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Сопоставимая смертность в результате пери-трансплантации и распространенность фебриловой нейтропении после высоких доз Мелфалана и автологической трансплантации стволовых клеток у пациентов с плазменными клеточными дискразиями, которые рассматривались как амбулаторные или стационарные.

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… TABLE 2 Stem cell transplantation metrics. a Five outpatients had blood cultures positive for more than one organism. b Gram‐negative organisms other than E. coli include Bacteroides species ( n = 2), Leptotrichia wadei ( n = 1), Capnocytophaga ( n = 1), Pseudomonas aeruginosa ( n = 1), Enterobacter …

Efficacy and safety of endoscopic ultrasound-guided gastrojejunostomy in patients with malignant gastric outlet obstruction and ascites.

Background and study aims  Endoscopic ultrasound-guided gastrojejunostomy (EUS-GJ) is an endoscopic procedure for treating gastric outlet obstruction (GOO). Limited data exist regarding the safety and efficacy of EUS-GJ in patients with malignant GOO with ascites. Thus, we aimed to study the outcomes and safety of EUS-GJ in GOO patients with vs. without ascites. Patients and methods  This is a retrospective cohort study of patients with malignant GOO who underwent successful EUS-GJ at a tertiary care academic center. Primary outcomes included the efficacy and safety of EUS-GJ. Secondary outcom

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… count | 55 | 121 | 10,896 PMN (%) | 18 | 33 | 94 Lymphocytes (%) | 36 | 26 | 1 Monocytes/macrophages (%) | 43 | 34 | 5 Bilirubin (mg/dL) | – | – | – Glucose (U/L) | – | – | 103 Total Protein (g/dL) | 1.1 | 1.3 | 0.7 Albumin (g/dL) | 0.5 | 0.9 | 0.6 SAAG | 2.3 | 2.5 | – Culture | No growth | No growth | Leptotrichia …

Комплексное исследование двустороннего взаимодействия между микробиомами человека и злокачественными заболеваниями крови и гематологическими условиями: акцент на новых терапевтических стратегиях.

Микробиота человека играет ключевую роль в поддержании хомостаза, регулируя иммунную реакцию, метаболизм и гематопоисис. Микробиальный дисбиоз все чаще ассоциируется с иммунной дисфункцией, воспалением и аномалиями костного мозга, которые могут привести к гематологическим заболеваниям. В настоящем обзоре резюмируются текущие данные о роли микробиота в нормальном гематопоисе и ее потенциальной причастности к доброкачественным и злокачественным гематологическим расстройствам.МЕТОДЫ: Обзор описательной литературы был проведен на основе всестороннего поиска основных научных баз данных без временны

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… Among genera, Streptococcus was the most abundant, accounting for 21% of sequences, with Prevotella (13%), Veillonella (10%), Leptotrichia (9.7%), Neisseria (7%), Fusobacterium (4%), Actinomyces (4%), Haemophilus (4%), and Rothia (3.4%) following. … Analysis of differential taxa revealed distinct microbial shifts linked to H. pylori ‐negative gastric MALT lymphoma: levels of Actinobacillus , Lactobacillus , and Chryseobacterium were elevated in these patients, whereas Veillonella , Atopobium , Leptotrichia , Catonella , Filifactor , and Escherichia …

Gene editing and CRISPR in the clinic: current and future perspectives.

Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly interspaced short palindromic repeat DNA sequences)/Cas9 are rapidly progressing into clinical trials. Most clinical use of CRISPR to date has focused on ex vivo gene editing of cells followed by their re-introduction back into the patient. The ex vivo editing approach is highly effective for many disease states, including cancers and sickle cell disease, but ideally genome editing would also be applied to diseases whic

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… Two of the best characterized Cas13 proteins are Leptotrichia wadei Cas13a (LwaCas13a) and Leptotrichia shahii Cas13a (LshCas13a, previously known as LshC2c2), both studied by Abudayyeh et al [236 ]. …

Bloodstream Infections in Patients with Hematologic Diseases: Causative Organisms and Factors Associated with Resistance.

