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Vertebral Primary Bone Lesions: Review of Management Options.

The assessment and treatment of vertebral primary bone lesions continue to pose a unique yet significant challenge. Indeed, there exists little in the literature in the way of compiling and overviewing the various types of vertebral lesions, which can often have complicated intervention strategies. Given the severe consequences of mismanaged vertebral bone tumors-including the extreme loss of motor function-it is clear that such an overview of spinal lesion care is needed. Thus, in the following paper, we aim to address the assessment of various vertebral primary bone lesions, outlining the re

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… For more posterior, uncomplicated vertebral damage, balloon kyphoplasty and vertebroplasty are used to reinforce the remaining bone with cement [ 89 , 90 ]. Figure 6 Schematic of laminectomy protocol. … Percutaneous kyphoplasty for the treatment of spinal metastases. Oncol. Lett. 2016;11:1799–1806. doi: 10.3892/ol.2016.4121. 93. Ko Y.-K., Kim Y.-H. Percutaneous vertebroplasty for painful spinal metastasis: A good option for better quality of life. Korean J. …

SEOM Clinical Guideline for bone metastases from solid tumours (2016).

Bone metastases are common in many advanced solid tumours, being breast, prostate, thyroid, lung, and renal cancer the most prevalent. Bone metastases can produce skeletal-related events (SREs), defined as pathological fracture, spinal cord compression, need of bone irradiation or need of bone surgery, and hypercalcaemia. Patients with bone metastases experience pain, functional impairment and have a negative impact on their quality of life. Several imaging techniques are available for diagnosis of this disease. Bone-targeted therapies include zoledronic acid, a potent biphosfonate, and denosu

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… Vertebroplasty and Kyphoplasty are reserved for patients with symptomatic vertebral body fractures without epidural disease or retropulsion of bone fragments into the spinal cord. … Kyphoplasty and vertebroplasty may be useful for the treatment of lytic osteoclastic spine metastases or in cases of spinal instability, where surgery is not feasible or indicated; they do not obviate the need for external beam RT. …

Fixation, Stabilization, Dynamic Stabilization, Fusion, and Reconstruction in Spine Surgery- Decoding Terminologies!

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… Minimally invasive augmentation techniques such as kyphoplasty and vertebral body stenting can also be used to reconstruct the anterior column and restore the vertebral height. …

Robotic assisted surgeries for the treatment of spine tumors.

BACKGROUND: Surgery plays an important role in the treatment of patients with metastatic or primary spine tumors. In recent years, various new techniques, such as robotic assisted spine surgery have been developed which has shown some promising results by improving the accuracy of spinal instrumentation and reducing potential complications. The purpose of this study was to evaluate our early experience using robotic guidance in the treatment of spinal tumors. METHODS: Data were collected from medical records for each surgery in which the robotic system was used to assist with biopsy, pedicle

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… This technology is also useful for non-pedicle-screw procedures such as biopsies and vertebral augmentations (vertebroplasty and kyphoplasty). …

Radiographic Detection of Osteoporotic Vertebral Fracture without Collapse.

BACKGROUND: On retrospective basis, we investigated the detection of osteoporotic vertebral fractures (OVFs) without radiologic collapse using a modified Yoshida's classification, which was designed by the authors. METHODS: We observed 82 cases in 76 patients with confirmed OVFs without collapse at the thoracolumbar junction. The following factors were measured: age, gender, body mass index (BMI, kg/m(2)), bone mineral density (BMD, mg/cm(3)), type of a modified Yoshida's classification. The correct diagnosis rate for the presence and location of OVFs and the correct diagnosis rate according

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… Among the 61 patients who had surgery, 39 cases and 22 cases underwent vertebroplasty kyphoplasty, respectively. Fig. 2 An 87-year-old woman with occult osteoporotic vertebral fractures of L1 (A), confirmed by magnetic resonance imaging (B). …

Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III trial.

INTRODUCTION: Multiple myeloma is a bone marrow cancer, which predominantly affects older people. The incidence is increasing in an ageing population.Over the last 10 years, patient outcomes have improved. However, this is less apparent in older, less fit patients, who are ineligible for stem cell transplant. Research is required in this patient group, taking into account frailty and aiming to improve: treatment tolerability, clinical outcomes and quality of life. METHODS AND ANALYSIS: Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma is a nati

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… This would include surgical intervention for relief of cord compression but does not include vertebroplasty or kyphoplasty. … This does not include vertebroplasty or kyphoplasty. Systemic treatment, within 14 days before the first dose of ixazomib with strong CYP3A inducers (eg, rifampicin, rifabutin, carbamazepine, phenytoin, phenobarbital), or use of St. John’s wort. …

Текущее качество жизненных вопросников не имеет значения для оценки проблем QOL у многих пациентов миэломы в эпоху современной терапии: результаты обследования, проведенного с пациентами миэломы и специалистами в области здравоохранения миеломы.

