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Synthesis and biological evaluation of a new polymeric conjugate and nanocarrier with osteotropic properties.

Bone-seeking (osteotropic) drug delivery systems (ODDS) represent an interesting solution for targeting different types of drugs to the bones. In particular, anticancer and antibacterial agents could take advantage of such therapeutic strategy. We have recently developed an innovative approach to this aim: a new osteotropic biomaterial was prepared, based on the conjugation of a poly(lactide-co-glycolide) (PLGA) with the bisphosphonate drug alendronate (PLGA-ALE); its hemo- and cytocompatibility were verified. Starting with this copolymer, an osteotropic nanoparticle system (NP) was produced f

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… ‘Magic bullets’ for bone diseases: Progress in rational design of bone-seeking medicinal agents Chem. Soc. Rev. 2007 36 507 531 10.1039/b512310k 17325789 22. Bauss F. Esswein A. Reiff K. Sponer G. Müller-Beckmann B. …

Psychometric properties of two physical activity questionnaires, the AQuAA and the PASE, in cancer patients.

BackgroundThis study aimed to evaluate the reliability and validity of two self-report physical activity (PA) questionnaires - the AQuAA (Activity Questionnaire for Adults and Adolescents) and PASE (Physical Activity Scale for the Elderly) - in cancer patients.MethodsTest-retest reliability was determined by administering the questionnaires twice within 5 days. Intraclass correlation coefficient (ICC), standard error of measurement (SEM) and smallest detectable difference (SDD) were calculated. Construct validity was determined by comparing the questionnaire results with ActiGraph acceleromete

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… The magical number seven, plus or minus two: some limits on our capacity for processing information. 1956. Psychol Rev. 1994;101:343–352. doi: 10.1037/0033-295X.101.2.343. Forsen L, Loland NW, Vuillemin A, Chinapaw MJ, van Poppel MN, Mokkink LB. et al. …

Clinical applications of antibody-drug conjugates in advanced non-small cell lung cancer.

Lung cancer remains the leading cause of cancer-related incidence and mortality worldwide, with non-small cell lung cancer (NSCLC) constituting the majority of cases. Current treatment modalities are constrained by significant limitations: conventional chemotherapy exhibits poor tumor selectivity and systemic toxicity, while monoclonal antibodies frequently demonstrate inadequate therapeutic efficacy. Antibody-drug conjugates (ADCs)-engineered biotherapeutics comprising tumor-targeting antibodies conjugated to potent cytotoxic agents through optimized linkers-have emerged as a transformative s

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… Composition, evolution, and mechanism of action of ADCs The conceptual foundation for ADCs traces back to Paul Ehrlich’s visionary “magic bullet” hypothesis, which proposed the development of therapeutics capable of selectively targeting diseased tissues while sparing healthy cells ( 13 ). … Paul Ehrlich’s magic bullet concept: 100 years of progress . Nat Rev Cancer . ( 2008 ) 8 : 473–80 . doi: 10.1038/nrc2394 , PMID: 18469827 14 Chau CH Steeg PS Figg WD . Antibody-drug conjugates for cancer . …

Antibody drug conjugates in the clinic.

Antibody-drug conjugates (ADCs), chemotherapeutic agents conjugated to an antibody to enhance their targeted delivery to tumors, represent a significant advancement in cancer therapy. ADCs combine the precise targeting capabilities of antibodies and the potent cell-killing effects of chemotherapy, allowing for enhanced cytotoxicity to tumors while minimizing damage to healthy tissues. Here, we provide an overview of the current clinical landscape of ADCs, highlighting 11 U.S. Food and Drug Administration (FDA)-approved products and discussing over 500 active clinical trials investigating newer

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… treatments tend to focus on the cancer's location or histological features rather than on specific molecular changes. 3 Recent advances in molecular and tumor biology have shifted cancer treatment from these broad approaches to more personalized and precise therapies. 3 Inspired by Paul Ehrlich's “magic … Paul Ehrlich's magic bullet concept: 100 years of progress . Nat Rev Cancer . 2008 ; 8 ( 6 ): 473 ‐ 480 . 18469827 10.1038/nrc2394 12 Dumontet C , Reichert JM , Senter PD , Lambert JM , Beck A . Antibody–drug conjugates come of age in oncology . …

Психологические исследования в области расстройств питания/безпорядкового питания по типу 1 диабет: систематический обзор с использованием модели НГП для разработки поведенческих мер.

