bone (definitive callus). bridging c. bridging the callus gap. external c. around the outside of a fracture, consisting of periosteal new bone. hard c. fully mineralized. hypertrophic c. a form of delayed healing in which fibrocartilage …

Microgel-Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function.

Driven by rapid technological innovation and an increasing demand for personalized medicine, microgel-based bioprinting emerges as a versatile strategy for generating physiologically relevant tissue models and patient-specific constructs. By integrating microgel systems with 3D bioprinting, this approach enables the creation of complex, cell-laden architectures that closely recapitulate native tissue architecture and function. Pivotal to this potential are microgels that offer significant advantages over conventional hydrogel-based bioinks, including tunable rheological behavior, enhanced prin

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… MSC aggregates form cartilage‐like tissue with hMSC maturation and ECM deposition | — | [ 121 ] | Bioactive | Tyramine‐modified HA | Human auricular chondrocytes | Mechanical sizing of bulk gels through meshes | High cytocompatibility; Cell viability >90% for 21 days in vitro; Development of mature fibrocartilage …

Abstracts from the 13th International Conference for Healthcare and Medical Students (ICHAMS).

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Musculoskeletal Organs-on-Chips: An Emerging Platform for Studying the Nanotechnology-Biology Interface.

Nanotechnology-based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their clinical translation requires a deep understanding of the complex interplay between nanotechnology and MSK biology. Organ-on-a-chip (OoC) systems have emerged as an innovative and versatile microphysiological platform to replicate the dynamics of tissue microenvironment for studying nanotechnology-biology interactions. This review first covers recent advances and applications of MSK OoCs and their ability to mimic the biophysic

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… In native fibrocartilage, mechanotransduction plays a pivotal role in coordinating cellular responses to the physical microenvironment, encompassing intrinsic ECM properties and externally applied mechanical cues, such as shear induced by medium flow. …

ЭПОС/ПОНСА Резюме

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Proceedings of the RAMI Intern Section Meeting.

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Integumentary System

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ISEV2025 Резюме книги.

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