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Longitudinal symptom network patterns in cancer patients during the end of life.

Patients with cancer at the end of life experience a wide range of distressing physical and psychological symptoms, which often interact and intensify each other. Understanding how these symptoms are connected is essential for improving quality of life and providing effective palliative care. This study analyzed data from 26,318 medical visits of 8,026 patients receiving palliative care, focusing on symptom interactions during the final months of life. Symptom networks were estimated using the Ising Model across six time periods prior to death, with centrality measures used to identify key sym

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… Their network analysis revealed that anhedonia (loss of pleasure) was the most central symptom. Sleep disturbances, fatigue, suicidal thoughts, feelings of worthlessness, and depressed mood were among the symptoms closely related to each other and to anhedonia. …

Алекситимия и привязанность к психическому здоровью людей с множественным склерозом: посредническая роль воспринимаемой социальной поддержки и одиночества.

Множественный склероз и его прогрессивный релапсирующий характер для пациентов с НР сопряжены с трудностями и оказывают значительное воздействие на психическое здоровье людей с НР. Мы изучили прямое воздействие алекситимии и привязанности на психическое здоровье и косвенное воздействие привязанности, алекситимии, одиночества и воспринимаемой социальной поддержки на психическое здоровье людей с MS. МАТЕРИАЛЫ И МЕТОДЫ: Триста сорок пять диагностированных множественных склерозов (MS) были признаны приемлемыми для включения в исследование и отобраны через Иранскую ассоциацию MS. К числу таких мер

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… 2020) showed that there is a relationship between alexithymia and mental health problems in MS patients.[ 60 ] Our study is in line with previous research, which showed that the mental health of alexithymic MS patients stems from their tendency toward alexithymia and their inclination to experience anhedonia …

[Iron deficiency: A diagnostic and therapeutic perspective in psychiatry].

BACKGROUND: Iron plays an essential role in balancing the various metabolism in the body. It is also involved in the synthesis of several ne … ter synthesis-promoting action - in hyperemotivity, anxiety, irritability, aggressiveness, sadness, anhedonia, apathy, asthenia, sleep disorders, dysautonomia symptoms, eating disorders, restless-leg syndrome, cognitive performance and the likelihood of resorting to psychiatric admission. A daily elemental iron dose intake between 50 and 200mg/day by defici …

[A rare and not very studied disorder: childhood-onset schizophrenia. A case report].

UNLABELLED: Childhood-onset schizophrenia is rare: its prevalence is about 50 times lower than the one observed in adulthood. It is also fre … ng catatonic rigidity and negativism and bizarre postures) was also observed. Negative symptoms (eg anhedonia, affective flattening, and alogia) were noted. Her IQ scores were 74 in the verbal subtests and 53 in the performance subtests. Because the diagnostic of childhood-onset schizophrenia was suspected, a neuroleptic treatment, haloperidol 3 mg/day, was …

Advancing Palliative Care Integration in Hematology: Building Upon Existing Evidence.

Opinion statementPatients with hematologic malignancies and their families are among the most distressed of all those with cancer. Despite high palliative care-related needs, the integration of palliative care in hematology is underdeveloped. The evidence is clear that the way forward includes standard-of-care PC integration into routine hematologic malignancy care to improve patient and caregiver outcomes. As the PC needs for patients with blood cancer vary significantly by disease, a disease-specific PC integration strategy is needed, allowing for serious illness care interventions to be ind

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… The prolonged, socially isolating hospitalizations are associated with decreased patient-reported QOL, elevated levels of anxiety, and depressive symptoms including pronounced anhedonia [ 113 ]. … The impact of pretransplantation anhedonia on quality of life and fatigue in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant [Internet] 2020;26(8):1477–1481. doi: 10.1016/j.bbmt.2020.04.014. 114. Jim HSL, Sutton SK, Jacobsen PB, Martin PJ, Flowers ME, Lee SJ. …

Student Summer Research Awards - SSRAAbstracts of the SSRA September 2022 meeting, UCD School of Medicine.

