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[Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evaluation].

UNLABELLED: A promising direction of osteoarthritis (OA) therapy is currently being considered pharmaceutical compositions of Symptomatic Slow Acting Drugs for Osteoarthritis (SYSADOA), which include type II collagen. A clinical observational study was conducted. OBJECTIVE: To Identify the effect of physical activity complex effects with dietary supplements Cartilox (composition: hydrolyzed type II collagen, hyaluronic acid, boswellia, curcumin, piperine) on the severity of pain syndrome in OA knee and hip joint patients, low back pain (LBP); assessment of the need for the appointment of NSAI…

Antileishmanial Activities of Medicinal Herbs and Phytochemicals In Vitro and In Vivo: An Update for the Years 2015 to 2021.

Leishmaniasis is one of the most neglected tropical diseases that present areal public health problems worldwide. Chemotherapy has several l … cts determined in vitro were in a range of 0.88 µg/mL (polar fraction of dichloromethane extract of Boswellia serrata) to 98 µg/mL (petroleum ether extract of Murraya koenigii). Among the 15 plant extracts studied in vivo, the hydroalcoholic leaf extract of Solanum havanense reduced parasites by 93.6% in cutaneous leishmaniasis. Voacamine extracted from Tab …

Frankincense and myrrh essential oils and burn incense fume against micro-inhabitants of sacral ambients. Wisdom of the ancients?

ETHNOPHARMACOLOGICAL RELEVANCE: Essential oils obtained from resins of Boswellia carteri Birdw. and Commiphora myrrha (Nees) Engl., commonly known as frankincense and true myrrh respectively, have been used extensively since 2800 BCE for the treatment of skin sores, wounds, teeth, inflammation, and urinary tract diseases in traditional medicine; for preparation of mummification balms and unguents; and also as incense and perfumes. Since ancient times, burning of frankincense and myrrh in places of worship for spiritual purposes and contemplation (a ubiquitous practice across various religions)…

Curcumin in Autoimmune and Rheumatic Diseases.

Over recent decades, many clinical trials on curcumin supplementation have been conducted on various autoimmune diseases including osteoarthritis, type 2 diabetes, and ulcerative colitis patients. This review attempts to summarize the highlights from these clinical trials. The efficacy of curcumin either alone or in conjunction with existing treatment was evaluated. Sixteen clinical trials have been conducted in osteoarthritis, 14 of which yielded significant improvements in multiple disease parameters. Eight trials have been conducted in type 2 diabetes, all yielding significant improvement i

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… In addition, two studies administered oral Boswellia serrata in conjunction with curcumin supplementation [ 19 , 24 ]. … In 2013, Kizhakkedath et al. tested the effectiveness of curcumin and boswellia combination supplement versus celecoxib, a selective COX-2 pathway inhibitor [ 19 ]. The 500 mg curcumin and boswellia formulation contained 350 mg curcumin extract and 150 mg Boswellia serrata extract. …

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… Boswellic Acid Boswellic acids are phytochemicals obtained from the gum resin of the Boswellia species which belong to the family Burseraaceae [ 363 ]. Boswellic acids are the major constituents of Boswellia serrata commonly known as Salai guggal, white guggal and Indian olibanum [ 364 ]. … A number of researchers have reported that pentacyclic triterpenes of Boswellia, boswellic acids, are one of the most promising anticancer agents. …

Essential oils and their constituents as anticancer agents: a mechanistic view.

Exploring natural plant products as an option to find new chemical entities as anticancer agents is one of the fastest growing areas of research. Recently, in the last decade, essential oils (EOs) have been under study for their use in cancer therapy and the present review is an attempt to collect and document the available studies indicating EOs and their constituents as anticancer agents. This review enlists nearly 130 studies of EOs from various plant species and their constituents that have been studied so far for their anticancer potential and these studies have been classified as in vitr

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… EO of Boswellia sacra has also been reported to induce PARP cleavage in MDA-MB-231 cells [ 50 ]. Some of the mechanisms leading to apoptosis are summarised below. 4.1.1. … Boswellia sacra oil influences the Akt protein expression [ 50 ]. …

Respiratory and allergic diseases: from upper respiratory tract infections to asthma.

Patients with asthma and allergic rhinitis may benefit from hydration and a diet low in sodium, omega-6 fatty acids, and transfatty acids, b … sion and in collaboration with an experienced herbalist or practitioner of TCM. Safe herbs, such as Boswellia and gingko, may be used singly as adjuncts to a comprehensive plan of care if the patient and practitioner have an interest in trying them while staying alert for drug-herb interactions. No data on the long-term use of these single herbs in asthma e …

Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?

Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contri

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… 95 extracted in ethanol 99% (v/v) and 100% ethyl acetate +49–52 mg volatile oil from C. longa containing 22–23.4 mg aromatic turmerone + inactive excipients (120–140 mg) including phosphatidyl choline, medium chain TGs, glycerol, gelatin, yellow beeswax | ( 124 ) Curamin | 350 mg BCM-95 + 150 mg of Boswellia … extract (each tablet with 400 mg curcumin, 50 mg spirulina, and 50 mg Boswellia extract) to patients with benign thyroid nodules and reported the reduced nodule area without adverse side events. 81 Also, curcumin and fennel essential oil (FEO) tablets (2 capsules, a total of 84 mg curcumin with 50 mg …

Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review.

PurposePhytosome technology, an advanced lipid-based delivery system, offers a promising solution for enhancing the bioavailability and therapeutic efficacy of secondary metabolites, particularly in cancer treatment. These metabolites, such as flavonoids, terpenoids, and alkaloids, possess significant anticancer potential but are often limited by poor solubility and low absorption. This review aims to investigate how phytosome encapsulation improves the pharmacokinetic profiles and anticancer effectiveness of these bioactive compounds.Patients and methodsThis comprehensive review is based on a

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… Efficacy of Phytosome-Encapsulated Secondary Metabolites Against Various Cancer Cell Types, Showing Enhanced Therapeutic Outcomes Metabolite/Compound | Cancer Cell Type / Disease | Effectiveness/Efficacy | Ref Sinigrin Phytosome | Melanoma | Complete wound healing, potent anticancer activity | [ 111 ] Boswellia … Beneficial Effects on Abdominal Bloating with an Innovative Food‐Grade Formulation of Curcuma longa and Boswellia serrata Extracts in Subjects with Irritable Bowel Syndrome and Small Bowel Dysbiosis. Nutrients . 2022;14(3):416. doi: 10.3390/nu14030416 114. Sasongko RE, Surini S, Saputri FC. …

The Role of Hypoxia-Inducible Factor-1α (HIF-1α) in the Progression of Ovarian Cancer: Perspectives on Female Infertility.

Hypoxia-Inducible Factor-1α (HIF-1α) is crucial in the progression of ovarian cancer, especially in influencing its tumor microenvironment and promoting pathogenic pathways that worsen female infertility. In hypoxic settings, HIF-1α is stabilized and activates the transcription of genes associated with angiogenesis, metabolic reprogramming, epithelial-to-mesenchymal transition, and therapeutic resistance. Angiogenesis and glycolytic reprogramming mediated by HIF-1 tumor proliferation, survival, and metastasis. Its dysfunction concurrently impairs ovarian homeostasis, undermining follicular gro

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… Boswellia Serrata inhibits 5-LOX and NF-κB, thereby reducing inflammation in ovarian cancer and reproductive tissues. It reduces tumor-associated inflammation, inhibits metastasis, and enhances the efficacy of chemotherapy. … Boswellia enhances ovarian function and mitigates inflammatory damage in cases of infertility, thereby improving fertility outcomes [ 82 ]. Gingerol inhibits COX-2, TNF-α, and IL-6, thereby decreasing systemic inflammation. …

Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies.

Hematological malignancies (HMs) are a heterogeneous group of blood neoplasia generally characterized by abnormal blood-cell production. Detection of HMs-specific molecular biomarkers (e.g., surface antigens, nucleic acid, and proteomic biomarkers) is crucial in determining clinical states and monitoring disease progression. Early diagnosis of HMs, followed by an effective treatment, can remarkably extend overall survival of patients. However, traditional and advanced HMs' diagnostic strategies still lack selectivity and sensitivity. More importantly, commercially available chemotherapeutic dr

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… Bioactive Compounds Biogenic AuNPs (b-AuNPs) synthesized from Boswellia serrata or Lens culinaris displayed cytotoxicity toward Human HL-60/vcr, Murine C1498, and 32D-FLT3-ITD cells, which was comparable to the mitoxantrone. …

Research Progress on Chinese Herbal Medicine Components Targeting Ferroptosis for Cancer Therapy.

