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Preventive Healthcare and Management for Acute Lymphoblastic Leukaemia in Adults: Case Report and Literature Review.

Acute lymphoblastic leukaemia (ALL) is diagnosed by the presence of at least 20% lymphoblasts in the bone marrow. ALL may be aggressive and include the lymph nodes, liver, spleen, central nervous system (CNS), and other organs. Without early recognition and timely treatment, ALL will progress quickly and may have poor prognosis in clinical scenarios. ALL is a rare type of leukaemia in adults but is the most common type in children. Precipitating factors such as environmental radiation or chemical exposure, viral infection, and genetic factors can be associated with ALL. We report a rare case o

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… Polyuria, polydipsia, nocturia, hypercalciuria, nephrolithiasis, nephrocalcinosis, and renal failure are complications of hypercalcaemia in the renal system. Gastrointestinal symptoms include nausea, vomiting, anorexia, abdominal pain, peptic ulcers, and pancreatitis. …

Extraglandular Manifestations of Sjögren’s Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Confirmed by imaging Significant irreversible functional damage Confirmed by spirometry Renal impairment (any of the following) 2 Increased serum creatinine level or reduced GRF Long-lasting stable abnormalities Tubular acidosis Urinary pH >6 and serum bicarbonate <15 mmoles/L in 2 consecutive tests Nephrocalcinosis … Significant irreversible functional damage | Confirmed by spirometry | Renal impairment (any of the following) | | 2 Increased serum creatinine level or reduced GRF | Long-lasting stable abnormalities | Tubular acidosis | Urinary pH >6 and serum bicarbonate <15 mmoles/L in 2 consecutive tests | Nephrocalcinosis …

Potential Adverse Effects of Dexamethasone Therapy on COVID-19 Patients: Review and Recommendations.

In the context of the coronavirus disease 2019 (COVID-19) pandemic, the global healthcare community has raced to find effective therapeutic agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To date, dexamethasone is the first and an important therapeutic to significantly reduce the risk of death in COVID-19 patients with severe disease. Due to powerful anti-inflammatory and immunosuppressive effects, dexamethasone could attenuate SARS-CoV-2-induced uncontrolled cytokine storm, severe acute respiratory distress syndrome and lung injury. Nevertheless, dexamethasone tre

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… On the other hand, in clinical studies, dexamethasone could contribute to renal calcification formation by increasing urinary calcium excretion [ 130 ], with nephrocalcinosis occurring in 15 (83%) of 18 infants [ 131 ] (Table 1 ). … Cranefield DJ Odd DE Harding JE Teele RL High incidence of nephrocalcinosis in extremely preterm infants treated with dexamethasone Pediatr Radiol 2004 34 138 142 14624322 10.1007/s00247-003-1090-7 132. …

Abstracts from the 6th Annual Conference of Emirates Society of Internal Medicine (ESIM) 2025.

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Почечная трансплантация у пациентов с множественной миеломой: текущие доказательства, вызовы и будущие направления.

Вовлечение реналов является важным осложнением множественной миэломы (ММ) и связано не только с худшими клиническими результатами, но и с более низким качеством жизни, особенно когда речь идет о почечных заболеваниях конечной стадии. Традиционно пациенты ММ не считались имеющими право на трансплантацию почек; однако эти парадигмы меняются. Новая эра лечения MM привела к протеазным ингибиторам, иммуномодулятивным препаратам, моноклональным антителам и, совсем недавно, к клеточной терапии, что привело к более продолжительному выживанию и устойчивой гематологической реакции. Знания цитогенетическ

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… It is also associated with nephrocalcinosis, with calcium deposits in renal parenchyma and tubular damage [ 10 , 12 ]. …

The Risk of Sarcoidosis Misdiagnosis and the Harmful Effect of Corticosteroids When the Disease Picture Is Incomplete.

Sarcoidosis is a complex granulomatous disease of unknown etiology. Due to the heterogeneity of the disease, the diagnosis remains challenging in many cases, often at the physician's discretion, requiring a thorough and complex investigation. Many other granulomatous diseases have the potential to mimic sarcoidosis, whether infectious, occupational, or autoimmune diseases and starting an unnecessary corticosteroid treatment can worsen the patient's prognosis, leading to side effects that can be harder to treat than the actual disease.

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… palpitations, dyspnoea, syncope Arrythmias—total heart block, tachyarrhythmias, cardiac failure Musculoskeletal involvement 5–15% of cases for joint involvement | Sarcoid arthropathy, sarcoid myopathy, chronic sarcoid arthritis Renal involvement Up to 20% of cases | Granulomatous interstitial nephritis, nephrocalcinosis …

Hypercalcaemia and hypocalcaemia: finding the balance.

