Результаты поиска

Metabolomics of the anti-inflammatory effect of Pueraria lobata and Pueraria lobata var. Thomsonii in rats.

ETHNOPHARMACOLOGICAL RELEVANCE: Pueraria lobata (Willd.) Ohwi and Pueraria lobata var. Thomsonii (Benth.) Maesen are essential medicinal and … swelling in mice induced by xylene, an acute inflammation model of foot swelling in rats induced by carrageenan gum, and a chronic inflammation model of cotton ball granuloma in rats. Then we examined the weight and swelling rate of auricular swelling in mice; the residence time, contact area, and mean contact pressure in rats on the gait meter; and the weigh …

Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.

The antiinflammatory action of aspirin generally has been attributed to direct inhibition of cyclooxygenases (COX-1 and COX-2), but additional mechanisms are likely at work. These include aspirin's inhibition of NFkappaB translocation to the nucleus as well as the capacity of salicylates to uncouple oxidative phosphorylation (i.e., deplete ATP). At clinically relevant doses, salicylates cause cells to release micromolar concentrations of adenosine, which serves as an endogenous ligand for at least four different types of well-characterized receptors. Previously, we have shown that adenosine me

Anti-inflammation effects of corn silk in a rat model of carrageenin-induced pleurisy.

Pleurisy is an inflammation of the pleural layers that surround the lungs. Despite much research into inflammatory diseases, no drugs with favorable safety profiles are available yet for their treatment. Corn silk has been used in many parts of the world for the treatment of edema, cystitis, gout, kidney stones nephritis, and prostitutes. However, no scientific reports on the anti-inflammatory effects of corn silk were so far available. To test the anti-inflammatory efficacy of corn silk extract (CSEX) in a rat model of carrageenin (Cg)-induced pleurisy, exudate formation, and cellular infiltr

Role of cyclopentenone prostaglandins in rat carrageenin pleurisy.

In this study, using rat carrageenin-induced pleurisy, we found that treatment of rats with either indomethacin or NS-398 suppressed the pleurisy at 2 h but significantly exacerbated this reaction at 48 h. Exacerbated inflammation was associated with reduced prostaglandin D(2) levels, decreased heat shock factor 1 (HSF1) activation, reduced hsp72 expression and increased activation of nuclear factor kappaB (NF-kappaB). Replacement of cyclopentenone prostaglandins by treating rats with either prostaglandin J(2) or prostaglandin D(2) reversed the exacerbating effects of cyclooxygenase inhibitors

Dual COX-2/TNF-α Inhibitors as Promising Anti-inflammatory and Cancer Chemopreventive Agents: A Review.

Cyclooxygenases (COX) play a pivotal role in inflammation and are responsible for the production of prostaglandins (PGs). Two types of COXs have been identified as key biological targets for drug design: Constitutive COX-1 and inducible COX-2. Nonsteroidal anti-inflammatory drugs (NSAIDs) target COX-1, while selective COX-2 inhibitors are designed for COX-2. These COX isoforms are involved in multiple physiological and pathological pathways throughout the body. Overproduction of tumor necrosis factor-alpha (TNF-α) plays a role in COX-2's inflammatory activity. Tumor necrosis factor-alpha can c

Совпадение в полном тексте источника
… Furthermore, compound 8 reduced effusion in carrageenan-induced paw edema models of inflammation, while significantly lowering PGE2 concentrations. Figure 11. … The partially synthesized xanthone analogs were administered orally to carrageenan-induced paw edema rat models, and their efficacy in reducing inflammation was measured at specific time points. …

A novel role for phospholipase A2 isoforms in the checkpoint control of acute inflammation.

Acute inflammation can be considered in terms of a series of checkpoints where each phase of cellular influx, persistence, and clearance is controlled by endogenous stop and go signals. It is becoming increasingly apparent that in addition to initiating the inflammatory response, eicosanoids may also mediate resolution. This suggests there are two phases of arachidonic acid release: one at onset for the generation of proinflammatory eicosanoids and one at resolution for the synthesis of proresolving eicosanoids. What is unclear is the identity of the phospholipase (PLA2) isoforms involved in t

In vitro and in vivo study of poly(ethylene glycol) conjugated ketoprofen to extend the duration of action.

