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Cardiovascular Considerations Before Cancer Therapy: Gaps in Evidence and JACC: CardioOncology Expert Panel Recommendations.

Baseline cardiovascular assessment before the initiation of potentially cardiotoxic cancer therapies is a key component of cardio-oncology, aiming to reduce cardiovascular complications and morbidity in patients and survivors. Recent clinical practice guidelines provide both general and cancer therapy-specific recommendations for baseline cardiovascular toxicity risk assessment and management, including the use of dedicated risk scores, cardiovascular imaging, and biomarker testing. However, the value of such interventions in altering disease trajectories has not been established, with many re

Role of phytoconstituents in the management of COVID-19.

BackgroundCOVID-19, a severe global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged as one of the most threatening transmissible disease. As a great threat to global public health, the development of treatment options has become vital, and a rush to find a cure has mobilized researchers globally from all areas.Scope and approachThis review focuses on deciphering the potential of different secondary metabolites from medicinal plants as therapeutic options either as inhibitors of therapeutic targets of SARS-CoV-2 or as blockers of viral particles entry

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… Sildenafil citrate Phospho-diesterase inhibitor Dilates blood vessles Under phase 3 of clinical trials [ 13 ] Losartan Angiotensin II receptor antagonist Targets ACE2 Under phase 1 of clinical trials [ 13 ] Telmisartan Antifibrotic Angiotensin receptor blocker Under phase 2 of clinical trials [ 13 ] Atorvastatin … Phospho-diesterase inhibitor | Dilates blood vessles | Under phase 3 of clinical trials | [ 13 ] Losartan | Angiotensin II receptor antagonist | Targets ACE2 | Under phase 1 of clinical trials | [ 13 ] Telmisartan | Antifibrotic | Angiotensin receptor blocker | Under phase 2 of clinical trials | [ 13 ] Atorvastatin …

Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?

Acute myeloid leukemia (AML) is a clinically and genetically heterogenous malignancy of myeloid progenitor cells that affects patients of all ages. Despite decades of research and improvement in overall outcomes, standard therapy remains ineffective for certain subtypes of AML. Current treatment is intensive and leads to a number of secondary effects with varying results by patient population. Due to the high cost of discovery and an unmet need for new targeted therapies that are well tolerated, alternative drug development strategies have become increasingly attractive. Repurposing existing d

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… Currently, there are two clinical trials ongoing including a phase I/II study of lovastatin with high-dose cytarabine for refractory or relapsed AML ( NCT00583102 ) and a pilot trial of atorvastatin in tumor protein 53 mutant and p53 wild-type malignancies ( NCT03560882 ). 2.2.2. …

Legal access to medications: a threat to Brazil's public health system?

BackgroundIn Brazil, health is fundamental human right guaranteed by the Constitution of 1988, which created the Brazilian Universal Health System (Sistema Único de Saúde - SUS). The SUS provides medications for outpatient care via policy of pharmaceutical assistance (PA) programmes. Despite the advances in PA policies which include the improvement in access to medications, there has been a significant increase in lawsuits related to health products and services. This study aimed to characterize the medication processes filed between 2010 and 2014 against the Secretary of State for Health of S

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… However, for the last three items, in the therapeutic indications for which they are routinely used, other medicines present in the PA programmes are regularly provided, including metformin, atorvastatin, and bisphosphonates. …

Forecasting drug utilization and expenditure in a metropolitan health region.

BackgroundNew pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm, Sweden, a model has been developed including early warning (horizon scanning), forecasting of drug utilization and expenditure, critical drug evaluation as well as structured programs for the introduction and follow-up of new drugs. The aim of this

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… In June 2009, the TLV decided on certain reimbursement restrictions, e.g. excluding atorvastatin 10 mg and rosuvastatin 5 mg from the reimbursement scheme [ 30 ]. This resulted in a 9% decrease in expenditures. …

A Systematic Review of Glioblastoma-Targeted Therapies in Phases II, III, IV Clinical Trials.