Calcium metabolism in cancer and hypercalcaemia of malignancyThe balance between bone formation and resorption may be disrupted in patients with cancer, leading either to increased bone resorption, calcium release, and possibly hypercalcaemia, or to increased bone formation, sequestration of calcium, and possibly hypocalcaemia. In adults, hypercalcaemia of malignancy is most common in patients with tumours that produce factors that induce osteoclast activation and enhance bone resorption. Impaired renal function and increased renal tubular calcium resorption may further affect calcium levels.T

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… Ibandronate for the treatment of hypercalcemia or nephrocalcinosis in patients with multiple myeloma and acute renal failure: case reports. Acta Haematol. 2006;116(3):165–172. doi: 10.1159/000094676. 55. Body JJ, Diel IJ, Tripathy D, Bergstrom B. …

Биология и болезни крыс

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Management of urinary stones by experts in stone disease (ESD 2025).

The formation of kidney stones is a complex biologic process involving interactions among genetic, anatomic, dietary, and environmental fact … sually manifests in adulthood, primarily with recurrent urinary lithiasis, and less frequently with nephrocalcinosis. In all stone formers stone analysis and a basic metabolic evaluation, including blood biochemistry, urine sediment examination, urinary pH and culture are mandatory, in contrast high-risk stone formers require a more specific metabolic evaluation, …

Denosumab in pediatric bone disorders and the role of RANKL blockade: a narrative review.

BACKGROUND AND OBJECTIVE: Denosumab is a valuable and safe therapy for skeletal disorders in adults and has received regulatory approval to treat osteoporosis and bone metastases. However, denosumab is not licensed for pediatric use due to a lack of high-quality prospective research on children. This study aimed to describe and discuss the benefits and disadvantages of denosumab in treating bone diseases in children and to summarize the current understanding of the role of denosumab therapy in children. METHODS: A narrative review was conducted using the literature retrieved from the PubMed,

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… hypercalcemia Uehara et al. ( 15 ) | 2017 | 1 child age 14 years | Every 6 months | 24 months | Increased BMD | None | Unknown Trejo et al. ( 16 ) | 2018 | 4 children age 1.9–9 years (type 6) | 1 mg per kg every 3 months | Mean 24 months | Increased BMD | Mild hypercalcemia and persistent hypercalciuria, nephrocalcinosis …

Turning Points in Cross-Disciplinary Perspective of Primary Hyperparathyroidism and Pancreas Involvements: Hypercalcemia-Induced Pancreatitis, MEN1 Gene-Related Tumors, and Insulin Resistance.

We aimed to provide an in-depth analysis with respect to three turning points in pancreas involvement in primary hyperparathyroidism (PHP): hypercalcemia-induced pancreatitis (HCa-P), MEN1 (multiple endocrine neoplasia)-related neuroendocrine tumors (NETs), and insulin resistance (IR). This was a comprehensive review conducted via a PubMed search between January 2020 and January 2024. HCa-P (n = 9 studies, N = 1375) involved as a starting point parathyroid NETs (n = 7) or pancreatitis (n = 2, N = 167). Case report-focused analysis (N = 27) showed five cases of pregnancy PHP-HCa-P and three rep

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… Thakker 2023 [ 34 ] | case report | 55-year-old female | acute pancreatitis | cystic parathyroid adenoma | first admission for diabetic ketoacidosis +papillary thyroid carcinoma +hypertrophic obstructive cardiomyopathy Sarwal 2023 [ 56 ] | case report | 56-year-old male | necrotizing pancreatitis | nephrocalcinosis …

Acute Kidney Injury in Monoclonal Gammopathies.

Monoclonal gammopathies (MG) encompass a variety of disorders related to clonal expansion and/or malignant transformation of B lymphocytes. Deposition of free immunoglobulin (Ig) components (light or heavy chains, LC/HC) within the kidney during MG may result over time in multiple types and degrees of injury, including acute kidney injury (AKI). AKI is generally a consequence of tubular obstruction by luminal aggregates of LC, a pattern known as "cast nephropathy". Monoclonal Ig LC can also be found as intracellular crystals in glomerular podocytes or proximal tubular cells. Proliferative glom

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… Chronic hypercalcemia may also induce medullary deposition of Ca 2+ salts, or nephrocalcinosis, with longer-lasting effects on renal function. One last potential cause of AKI in MG is renal vein thrombosis, once again a known complication of the NS [ 32 , 33 ]. …

The multiple roles of interferon regulatory factor family in health and disease.

Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains essential for interactions with other transcription factors and cofactors. These interactions allow IRFs to modulate a broad spectrum of physiological processes, encompassing host defense, immune response, and cell development. Conversely, their pivotal role in immune regulation implicates them in the pathophysiology of v

From Sjögren syndrome to Sjögren disease: rethinking classification and diagnostic complexity.