BackgroundPatients with hematologic diseases are at high risk of bloodstream infections (BSIs). This study aimed to analyze clinical features and distributions of microorganisms in patients with hematologic diseases presenting at a tertiary care university-affiliated hospital in Korea.Materials and methodsWe retrospectively reviewed all BSI episodes recorded in patient medical records at two hematologic wards of the Catholic Hematology Hospital from January to December 2020. Our aim was to analyze demographic and clinical characteristics relevant to BSIs. We also described the antimicrobial re

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… (n = 1), Leptotrichia trevisanii (n = 1), and Morganella morganii (n = 1). b Enterococcus gallinarum (n = 5) and Enterococcus avium (n = 1). c All Streptococcus species other than viridans streptococci such as Streptococcus agalactiae (n = 2), Streptococcus dysgalactiae (n = 1), and Streptococcus pneumoniae …

Гут Микробиота Нарушение гематологовой терапии рака: Молекулярное понимание и последствия для эффективности лечения.

Гематологическая магнелезность (ГМ), включая лейкемию, лимфому и множественные миеломы, связана с бесконтрольным распространением аномальных кровеносных клеток, что создает серьезные клинические проблемы из-за их неоднородности и различных методов лечения. Несмотря на недавние достижения в области лечения, благодаря которым повысились показатели выживаемости, особенно в случае хронической лимфоцитической лейкемии и острой лимфоболической лейкемии, такие методы лечения, как химиотерапия и трансплантация стволовых клеток, часто нарушают микробиоту, что может негативно сказаться на результатах ле

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… . | [ 104 ] Blautia | Decrease Prevotella Leptotrichia 20 patients 5 controls | AML ALL | Species | Lactobacillus fermentum | Increase | Antimicrobial prophylaxis is not used. | The microbiota is altered by chemotherapy. | [ 105 ] Coprococcus catus Bacteroides coprocola 8 patients | NHL | Genus | Bacteroides … | Lactobacillus | Increase | Received antibacterial (fluoroquinolone), antifungals (azoles), and antibiotics (carbapenem) after. | They report that low bacterial diversity in stool samples is associated with the development of infections during chemotherapy. | [ 104 ] Blautia | Decrease Prevotella Leptotrichia …

Лекарства, модифицирующие течение болезни, связаны с улучшением обонятельной функции через взаимодействие клеток NK и микробиоты при множественной склерозе.

ЦЕЛЬ: изучение связей носовой микробиоты с терапией, изменяющей заболевания (ДМТ), подмножеством лимфоцитов и функцией обоняния в множестве склерозов (МС). МЕТОДЫ: Thirty больные с синдромом MS и 30 Были приняты меры по контролю за здоровым здоровьем (ЗП) в разбивке по возрасту и полу. Пациенты были отнесены к категории пациентов, проходящих лечение по линии ДМТ (MS[DMT+]), или к категории пациентов, не прошедших лечение (MS[DMT-). Оличественная функция оценивалась с помощью теста на идентификацию запаха Пенсильванского университета (UPSIT). Подмножества лимфоцитов измерялись с помощью цитомет

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… TX3, Flavihumibacter cheonanensis , Leptotrichia sp. PG10, Marinococcus sp. GSP32, Nocardioides sp. S2_84, Paenibacillus sp. YJ01, Selenomonas lacticifex , Sphingobacterium thalpophilum )enriched in MS(DMTs+) and 2( Azospirillum sp. …

Bisphosphonate-Related Osteonecrosis of the Jaw and Oral Microbiome: Clinical Risk Factors, Pathophysiology and Treatment Options.