Поскольку многие пациенты миеломы (ММ) живут дольше, поддержание качества жизни (КОЛ) стало важной целью лечения. В то же время широко используемые вопросники по общему качеству жизни (QOLQs) были разработаны по сравнению с 20 Много лет назад. В этом обследовании 224 Пациенты ММ и 48 К специалистам в области здравоохранения (ХЦП) была обращена просьба оценить актуальность и важность предметов КОЛ из 9 аттестованные, часто используемые MM QOLQs. Результаты этого обследования выявили значительные расхождения в восприятии пациентами из числа ММ и ХЦП важных и актуальных вопросов КОЛ. Несмотря на

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… Spinal bracing, kyphoplasty and vertebroplasty can be considered for those with painful vertebral fractures but more studies are needed as data regarding clinical outcomes and QOL on patients with spinal interventions is scarce. …

Е-постеры.

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Effectiveness of Erector Spinae Muscle Block in Vertebral Oncologic Fracture.

Objectives An observational, retrospective, longitudinal, and analytical study aimed to evaluate the effectiveness of the erector spinae plane (ESP) block in managing pain in patients with vertebral fractures secondary to tumoral activity. This study included patients treated at the Pain Clinic who underwent ESP block. The objectives were to describe demographic characteristics, oncological diagnosis, vertebral fracture features, imaging techniques, medications used, and the level of ESP block. Additionally, pain levels were assessed using a numerical analog scale, and the consumption of opioi

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… Vertebral fractures can be treated using vertebroplasty and kyphoplasty techniques; however, not all patients are candidates for these procedures. …

Evaluating the Accuracy and Efficiency of Imaging Modalities in Guiding Ablation for Metastatic Spinal Column Tumors: A Systematic Review.

Background/objectivesSpinal metastases are a frequent and serious complication in cancer patients, often causing severe pain, instability, and neurological deficits. Thermal ablation techniques such as radiofrequency ablation (RFA), microwave ablation (MWA), and cryoablation (CA) have emerged as minimally invasive treatments. These techniques rely on precise imaging guidance to effectively target lesions while minimizing complications. This systematic review aims to compare the efficacy of different imaging modalities-computed tomography (CT), magnetic resonance imaging (MRI), fluoroscopy, and

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… Radiofrequency Ablation and Balloon Kyphoplasty for Palliation of Painful Spinal Metastases Eur. Spine J. 2021 30 2874 2880 10.1007/s00586-021-06858-5 33961090 57. Tatsui C.E. Stafford R.J. Li J. Sellin J.N. Amini B. Rao G. Suki D. Ghia A.J. Brown P. Lee S.-H. … A Preliminary Study of the Safety and Efficacy of Radiofrequency Ablation with Percutaneous Kyphoplasty for Thoracolumbar Vertebral Metastatic Tumor Treatment Med. Sci. Monit. 2014 20 556 563 10.12659/MSM.889742 24699431 PMC3983101 67. Mayer T. Cazzato R.L. De Marini P. Auloge P. Dalili D. Koch G. …

Holistic Approach to the Diagnosis and Treatment of Patients with Tumor Metastases to the Spine.

The treatment of neoplastic spine metastases requires multi-faceted assessment and an interdisciplinary approach to patients. The metastases do not show specific symptoms but are often the first confirmation of the presence of a primary tumor in a patient. The diagnostic process includes imaging and invasive procedures, e.g., biopsy. It is essential to qualify the patient for an appropriate treatment using dedicated scales. Decompression of the spinal cord is a critical issue to save or restore neurological function in a patient with spine metastases. Surgical treatment ought to meet three cri

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… Kyphoplasty is the procedure’s modification used to regain the height of the broken vertebra and reduce the risk of dislocation of the bone cement to the spinal canal. The balloon is first introduced into the vertebral body and makes the space for bone cement [ 90 , 91 ]. 5. … Safety and utility of kyphoplasty prior to spine stereotactic radiosurgery for metastatic tumors: A clinical and dosimetric analysis. J. Neurosurg. Spine. 2018;28:72–78. doi: 10.3171/2017.5.SPINE1746. 92. Yahanda A.T., Buchowski J.M., Wegner A.M. …

Diagnosis and treatment of bone metastasis: comprehensive guideline of the Japanese Society of Medical Oncology, Japanese Orthopedic Association, Japanese Urological Association, and Japanese Society for Radiation Oncology.

Diagnosis and treatment of bone metastasis requires various types of measures, specialists and caregivers. To provide better diagnosis and treatment, a multidisciplinary team approach is required. The members of this multidisciplinary team include doctors of primary cancers, radiologists, pathologists, orthopaedists, radiotherapists, clinical oncologists, palliative caregivers, rehabilitation doctors, dentists, nurses, pharmacists, physical therapists, occupational therapists, medical social workers, etc. Medical evidence was extracted from published articles describing meta-analyses or random

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… Balloon kyphoplasty is performed to attempt kyphosis of the diseased vertebra to avoid leakage. 47 Ablation (CQ 10) ‘Ablation is beneficial for pain relief’. Radiofrequency ablation (RFA) is used to kill tumours by heating, using image-guided needle centesis. … Percutaneous vertebroplasty and kyphoplasty for pathologic vertebral fractures in the Medicare population: safer and less expensive than open surgery. J Vasc Interv Radiol 2012;23:1423–9. 10.1016/j.jvir.2012.08.010 47. Mendel E, Bourekas E, Gerszten P et al. …

A tertiary care centre experience with Elranatamab: A report of three cases.