Sjögren syndrome (SS), traditionally regarded as a sicca-predominant condition, is now recognized as a systemic autoimmune disease characterized by type I interferon activation, B-cell hyperactivity, and periepithelial lymphocytic infiltration. This conceptual shift has prompted changes in terminology, with "SS" increasingly replaced by "Sjögren disease (SjD)" and "secondary SS" by "associated SjD," reflecting the concept of polyautoimmunity and ensuring equal clinical standing. In this review, we trace the historical evolution of SS classification criteria and examine their limitations in rea

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… Although uncommon, hypokalemia of undetermined etiology, persistently alkaline urine, or evidence of medullary nephrocalcinosis— reflecting distal renal tubular acidosis—may also suggest SjD [ 38 ] Fifth, over-reliance on serological markers can be misleading, as autoantibodies may be present in the …

Библиометрический и биоинформатический анализ перерождения в многократной миеломе: тенденции и горячих точек исследований и связанные с ними генетические пути (Associated Geneal Pathways)2000-2023).

ЦЕЛЬ: Цель настоящего исследования заключается в проведении библиометрического визуального анализа и биоинформатического анализа для изучения исследовательских горячих точек и тенденций развития почечных расстройств в множестве миелом, включая соответствующие гены и каналы сигнала в прошлом. two десятилетиями. МЕТОДЫ: База данных &quot; Web of Science Core Collection &quot; использовалась в качестве источника данных для извлечения литературы о дефектах почек в множестве миеломы. 2000 в адрес 2023. Выбранная литература была проанализирована с использованием библиометрического и биоинформатическ

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… Hypercalcemia, often a result of increased bone resorption in MM, can lead to nephrocalcinosis and acute kidney injury (AKI). …

Improving Kidney Disease Care: One Giant Leap for Nephrology.

Nephrology is an ever-evolving field of medicine. The importance of such a discipline is related to the high clinical impact of kidney disease. In fact, abnormalities of kidney function and/or structure are common in the general population, reaching an overall prevalence of about 10%. More importantly, the onset of kidney damage is related to a strikingly high risk of cardiovascular events, mortality, and progression to kidney failure which, in turn, compromises quality and duration of life. Attempts to comprehend the pathogenesis and molecular mechanisms involved in kidney disease occurrence

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… Rare Nephrolithiasis (High-Grade Evidence) Primary Hyperoxaluria (PH) is a rare autosomal-recessive disorder characterized by abnormal liver production of oxalate, leading to hyperoxaluria, nephrolithiasis, and nephrocalcinosis, with subsequential progressive kidney failure and systemic oxalosis. …

Hypophosphatasia.

Hypophosphatasia (HPP) is an inherited metabolic disease caused by loss-of-function mutations in the tissue non-specific alkaline phosphatase (TNAP) gene. Reduced activity of TNAP leads to the accumulation of its substrates, mainly inorganic pyrophosphate and pyridoxal-5'-phosphate, metabolic aberrations that largely explain the musculoskeletal and systemic features of the disease. More than 400 ALPL mutations, mostly missense, are reported to date, transmitted by either autosomal dominant or recessive mode. Severe disease is rare, with incidence ranging from 1:100,000 to 1:300,000 live births

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… In addition, the combination of high calcium levels in serum and urine explains the nephrocalcinosis seen in many perinatal cases, which may jeopardize renal function. …

The Onco-Nephrology Field: The Role of Personalized Chemotherapy to Prevent Kidney Damage.

In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic dissemination) or by chemotherapy, as it is potentially nephrotoxic. Kidney damage can manifest as acute kidney injury or represent a worsening of pre-existing chronic kidney disease. In cancer patients, physicians should try to set preventive strategies

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… In the presence of TLS, the AKI onset is due to a combination of inflammatory tubular injury, acute uric acid nephropathy and acute nephrocalcinosis [ 10 ]. 7. …

Storage diseases with hypertrophic cardiomyopathy phenotype.

Never judge a book by its cover, nor assume hypertrophic cardiomyopathy (HCM) as sarcomeric, as appearances can deceive. HCM phenocopies account for a 5-10% of the cases, mainly represented by storage diseases, flagged by the increasing prevalence of senile cardiac amyloid in developing countries. Multisystemic and heterogeneous presentation of these entities is a challenge for clinicians, and time delay in diagnosis is a major concern. Promising drugs and gene-specific tailored therapies are under development, therefore, more than ever, appropriate understanding of these conditions is mandato

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… Urolithiasis, nephrocalcinosis and progressive renal failure, complete the rest of this syndrome’s picture 46 . 2 Intracellular deposit storage diseases There are more than 50 lysosomal storage disorders described 47 . …

Review of oncological emergencies in small animal patients.

Oncological emergencies can occur at any time during the course of a malignancy and need to be recognized promptly to maximize successful outcomes. Emergencies are characterized as chemotherapy-induced, paraneoplastic syndromes, or directly related to the neoplasm. Prompt identification with treatment of these emergencies can prolong survival and improve quality of life, even in the setting of terminal illness. This review aims to educate the reader on the pathophysiology, clinical presentation and treatment of some of these emergencies, and to review the current veterinary literature to help

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… Subsequent azotaemia can be worsened by acute tubular necrosis from the toxic effects of calcium on renal epithelium, nephrocalcinosis and tubulointerstitial inflammation (Scheck et al . 2011 ). …