Ketoprofen-polyethylene glycol (PEG) conjugates (KPEG) were prepared and their potential as a prolonged release system was investigated. Three KPEG conjugates were synthesized from ketoprofen and methoxy PEG with three different molecular weights by esterification in the presence of DCC. The KPEG conjugates were characterized by FT-IR and (1)H NMR spectroscopy. The rate of hydrolysis profile showed a specific acid-base catalysis pattern with a minimum at pH 4-5. The pharmacokinetic study after the intravenous and intramuscular administration of KPEG750 showed that the plasma levels of KP incre

Anti-inflammatory activity of macrolide antibiotics.

The effect of four macrolide antibiotics (roxithromycin, clarithromycin, erythromycin, and azithromycin) on the generation of some mediators and cytokines involved in the inflammatory process has been studied both in vivo and in vitro. Rat carrageenin pleurisy was used as a model of acute inflammation, and the macrolides were administered (10, 20, and 40 mg/kg p.o.) 1 h before the carrageenin challenge. Exudate volume and leukocyte accumulation were both dose-dependently reduced by roxithromycin, clarithromycin and erythromycin in either normal or adrenalectomized animals. Furthermore, in norm

Nuclear factor-kappaB activation mediates inducible nitric oxide synthase expression in carrageenin-induced rat pleurisy.

We studied the involvement of nuclear factor-kappaB (NF-kappaB) in the regulation of inducible nitric oxide synthase expression in carrageenin-induced rat pleurisy. Injection of 0.2 ml of 1% lambda-carrageenin into the pleural cavity of male Wistar rats caused after 6 h: (a) exudate formation and leukocyte migration into the pleural cavity; (b) inducible NO synthase protein expression and accumulation of NO2- plus NO3- in pleural exudate; (c) increase in p50/p65 nuclear level as well as NF-kappaB/DNA binding activity. Treatment of rats with pyrrolidine dithiocarbamate (10, 30, and 100 mg/kg) a

A comprehensive review on pain: Model, target, therapy, and prospect (Review).

Pain serves as both a protective physiological response essential for species survival and a global health issue affecting human well‑being and societal development. The present review systematically summarized and analyzed the research progresses on pain through a multidimensional analytical framework encompassing animal models, molecular targets, therapeutic approaches and future prospects. In animal modeling, neuropathic pain paradigms have evolved from traditional mechanical compression to composite models that combine dynamic displacement and chemical stimulation. Cancer‑induced pain mode

Совпадение в полном тексте источника
… Inflammation pain model | SD rats | 1% carrageenan injection into left hindpaw plantar region | 7 days | Spontaneous pain | Rapid inflammatory response | Transient hypersensitivity; unsuitable for chronic studies | ( 121 ) Carrageenan-induced pain model Local carrageenan injection triggers biphasic … Additionally, systemic administration of the non-competitive mGlu5 antagonist MPEP reversed mechanical hyperalgesia induced by inflammatory mediators such as CFA and carrageenan. …

Microgel-Based 3D Bioprinting: A Convergent Strategy Integrating Material Design, Jamming Dynamics, and Biological Function.

Driven by rapid technological innovation and an increasing demand for personalized medicine, microgel-based bioprinting emerges as a versatile strategy for generating physiologically relevant tissue models and patient-specific constructs. By integrating microgel systems with 3D bioprinting, this approach enables the creation of complex, cell-laden architectures that closely recapitulate native tissue architecture and function. Pivotal to this potential are microgels that offer significant advantages over conventional hydrogel-based bioinks, including tunable rheological behavior, enhanced prin

Совпадение в полном тексте источника
… On the other hand, natural polymer‐based supports, including agar and k‐carrageenan microgels, have demonstrated remarkable self‐healing and load‐bearing capabilities [ 119 , 120 , 121 , 122 , 123 ]. … Firmly compacted agar microgels (> 0.5% w/v) enabled 3D printing of hollow helical and triangular structures [ 119 ], while k‐carrageenan sub‐microgels (∼ 642 nm) at concentrations as low as 0.3% (w/v) facilitated the bioprinting of organ‐like constructs [ 120 ]. …

Следует ли улучшить сопоставление между рационами питания?