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… Anhedonia was evaluated using the Snaith-Hamilton Pleasure Scale (SHAPS). Repeated measures ANOVA and mixed ANOVA tests with Bonferroni post hoc testing were performed to assess changes in anhedonic symptoms. … These preliminary findings suggest an association between cannabis abstinence and improvements in anhedonia. Reference De Fruyt J, Sabbe B, Demyttenaere K. Anhedonia in depressive disorder: A narrative review. Psychopathology. 2020;53(5-6):274–81. …

Мультикорректный перекрестный анализ показывает механизмы заболеваний и лечебные цели HTLV-1-associated Миэлопатия, забытое нейро-воспалительное расстройство.

HTLV-1 это загадочный ретровирус, вызывающий изнурительное нервно-воспалительное заболевание, HTLV-1-associated Миэлопатия (HAM) с неизвестным патогенезом. Обе HTLV-1 Инфекция и ХАМ затрагивают главным образом женщин и небелые группы населения, которым не уделяется должного внимания. HAM не имеет лечения, которое могло бы привести к изменению болезней, поскольку нынешнее лечение в основном является симптоматическим и вдохновляет либо HIV-1 или множественные терапевтические стратегии склероза. Мы использовали системный биологический анализ новых и общедоступных данных, включая (эпи)геномику, тр

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… Phenome-wide screening in the UK Biobank ( Fig. 2E ) identified monocyte count as the top hit, alongside associations with broad neurological phenotypes (alcohol use related traits, anhedonia and depression) and neurocognitive skills (Snap-button test for reaction time). …

IGF-1 defends against chronic-stress induced depression in rat models of chronic unpredictable mild stress through the PI3K/Akt/FoxO3a pathway.

This study aims to investigate the role of IGF-1 in chronic-stress induced depression through the PI3K/Akt/FoxO3a pathway. A rat model of chronic unpredictable mild stress (CUMS) was established. In total, 48 rats were randomized into control (normal rats), CUMS (CUMS modeled rats) and CUMS + IGF-1 (injection of IGF-1 before CUMS modeling) groups. Body weight, horizontal (number of horizontal crossing) and vertical activity (rearing times), and sucrose consumption were identified one day before and after the open-field test. The mRNA and protein expression of PI3K, Akt, FoxO3a and Bim in the h

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… In 1987, Willner et al. established the rodent CUMS model in order to induce anhedonia‐like behavioral change (including inability to experience pleasure), which was a major symptom of human depression [20] . Chronic stress is a major risk factor for depression [5] . …

Psychometric Properties of the Depression Anxiety Stress Scales (DASS-42 and DASS-21) in Patients with Hematologic Malignancies.

Background/Objectives: Patients with hematologic malignancies undergo prolonged, intensive treatments involving frequent hospitalizations and experience debilitating side effects. Consequently, they are at increased risk of developing symptoms of depression, anxiety, and stress, which can undermine their quality of life. However, there is a scarcity of instruments validated for the simultaneous assessment of depression, anxiety, and stress within hematologic cancer populations. The aim of this study is to examine the construct validity, convergent and discriminant validity, and reliability of

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… The depression subscale assesses the presence and severity of depressive symptoms, including self-deprecation, lack of interest in daily activities, inertia, hopelessness, dysphoria, devaluation of life, and anhedonia. … For example, these changes were measured in the depression subscale with anhedonia (loss of interest or pleasure in daily activities) and inertia (feeling slowed down or lacking energy), which can also be related to anxiety and stress symptoms. …

Pharmacological and non-pharmacological treatments for impulsive-compulsive behaviors in Parkinson's disease.

RATIONALE: Impulsive-compulsive behaviors (ICBs) in Parkinson's disease are associated with psychiatric comorbidities, reduced quality of li … t outcomes were change in: quality of life, neuropsychiatric symptoms (depression, anxiety, apathy, anhedonia), impulsivity, cognition, motor and non-motor symptoms associated with ICBs in Parkinson's disease. RISK OF BIAS: We used the revised Cochrane risk of bias tool for randomized trials (RoB 2) for outcomes reported in the summary of findings tables. …

МРТ корреляции депрессии и тревоги при множественном склерозе.

