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Effects of TTP-PECS Block Under Opioid-Sparing General Anesthesia on Postoperative Analgesia and Early Recovery Quality in Patients Undergoing Modified Radical Mastectomy.

INTRODUCTION: Potent analgesics such as sufentanil and remifentanil play a pivotal role in general anesthesia, but these medications have disadvantages, including respiratory depression, nausea, vomiting, immune system suppression, and gastrointestinal function inhibition. This study aimed to evaluate the effects of the transversus thoracic muscle plane-pectoral nerves (TTP-PECS) block on postoperative analgesia, immune function and early postoperative recovery quality in patients undergoing modified radical mastectomy under opioid-sparing general anesthesia. METHODS: A total of 100 patients …

Effect of propofol combined with remimazolam besylate on blood pressure during general anesthesia induction in patients undergoing gynecological laparoscopic surgery: single-centre randomized controlled trial.

BACKGROUND: Hypotension often occurs during intraoperative anesthesia induction in gynecological laparoscopic surgery. Remimazolam is report … /kg, and rocuronium bromide 0.8 mg/kg; the anesthesia was maintained with propofol 4-10 mg/kg/h and remifentanil 0.1-0.3 μg/kg/min. The primary outcome was the incidence of hypotension after anesthesia induction. Hypotension was defined as a mean arterial pressure (MAP) reduced 30% or more from the baseline MAP value or MAP < 65 mmHg. Blood pressure was record …

Electroencephalogram-guided anesthesia and postoperative anxiety and depression in elderly gastric cancer patients with sleep disorders.

BACKGROUND: Preoperative sleep disorders are common in elderly gastric cancer patients and may increase the risk of postoperative anxiety an … ced anesthetic drug consumption (propofol: 5.8 ± 1.2 mg/kg/hour vs 7.3 ± 1.4 mg/kg/hour, P < 0.001; remifentanil: 0.18 ± 0.04 μg/kg/minute vs 0.24 ± 0.05 μg/kg/minute, P < 0.001) and achieved 18.6% cost reduction. Primary outcomes showed the EEG group had significantly lower postoperative anxiety and depression scores at 3 days (HADS total: 11.8 ± 3.7 vs 15.9 …

The esketamine-based multimodal low-opioid anaesthesia improves quality of recovery in elderly patients undergoing radical lung cancer surgery: a randomized controlled trial.

BACKGROUND: The elderly population experiences diminished physiological function and reduced tolerance to surgery and anesthesia. This study … tamine group exhibited a significant reduction in perioperative opioid requirement (sufentanil plus remifentanil: 25 ± 4.62 ug vs. 38 ± 8.60 ug; 2.1 ± 0.35 mg vs. 2.5 ± 0.72 mg, p < 0.001) and propofol consumption (866.56 ± 76.44 mg vs. 968.36 ± 68.87 mg, p < 0.001). Esketamine provides dynamic and bidirectional regulation of blood pressure throughout differen …

Clevidipine for controlled hypotension during spinal surgery in adolescents.

INTRODUCTION: Clevidipine is an ultra-shorting acting, intravenous calcium channel antagonist of the dihydropyridine class. Metabolism by bl … . Propofol was started at 100 microg/kg/min and titrated to maintain the bispectral index at 40-60. Remifentanil was started at 0.1 microg/kg/min and increased up to 0.3 microg/kg/min as needed to control MAP. If the MAP was > or = 65 mmHg, clevidipine was added to maintain the MAP at 50-65. The clevidipine infusion was started at 0.5-1 microg/kg/min and incre …

Effect of co-administration of intravenous lidocaine and dexmedetomidine on the recovery from laparoscopic hysterectomy: a randomized controlled trial.

BACKGROUND: Some evidences have reported that intravenous lidocaine and dexmedetomidine alone can improve the quality of recovery after surg … quality of recovery-40 (QoR-40) scores on postoperative day 1 (POD1). The quality of sleep on POD1, remifentanil total dose, visual analog scale (VAS) pain scores, the number of patients with self-press the pump, time to open eye and extubation, length of postanesthesia care unit (PACU) stay, the incidence of intraoperative bradycardia, hypotension, arrhythmia …

[Epidural anesthesia for fetoscopy : Retrospective analysis of a one-year cohort].

