Результаты поиска

Safety, tolerability, pharmacokinetics, and antimalarial efficacy of a novel Plasmodium falciparum ATP4 inhibitor SJ733: a first-in-human and induced blood-stage malaria phase 1a/b trial.

BACKGROUND: (+)-SJ000557733 (SJ733) is a novel, orally bioavailable inhibitor of Plasmodium falciparum ATP4. In this first-in-human and induced blood-stage malaria phase 1a/b trial, we investigated the safety, tolerability, pharmacokinetics, and antimalarial activity of SJ733 in humans. METHODS: The phase 1a was a single-centre, dose-escalation, first-in-human study of SJ733 allowing modifications to dose increments and dose-cohort size on the basis of safety and pharmacokinetic results. The phase 1a took place at St Jude Children's Research Hospital and at the University of Tennessee Clinica…

National Toxic Substances Incidents Program - Nine States, 2010-2014.

PROBLEM/CONDITION: Every year in the United States, thousands of toxic substance incidents harm workers, first responders, and the public wi … ticipated in NTSIP surveillance: California, Louisiana, North Carolina, New York, Missouri, Oregon, Tennessee, Utah, and Wisconsin. The states conducted surveillance on acute toxic substance incidents, defined as an uncontrolled or illegal acute (lasting <72 hours) release of any toxic substance including chemical, biologic, radiologic, and medical material …

Population-Based Active Surveillance for Culture-Confirmed Candidemia - Four Sites, United States, 2012-2016.

PROBLEM/CONDITION: Candidemia is a bloodstream infection (BSI) caused by yeasts in the genus Candida. Candidemia is one of the most common health care-associated BSIs in the United States, with all-cause in-hospital mortality of up to 30%. PERIOD COVERED: 2012-2016. DESCRIPTION OF SYSTEM: CDC's Emerging Infections Program (EIP), a collaboration among CDC, state health departments, and academic partners that was established in 1995, was used to conduct active, population-based laboratory surveillance for candidemia in 22 counties in four states (Georgia, Maryland, Oregon, and Tennessee) with …

Community wide interventions for increasing physical activity.

BACKGROUND: Multi-strategic community wide interventions for physical activity are increasingly popular but their ability to achieve populat … ealth, Queensland University of Technology, the University of Central Queensland; the University of Tennessee and Washington University; and handsearched six relevant journals. The searches were last updated to the end of November 2009 and were not restricted by language or publication status. SELECTION CRITERIA: Cluster randomised controlled trials, rando …

High-grade B-cell Lymphoma With MYC Rearrangement and Without BCL2 and BCL6 Rearrangements Is Associated With High P53 Expression and a Poor Prognosis.

Patients with MYC/BCL2 double-hit lymphoma (DHL) are known to have an aggressive clinical course and to respond poorly to various therapies including intensive chemotherapy and stem cell transplant. Less is known about high-grade B-cell lymphoma with MYC rearrangement without concomitant BCL2 and BCL6 rearrangement, designated here as single-hit lymphoma (SHL). In this study, we assessed 61 cases of SHL and compared them with 83 cases of DHL, all confirmed by MYC, BCL2, and BCL6 fluorescence in situ hybridization studies. Although many clinicopathologic features overlap between patients with S

Implementation of a model integrating primary and oncology pharmacists' care for patients taking oral anticancer agents (OAA).

Improvements in chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), and multiple myeloma (MM) treatment options have increased the 5-year survival rates for patients with these hematologic malignancies. In addition to cancer management, these patients may need help to manage multiple chronic conditions (MCC). The overall objective of this study is to examine the impact and implementation of a model that coordinates care between oncology and primary care pharmacists for people taking an oral anti-cancer agent (OAAs) and medications for comorbid chronic conditions. This is a mult

Совпадение в полном тексте источника
… Our conflicts of interest include the funding of this study by AstraZeneca, with an independent investigator grant to the University of Tennessee Center for Health Sciences. … Acknowledgements Funding: This work was supported by a grant from Astra Zeneca to the University of Tennessee Center for Health Sciences, Nashville, TN, with subawards to the University of Michigan and Vanderbilt University. …

