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Evaluation of the clinical efficacy of Xanthoceras sorbifolium leaves in intervening in hyperuricemia and research on its uric acid-lowering mechanism.

BACKGROUND: Hyperuricemia is a metabolic disorder caused by the malfunction of uric acid metabolism. It is a common risk factor for gout and kidney disease. Currently, first-line pharmacotherapies for hyperuricemia, such as xanthine oxidase inhibitors (e.g., allopurinol and febuxostat) and uricosuric agents (e.g., benzbromarone), effectively lower serum uric acid levels. However, their clinical use is often limited by adverse effects, including hepatorenal toxicity, gastrointestinal disturbances, and hypersensitivity reactions. These limitations highlight the need for safer, better-tolerated t…

Interventions for tophi in gout.

BACKGROUND: Tophi develop in untreated or uncontrolled gout. Their presence can lead to severe and potentially fatal complications. To date … i in gout in adults. Possible interventions included urate-lowering pharmacological treatment (e.g. benzbromarone, probenecid, allopurinol, febuxostat, pegloticase), surgical removal or other interventions such as haemodialysis. DATA COLLECTION AND ANALYSIS: Two review authors extracted data from titles, abstracts and selected studies for detailed review, and …

A practical approach to joint pain in primary care.

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… Alternative ULT options include another xanthine oxidase inhibitor (i.e., febuxostat) or a uricosuric agent (e.g., probenecid, benzbromarone).[ 19 ] Uricosuric agents are contraindicated in those with a history of urolithiasis and may be less effective or unsuitable in renal impairment (estimated glomerular …

Pulmonary hypertension and the potential of 'drug' repurposing: A case for African medicinal plants.

AbstractPulmonary hypertension (PH) is a haemodynamic disorder in which elevated blood pressure in the pulmonary circulation is caused by abnormal vascular tone. Despite advances in treatment, PH mortality remains high, and drug repurposing has been proposed as a mitigating approach. This article reviews the studies that have investigated drug repurposing as a viable option for PH. We provide an overview of PH and highlight pharmaceutical drugs with repurposing potential, based on limited evidence of their mechanisms of action. Moreover, studies have demonstrated the benefits of medicinal plan

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… Repurposing benzbromarone for pulmonary arterial hypertension: Can channelling the past deliver the therapy of the future? Eur Respir J. 2019;53(6):1900583. doi: 10.1183/13993003.00583-2019. 13. Maarman GJ. …

Italian Real-Life Experience of Patients with Hereditary Transthyretin Amyloidosis Treated with Patisiran.

Hereditary transthyretin amyloidosis (ATTRv) is a multisystemic, rare, inherited, progressive and adult-onset disease, affecting the sensorimotor nerves, heart, autonomic function and other organs. The actual scenario of pharmaceutical approaches for ATTRv amyloidosis includes five main groups: TTR stabilizers, TTR mRNA silencers, TTR fibril disruptors, inhibitor of TTR fibril seeding and gene therapy. Patisiran is a small, double-stranded interfering RNA encapsulated in a lipid nanoparticle, able to penetrate into hepatocytes, where it selectively targets TTR mRNA, reducing TTR production. We

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… multidisciplinary approach is on demand. 5 In the last years, several disease-modifying therapies have been developed: the actual scenario of current pharmaceutical approaches for ATTRv amyloidosis includes five main groups: TTR stabilizers (tafamidis, diflunisal, Epigallocatechin-3-Gallate, tolcapone, benzbromarone …

Nucleotide Metabolism in Health and Disease.

Nucleotide metabolism is a fundamental biochemical process, providing the building blocks for DNA and RNA synthesis while driving critical cellular functions like energy transfer, signal transduction, and coenzyme synthesis. The precise regulation of nucleotide de novo synthesis, salvage, and degradation pathways is imperative for maintaining genomic stability and tissue homeostasis. Aberrations in these networks are increasingly recognized as primary drivers in various pathologies; notably, cancer cells exploit metabolic-functional reprogramming to enable rapid proliferation and therapeutic r

Drugging the efferocytosis process: concepts and opportunities.

The daily removal of billions of apoptotic cells in the human body via the process of efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid phenotypic changes occur in the phagocytes enabling them to engulf and digest the apoptotic cargo. In addition, efferocytosis is actively anti-inflammatory and promotes resolution. Owing to its ubiquitous nature and the sheer volume of cell turnover, efferocytosis is a point of vulnerability. Aberrations in efferocytosis are associated with numerous inflammatory pathologies, including atherosclerosis, cancer and infe

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… Inhibition of TMEM16F by niclosamide or benzbromarone reduced the PS exposure on cells expressing the Spike protein, and, in turn, dramatically reduced syncytia 231 . …