АИСЮ: расстройства питания по типу 1 диабет 2.4 Временами больше, чем у тех, у кого нет диабета. Цель заключалась в проведении систематического обзора психологического вмешательства в IRDEB (поведение, связанное с расстройствами питания, связанными с инулином)/поглощающих расстройства у взрослых, имеющих тип 1 диабет. В обзоре описываются тип и качество исследований с группами контроля/сопоставимости, а также качественные исследования и обобщаются результаты исследований в соответствии с моделью развития поведенческих мер, разработанной на этапе НГП. Классификация в соответствии с моделью позв

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… In workshop one, adults with IRDEB/eating disorders discussed how they believed ‘insulin equals fat’, and that ‘insulin omission is my magic weight loss tool’, with a recommendation to focus on insulin titration and the need for taking small steps. …

Метод пилатеса как биопсихосоциальное вмешательство на современном рабочем месте: систематический обзор физических, психических и профессиональных пособий.

Справочная информация/задачи: На здоровье и производительности рабочей силы существенно сказываются связанные с работой расстройства мускулоскелета (ВМСД) и профессиональный стресс. Цель этого систематического обзора заключалась в обобщении данных об эффективности метода пилатеса как биопсихосоциального вмешательства для работников, а также в изучении его воздействия на физические, психологические и профессиональные результаты. Методы: Был проведен систематический поиск по основным электронным базам данных и поисковым системам (PubMed, Scopus, Web of Science, PEDro и Google Scientific) после P

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… The most frequent intervention type was Matwork Pilates, often supplemented with accessories like small balls or magic circles, while Reformer-based programs were also utilized. Protocol durations typically ranged from 4 to 12 weeks, with a frequency of 2 to 3 sessions per week. …

Prognosis After Withdrawal of Cardioprotective Therapy in Patients With Improved Cancer Therapeutics-Related Cardiac Dysfunction.

BackgroundThe long-term prognosis after the discontinuation of cardioprotective therapy (CPT) in patients with cancer therapeutics-related cardiac dysfunction (CTRCD) that has shown improvement remains unclear.ObjectivesThis study aims to assess the prognosis after CPT withdrawal in patients exhibiting improved CTRCD.MethodsIn this retrospective analysis of a single-center prospective cohort study, patients with improved CTRCD, defined as an increase in left ventricular ejection fraction (LVEF) ≥10 percentage points from the time of CTRCD diagnosis, were included. We analyzed their clinical ou

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… Myocardial recovery and the failing heart: myth, magic, or molecular target? J Am Coll Cardiol 60 2012 2465 2472 23158527 10.1016/j.jacc.2012.06.062 PMC3522780 16 Ambardekar A.V. Buttrick P.M. …

The effect of anticancer treatment on cancer patients with COVID-19: A systematic review and meta-analysis.

BackgroundThe relationship between cancer and COVID-19 has been revealed during the pandemic. Some anticancer treatments have been reported to have negative influences on COVID-19-infected patients while other studies did not support this hypothesis.MethodsA literature search was conducted in WOS, PubMed, Embase, Cochrane Library, CNKI and VIP between Dec 1, 2019 and Sept 23, 2020 for studies on anticancer treatments in patients with COVID-19. Cohort studies involving over 20 patients with cancer were included. The characteristics of the patients and studies, treatment types, mortality, and ot

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… Dual‐targeted phototherapeutic agents as magic bullets for cancer . Bioconjug Chem . 2020 ; 31 ( 3 ): 474 ‐ 482 . 31940166 10.1021/acs.bioconjchem.9b00836 49 Stahel PF . How to risk‐stratify elective surgery during the COVID‐19 pandemic? …

A New Generation of Vaccines in the Age of Immunotherapy.

