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Effects of Transcranial Stimulation on Resistance Exercise in Mentally Fatigued Subjects.

The objective was to analyze the effect of anodic transcranial direct current stimulation over the the primary motor cortex (M1) on resistance exercise in mentally fatigued individuals. Thirty-five participants performed a Stroop task to induce mental fatigue until they reached 50 mm on the visual analogue scale under three different conditions in a randomized, double-blind, crossover experimental trial. The participants completed a resistance training session with six sets for muscle failure with fixed load (Vload=1 ms-1) after the Stroop task. During the resistance training session, performa…

Elevated adipokines and myokines are associated with fatigue in long COVID patients.

BACKGROUND: Persistent fatigue is one of the most common and debilitating symptoms experienced by patients recovering from COVID-19, contributing significantly to the burden of "long COVID" or post-COVID-19syndrome. However, the underlying pathophysiological mechanisms remain inadequately understood. Few studies have examined the association between fatigue and pulmonary or cardiac function, systemic biomarkers, or morphological changes in the lungs and diaphragm. Furthermore, the potential influence of vaccination on the persistence of fatigue has not been fully explored. This study aims to i…

Monitoring Visual Fatigue with Eye Tracking in a Pharmaceutical Packing Area.

This study investigates visual fatigue in a real-world pharmaceutical packaging environment, where operators perform repetitive inspection and packing tasks under frequently suboptimal lighting conditions. A human-centered methodology was adopted, combining adapted self-report questionnaires, high-frequency eye-tracking data collected with Tobii Pro Glasses 3, and lux-level measurements. Key eye-movement metrics-including fixation duration, visit patterns, and pupil diameter-were analyzed within defined work zones (Areas of Interest). To reduce data complexity and uncover latent patterns of vi…

The Effects of Varying Intensities of Unilateral Handgrip Fatigue on Bilateral Movement.

Background/Objectives: The ability to maintain movement quality despite muscle fatigue is essential for daily activities and preserving independence after motor impairments. Many real-life situations involve asymmetrical muscle activation, leading to unilateral muscle fatigue. Repeated unilateral handgrip contractions at submaximal force have been linked to neural changes in both contralateral and ipsilateral motor areas, as well as improved contralateral response times in a button-press task. However, it remains unclear whether these improvements in response latency extend to higher-level ben…

Acephalgic Migraine Presenting as Episodic Fatigue and Nausea: A Case Report.

Acephalgic migraine (AM), or migraine aura without headache, is a subtype of migraine, characterized by transient neurological symptoms without the accompanying headache phase. Its diagnosis remains challenging due to varied clinical presentation and the tendency to misattribute symptoms to other neurological, psychiatric, or systemic disorders. This case report describes a female patient, age 38 years, presenting with episodic, incapacitating fatigue, nausea, and cognitive dysfunction, initially leading to an extensive but inconclusive diagnostic workup. Partial symptom relief with ondansetro…

Fatigue in the Preataxic and Ataxic Stages of Spinocerebellar Ataxia Type 3.

OBJECTIVE: Fatigue is a significant symptom in patients with spinocerebellar ataxia type 3 (SCA3). This study explores the role of fatigue in SCA3, examining its impact on quality of life and its potential as an indicator of disease progression. METHODS: We prospectively recruited 128 molecularly confirmed SCA3 patients and 125 sex-, age-, and education-matched healthy controls (HCs). Age at onset, disease duration, length of normal and expanded CAG repeats, and 14-item Fatigue Scale score were compared. MRIs evaluated the cerebellum and brain lesions. RESULTS: Our study found that the preat…

Establishment and validation of a prediction model for compassion fatigue in nursing students.

BACKGROUND: Compassion fatigue is a common issue nursing students face during clinical internships. Prolonged exposure to patients' suffering and trauma can lead to emotional exhaustion and psychological stress. Compared to formal healthcare workers, nursing students have less professional experience and weaker emotional regulation abilities, making them more vulnerable to secondary trauma and other negative emotions, which exacerbates compassion fatigue. Early identification and intervention in compassion fatigue are crucial for improving the mental health of nursing students and the quality …

Fatigue behavior and estimated lifetime of implant/abutments of different diameters.

OBJECTIVES: Narrow-diameter (ND) implants may show distinct long-term mechanical behavior compared to standard-diameter (SD) implants when subjected to fatigue. This study evaluated the longevity of implant systems with different diameters by assessing structural damage and loosening after fatigue challenge. METHODS: This in vitro study used sixty internal conical connection implants/abutments that were divided into two groups (n = 30) based on their diameters (3.0mm-ND and 4.0mm-SD). The manufacturer recommended torque was achieved for each abutment using a digital torque wrench. In order to…

Determinants of fatigue in patients with Marfan syndrome: a study using PROMS.

BACKGROUND: Fatigue is often reported by individuals with Marfan syndrome (MFS). However, the determinants of fatigue and its impact on the daily lives of patients with MFS remain poorly understood. We sought to assess the level of fatigue and its determinants in individuals with MFS. METHODS: We conducted a cross-sectional study in ComPaRe Marfan, an e-cohort of MFS patients. Fatigue was assessed using the FACIT questionnaire already used in a wide range of chronic diseases. Pain and its interference with daily life were assessed using the Brief Pain Inventory. We performed univariate and mu…

[Study on the mediating effect of fatigue on neck WMSDs in the footwear industry].

Objective: To construct a structural equation model for neck work-related musculoskeletal disorders (WMSDs) in the footwear industry and analyze the mediating effect of fatigue in the model. Methods: From November 2018 to December 2019, stratified cluster sampling was adopted to select all the workers (3565 people) from 7 footwear enterprises in Fujian Province as the research subjects. The incidence of WMSDs, fatigue and work-related condition were investigated by using the Chinese version of the Musculoskeletal Disorders Questionnaire. A structural equation model of individual factors, work …

Establishment and Evaluation of Fatigue Mice Model in the Convalescence Phase of Influenza A.