BACKGROUND: The introduction of routine prenatal screening using ultrasound has led to a substantial increase in diagnoses of fetal disorder … rognosis and who underwent two separate procedures demanded additional sedation, for which we chose remifentanil. Another patient was hypotensive after intravenous administration of the tocolytic drug atosiban. A stable hemodynamic condition was quickly restored in this patient with administration of cafedrine/theodrenaline and i. v. fluids. All procedures wer …

Резюме МКАРЕ 2023 77th Национальный конгресс &quot; СИААРТИ &quot;

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… In the operating room, after multiparametric monitoring, general anesthesia was induced with propofol in Target Controlled Infusion (TCI) 3 mcg/ml and remifentanil TCI 2 ng/ml. … “Measurement of the nociceptive balance by Analgesia Nociception Index and Surgical Pleth Index during sevoflurane-remifentanil anesthesia.” Minerva Anesth 2015; 81: 480-9. Fig. 1 (abstract A17). …

Effects of different doses of alfentanil on tracheal intubation stress responses in ambulatory hysteroscopic surgery: a randomized, double-blind, clinical comparative study.

BACKGROUND: This randomized, double-blind, clinical comparative study aims to compare the tracheal intubation stress responses of different … art of the standardized induction protocol. Anesthesia maintenance was maintained with propofol and remifentanil in all groups. The primary outcome measure was the plasma norepinephrine (NE) level at 1 min after tracheal intubation (T2). Secondary outcomes included plasma NE and epinephrine (E) levels at baseline (T0, before anesthesia induction), T2 (excludin …

[Esketamine Alleviates Postoperative Depressive Symptoms in Frail Elderly Patients Undergoing Thoracoscopic Radical Resection of Lung Cancer: A Randomized Double-Blind Controlled Trial].

OBJECTIVE: To investigate the effect of esketamine on postoperative depression in frail elderly patients undergoing thoracoscopic radical re … erum NSE were significantly lower at T1 and T2 (P < 0.01); the consumption of propofol, sufentanil, remifentanil, and sevoflurane during surgery in the Esk group was significantly reduced (P < 0.05 or 0.01); the incidence of postoperative nausea/vomiting and hyperalgesia was significantly lower (P < 0.01); the duration of postoperative mechanical ventilation, …

The LiberAction Project: Implementation of a Pediatric Liberation Bundle to Screen Delirium, Reduce Benzodiazepine Sedation, and Provide Early Mobilization in a Human Resource-Limited Pediatric Intensive Care Unit.

Background: Delirium, bed immobilization, and heavy sedation are among the major contributors of pediatric post-intensive care syndrome. Rec … 3 (IQR: 0.53-1.31) vs. 0.74 (IQR: 0.55-1.16), p = 0.0001]. The median cumulative doses of fentanyl, remifentanil, and morphine corrected for the total number of sedation days were lower in the post-implementation period, but these differences were not significant. The median number of mobilizations per patient and the duration of each mobilization significantl …

[Analysis of sugammadex for antagonistic neuromuscular block in patients with radical resection of lung cancer under thoracoscope].

Objective: To investigate the efficacy and safety of sugammadex for antagonistic neuromuscular block in patients with radical resection of lung cancer under thoracoscope. Methods: One hundred patients undergoing radical resection of lung cancer under thoracoscope in Affiliated Cancer Hospital of Zhengzhou University from March to September in 2019, were randomly divided into control group (group C) and sugammadex group (group S). All patients were anaesthetized (induced and maintained) with intravenous target-controlled infusion of propofol and remifentanil, and intermittent intravenous inject…

Upper-limb somatosensory evoked potential monitoring in lumbosacral spine surgery: a prognostic marker for position-related ulnar nerve injury.

BACKGROUND CONTEXT: Somatosensory evoked potential (SSEP) is used to monitor integrity of the brain, spinal cord, and nerve roots during spi … ane) and propofol infusion with and without minimal infusion of narcotics (fentanyl, sufentanyl, or remifentanil). Intraoperative neurophysiologic monitoring of upper-limb or ulnar SSEP was achieved by continuously recording cortical and subcortical responses after alternate stimulation of the ulnar nerve at the wrist. In our institutional protocol, a greater …

Safety and efficacy of low-dose esketamine weakly opioidized anesthesia in elderly patients with lumbar spinal stenosis undergoing surgery: a prospective, double-blind randomized controlled trial.