Множественный склероз (MS) является нейродегенеративным и хроническим воспалительным заболеванием, которое часто ассоциируется с психиатрической коморбидией, особенно депрессией и тревогой, которые играют важную роль в инвалидности, когнитивной дисфункции и качестве жизни. Растущие данные свидетельствуют о том, что симптомы воздействия в MS связаны не только с психосоциальным бременем, но и со структурными и функциональными аномалиями в мозге, которые могут быть выявлены с помощью магнитного резонансного изображения (MRI). МЕТОДЫ: Был проведен систематический поиск базы данных в целях выявлени

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… This leads to core depressive features such as apathy and anhedonia. From a clinical perspective, it was noteworthy that anhedonia linked to pallidal dysfunction may be, at least partially, reversible through dopaminergic modulation [ 78 ]. …

Why do patients with cancer die?

Cancer is a major cause of global mortality, both in affluent countries and increasingly in developing nations. Many patients with cancer experience reduced life expectancy and have metastatic disease at the time of death. However, the more precise causes of mortality and patient deterioration before death remain poorly understood. This scarcity of information, particularly the lack of mechanistic insights, presents a challenge for the development of novel treatment strategies to improve the quality of, and potentially extend, life for patients with late-stage cancer. In addition, earlier depl

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… Intriguingly, anhedonia – a lack of ability to experience pleasure – occurs in many patients ( 91 ). The mechanistic causes of this are unclear, but it is not restricted to patients with brain metastasis suggesting that circulating systemic factors may play a role. … Anhedonia and depression are frequent in cancer patients, impacting their overall well-being, treatment adherence, and outcomes including mortality ( 98 ). These psychological challenges often intertwine with physical symptoms, compounding the burden of each ( 99 ). …

The habenula as a novel link between the homeostatic and hedonic pathways in cancer-associated weight loss: a pilot study.

BACKGROUND: Little is known about the brain mechanisms underlying cancer-associated weight loss (C-WL) in humans despite this condition negatively affecting their quality of life and survival. We tested the hypothesis that patients with C-WL have abnormal connectivity in homeostatic and hedonic brain pathways together with altered brain activity during food reward. METHODS: In 12 patients with cancer and 12 healthy controls, resting-state functional connectivity (RSFC, resting brain activity observed through changes in blood flow in the brain which creates a blood oxygen level-dependent signa

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… In this particular study, fMRI based on https://en.wikipedia.org/wiki/Blood-oxygen-level_dependent signals were analysed while the patients perceived pleasant and unpleasant food pictures based on a food preference questionnaire provided to patients. 41 , 42 Generalized anhedonia has been reported in …

Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications.

Omega-3 polyunsaturated fatty acids (PUFAs) are considered immunonutrients and are commonly used in the nutritional therapy of cancer patients due to their ample biological effects. Omega-3 PUFAs play essential roles in cell signaling and in the cell structure and fluidity of membranes. They participate in the resolution of inflammation and have anti-inflammatory and antinociceptive effects. Additionally, they can act as agonists of G protein-coupled receptors, namely, GPR40/FFA1 and GPR120/FFA4. Cancer patients undergo complications, such as anorexia-cachexia syndrome, pain, depression, and p

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… Corroborating these data, Aizawa et al. (2016) demonstrated that FFA1 knockout mice exhibited augmented anhedonia and altered levels of serotonin, dopamine, and noradrenaline in the hippocampus [ 138 ]. Similar effects were observed in FFA1 knockout female mice. … In addition to the increased anhedonia, female mice presented reduced maternal care, such as negligence and infanticide; reduced locomotor activity; and decreased social interaction [ 139 ]. …

Psychosocial Functioning, Quality of Life, Depressive Symptoms, and Meaning in Life in Older Adults with Multiple Myeloma: A Cross-Sectional Study.

(1) Background: Older adults with multiple myeloma (MM) contend with multifaceted physical, psychological, and existential challenges that may compromise quality of life (QoL). This study examined associations between physical symptom burden, functional capacity, depression severity, meaning in life, and QoL in older adults with MM. (2) Methods: Fifty outpatients (mean age = 67.7 ± 8.8 years) completed the EORTC QLQ-C30, PHQ-9, and Meaning in Life Questionnaire (MLQ). QoL was the primary outcome. Secondary outcomes included physical symptom burden (fatigue and pain), functioning domains, depre

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… Additional factors like limited understanding or acceptance of the prognosis, personal and financial concerns, as well as family strain and anhedonia, emerged as common stressors that added a burden to MM [ 7 , 8 ]. …

Assessment of depression symptoms among cancer patients: a cross-sectional study from a developing country.