Glioblastoma (GBM), the most frequent and aggressive glial tumor, is currently treated as first line by the Stupp protocol, which combines, after surgery, radiotherapy and chemotherapy. For recurrent GBM, in absence of standard treatment or available clinical trials, various protocols including cytotoxic drugs and/or bevacizumab are currently applied. Despite these heavy treatments, the mean overall survival of patients is under 18 months. Many clinical studies are underway. Based on clinicaltrials.org and conducted up to 1 April 2020, this review lists, not only main, but all targeted therapi

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… Two Ras-MAPK inhibitors are in Phase II clinical trials: LY2228820 and atorvastatin. The latter molecule could potentiate the effects of TMZ in vitro and in vivo [ 210 ]. …

Риск инсульта при заболеваниях, изменяющий методы лечения множественных склерозов: систематический обзор.

Эпидемиологические исследования свидетельствуют об увеличении числа случаев цереброваскулярных расстройств у пациентов с множественным склерозом (МС). ЦЕЛИ: Цель настоящего систематического обзора состояла в том, чтобы изучить потенциальную связь между лечением, изменяющим заболевания (ДМТ), и риском инсульта в популяциях пациентов, страдающих НР. ИСТОЧНИКИ ДАННЫХ И МЕТОДЫ: В период до апреля в базах данных MedLINE и SCOPUS проводился систематический поиск литературы 6, 2024, для выявления случайных контролируемых клинических испытаний (РКТ), исследований на основе реестров и когортных исследо

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… neurorehabilitation de Falco et al. (2020) 40 Teriflunomide M/47 1 year N/A Thalamic infarct 1 Intravenous alteplase (0.9 mg/kg) Thrombolysis complicated by parenchymal hematoma; clinical improvement Ketabforoush et al. (2023) 41 Teriflunomide F/48 35 days N/A Lacunar infarction 1 Antiplatelets and atorvastatin …

β-caryophyllene and β-caryophyllene oxide-natural compounds of anticancer and analgesic properties.

Natural bicyclic sesquiterpenes, β-caryophyllene (BCP) and β-caryophyllene oxide (BCPO), are present in a large number of plants worldwide. Both BCP and BCPO (BCP(O)) possess significant anticancer activities, affecting growth and proliferation of numerous cancer cells. Nevertheless, their antineoplastic effects have hardly been investigated in vivo. In addition, both compounds potentiate the classical drug efficacy by augmenting their concentrations inside the cells. The mechanisms underlying the anticancer activities of these sesquiterpenes are poorly described. BCP is a phytocannabinoid wit

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… Aarestrup . 2015 Atorvastatin and trans‐caryophyllene for the prevention of leukopenia in an experimental chemotherapy model in Wistar rats . Mol. Clin. Oncol. 3 : 825 – 828 . 26171189 10.3892/mco.2015.544 PMC4487044 37 Kim , C. , S. K. Cho , K.‐D. Kim , D. Nam , W.‐S. Chung , H.‐J. …

Anticoagulation challenges in cancer patients: prevention, detection, and treatment strategies.

Cancer-associated thrombosis is one of the most common and serious complications in oncology patients, contributing significantly to morbidity and mortality. This prothrombotic state is driven by cancer-related factors, systemic inflammation, and treatment-induced endothelial injury. Anticoagulation management in these patients is challenging, as both thrombotic and bleeding risks must be carefully balanced, particularly in those with cardiovascular comorbidities. This review examines the complexities of anticoagulation in cancer-associated thrombosis through three clinical cases. Case 1 focus

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… Consequently, aspirin 81 mg daily and atorvastatin 40 mg were initiated for cardiovascular protection. Approximately one month later, the patient developed right leg swelling. A venous Doppler ultrasound revealed a positive finding for deep vein thrombosis (DVT), while a CT-PE scan was negative. …

Discovering KYNU as a feature gene in hidradenitis suppurativa.

BackgroundHidradenitis suppurativa (HS) is a chronic auto-inflammatory skin condition characterized by nodules, abscesses, and fistulae in skin folds. The underlying pathogenesis of HS remains unclear, and effective therapeutic drugs are limited.MethodsWe acquired mRNA expression profiles from the Gene Expression Omnibus (GEO) database and conducted differential expression analysis between control and HS samples using R software. Four machine learning algorithms (SVM, RF, ANN, and lasso) and WCGNA were utilized to identify feature genes. GO, KEGG, Metascape, and GSVA were utilized for the enri

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… In fact, metabolic syndrome is detected in 32.4% of individuals with HS. 36 This aligns with the drugs we identified based on DEGs, which include Insulin and Atorvastatin. …

Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity.

Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two. The deficiency of Nrf2 elevates the expression of NF-κB, leading to increased production of inflammatory factors, while NF-κB can affect the expression of downstream target genes by regulating the transcription and activity of Nrf2. At the same time, many therapeutic drug-induced organ toxicities, including hepatotoxicity, nephrotoxicity, cardiotoxicity, pulmonary toxicity, dermal toxicity, and neurotoxi

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… expression and downregulating Keap1 expression | Wu et al. (2014) , Song et al. (2019) , Bai et al. (2014) Sedum sarmentosum extract | • Decreasing the activity of the NF-κB signaling pathway, resulting in down-regulated expression of NF-κB-controlled chemokines and pro-inflammatory cytokines Contrast | Atorvastatin …

Carfilzomib in multiple myeloma: unraveling cardiac toxicities - from mechanisms to diagnosis and management.

The survival rates of patients with hematological malignancies such as multiple myeloma have improved with advances in cancer treatment. However, the risk of cardiovascular disease associated with novel therapeutic agents, including proteasome inhibitors (PIs), is becoming increasingly evident. PIs act on proteasome peptidases, leading to cell cycle arrest or apoptosis. Carfilzomib (CFZ), an intravenously administered irreversible PI, exhibits pronounced cardiovascular toxicity that is characterized by heart failure, hypertension, arrhythmia, and ischemic heart disease (IHD). This review focus

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… In addition, metformin ( Efentakis et al., 2024 ; Efentakis et al., 2021 ), atorvastatin ( Efentakis et al., 2024 ), bupropion ( Imam et al., 2024 ), and zingerone ( Alam et al., 2022 ) have been proposed as interventions to mitigate CFZ-induced CVAEs; however, these drugs are still far from being used …

Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats.

The COVID-19 pandemic exposed a global deficiency of systematic, data-driven guidance to identify high-risk individuals. Here, we illustrate the utility of routinely recorded medical history to predict the risk for 1741 diseases across clinical specialties and support the rapid response to emerging health threats such as COVID-19. We developed a neural network to learn from health records of 502,489 UK Biobank participants. Importantly, we observed discriminative improvements over basic demographic predictors for 1546 (88.8%) endpoints. After transferring the unmodified risk models to the All

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… Lowering LDL cholesterol in 10,000 individuals at increased risk by 2 mmol/L with atorvastatin 40 mg daily (~ 2€ per month) for 5 years is estimated to prevent 500 vascular events, reducing the individual relative risk by more than a third 49 , 50 . …

A role for curcumin in preventing liver fibrosis in animals: a systematic review and meta-analysis.

ObjectiveThis meta-analysis aimed to determine the efficacy of curcumin in preventing liver fibrosis in animal models.MethodsA systematic search was conducted on studies published from establishment to November 2023 in PubMed, Web of Science, Embase, Cochrane Library, and other databases. The methodological quality was assessed using Sycle's RoB tool. An analysis of sensitivity and subgroups were performed when high heterogeneity was observed. A funnel plot was used to assess publication bias.ResultsThis meta-analysis included 24 studies involving 440 animals with methodological quality scores

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… Curcumin, quercetin and atorvastatin protected against the hepatic fibrosis by activating AMP-activated protein kinase . J. Funct. Foods 40 ( January ), 341 – 348 . 10.1016/j.jff.2017.11.020 Kamm D. R. McCommis K. S. ( 2022 ). Hepatic stellate cells in physiology and pathology . J. …

HIV infection in the elderly.

In the US, an estimated 1 million people are infected with HIV, although one-third of this population are unaware of their diagnosis. While HIV infection is commonly thought to affect younger adults, there are an increasing number of patients over 50 years of age living with the condition. UNAIDS and WHO estimate that of the 40 million people living with HIV/AIDS in the world, approximately 2.8 million are 50 years and older. With the introduction of highly active antiretroviral therapy (HAART) in the mid-1990s, survival following HIV diagnosis has risen dramatically and HIV infection has evol

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… Alternative statins with limited to no clinically significant drug interactions with PIs include Fluvastatin, Pravastatin, and low-dose Atorvastatin. Another potent statin option available for the management of hyperlipidemia in HIV-negative patients is Rosuvastatin. …

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review.

BackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and approachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key findings and conclusionsThe literature

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… blood cells (RBC), lymphocytes levels | D ( 40°C; 96 h) >> M (60 mm mesh sieve) >> Snack (25%) | Shasha market, Akure, Ondo State, Nigeria | PN : Shallot BN : A. ascalonicum P : bulb | ( 65 ) Effect on lipid profile | In vivo A/M : Atherogenic feed → hypercholesterolemia O : Rattus novergicus PC : Atorvastatin … Another similar study that used atorvastatin as positive control documented that a dose of 200 mg/kg of fermented shallot has a strong effect in decreasing cholesterol levels ( 92 ), but the methodology used for extracting the essential oil is lacking and besides that, the authors did not evaluate the …

Guarding the heart in the era of immunotherapies: insights for cardio-oncology practice.

The advent of cancer immunotherapies, including immune checkpoint inhibitors (ICI), Chimeric antigen receptor (CAR-T) cell therapies, and bispecific antibodies and other immune-activating platforms such as therapeutic vaccines and oncolytic viruses (often used in combination regimens) has revolutionized oncology by improving patient outcomes across diverse malignancies. However, these therapies are increasingly linked to cardiovascular toxicities such as myocarditis, arrhythmias, and heart failure, posing significant clinical challenges. Here we review current evidence on the mechanisms, clini

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… Preventive role of high dose of atorvastatin. Basic Res. Cardiol. 120 (1), 263–286. 10.1007/s00395-024-01046-0 Escudier M., Cautela J., Malissen N., Ancedy Y., Orabona M., Pinto J., et al. (2017). Clinical features, management, and outcomes of immune checkpoint inhibitor-related cardiotoxicity. …

Beyond Hyperglycemia: The Role of Sodium-Glucose Cotransporter 2 Inhibitors in Cancer Treatment-related Cardiac Dysfunction.

Recent data suggest that sodium-glucose cotransporter 2 inhibitors have cardioprotective benefits. This effect may extend towards cardioprotection in cancer therapy-related cardiac dysfunction, with proposed mechanisms extending beyond glycemic control to include anti-inflammatory effects, oxidative stress reduction, and metabolic reprogramming. This review synthesizes potential mechanisms, observational data, and emerging trial evidence to support sodium-glucose cotransporter 2 inhibitors as a primary prevention strategy for cancer therapy-related cardiac dysfunction, particularly in anthracy

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… Acar Z Kale A Turgut M Efficiency of atorvastatin in the protection of anthracycline-induced cardiomyopathy. J Am Coll Cardiol 2011 58 988 9 10.1016/j.jacc.2011.05.025 21851890 55. Anker SD Butler J Filippatos G Empagliflozin in heart failure with a preserved ejection fraction. …

Double Repositioning: Veterinary Antiparasitic to Human Anticancer.

Drug repositioning, the approach of discovering different uses for existing drugs, has gained enormous popularity in recent years in the anticancer drug discovery field due to the increasing demand for anticancer drugs. Additionally, the repurposing of veterinary antiparasitic drugs for the treatment of cancer is gaining traction, as supported by existing literature. A prominent example is the proposal to implement the use of veterinary antiparasitics such as benzimidazole carbamates and halogenated salicylanilides as novel anticancer drugs. These agents have revealed pronounced anti-tumor act

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… Additionally, MZ, in combination with metformin, doxycycline, and atorvastatin, has been used on cancer to check the safety, tolerability, and efficacy of combination treatments ( NCT02201381 ). …

Mass spectrometry-based metabolomics in health and medical science: a systematic review.

Metabolomics is the study of the investigation of small molecules derived from cellular and organism metabolism, which reflects the outcomes of the complex network of biochemical reactions in living systems. As the most recent member of the omics family, there has been notable progress in metabolomics in the last decade, mainly driven by the improvement in mass spectrometry (MS). MS-based metabolomic strategies in modern health and medical science studies provide innovative tools for novel diagnostic and prognostic approaches, as well as an augmented role in drug development, nutrition science

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… Jia H. et al. , A Pharmacometabonomic Approach To Predicting Metabolic Phenotypes and Pharmacokinetic Parameters of Atorvastatin in Healthy Volunteers J. Proteome Res. 2015 14 9 3970 3981 10.1021/acs.jproteome.5b00440 26216528 Backshall A. Sharma R. Clarke S. …