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Extensive osteonecrosis of the maxilla caused by bisphosphonates: Report of a rare case.

INTRODUCTION: The objective of this study was to investigate the expression of serum miR-7 and erythrocyte sedimentation rate (ESR) levels in patients with acute herpes zoster (HZ) and their evaluation value for postherpetic neuralgia (PHN). MATERIAL AND METHODS: A total of 98 patients with acute HZ and 97 healthy people were enrolled in this study. The levels of miR-7 and ESR were analyzed in patients with HZ and healthy people. According to whether PHN occurred within 3 months after lesion regression, the patients were divided into HZ patients with PHN and HZ patients without PHN, and the l

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… Pentoxifylline and Tocopherol were used in this case in order to improve vascularization, accelerate healing and to avoid fibrosis of adjacent soft tissues. … Pentoxifylline is used in the management of vascular diseases, such as ischemic heart disease and intermittent claudication, improves peripheral blood flow, increasing flexibility and vasodilation of erythrocytes. …

How we manage medication-related osteonecrosis of the jaw.

Bone-modifying agents (BMAs) are integral to managing patients with advanced cancer. They improve quality of survival by reducing skeletal-related events, treating hypercalcaemia and chemotherapy-induced bone loss (Coleman in Clin Cancer Res 12: 6243s-6249s, 2006), (Coleman in Ann Oncol 31: 1650-1663, 2020). Two decades ago, medication-related osteonecrosis of the jaw (MRONJ) was first reported following BMA therapy (Marx in J Oral Maxillofac Surg 61: 1115-1117, 2003). The risk of MRONJ extends over a decade following BMA treatment with bisphosphonates, complicating dental care such as extract

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… Pentoxifylline and tocopherol (PENTE) has been originally cited for their benefits in the management of osteoradionecrosis [ 57 ]. … Data were limited to 3 observational studies and 2 abstracts for the use of pentoxifylline and tocopherol in the medical management of MRONJ, however promising results were yielded from all studies [ 58 ]. …

Endometriosis: in search of optimal treatment.

Endometriosis is an enigmatic, debilitating disease which affects as many as 15% of all women of reproductive age and is characterized by pelvic pain and infertility. Current treatment regimes used to manage the disease do so by inducing a hypoestrogenic state. While the absence of circulating estrogen levels lead to a regression of the disease, this hypoestrogenism also induces many unpleasant and unwanted side-effects. As such, these and other shortcomings of current drug therapies emphasize their limitations and the necessity for the development of novel endometriosis treatments. In this re

A randomized placebo-controlled trial of lisofylline in HLA-identical, sibling-donor, allogeneic bone marrow transplant recipients. The Lisofylline Marrow Transplant Study Group.

The purpose of the study was to evaluate the effect of lisofylline (LSF) on engraftment, regimen-related toxicities (RRT), and mortality in patients undergoing allogeneic bone marrow transplantation (BMT). We performed a multicenter, randomized placebo-controlled trial in 60 patients with hematologic malignancies receiving BMT from HLA-identical sibling donors. Patients were randomized to receive either placebo, 2 mg/kg LSF or 3 mg/kg LSF every 6 h, beginning before conditioning and continuing to day 21 or hospital discharge. Treatment groups were balanced with respect to conditioning regimen

Antifibrotic therapy for Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia.

BACKGROUND: Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia (LUTS/BPH) are a ubiquitous condition estimated to affect over 50% of men over the age of 50 years. Various treatment options exist for men presenting with LUTS/BPH, including lifestyle and behavioral modification and medical or surgical treatment. Although multiple medical treatments exist, innovation for the medical treatment of BPH has not significantly progressed. METHODS: A comprehensive narrative review was performed to evaluate prostate fibrosis as a contributor to LUTS/BPH and to identify potential anti

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… Similar evidence can be seen with the drug pentoxifylline, a non-specific cAMP-PDE inhibitor, often used off-label in the treatment of Peyronie’s disease, a condition in which fibrotic plaques develop in the penile tunica albuginea. … Studies assessing the effectiveness of PDE inhibition in attenuating fibrosis in a rat model of Peyronie’s disease found that vardenafil and pentoxifylline were both effective in reversing fibrosis ( Fig. 2 ) [ 40 , 42 ]. …

The Role of Dental Practitioners in the Management of Oncology Patients: The Head and Neck Radiation Oncology Patient and the Medical Oncology Patient.

This narrative review addresses the role of a dentist in the management of oncology patients, highlighting the oral complications that arise in head and neck radiation oncology patients and medical oncology patients. The prevention and management of these complications are discussed.

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… In our experience, head and neck surgical oncologists now consider the use of pentoxifylline and tocopherol protocol as the typical first line management for ORN, and it has decreased the rate of major surgical resection and reconstruction. 1.5. … The use of other non-surgical options, such as pentoxifylline and tocopherol +/− antibiotics; photobiomodulation (low-level laser therapy); and teriparatide have shown great promise as effective management adjuncts [ 97 , 98 , 99 , 100 , 101 ]. …

Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis.

