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A novel composite microbial agent controls kiwifruit bacterial canker and modulates bark bacterial communities.

Kiwifruit bacterial canker (KBC), caused by Pseudomonas syringae pv. actinidiae (Psa), is an important disease limiting kiwifruit production … on of FKYJ provided lesion-suppression efficacy comparable to that of 200-fold dilutions of ZSM and Bacillus amyloliquefaciens Ba168 (Ba168). Across two consecutive years of field trials, FKYJ provided more than 80% control efficacy against trunk canker and more than 75% efficacy against blossom blight, exceeding the efficacy of the single-agent treatments. Quantitative PCR …

Combining Bacillus and Trichoderma in Bio-Organic Fertilizers with Reduced Chemical Fertilizer: An Effective Strategy Against Cucumber Fusarium Wilt.

Integrated fertilization using reduced chemical fertilizers and bio-organic fertilizers can maintain soil fertility with lower chemical inputs, yet its systemic effects on disease control, soil microbes, yield, and quality are not fully clear. This study aimed to: (1) evaluate the effects of Bacillus amyloliquefaciens Z2 and Trichoderma harzianum T22, alone or combined, on suppressing Fusarium wilt (Fusarium oxysporum f. sp. cucumerinum) and promoting cucumber growth in pot experiments; and (2) assess the field efficacy of reduced chemical fertilizer (75% N) plus microbial bio-organic fertiliz…

Host-recruited Bacillus and Pseudomonas strains provide potential biocontrol and yield protection against rice bacterial leaf blight.

Bacterial leaf blight (BLB), caused by Xanthomonas oryzae pv. oryzae (Xoo), threatens global rice production while growing bactericide resistance and environmental concerns necessitate sustainable disease management alternatives. We employed a microbiome-guided, habitat-specific isolation strategy targeting naturally recovered plants from BLB-endemic hotspots across ten districts of Punjab, Pakistan operating on the ecological premise that plants under pathogen pressure selectively enrich protective microbial taxa, making disease-affected hosts the most coherent source of adapted biocontrol ag

Targeted detection of microbes in synbiotic medical foods SBD111 and SBD121 to evaluate gut persistence: a randomised, open label trial.

The viability and persistence of orally administered microbes in the human gut are essential to their biological function. We previously des … ncing for a median of seven days and three days during the follow-up period, respectively. However, Bacillus amyloliquefaciens was consistently detected for seven days by both methods. Culture-based assays confirmed the presence of viable strains from both synbiotic medical foods in stool samples up to one-week post-consumption. Faecal metagenome diversity and metabolic fun …

Optimistic effects of dual nano-encapsulated probiotics on breeders laying performance, intestinal barrier functions, immunity and resistance against Salmonella Typhimurium challenge.

Dual nano encapsulation of multi-strain probiotic bacteria can enhance their viability within the avian gastrointestinal tract and improve their effectiveness in disease prevention. So that this study spotted the light on the effect of dual nano encapsulated multi strain of probiotics (LEBB-NPs) contained Enterococcus faecium NCTC 7171, Bacillus amyloliquefaciens probiotic CECT 5940, Lacticasei bacillus casei ATTC334 and Bifidobacterium breve JCM1192 on laying performance, egg quality, immune defence, and resistance against Salmonella Typhimurium challenge. A total of 250 Ross 308 laying breed…

Alterations in bacterial metabolites, cytokines, and mucosal integrity in the caecum of broilers caused by feed additives and host-related factors.

A total of 2,880 one-day-old male and female broiler chicks from two breeds, Ross308 and Cobb500 were randomly assigned to 72 pens. Broilers were offered three diets: a wheat-soybean diet without (CO), or with either a probiotic (probiotic; 2.4 x 109 CFU/kg diet of Bacillus subtilis DSM32324 and DSM32325 and B. amyloliquefaciens DSM25840) or a phytobiotic (phytobiotic; grape extract with 165 ppm procyanidin and 585 ppm polyphenol) product. The trial was conducted with a 3 × 2 × 2 factorial arrangement of diet, breed and sex in a completely randomized design and consisted of 6 replicate-pens pe

Impact of feed additives and host-related factors on bacterial metabolites, mucosal integrity and immune response in the ileum of broilers.

The present study aimed to investigate the effect of age, breed, and sex of broilers, as well as a probiotic or phytobiotic product on mucosal morphology, bacterial metabolites, and immune traits in the ileum of broilers. A total of 2,880 one-day-old male and female broiler chicks from two breeds (Ross308® and Cobb500®) were randomly assigned to 72 pens. Broilers were offered a wheat-soybean diet without (CO), or with either a probiotic (PO; 2.4 × 109 CFU/kg of Bacillus subtilis DSM32324 and DSM32325 and B. amyloliquefaciens DSM25840) or a phytobiotic (PY; grape extract, 165 ppm procyanidin an

Molecular characterization of an endophytic strain of Bacillus subtilis with plant growth-promoting properties from a wild relative of papaya.

AIM: Bacillus subtilis is usually found in soil, and their biocontrol and plant growth-promoting capabilities are being explored more recently than ever. However, knowledge about metabolite production and genome composition of endophytic B. subtilis from seeds is limited. In the present study, B. subtilis EVCu15 strain isolated from the seeds of Vasconcellea cundinamarcensis (mountain papaya) was subjected to whole genome sequencing and detailed molecular and functional characterization. METHODS AND RESULTS: Whole genome sequencing and sequence analysis of the endophytic bacterium from mounta

Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome.