Питание считается возможным кофактором, который влияет на иммунную систему и потенциально вызывает дисрегулирование кишечного гомеостаза и воспаления. Цель этого исследования заключалась в анализе качества данных о воздействии конкретного состава рациона питания на симптомы иммунопосредованных подстрекательских заболеваний (ИМИД), включая ревматоидный артрит (RA), спондилоартрит, множественный склероз (MS), воспалительный кишечник (IBD) [восстановление болезни Крона и язвительный колит], псориоз и псориатический артрит у взрослых пациентов. Мы провели обзор метаанализов и систематических обзор

Совпадение в полном тексте источника
… The level of evidence for the Alberta-based anti-inflammatory diet or the carrageenan-free diet ( Supplementary Table S2 ), reducing clinical relapse rates in inactive UC, was also very low. Inactive UC. … The CDED, specifically designed for CD patients, is a whole food diet combined with PEN and excluding processed foods, emulsifiers, animal fat, red and processed meat, carrageenan, gluten, and dairy products among others [ 77 , 79 ]. …

Possible new role for NF-kappaB in the resolution of inflammation.

Inflammation involves the sequential activation of signaling pathways leading to the production of both pro- and anti-inflammatory mediators. Although much attention has focused on pro-inflammatory pathways that initiate inflammation, relatively little is known about the mechanisms that switch off inflammation and resolve the inflammatory response. The transcription factor NF-kappaB is thought to have a central role in the induction of pro-inflammatory gene expression and has attracted interest as a new target for the treatment of inflammatory disease. We show here that NF-kappaB activation in

Proceedings of the CIMAGO Congress - Environment, Genetics and Oncobiology in the 21st Century - Challenges and Opportunities.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Conclusions: Carrageenans, sulphated polysaccharides fulfilling essential functions in cells walls interstitial spaces and intercellular adhesion, show the best results either in vitro & in vivo . … Iota carrageenan has sulphate groups in C-2 position of D-galactose and 3,6-anhydro-galactose units sensitive to Ca2+, leading to distinct interactions with biological molecules. Kappa carrageenan sulphate groups are in C-4 & C-2 positions of D-galactose interacting with K + . …

Açai Berry Attenuates Cyclophosphamide-Induced Damage in Genitourinary Axis-Modulating Nrf-2/HO-1 Pathways.

Cyclophosphamide (CYP) is used to treat different malignancies and autoimmune disorders in men. This chemotherapy frequently reduces tumors, which is beneficial, but also causes infertility because of severe oxidative stress, inflammation, and apoptosis in the bladder and testes brought on by its metabolite, acrolein. The goal of this study was to assess the efficacy of a novel food, açai berry, in preventing CYP-induced damage in the bladder and testes.MethodsCYP was administered intraperitoneally once during the experiment at a dose of 200 mg/kg body weight diluted in 10 mL/kg b.w. of water.

Совпадение в полном тексте источника
… Nuts Counteract Oxidative Stress and Inflammation in an Acute Experimental Model of Carrageenan-Induced Paw Edema. Antioxidants. 2020;9:660. doi: 10.3390/antiox9080660. 33. … Impellizzeri D., Cordaro M., Bruschetta G., Crupi R., Pascali J.P., Alfonsi D., Marcolongo G., Cuzzocrea S. 2-pentadecyl-2-oxazoline: Identification in coffee, synthesis and activity in a rat model of carrageenan-induced hindpaw inflammation. Pharmacol. …

Pharmacological and toxicological evaluation of Urtica dioica.

CONTEXT: Medicinal plants are a largely unexplored source of drug repository. Urtica dioica L. (Urticaceae) is used in traditional medicine to treat diverse conditions. OBJECTIVE: The present study describes the antidiabetic, antiinflammatory, antibacterial activity, and toxicological studies of Urtica dioica. MATERIALS AND METHODS: U. dioica leaves were subjected to solvent extraction with hexane, chloroform, ethyl acetate, methanol, and aqueous, respectively, and screened for antidiabetic (300 mg/kg bw by glucose tolerance test; GTT), antiinflammatory (200 mg/kg bw by rat paw edema assay)

Pulmonary hypertension and the potential of 'drug' repurposing: A case for African medicinal plants.