Certain strains of Influenza A virus (IAV), a primary cause of influenza, can lead to pneumonia. Patients recovering from influenza pneumonia may experience physical discomfort akin to post-acute sequelae of COVID-19 (PASC). Despite extensive clinical research on viral pneumonia during convalescence, animal model studies are scarce, highlighting the need for a reliable model for pharmaceutical research. In this study, BALB/c mice were divided into three groups: NC (control), MC (infected with IAV), and Model (treated with oseltamivir post-infection for five days). A fatigue model was then indu…

Влияние уродинамических наблюдений на утомление и депрессию у людей с множественным склерозом.

Фон: Усталость и депрессия являются распространенными симптомами множественного склероза (МС), которые серьезно ухудшают качество жизни. Факторы, влияющие на обе стороны, представляют все больший интерес для создания терапевтического синергизма. Были описаны корреляции между симптомами нейрогенной дисфункции нижних мочевых путей (NLUTD), усталости и депрессии, однако до сих пор не было изучено воздействие результатов патологического уродинамического исследования (UDS). Метод: Это ретроспективное, наблюдательное исследование соотнесо с MS (PwMS) выводы 274 человек, полученные в период с февраля

Совпадение в аннотации оригинала
Background: Fatigue and depression are common symptoms of multiple sclerosis (MS) that severely impair quality of life. The factors influencing both are of increasing interest for establishing therapeutic synergisms. Correlations between the symptoms of neurogenic lower urinary tract dysfunction (NLUTD), fatigue, and depression have been described, but the i…

Effect of Fatigue on Movement Patterns During a Loaded Ruck March.

INTRODUCTION: Loaded ruck marching is a common training and operational task for many members of the military. It is known to cause fatigue, affect soldier readiness, and can lead to traumatic and overuse injuries. Quantifying the gait changes that occur over the course of a loaded ruck march may provide a better understanding of injury mechanisms and potentially allow for development of individualized injury-prevention training programs. This study examined the change in soldiers' gait patterns over the course of a loaded ruck march in order to examine the correlation between fatigue and kine…

Burnout, Compassion Fatigue, and the Long Haul of Caring for Long COVID.

The current landscape of clinician burnout is prompting the need for our health care system to revise its approach toward complex conditions such as long coronavirus disease (COVID), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and other postinfectious fatiguing illnesses (PIFIs). We discuss our efforts here at Family Health Center of San Diego (FHCSD) to help share insight and glean perspective from clinicians who have participated in our Centers for Disease Control and Prevention (CDC)-funded 3-year continuing professional development initiative. The Long COVID and Fatiguing …

Fatigue and associated factors in myasthenia gravis: a nationwide registry study.

Fatigue is commonly associated with myasthenia gravis (MG), but factors contributing to fatigue development in MG are incompletely understood. This nationwide cross-sectional registry study included 1464 patients diagnosed with autoimmune MG, recruited between February 2019 and April 2023. Frequency and severity of fatigue was assessed at study inclusion using the patient-reported Chalder Fatigue Questionnaire (CFQ). Frequency of fatigue was 59%. Fatigue severity strongly correlated with both patient-reported and physician-assessed MG outcome measures (MG-ADL, MG-QoL15, QMG and MGFA classes) a…

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: the biology of a neglected disease.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, debilitating disease characterised by a wide range of symptoms that severely impact all aspects of life. Despite its significant prevalence, ME/CFS remains one of the most understudied and misunderstood conditions in modern medicine. ME/CFS lacks standardised diagnostic criteria owing to variations in both inclusion and exclusion criteria across different diagnostic guidelines, and furthermore, there are currently no effective treatments available. Moving beyond the traditional fragmented perspectives that have limited o…

Quality of life, fatigue and markers in sarcoidosis: A section from Turkey.

BACKGROUND AND AIM: Sarcoidosis can affect every organ with varying frequency based on ethnicity, gender and age. We aimed to evaluate the health-related quality of life (HRQoL) and fatigue levels of our sarcoidosis patients. However, our second aim is to determine whether patient or disease markers correlate with quality of life assessment questionnaires. MATERIALS AND METHODS: Pulmonary sarcoidosis patients who were followed up in the chest diseases outpatient clinic of our hospital were included in this prospective study. In the follow-up of 2023, routine blood tests, angiotensin-convertin…

Fatigue of oncological patients - incompatible perspectives of patients and medical staff.

BACKGROUND: Cancer-related fatigue is a complex syndrome and the most frequently reported complaint, especially during treatment. Sometimes a large discrepancy in patient fatigue estimations between the patients themselves and medical staff is observed. The main goal of this study was to compare fatigue from the patients' and the medical staff's perspectives. PARTICIPANTS AND PROCEDURE: The methods used included author-designed surveys for both the patient (questions about fatigue, intensity, causes and influence on life constructed mostly in the form of numerical rating scales) and the medic…

Cardiovascular training versus resistance training for fatigue in people with cancer.

BACKGROUND: With prevalence estimates between 50% and 90% of people with cancer, cancer-related fatigue is one of the most common morbidities related to cancer and its treatment. Exercise is beneficial for the treatment of cancer-related fatigue. However, the efficacy of different types of exercise (i.e. cardiovascular training and resistance training) have not yet been investigated systematically and compared directly in a meta-analysis. OBJECTIVES: To compare the benefits and harms of cardiovascular training versus resistance training for treatment or prevention of cancer-related fatigue in…