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) represents a serious health condition, impacting the lives of many patients worldwide. The condition challenges clinical care due to its complex etiology and limited therapeutic options. A thorough understanding of the pathophysiological and patient-related factors that promote disease development is essential. Recently, the oral microbiome has been implicated as a potential driver and modulating factor of BRONJ by several studies. Modern genomic sequencing methods have provided a wealth of data on the microbial composition of BRONJ lesio

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… The study unveiled a wide range of bacteria in the BRONJ cohort, for instance Gram-positive genera such as Parvimonas , Eubacterium , Gemella , Leptotrichia , and Selenomonas . …

From Pathogenesis to Intervention: The Importance of the Microbiome in Oral Mucositis.

Oral mucositis (OM) is a common and impactful toxicity of standard cancer therapy, affecting up to 80% of patients. Its aetiology centres on the initial destruction of epithelial cells and the increase in inflammatory signals. These changes in the oral mucosa create a hostile environment for resident microbes, with oral infections co-occurring with OM, especially at sites of ulceration. Increasing evidence suggests that oral microbiome changes occur beyond opportunistic infection, with a growing appreciation for the potential role of the microbiome in OM development and severity. This review c

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… Similarly, a reduction in microbial diversity and compositional changes has been observed following radiotherapy, with changes observed in several oral taxa, including Lactobacillus, Streptococcus, Gemella, Leptotrichia, Neisseria, Capnocytophaga, Neisseria, Olsenella, Parviomonas, Tannerella and Capnocytophaga …

CRISPR-Cas: Converting A Bacterial Defence Mechanism into A State-of-the-Art Genetic Manipulation Tool.

Bacteriophages are pervasive viruses that infect bacteria, relying on their genetic machinery to replicate. In order to protect themselves from this kind of invader, bacteria developed an ingenious adaptive defence system, clustered regularly interspaced short palindromic repeats (CRISPR). Researchers soon realised that a specific type of CRISPR system, CRISPR-Cas9, could be modified into a simple and efficient genetic engineering technology, with several improvements over currently used systems. This discovery set in motion a revolution in genetics, with new and improved CRISPR systems being

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… A recent study found no such effects when the Leptotrichia wadei variant, LwaCas13a, was used in mammalian cells [ 122 ], implying that this collateral effect might be absent or undetectable in eukaryotic cells. 8.3. …

From Cells to Environment: Exploring the Interplay between Factors Shaping Bone Health and Disease.

The skeletal system is an extraordinary structure that serves multiple purposes within the body, including providing support, facilitating movement, and safeguarding vital organs. Moreover, it acts as a reservoir for essential minerals crucial for overall bodily function. The intricate interplay of bone cells plays a critical role in maintaining bone homeostasis, ensuring a delicate balance. However, various factors, both intrinsic and extrinsic, can disrupt this vital physiological process. These factors encompass genetics, aging, dietary and lifestyle choices, the gut microbiome, environment

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… For instance, Rosier et al. [ 95 ] highlighted the influence of nitrate as a prebiotic in altering the composition of the oral microbiome, notably by reducing periodontopathogen bacteria such as Porphyromonas , Fusobacterium , Leptotrichia , and Prevotella . …

Human microbiomes in cancer development and therapy.

Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis and disease progression were link to microbiomes. Different organ sources, their microbial species, and their metabolites are different; the mechanisms of carcinogenic or procancerous are also different. Here, we summarize how microbiomes contribute to carcinogenesis and disease progression in cancers of the skin, mouth, esophagus, lung, gastrointestinal, genital, blood, and lymph malignancy

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… Other microbes, such as Lactobacillus , Bifidobacterium , Clostridium butyricum , Bacillus subtilis , Bifidobacteria , Lactobacoilli , Streptococcus thermophilus , Leptotrichia , Bacteroides thetaiotaomicron , and Faecalibacterium prausnitzii , can inhibit cancer progression. …

Влияние лечения рака на оральные структуры и лицо черепа - последствия для протезирования и онкологического риска.