The effects of anti-inflammatory drugs on glial immunity and neuropathology were determined in a severe combined immune deficiency (SCID) mouse model of HIV-1 encephalitis. HIV-1-infected human monocyte-derived macrophages (MDM) are stereotactically inoculated into basal ganglia resulting in a multinucleated giant cell encephalitis. A platelet activating factor antagonist and a matrix metalloproteinase inhibitor, which also inhibits tumor necrosis factor alpha release, were administered to animals at the time of the MDM inoculation. The drugs administered in combination markedly reduced brain

Interventions for preventing oral mucositis for patients with cancer receiving treatment.

BACKGROUND: Treatment of cancer is increasingly more effective but is associated with short and long term side effects. Oral side effects re … ne gel, honey, hydrolytic enzymes, ice chips, iseganan, keratinocyte GF, misonidazole, pilocarpine, pentoxifylline, povidone, prednisone, propantheline anticholinergic, prostaglandin, sucralfate, systemic antibiotic clarithromycin, traumeel, zinc sulphate. Of the 33 interventions included in trials, 12 showed some evidence of a benefit (albeit sometimes weak) fo …

Interventions for preventing oral mucositis for patients with cancer receiving treatment.

BACKGROUND: Treatment of cancer is increasingly more effective but is associated with short and long-term side effects. Oral side effects re … , GM-CSF, honey, hydrolytic enzymes, ice chips, iseganan, keratinocyte GF, misonidazole, oral care, pentoxifylline, povidone, prednisone, propantheline, prostaglandin, sucralfate, traumeel and zinc sulphate. Of the 29 interventions included in trials, 10 showed some evidence of a benefit (albeit sometimes weak) for either preventing or reducing the severity of m …

Granulocyte transfusions for neonates with confirmed or suspected sepsis and neutropaenia.

BACKGROUND: Neonatal sepsis causes significant neonatal mortality and morbidity. Neonates, especially preterm infants, have an immaturity of … antibiotics aimed at improving host defence mechanisms such as colony stimulating factors, IVIG and pentoxifylline should also be tested in RCTs.

Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors.

The proinflammatory Th1 cytokine, tumor necrosis factor-alpha (TNF alpha), the cell death signaling molecule FasL, and several extracellular matrix degrading metalloproteinases have been implicated in the pathogenesis of multiple sclerosis (MS). The latter enzymes, as well as TNF alpha-converting enzyme and FasL-converting enzyme, can be blocked by matrix metalloproteinase inhibitors (MMPIs). In this study, we show that a potent MMPI was clinically effective in an animal model for MS, experimental autoimmune encephalomyelitis (EAE) in the SJL/J mouse. Efficacy was remarkable, as indicated by b

Low molecular weight heparin for the prevention of hepatic veno-occlusive disease (VOD) after hematopoietic stem cell transplantation: a prospective phase II study.

We evaluated 40 patients undergoing high-dose chemo/radiotherapy (HDCT) and hematopoietic stem cell transplantation (HSCT) (allogeneic (22), autologous (18)) to determine the safety and feasibility of administering low molecular weight heparin (LMWH) as hepatic veno-occlusive disease (VOD) prophylaxis. Patients received a once daily subcutaneous injection of dalteparin 2500 anti-Xa i.u. commencing the day prior to starting HDCT, and continuing until day +30 post HSCT or hospital discharge, whichever came first. Dosage adjustments were made for patients developing renal failure. All bleeding ep

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… Prevention of regimen-related toxicities after bone marrow transplantation by pentoxifylline: a prospective, randomized trial. Blood. 1993;82:732. 16. Clift RA, Bianco JA, Appelbaum FR. … A randomized controlled trial of pentoxifylline for the prevention of regimen-related toxicities in patients undergoing allogeneic marrow transplantation. Blood. 1993;892:2025. 17. Essell JH, Schroeder MT, Harman GS. …

Interventions for frostbite injuries.

BACKGROUND: Frostbite is a thermal injury caused when tissue is exposed to sub-zero temperatures (in degrees Celsius) long enough for ice crystals to form in the affected tissue. Depending on the degree of tissue damage, thrombosis, ischaemia, necrosis (tissue death), gangrene and ultimately amputation may occur. Several interventions for frostbite injuries have been proposed, such as hyperbaric oxygen therapy, sympathectomy (nerve block), thrombolytic (blood-thinning) therapy and vasodilating agents such as iloprost, reserpine, pentoxifylline and buflomedil, but the benefits and harms of thes…

Feline Coronavirus Infection

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… The prednisolone dose was decreased to 5 mg q48h and pentoxifylline treatment was discontinued. One month later, albumin and globulin concentrations were 3.3 and 5.1 g/dL, respectively, and the prednisolone dose was reduced to 2.5 mg q48h. … Treatment with cyproheptadine was initiated and the chlorambucil and pentoxifylline discontinued. However, inappetence continued, and persistent pyrexia (103.4° to 104°F), hematochezia, and tachypnea developed over the next few days. …

