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Potential drug development and therapeutic approaches for clinical intervention in COVID-19.

While the vaccination is now available to many countries and will slowly dissipate to others, effective therapeutics for COVID-19 is still illusive. The SARS-CoV-2 pandemic has posed an unprecedented challenge to researchers, scientists, and clinicians and affected the wellbeing of millions of people worldwide. Since the beginning of the pandemic, a multitude of existing anti-viral, antibiotic, antimalarial, and anticancer drugs have been tested, and some have shown potency in the treatment and management of COVID-19, albeit others failed to leave any positive impact and a few also became cont

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… They are Ashwagandha, Guduchi + Pippali Yashtimadhu, and a polyherbal formulation (AYUSH-64). [253] , [254] The compositions of AYUSH-64 are stem bark of Alstonia scholaris , roots of Picrorhiza kurroa , Swertia chirata , and the seed of Caesalpinia crista [255] . … Seed extract of Caesalpinia crista increase antibody production in rats demonstrating favorable immunostimulant properties. It also displayed analgesic, anti-inflammatory, and antipyretic activities [262] , [263] , [264] . …

New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy.

Phytocompounds have been evaluated for their anti-glioblastoma actions for decades, with promising results from preclinical studies but only limited translation into clinics. Indeed, by targeting multiple signaling pathways deregulated in cancer, they often show high efficacy in the in vitro studies, but their poor bioavailability, low tumor accumulation, and rapid clearance compromise their efficacy in vivo. Here, we present the new avenues in phytocompound research for the improvement of glioblastoma therapy, including the ways to enhance the response to temozolomide using phytochemicals, th

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… Sixteen diterpenoids isolated from the aboveground parts of Caesalpinia pulcherrima (L.) were studied by Chen et al. [ 87 ]. … Cassane Diterpenoids from the Aerial Parts of Caesalpinia pulcherrima and Their Antibacterial and Anti-Glioblastoma Activity. Phytochemistry. 2022;196:113082. doi: 10.1016/j.phytochem.2021.113082. 88. Hua D., Zhao Q., Yu Y., Yu H., Yu L., Zhou X., Wang Q., Sun C., Shi C., Luo W., et al. …

Pharmacological Therapies for the Management of Inflammatory Bone Resorption in Periodontal Disease: A Review of Preclinical Studies.

Periodontitis, a highly prevalent multicausal chronic inflammatory and destructive disease, develops as a result of complex host-parasite interactions. Dysbiotic bacterial biofilm in contact with the gingival tissues initiates a cascade of inflammatory events, mediated and modulated by the host's immune response, which is characterized by increased expression of several inflammatory mediators such as cytokines and chemokines in the connective tissue. If periodontal disease (PD) is left untreated, it results in the destruction of the supporting tissues around the teeth, including periodontal li

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… Caesalpinia toxic plant genus in the legume family Caesalpiniaceae; contains tannins; causes vomiting, diarrhea. Includes C. gilliesii . Called also bird of paradise tree. caesarean [ s -za′re- n ] cesarean . CAEV caprine arthritis–encephalitis virus. …

Навигатор биомаркеров человека.

Биомаркеры играют ключевую роль в современных исследованиях медицины, особенно в ранней диагностике заболеваний и персонализированном лечении. Несмотря на то, что предыдущие исследования систематически обзоры маркеров в различных областях заболеваний, интегрированная система, которая связывает основные физиологические системы, охватывает множество органов и охватывает широкий спектр заболеваний, все еще отсутствует. В контексте современных вызовов здоровья, характеризующихся высокой распространенностью хронических заболеваний и широкими сопутствующими заболеваниями, создание панорамной системы