BACKGROUND: The perioperative use of esketamine may reduce opioid use and their adverse effects. We aimed to evaluate the intraoperative saf … on (T3), at the time of extubation (T4), and 30 min after surgery (T5), intraoperative propofol and remifentanil dosage, and the incidence of adverse reactions within 5 days postoperatively, etc. RESULTS: The cumulative perioperative sufentanil dosage and the number of patients undergoing postoperative PACU remedial analgesia were significantly lower in the HS …

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

Совпадение в полном тексте источника
… heroin or hydrocodone or hydromorphone or ketobemidone or levorphanol or lofentanil or meperidine or meptazinol or methadone or methadyl acetate or morphine or nalbuphine or opium or oxycodone or oxymorphone or pentazocine or phenazocine or phenoperidine or pirinitramide or promedol or propoxyphene or remifentanil … heroin or hydrocodone or hydromorphone or ketobemidone or levorphanol or lofentanil or meperidine or meptazinol or methadone or methadyl acetate or morphine or nalbuphine or opium or oxycodone or oxymorphone or pentazocine or phenazocine or phenoperidine or pirinitramide or promedol or propoxyphene or remifentanil …

The Nimodipine-Sparing Effect of Perioperative Dexmedetomidine Infusion During Aneurysmal Subarachnoid Hemorrhage: A Prospective, Randomized, Controlled Trial.

Background: Nimodipine can block the influx of calcium into the vascular smooth muscle cell and prevent secondary ischemia in patients with … ntly decreased MAP from T5 to T9 compared with group D1 (P < 0.05). The consumption of sevoflurane, remifentanil, dexmedetomidine, and nimodipine were all significantly reduced in groups D1 and D2 during surgery (P < 0.05). Compared with group C, MAP was significantly decreased in groups D1 and D2 during the first 48 h after surgery (P < 0.05). Compared with g …

Pharmacological Treatments and Therapeutic Drug Monitoring in Patients with Chronic Pain.

Pain is an unpleasant sensory and emotional experience that affects every aspect of a patient's life and which may be treated through different pharmacological and non-pharmacological approaches. Analgesics are the drugs most commonly used to treat pain, and in specific situations, the use of opioids may be considered with caution. These drugs, in fact, do not always induce optimal analgesia in patients, and several problems are associated with their use. The purpose of this narrative review is to describe the pharmacological approaches currently used for the management of chronic pain. We rev

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… The literature lacks specific studies on humans; however, one study performed on adolescents undergoing surgery for scoliosis and receiving an intraoperative remifentanil infusion demonstrated that these patients required significantly more postoperative morphine than those receiving intermittent morphine … boluses, suggesting that the remifentanil infusion was associated with the development of acute clinically relevant opioid tolerance or hyperalgesia [ 194 ]. …

[Effect of dexmedetomidine on perioperative stress and postoperative pain in patients with radical resection of esophageal cancer under combined thoracoscope and laparoscope].

Objective: To investigate the effects of dexmedetomidine on perioperative stress and postoperative pain in patients with radical resection o … sthetized (induced and maintained) with intravenous target-controlled infusion(TCl) of propofol and remifentanil, and intermittent intravenous injection of cisatracuriumbesylate. Bispectral index(BIS) was used to monitor the depth of anesthesia and maintained between 45-60 during operation.All patients received sufentanil (0.3 μg/kg) 30 min before the end of t …

Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life.

Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual response to opioid therapy remains a challenge for clinicians. While studies are few, the KCNJ6 gene is a promising target for investigating genetic factors that contribute to pain and analgesia response. This is the first association study on polymorphisms in KCNJ6 and response to methadone for pain management in advanced cancer. Fifty-four adult patients with advanced cancer were recruited across two study sites in a prospective, open lab

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… Elens et al . 22 investigated the association of rs6517442 and opioid requirements (morphine or remifentanil) in 34 preterm infants requiring endotracheal intubation, reporting that those with the AA genotype needed more time to reach a pain-free state after intubation than infants with the AG or GG …

37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3) : Brussels, Belgium. 21–24 March 2017

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