Липодерматосклероз-подобная клиническая презентация с гистопатологией, подобной PXE, у пациента с недавно диагностированным синдромом сосудистого элерса-Данлоса.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Bilateral lower extremities 2 months after initiation of potent topical steroids, and pentoxifylline (B) . Close up view of the lower extremities 6 months after initiation of treatment (C) . … The patient was treated with potent topical steroids and pentoxifylline, and subsequently reported decreased skin tightness, reduced swelling, and improvement of nighttime discomfort ( Fig 1 , B and C ). …

Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis affecting 5 million adults in the United States, with an age-adjusted prevalence of 4% to 15% and increasing up to 30% with age and the presence of cardiovascular risk factors. In this article we focus on lower extremity PAD and specifically on the superficial femoral and proximal popliteal artery (SFPA), which are the most common anatomic locations of lower extremity atherosclerosis. We summarize current evidence and perform a systematic review on the diagnostic evaluation as well as the medical, endovascular and s

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… In a trial comparing cilostazol, pentoxifylline and placebo, pentoxifylline was inferior to cilostazol and no better than placebo for relief from claudication [ 70 ]. … A comparison of cilostazol and pentoxifylline for treating intermittent claudication. Am J Med. 2000;109:523–30. doi: 10.1016/s0002-9343(00)00569-6. 71. Hood SC, Moher D, Barber GG. Management of intermittent claudication with pentoxifylline: meta-analysis of randomized controlled trials. …

Pharmacological treatment for Buerger's disease.

BACKGROUND: Buerger's disease (thromboangiitis obliterans) is a non-atherosclerotic, segmental inflammatory pathology that most commonly aff … with placebo. No studies assessed other pharmacological agents such as cilostazol, clopidogrel and pentoxifylline or compared oral versus intravenous prostanoid.Compared with aspirin, intravenous prostacyclin analogue iloprost improved ulcer healing (risk ratio (RR) 2.65; 95% confidence interval (CI) 1.15 to 6.11; 98 participants; one study; moderate quality ev …

Pharmacological treatment for Buerger's disease.

BACKGROUND: Buerger's disease (thromboangiitis obliterans) is a non-atherosclerotic, segmental inflammatory pathology that most commonly aff … with placebo. No studies assessed other pharmacological agents such as cilostazol, clopidogrel and pentoxifylline or compared oral versus intravenous prostanoid.Compared with aspirin, intravenous prostacyclin analogue iloprost improved ulcer healing (risk ratio (RR) 2.65; 95% confidence interval (CI) 1.15 to 6.11; 98 participants; one study; moderate quality ev …

Радиологическое и патологическое восприятие остеонекроза, связанного с лекарственными препаратами, у < < Жо > > , больного миеломой: доклад 3 Дела.

Связанный с лекарственными препаратами остеонекроз челюсти (MRONJ) является редким побочным эффектом некоторых лекарственных средств, главным образом тех, которые используются при лечении конкретных раковых заболеваний и при первоначальном лечении ненеопластических заболеваний. Первые случаи остеонекроза челюсти были зарегистрированы в ходе 2 десятилетия назад у пациентов, употребляющих бисфофонаты (БП). После идентификации номенклатура перешла от остеонекроза челюсти (BRONJ) к MRONJ, поскольку другие лекарства могут вызвать такую же реакцию. Инвазивные стоматологические услуги, такие, как экс

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… Management of medication-related osteonecrosis of the jaw in multiple myeloma patients with pentoxifylline and tocopherol: case reports Case Rep Dent 2025 1 2025 1 5 10.1155/crid/2765925 PMC12077977 40370694 27 Mcgowan K, Ivanovski TMS. … Pentoxifylline and tocopherol protocol to treat medication-related osteonecrosis of the jaw: a systematic literature review J Cranio-Maxillofacial Surg [Internet] 48 11 2020 1080 1086 10.1016/j.jcms.2020.09.008 Available from: 32998853 Competing Interests: The authors declare that they have no known …

Livedoid vasculopathy: A multidisciplinary clinical approach to diagnosis and management.

Livedoid vasculopathy (LV) is a rare, chronic, and occlusive disease of the veins supplying the upper parts of the skin. The pathogenesis of the disease is not precisely understood, and its attacks are often unpredictable but tend to worsen during the summer. LV affects women more often. This increased risk for LV in women might be related to sex-specific physiological conditions, such as pregnancy, or a higher incidence of LV-associated conditions, such as connective tissue diseases, hypercoagulable states, and venous stasis in women. The typical clinical appearance of LV consists of three ma

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… Dipyridamole and pentoxifylline (600 mg twice daily) can be favored in combination with aspirin in unresponsive cases or alone in patients who cannot tolerate aspirin. … Therapy with pentoxifylline Arch Dermatol 124 5 1988 684 687 3364993 Sankar A Hinshaw K. Livedoid vasculopathy and pregnancy Int J Gynaecol Obstet 107 3 2009 248 249 19647821 10.1016/j.ijgo.2009.06.020 Saoji V Madke B. …