ЦЕЛЬ ОБЗОРА: Настоящее исследование направлено на выявление осложнений и трудностей при проведении остеоинтеграции имплантатов в онкологических пациентах, учитывая влияние лечения на микроархитектуру краниофасциальной области, микробиомо рта и воспаление полости рта. НОВЫЕ ДАННЫЕ: Хирургическая резекция, радиотерапия, химиотерапия и таргетная терапия значительно влияют на состояние костей, слизистых оболочек и мягких тканей, а также на возможности и ограничения протезирования. Химиотерапия значительно влияет на метаболизм кальция и фосфора. Было замечено, что существует увеличенный риск перел

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… In addition, there is a slight increase in the number of Gram-negative bacteria such as Prevotella spp., Selenomonas spp., Leptotrichia spp., Tannerella spp., Campylobacter spp., Capnocytophaga spp., and Parvimonas spp. …

Pharmacomicrobiomics in precision cancer therapy: bench to bedside.

The burgeoning field of pharmacomicrobiomics offers promising insights into the intricate interplay between the microbiome and cancer, shaping responses to diverse treatment modalities. This review aims to analyze the molecular mechanisms underlying interactions between distinct microbiota types and cancer, as well as their influence on treatment outcomes. We explore how the microbiome impacts antitumor immunity, and response to chemotherapy, immunotherapy, and radiation therapy, unveiling its multifaceted roles in cancer progression and therapy resistance. Moreover, we discuss the challenges

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… A study examining the urogenital microbial community in bladder cancer patients revealed an increased presence of Leptotrichia , Roseomonas , and Propionibacterium , along with a reduction in certain bacterial genera, such as Prevotella and Massilia , among those exhibiting PD-L1 expression on cancerous …

Precision in Action: The Role of Clustered Regularly Interspaced Short Palindromic Repeats/Cas in Gene Therapies.

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated enzyme-CAS holds great promise for treating many uncured human diseases and illnesses by precisely correcting harmful point mutations and disrupting disease-causing genes. The recent Food and Drug Association (FDA) approval of the first CRISPR-based gene therapy for sickle cell anemia marks the beginning of a new era in gene editing. However, delivering CRISPR specifically into diseased cells in vivo is a significant challenge and an area of intense research. The identification of new CRISPR/Cas variants, particularly

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… Another example of CAS effectors includes Cas13a, which was isolated from Leptotrichia shahii and shown to have cleavage functions in many studies [ 41 , 164 ]. Compact Cas12f was also identified as having comparable genome editing to SpCas9 [ 108 ]. …

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine.

CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated proteins) has undergone marked advancements since its discovery as an adaptive immune system in bacteria and archaea, emerged as a potent gene-editing tool after the successful engineering of its synthetic guide RNA (sgRNA) toward the targeting of specific DNA sequences with high accuracy. Besides its DNA editing ability, further-developed Cas variants can also edit the epigenome, rendering the CRISPR-Cas system a versatile tool for genome and epigenome manipulation and a pioneering force in precision medic

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one : National Harbor, MD, USA. 9-13 November 2016

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… The most abundant species in each of the labeled crOTUs are 1614: Eubacterium limosum. 2022-3: Streptococcus sinensis. 1638: Eubacterium limosum. 1630-1: Eubacterium limosum. 1790: Parvimonas micra. 0951-3: Leptotrichia hongkongensis 2986: Flavonifractor plautii. 1439: Actinomyces odontolyticus Fig. … The most abundant species in each of the labeled crOTUs are 1614: Eubacterium limosum. 2022-3: Streptococcus sinensis. 1638: Eubacterium limosum. 1630-1: Eubacterium limosum. 1790: Parvimonas micra. 0951-3: Leptotrichia hongkongensis 2986: Flavonifractor plautii. 1439: Actinomyces odontolyticus Results …

2021 International Cancer Education Conference Program and Abstracts.

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SEDCYDO - SGER - SEMO ConГРЕСС МАДРИД 2025, 8-10 Возможно. Ход работы и резюме.

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Proceedings of Reanimation 2023, the French Intensive Care Society International Congress.

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