The eosinophilia-myalgia syndrome (EMS) outbreak that occurred in the USA and elsewhere in 1989 was caused by the ingestion of Showa Denko K.K. (SD) L-tryptophan (L-Trp). "Six compounds" detected in the L-Trp were reported as case-associated contaminants. Recently the final and most statistically significant contaminant, "Peak AAA" was structurally characterized. The "compound" was actually shown to be two structural isomers resulting from condensation reactions of L-Trp with fatty acids derived from the bacterial cell membrane. They were identified as the indole C-2 anteiso (AAA1-343) and lin

High-performance thin-layer chromatography (HPTLC) for the simultaneous quantification of the cyclic lipopeptides Surfactin, Iturin A and Fengycin in culture samples of Bacillus species.

A high-performance thin-layer chromatography method has been established for the identification and simultaneous quantification of the cyclic lipopeptides Surfactin, Iturin A and Fengycin in Bacillus culture samples. B. subtilis DSM 10T, B. amyloliquefaciens DSM 7T and B. methylotrophicus DSM 23117 were used as model strains. Culture samples indicated that a sample pretreatment is necessary in order to run HPTLC analyses. A threefold extraction of the cell-free broth with the solvent chloroform/methanol (2:1, v/v) gave best results, when all three lipopeptides were included in the analysis. Fo

Effect of Supplementing a Bacillus Multi-Strain Probiotic to a Post-Weaning Diet on Nutrient Utilisation and Nitrogen Retention of Piglets.

Probiotics are suggested to improve pig health, nutrient utilisation, performance, and they may reduce nitrogen (N) pollution. However, the effectivity of a single strain might be different from that of a multi-strain. The study was conducted to investigate the effect of a novel Bacillus multi-strain on nutrient digestibility, energy utilisation, and N retention in weaned piglets using an European diet. The experiment consisted of a control diet (CD) and a supplemented diet (SD). The probiotic used for SD consisted of B. amyloliquefaciens-516 and B. subtilis-541. A total of eight boars/treatme

Влияние ПГПР на структуру микробиологической сообщества ризосферы и урожайность солончаковых зерновых культур.

Растворяющиеся в почве бактерии, способствующие росту растений (PGPR), могут защищать растения от почвенных заболеваний и абиотических стрессовых условий. Основная цель данного исследования заключалась в оценке влияния различных PGPR (TF1, TF2, TF3 и TF4) на микробную сообщество ризосферы зерна для корма в солончаково-щелочной поле с использованием высокопроизводительной технологии последовательного секвенирования Illumina MiSeq. Результаты показали, что различные PGPRs значительно увеличили плотность уборки (на 21,31–45,16%), высоту растения (на 9,12–19,98%), диаметр стебля (на 30,07–45,78%)

Microorganisms Associated with the Marine Sponge Scopalina hapalia: A Reservoir of Bioactive Molecules to Slow Down the Aging Process.

Aging research aims at developing therapies that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to slow aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge Scopalina hapalia was investigated by metagenomic analysis. Twenty-s

A review on clinical cases of rare mold infections and their antifungal treatment strategies.

In recent years, with the growing population of immunocompromised individuals, infections caused by rare environmental molds have become increasingly prevalent and clinically significant. Due to frequent misdiagnosis and difficult clinical management, the overall disease burden of such infections poses a major challenge in clinical practice. This article aims to fill the knowledge gap by reviewing cases of rare mold infections from January 2020 to February 2026, analyzing the susceptible populations, identification techniques, antifungal susceptibility testing, and antifungal treatment strateg

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… Xin Xu et al. isolated and identified the strain bacillus amyloliquefaciens HY2-1 from the marine environment. …

Melatonin: Facts, Extrapolations and Clinical Trials.

Melatonin is a fascinating molecule that has captured the imagination of many scientists since its discovery in 1958. In recent times, the focus has changed from investigating its natural role as a transducer of biological time for physiological systems to hypothesized roles in virtually all clinical conditions. This goes along with the appearance of extensive literature claiming the (generally) positive benefits of high doses of melatonin in animal models and various clinical situations that would not be receptor-mediated. Based on the assumption that melatonin is safe, high doses have been a

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… Jiao et al. [ 97 ] reported a thorough study on eight strains of bacteria and found melatonin in only four: Agrobacterium tumefaciens , Bacillus amyloliquefaciens , Bacillus thuringiensis and barely in Pseudomonas sp. …

Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells: A Review of Recent Advances.

Cancer stem cells (CSCs) are a subpopulation of cells that can initiate, self-renew, and sustain tumor growth. CSCs are responsible for tumor metastasis, recurrence, and drug resistance in cancer therapy. CSCs reside within a niche maintained by multiple unique factors in the microenvironment. These factors include hypoxia, excessive levels of angiogenesis, a change of mitochondrial activity from aerobic aspiration to aerobic glycolysis, an upregulated expression of CSC biomarkers and stem cell signaling, and an elevated synthesis of the cytochromes P450 family of enzymes responsible for drug

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… In this regard, magnetic NPs were surface modified with a fusion protein composed of the small protein, Barstar (Bs), synthesized by Bacillus amyloliquefaciens, which inhibits bacterial ribonuclease and the C-terminal part of the magnetite binding protein of magnetotactic bacteria (Mms6) [ 99 ]. …