AbstractPulmonary hypertension (PH) is a haemodynamic disorder in which elevated blood pressure in the pulmonary circulation is caused by abnormal vascular tone. Despite advances in treatment, PH mortality remains high, and drug repurposing has been proposed as a mitigating approach. This article reviews the studies that have investigated drug repurposing as a viable option for PH. We provide an overview of PH and highlight pharmaceutical drugs with repurposing potential, based on limited evidence of their mechanisms of action. Moreover, studies have demonstrated the benefits of medicinal plan

Совпадение в полном тексте источника
… TNF-α, IL-1β and IL-6) | Ajuwon et al., [58] Lee and Bae [59] | | In vitro model | | Lee and Bae [59] Ximenia caffra | Large sourplum | In vitro model | Inhibits the messenger RNA expression of proinflammatory genes (IL-6, iNOS and TNF-α) | Zhen et al. [62] Asparagus africanus | Wild asparagus | Carrageenan-induced … rat paw oedema and inflammation in Swiss albino and Wistar rats | Inhibition of inflammation by limiting proinflammatory cytokines | Ojewole [60] Aloe ferox | Aloe | Carrageenan-induced rat paw oedema and inflammation | Inhibition of inflammation due to a high content of malic acid acylated carbohydrates …

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.

1. DFU (5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furan one) was identified as a novel orally active and highly sele … 25 > CGP 28238 approximately etodolac > L-745,337 > DFU. 7. DFU inhibited dose-dependently both the carrageenan-induced rat paw oedema (ED50 of 1.1 mg kg-1 vs 2.0 mg kg-1 for indomethacin) and hyperalgesia (ED50 of 0.95 mg kg-1 vs 1.5 mg kg-1 for indomethacin). The compound was also effective at reversing LPS-induced pyrexia in rats (ED50 = 0.76 mg kg-1 vs 1. …

Естественные соединения серы в состоянии психического здоровья и неврологических расстройств: наблюдения и исследования.

За прошедшие годы глобальное бремя неврологических и психических расстройств значительно возросло, в результате чего они стали одной из наиболее серьезных проблем и вызовов для здоровья человека. В рамках новых методов лечения от болезней и болезней все больше внимания уделяется вопросам питания и здравоохранения. Питание серы, главным образом полученное из различных природных источников, играет решающую роль в многочисленных физиологических процессах, включая функцию мозга. В настоящем обзоре содержится обзор химического состава ряда естественных источников таких богатых серой веществ, как из

Совпадение в полном тексте источника
… Majority of them consists of green (ulvans), red (carrageenan), and brown algae (fucoidan) ( 39 ). … Red algae include galactans, which consist of galactose units, agarans, and carrageenans, which are the types of galactans that have 4-linked α -galactose residues of L-series and D-series, respectively ( 135 ). …

The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic Review.

Chemoresistance is a challenge in cancer treatment, limiting the effectiveness of chemotherapy. Mushroom extracts have shown potential as treatments for cancer therapies, offering a possible solution to overcome chemoresistance. This systematic review aimed to explore the role of mushroom extracts in enhancing chemotherapy and reversing chemoresistance in cancer cells. We searched the PubMed, Web of Science and Scopus databases, following the PRISMA guidelines, and registered on PROSPERO. The extracts acted by inhibiting the proliferation of cancer cells, as well as enhancing the effect of che

Совпадение в полном тексте источника
… Agaricus bisporus polysaccharides were microcapsulated in Alg/κ-carrageenan microcapsules as an oral administration system for colon cancer. … Alginate/κ-carrageenan oral microcapsules loaded with Agaricus bisporus polysaccharides MH751906 for natural killer cells mediated colon cancer immunotherapy Int. J. Biol. Macromol. 2022 205 385 395 10.1016/j.ijbiomac.2022.02.058 35183600 56. Chou T.C. …