2018 ACVIM Forum Research Report Program. Seattle, Washington, June 14 - 16, 2018.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Sommardahl 4 1 Equine Health Studies Program, Department of Veterinary Clinical Sciences, LSU, Baton Rouge, LA, USA, 2 University of Tennessee, College of Veterinary Medicine, Knoxvile, TN, USA, 3 Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, VA, USA, 4 University of Tennessee … , Knoxville, TN, USA, 2 Fayetteville Animal Clinic, Knoxville, TN, USA, 3 University of Tennessee College of Veterinary Medicine, knoxville, TN, USA, 4 University of Tennessee Institute of Agriculture, Knoxville, TN, USA The objective of this study was to observe the effect of extended meloxicam (NSAID …

Dynamic Field Theory of Executive Function: Identifying Early Neurocognitive Markers.

In this Monograph, we explored neurocognitive predictors of executive function (EF) development in a cohort of children followed longitudina … began in February 2019 and was completed in April 2022 on the Knoxville campus of the University of Tennessee. Our cohort included 20 children (13 female) all of whom were White (not Hispanic/Latinx) from an urban area in southern United States, and the sample annual family income distribution ranged from low to high (most families falling between $40,000 a …

Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years - Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022.

PROBLEM/CONDITION: Autism spectrum disorder (ASD). PERIOD COVERED: 2022. DESCRIPTION OF SYSTEM: The Autism and Developmental Disabilities Monitoring Network is an active surveillance program that estimates prevalence and characteristics of ASD and monitors timing of ASD identification among children aged 4 and 8 years. In 2022, a total of 16 sites (located in Arizona, Arkansas, California, Georgia, Indiana, Maryland, Minnesota, Missouri, New Jersey, Pennsylvania, Puerto Rico, Tennessee, Texas [two sites: Austin and Laredo], Utah, and Wisconsin) conducted surveillance for ASD among children a…

Surveillance for Sickle Cell Disease - Sickle Cell Data Collection Program, Two States, 2004-2018.

PROBLEM/CONDITION: Sickle cell disease (SCD), an inherited blood disorder affecting an estimated 100,000 persons in the United States, is as … . In 2019, nine states (Alabama, California, Georgia, Indiana, Michigan, Minnesota, North Carolina, Tennessee, and Virginia) were funded as part of an SCDC capacity-building initiative. The newly funded states developed strategies for SCD case identification and data linkage similar to those used by California and Georgia. As of 2021, the SCDC program had e …

Prospective and Multicenter Evaluation of Outcomes for Quality of Life and Activities of Daily Living for Balloon Kyphoplasty in the Treatment of Vertebral Compression Fractures: The EVOLVE Trial.

BACKGROUND: Osteoporotic and neoplastic vertebral compression fractures (VCF) are common and painful, threatening quality of life and increasing risk of morbidity and mortality. Balloon kyphoplasty is a percutaneous option for treating painful cancer- and osteoporosis-related VCFs, supported by 2 randomized trials demonstrating efficacy benefits of BKP over nonsurgical care. OBJECTIVE: To investigate 12-mo disability, quality of life, and safety outcomes specifically in a Medicare-eligible population, representing characteristic patients seen in routine clinical practice. METHODS: A total of

Совпадение в полном тексте источника
… An inflatable bone tamp (IBT) is inserted through each cannula into the vertebral body and inflated using radiopaque contrast and a pressure-measuring device (Kyphon Xpander I or II IBTs, Medtronic, Memphis, Tennessee). … The IBT(s) is deflated, removed, and the void created within the vertebral body is filled with viscous polymethylmethacrylate (Kyphon HV-R or Xpede, Medtronic, Memphis, Tennessee) bone cement. 11-14 Outcomes The primary objective was to show statistically significant improvement from baseline in 4 …