Purpose of reviewCancer vaccines are one of the most extensively studied immunotherapy type in solid tumors. Despite favorable presuppositions, so far, the use of cancer vaccines has been associated with disappointing results. However, a new generation of vaccines has been developed, promising to revolutionize the immunotherapy field.Recent findingsIn this review, we aim to highlight the advances in cancer vaccines and the remaining hurdles to overcome. Cancer vaccination has experienced tremendous progress in the last decade, with myriad promising developments. Future efforts should focus on

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… Overwijk WW Cancer vaccines in the era of checkpoint blockade: the magic is in the adjuvant Curr Opin Immunol England 2017 47 103 109 10.1016/j.coi.2017.07.015 28806603 16. Parkhurst MR, Yang JC, Langan RC, Dudley ME, Nathan D-AN, Feldman SA, et al. …

Взгляды пациентов и группы по уходу за почками на лечащую нагрузку и способность пожилых людей с хроническими заболеваниями почек: качественное исследование.

ЦЕЛЬ: Хроническая болезнь почек (КХД) часто является множественным заболеванием, а прогрессирование к более серьезным заболеваниям, как правило, связано с увеличением потребностей в управлении, включая изменение образа жизни, увеличение количества медикаментов и расширение участия клинических работников. В ходе этого исследования были изучены взгляды группы по уходу за пациентами и почками на характер и масштабы этой рабочей нагрузки (нагрузка на лечение), а также факторы, способствующие укреплению способности (способности управлять здоровьем) пожилых людей, имеющих ККД. DESIGN: Качественное п

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… Implementing shared decision making in the NHS: lessons from the magic programme. BMJ 2017;357:j1744. 26. Smith SG, Pandit A, Rush SR, et al. The role of patient activation in preferences for shared decision making: results from a national survey of U.S. adults. …

Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram.

Despite the introduction of new therapies for multiple myeloma (MM), many patients are still dying from this disease and novel treatments are urgently needed. We have designed a novel hybrid molecule, called NEO214, that was generated by covalent conjugation of the natural monoterpene perillyl alcohol (POH), an inducer of endoplasmic reticulum (ER) stress, to rolipram (Rp), an inhibitor of phosphodiesterase-4 (PDE4). Its potential anticancer effects were investigated in a panel of MM cell lines. We found that NEO214 effectively killed MM cells in vitro with a potency that was over an order of

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… Magic year for multiple myeloma therapeutics: Key takeaways from the ASH 2015 annual meeting Oncotarget 2017 8 10748 10759 10.18632/oncotarget.13314 27863374 PMC5354697 9. Scott K. Hayden P.J. Will A. Wheatley K. Coyne I. Bortezomib for the treatment of multiple myeloma Cochrane Database Syst. …

Oral mucositis induced by anticancer treatments: physiopathology and treatments.

Oral mucositis is a frequent and devastating side effect of anticancer treatments. It impairs the patient's quality of life and also can be life threatening because severe infections and delayed or incomplete anticancer treatments may result. This problem has been largely overlooked and underestimated in the past. However, recently studies have been performed to precisely identify the epidemiology, cost, consequences, physiopathology, and treatments of oral mucositis. Clinical guidelines have recently been published to help the daily management of this frequent complication. In addition, some

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… It is clear that treatment of mucositis is not based on a unique and non-existent magic drug, but rather on a logical and rational use of different modalities. …

Molecular Inhibitors of Growth Signals

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Therapeutic strategies against cancer cachexia.

Cancer cachexia has two main components: anorexia and metabolic alterations. The main changes associated with the development of this multi-organic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. The aim of this paper is to review the more recent therapeutic approaches designed to counteract the wasting suffered by the cancer patient with cachexia. Among the most promising approaches we can include the use of ghrelin agonists, beta-blockers, beta-adrenergic agonists, androgen receptor agonists and anti-myostatin peptides. The multi-targeted approach seems es

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… nutrition results in positive outcomes in cancer patients. 81–83 A multitarget approach including physical exercise During the last years, it has become apparent that a combination of nutrition, nutraceuticals and drugs is a much-preferred therapeutic approach than just looking for a single drug "magic …

Aspirin use and bleeding events during thrombocytopenia after autologous stem-cell transplantation for multiple myeloma.