Cancer patients experience psychological symptoms such as depression during the cancer treatment period, which increases the burden of symptoms. Depression severity can be assessed using the beck depression inventory (BDI II). The purpose of the study was to use BDI-II scores to measure depression symptoms in cancer patients at a large tertiary hospital in Palestine. A convenience sample of 271 cancer patients was used for a cross-sectional survey. There are descriptions of demographic, clinical, and lifestyle aspects. In addition, the BDI-II is a tool for determining the severity of depressio

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… Many of the symptoms needed to diagnose depression are often caused by cancer treatments (e.g. chemotherapy, biological therapy), such as fatigue, weight loss, anhedonia (the inability to feel pleasure in typically enjoyable activities) and psychomotor retardation. …

Content validation of the EORTC QLQ-C15-PAL with advanced cancer patients and health care professionals from palliative care services in Chile.

BackgroundThe assessment of patients' quality of life (QOL) is essential when evaluating the outcome of palliative care; however, no instruments have been validated for measuring symptoms and QOL in patients receiving palliative care in Chile. We aimed to investigate the content validity of the EORTC Quality of Life Questionnaire Core 15 Palliative Care (QLQ-C15-PAL), replicating the methods used previously to shorten the EORTC Quality of Life Questionnaire Core 30 (QLQ-C30) for use among patients in palliative care.MethodsThis cross-sectional study was conducted from October to November 2017

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… . | HCPs Satisfaction with care | 8 | 4 Satisfaction with health care professionals, satisfaction with the information received, adherence to treatment, effectiveness of medication and side effects | | Emotions | 5 | 7 Role loss, mood changes, sadness, anhedonia, fear | | Psychological support | …

Pain, Fatigue, Nausea, and Vomiting as the Predictors of Anxiety in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study.

The primary outcome was to assess the correlation between anxiety and pain, fatigue, nausea, and vomiting. The secondary outcome was to determine the predictive roles of pain, fatigue, nausea, and vomiting in anxiety among patients undergoing Hematopoietic Stem Cell Transplantation (HSCT). The present prospective cohort study was conducted on 200 patients treated by HSCT referred to the centers affiliated to Shiraz University of Medical Sciences. The data were collected using Spielberger Anxiety Questionnaire, Numerical Pain Scale, Brief Fatigue Inventory, and Rhodes Nausea and Vomiting Index.

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… The Impact of Pre-transplant Anhedonia on Quality of Life and Fatigue in Hematopoietic Stem Cell Transplantation Biol Blood Marrow Transplant 2020 26 1477 1481 10.1016/j.bbmt.2020.04.014 32407882 17. …

Деменция, расстройства настроения и старение.

С повышением возраста и продолжительности жизни в мире как в развитых, так и в развивающихся странах риск развития когнитивных потерь и расстройств настроения значительно возрастает в той мере, в какой после достижения возраста 65, этот риск почти удваивает каждый 5 Спустя годы. В результате, соответствующий рост неинфекционных заболеваний поразит людей со слабоумием и расстройствами настроения, связанными с болезнью Альцгеймера, множественным склерозом, депрессией и тревогой. На клинической основе многочисленные факторы риска и представления, которые связаны с утратой интеллектуальных способн

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… 122 – 124 Preservation of cognitive function through mitochondrial activation appears to be dependent, at least in part, on GLP-1 receptor activation 5 , 13 , 20 , 93 as well as on the presence of APOE for the maintenance of neuronal synaptic function. 11 , 125 Experimental models of depression, anhedonia …

Exploring novel therapeutic strategies: Could psychedelic perspectives offer promising solutions for Alzheimer's disease comorbidities?

The increasing prevalence of dementia within an ageing global population, combined with prolonged life expectancy, accentuates Alzheimer's disease (AD) as a multifaceted healthcare challenge. This challenge is further compounded by the limited therapeutic options currently available. Addressing the intricacies of AD management, the mitigation of comorbidities has emerged as a pivotal facet of treatment. Comorbid conditions, such as neurobehavioral symptoms, play a role in shaping the clinical course, management, and outcomes of this pathology; highlighting the importance of comprehensive care

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… Furthermore, psilocybin has been found to mitigate stress-induced anhedonia, indicated by increased preference for sucrose and heightened responsiveness in female urine sniffing tests (Hesselgrave et al. 2021 ). …