ASENT 2022 Annual Meeting.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Center; Ying Yu, Department of Pharmaceutical Sciences and Drug Discovery Center, Department of Neurobiology and Neuroscience Institute, The University of Tennessee Health Science Center; Jianxiong Jiang, Department of Pharmaceutical Sciences and Drug Discovery Center, Department of Neurobiology and … Neuroscience Institute, The University of Tennessee Health Science Center Abstract Background and hypothesis: The association between neuroinflammation and symptomatic cognitive impairments following acute brain injuries warrants more intense interrogations; Meanwhile, the relevant implications of …

Development and characterization of chimeric antigen receptor macrophages for amyloid clearance.

Systemic amyloidosis is a protein folding disorder characterized by the extracellular deposition of protein fibrils in tissues and vital organs, leading to dysfunction and mortality. While there are monoclonal antibody-based therapies that promote cell-mediated amyloid clearance in various stages of clinical development, there are currently no treatment options which focus on reducing the tissue amyloid burden. Therefore, the urgent need for a transformative approach to facilitate amyloid clearance and restore organ function remains paramount. We demonstrate that a short, polybasic peptide (p5

Совпадение в полном тексте источника
… The use of human-derived materials was approved by the University of Tennessee Health Science Center, College of Medicine-Knoxville Institutional Review Board. Staining for CAR expression using microscopy THP-1 and CAR-M cells (~7*10 5 /ml) were plated in 35 mm glass culture dishes (Cellvis). … Confocal microscopy was performed at the Advanced Microscopy & Imaging Center (AMIC) at the University of Tennessee, Knoxville, using a Leica SP8 or Stellaris White Light Laser confocal microscope. …

Strongyloides stercoralis hyperinfection after corticosteroid therapy: a report of two cases.

Two cases of Strongyloides stercoralis hyperinfection are described. Both patients were expatriates from the Indian subcontinent, and reported the use of corticosteroids. The first patient presented with severe pulmonary disease that necessitated respiratory support, followed by acute abdomen and intestinal obstruction and he succumbed to these diseases. The second patient also presented with acute pulmonary disease, which responded to antihelmintic treatment and supportive care; however, he died later due to his primary disease. The clinical features of S stercoralis hyperinfection are nonspe

Совпадение в полном тексте источника
… 2201067 10.1093/clinids/12.4.653 6 Rogers WA Jr Nelson B Strongyloidiasis and malignant lymphoma: “Opportunistic infection” by a nematode JAMA 1966 195 685 7 5951773 7 Berk SL Verghese A Alvaresz S Hall K Smith B Clinical and epidemiologic features of strongyloidiasis: A prospective study in rural Tennessee …

Эпидемиология множественного склероза: глобальные, региональные, национальные и субнациональные оценки и будущие прогнозы.

ИСТОРИЯ ВОПРОСА: Эпидемиология множественных склерозов (МС) является сложной в силу взаимодействия различных факторов риска. В настоящем исследовании дается оценка глобального, регионального, национального и субнационального бремени НР и прогнозируются будущие тенденции. МЕТОДЫ: Данные, полученные в ходе глобального исследования бремени болезней 2021 был проанализирован с целью оценки эпидемиологии MS 1990 в адрес 2021. Данные Всемирного банка использовались для определения социально-демографических прогнозов распространенности НР с использованием многовариантного анализа. РЕЗУЛЬТАТЫ: НА глоба

Совпадение в полном тексте источника
… Montana 4.96 5.25 5.8 Rhode Island 4.38 5.15 17.4 Wyoming 4.40 5.08 15.6 Idaho 4.57 4.93 8.0 Colorado 4.46 4.73 6.1 Michigan 4.26 4.55 6.8 New Hampshire 4.34 4.48 3.3 South Dakota 4.05 4.45 10.0 Washington 4.45 4.45 0.1 Wisconsin 4.44 4.44 0.1 Vermont 4.15 4.40 6.0 States with the lowest rates Tennessee …