BACKGROUND: In patients with cardiovascular (CV) comorbidities that necessitate antiplatelet therapy (APT), its optimal management during chemotherapy-induced thrombocytopenia remains elusive, as the risk of bleeding has to be balanced against the risk of CV events. The purpose of this study was to assess the risk for bleeding with APT during thrombocytopenia in patients with multiple myeloma undergoing high-dose chemotherapy and subsequent autologous stem-cell transplantation (ASCT) with and without acetylsalicylic acid (ASA) as comedication. METHODS: We assessed patients who underwent ASCT

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… Major cardiovascular and bleeding events with long-term use of aspirin in patients with prior cardiovascular diseases: 1-year follow-up results from the management of aspirin-induced gastrointestinal complications (MAGIC) study . …

Application of Chimeric Antigen Receptor T Cells in the Treatment of Hematological Malignancies.

T cell immune protection plays a pivotal role in the treatment of patients with hematological malignancies. However, T cell exhaustion might lead to the possibility of immune escape of hematological malignancies. Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. Of note, CD19, CD20, CD30, CD33, CD123, and CD269 as ideal targets have shown extraordinary potential for CAR-T cell therapy and other targets such as C

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… CD123 AML targeting by chimeric antigen receptors: a novel magic bullet for AML therapeutics? Oncoimmunology 2014 3 5, article e28835 10.4161/onci.28835 2-s2.0-84904052509 25083319 PMC4106165 56 John S. Chen H. Deng M. …

Carfilzomib boosted combination therapy for relapsed multiple myeloma.

Carfilzomib is a proteasome inhibitor that binds selectively and irreversibly to the 20S proteasome, the proteolytic core particle within the 26S proteasome, resulting in the accumulation of proteasome substrates and ultimately growth arrest and apoptosis of tumor cells. The development and ultimate approval of this medication by regulatory agencies has been an important step toward improving clinical outcomes in multiple myeloma. Although initially approved as a single agent for the treatment of multiply relapsed and/or refractory myeloma, in the USA, it is now widely used in the early relaps

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… J Sekhar J 3329 A Phase II Study of carfilzomib, pegylated liposomal doxorubicin, and dexamethasone for relapsed or refractory multiple myeloma Presented at: 58th Annual Meeting and Exposition December 3–6, 2016 San Diego, CA Accessed December 21, 2016 36 Zhang K Desai A Zeng D Gong T Lu P Wang M Magic …

Sjögren Disease-B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell-Targeted Therapies.

Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)-approved disease-modifying therapies for SjD. In this review, we explore the expanding field of SjD endotyping as a tool to enhance patient stratification, prognostication, and clinical decision-making. SjD endotypes driven by heightened B cell activity are linked to increased lymphoma risk. B cells play a ce

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… Bispecific antibodies for the treatment of hematologic malignancies: the magic is T‐cell redirection . Blood Rev 2025 ; 69 : 101251 . 39617677 10.1016/j.blre.2024.101251 81 Klein C , Brinkmann U , Reichert JM , et al. The present and future of bispecific antibodies for cancer therapy . …

Fate of Antibody-Drug Conjugates in Cancer Cells.

Antibody-Drug Conjugates (ADCs) are a class of cancer therapeutics that combines antigen specificity and potent cytotoxicity in a single molecule as they are comprised of an engineered antibody linked chemically to a cytotoxic drug. Four ADCs have received approval by the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) and can be prescribed for metastatic conditions while around 60 ADCs are currently enrolled in clinical trials. The efficacy of an ADC greatly relies on its intracellular trafficking and processing of its components to trigger tumor cell death. A limite

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… While the expectation of delivering a “magic bullet” to tumor cells in the form of an ADC may not be fully realized yet, new generations of ADCs are developed based on advances in antigen identification, linkers technology and warheads [ 18 ]. …

Advancement of NF-κB Signaling Pathway: A Novel Target in Pancreatic Cancer.

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and is the third highest among cancer related deaths. Despite modest success with therapy such as gemcitabine, pancreatic cancer incidence remains virtually unchanged in the past 25 years. Among the several driver mutations for PDAC, Kras mutation contributes a central role for its development, progression and therapeutic resistance. In addition, inflammation is implicated in the development of most human cancer, including pancreatic cancer. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is recogniz

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… Almost 4000 articles have been published on Curcumin, and some of the studies have named this molecule as a “magic bullet” [ 82 , 83 , 84 ]. Curcumin exerts its anti-cancer activities through a variety of mechanisms including inhibition of NF-κB [ 85 , 86 ]. …