IntroductionThe introduction of proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies has changed the treatment paradigm of multiple myeloma. With the advent of these new therapeutic options, life expectancy has substantially increased for myeloma patients which has led to an increased number of patients with triple-class refractory disease. Thus, there remains an unmet need for effective novel therapies with good tolerability and safety profile. Elranatamab, is the most widely used bispecific antibody currently in the Indian setting. However, it has only been used on a clin

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… At baseline, the patient had extramedullary disease with a vertebral mass causing extradural compression of the spinal cord and cauda equina nerve roots at L1-L3 vertebral level requiring kyphoplasty and radiotherapy to the spine. …

Editorial: Novel techniques of minimally invasive spine surgery for various pathologies.

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… Percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) PVP and PKP are surgical methods for the treatment of spinal compression fractures. Bone cement or graft bone are used to restore the interbody height and strengthen the vertebral body. …

Nutritional Status Is Associated With Survival Following Spinal Surgery in Patients With Metastatic Spinal Tumors.

Background Preoperative and postoperative nutritional statuses are reported to influence the outcomes and complications of multidisciplinary treatment, including patient survival. However, a causal relationship between nutritional status and survival following spinal surgery has not been demonstrated in patients with metastatic spinal tumors. The present study was, therefore, designed to evaluate the correlation between the nutritional status and survival following spinal surgery in patients with metastatic spinal tumors. Methods Nutritional status was evaluated using the Japanese version of t

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… The surgical procedures included posterior decompression in five patients, posterior fixation in 46 patients (including 42 patients with decompression), anterior fixation in one patient, anteroposterior fixation in four patients (including one patient with decompression), and balloon kyphoplasty in one …

Chinese expert consensus on the diagnosis and treatment of bone metastasis in lung cancer (2022 edition).

Lung cancer is the leading cause of cancer-related deaths worldwide. Bone is a common metastatic site of lung cancer, about 50% of bone metastatic patients will experience skeletal related events (SREs). SREs not only seriously impact the quality of life of patients, but also shorten their survival time. The treatment of bone metastasis requires multi-disciplinary therapy (MDT) and development of individualized treatment plan. In order to standardize the diagnosis and treatment of bone metastasis in lung cancer, the expert group of the MDT Committee of the Chinese Medical Doctor Association ha

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… The osteoplasty mainly includes percutaneous vertebroplasty, kyphoplasty, and the bone perfusion for systemic irregular bone and limb long bone. … .2017.12.023 PMC5842401 29317145 78 Callstrom MR Dupuy DE Solomon SB Percutaneous image-guided cryoablation of painful metastases involving bone: multicenter trial Cancer 119 5 2013 1033 1041 10.1002/cncr.27793 23065947 PMC5757505 79 Gao S Zhu X Zhang H Clinical application of C-arm CT in percutaneous kyphoplasty …

Е-постеры.

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MUKnine OPTIMUM protocol: a screening study to identify high-risk patients with multiple myeloma suitable for novel treatment approaches combined with a phase II study evaluating optimised combination of biological therapy in newly diagnosed high-risk multiple myeloma and plasma cell leukaemia.

INTRODUCTION: Multiple myeloma (MM) is a plasma cell tumour with over 5800 new cases each year in the UK. The introduction of biological therapies has improved outcomes for the majority of patients with MM, but in approximately 20% of patients the tumour is characterised by genetic changes which confer a significantly poorer prognosis, generally termed high-risk (HR) MM. It is important to diagnose these genetic changes early and identify more effective first-line treatment options for these patients. METHODS AND ANALYSIS: The Myeloma UK nine OPTIMUM trial (MUKnine) evaluates novel treatment

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… Kyphoplasty or vertebroplasty is not considered major surgery. … Kyphoplasty or vertebroplasty is not considered major surgery. …

Balloon-assisted sacroplasty as a successful procedure for osteoporotic sacral insufficiency fractures after failure of the conservative treatment.

Osteoporotic vertebral fractures without prior adequate traumatization are frequent diagnosed in orthopedics because of the increasing life expectancy and incidence of osteoporosis. The associated high mortality is caused by reduced mobilization which leads to a higher risk of infection and a bedridden state. On the other hand the diagnosis of sacral insufficiency fractures is often prolonged because of unspecific symptoms while being associated with similar risks. This article presents an overview of the present scientific literature and a retrospective analysis of patients treated via balloo

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… Since 2002, the interventional option of sacroplasty has been known, in whichthe insufficiency fracture is stabilised with bone cement similiar as in a kyphoplasty or vertebroplasty 17 . Numerous variants of the method exist, such as the percutaneous procedure with CT or radio frequency support. …