Recent studies indicate that ferroptosis shows unique advantages in oncotherapy, particularly in reversing multidrug resistance (MDR). Despite current therapeutic advancements, the treatment of high-incidence malignancies with dismal prognoses continues to face challenges, including limited clinical efficacy, significant side effects, and drug resistance. In recent years, Chinese herbal medicine (CHM) has gained increasing attention in anti-tumor therapy. CHM bioactive components are highly effective in inducing tumor cell ferroptosis, inhibiting tumor proliferation and migration, and reversin

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… Boswellia carterii n-hexane extract (BCHE) has been confirmed to exhibit potent inhibitory effects against MCF-7 and MDA-MB-231 cells both in vitro and in vivo. Mechanistically, this efficacy is driven by the dual modulation of key ferroptotic pathways. … AMP-activated protein kinase alpha As 4 S 4 | Tetraarsenic tetrasulfide ATF4 | Activating transcription factor 4 AURKA | Aurora kinase A B-ALL | B-cell acute lymphoblastic leukemia B-NHL | B-cell non-Hodgkin lymphoma Bax | Bcl-2-associated X protein BBB | Blood–brain barrier BBR | Berberine BCHE | Boswellia …

Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway.

Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for MM, the disease remains incurable for most patients owing to emergence of drug-resistant cancerous cells. Guggulsterone (GS), a phytosteroid, extracted from the gum resin of guggul plant, has displayed various anticancer activities in vitro and in vivo; however, the molecular mechanisms of its anticancer activity have not been evaluated in MM cells. Therefore, in this study,

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… Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases. Front. Pharmacol. 2018;9:686. doi: 10.3389/fphar.2018.00686. 17. Kim B.R., Kim J., Lee J.E., Lee E.J., Yoon J.S. …

The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review.

BACKGROUND AND AIM: Recently, optimal immune function has become a primary focus of worldwide attention not only in the prevention of chronic disease but also as one strategy to reduce the severity of acute illness. Inflammation, a process largely controlled by the immune system, has long been studied and recognized for its role in chronic disease. Optimizing immune function or managing inflammation using individual nutrients and phytonutrients is not well understood by the average person. Thus, this narrative literature review summarizes many of the more recent findings about how certain nutr

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… for 15 days and an additional 30 days of treatment with type 2 diabetes with kidney disease | Plasma malondialdehyde and LPS decreased significantly, proteins associated with Nrf2 system function and IκB kinase significantly increased, and urinary albumin excretion considerably reduced Frankincense ( Boswellia …

Dietary Supplements in Chemotherapy-Induced Peripheral Neuropathy: A New Hope?

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the main and most prevalent side effects of chemotherapy, significantly affecting the quality of life of patients and the course of chemotherapeutic treatment. Nevertheless, despite its prevalence, the management of the CIPN is considered particularly challenging, with this condition often being perceived as very difficult or even impossible to prevent with currently available agents. Therefore, it is imperative to find better options for patients diagnosed with this condition. While the search for the new agents must continue, anothe

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… One of the supplements, composed of ALA, Boswellia serrata , methylsulfonylmethane, and bromelain, was announced to reduce CIPN pain with no other toxicity, nor interactions [ 148 ]. …

Targeted phytotherapy: essential oils, multi-target cancer action & nanodelivery.

Biochemical components of essential oils (EOs) are an innovative but largely underexplored type of precision phytotherapy (PT) in oncology owing to their anticancer activity against many types of tumors. This article discusses the important multitargeted molecular mechanisms of EOs (apoptosis, cell cycle arrest, angiogenesis, metastasis, tumor microenvironment) and their role as antitumor agents. In particular, an effort has been made to emphasize on the most notable volatile EOs such as thymol, eugenol, limonene, β-caryophyllene, and their interaction with oncogenic signaling pathways (NF-κB,

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… values lower in MCF-7 than HepG2; CL+TH-nanoemulsion more cytotoxic than CL+TH-emulsion on both cell lines; CL+TH-nanoemulsion more effective and significantly cytotoxic than taxol on MCF-7; Increased activity of caspase-8 and caspase-9; Decreased VEGFR-2 activity in MCF-7 | ( 115 ) Frankincense ( Boswellia …

The Role of Myrrh Metabolites in Cancer, Inflammation, and Wound Healing: Prospects for a Multi-Targeted Drug Therapy.

BackgroundMyrrh extract is a well-known medicinal plant with significant therapeutic benefits attributed to the activity of its diverse metabolites. It has promising activity against cancer and inflammatory diseases, and could serve as a potential therapeutic alternative since most therapeutic agents have severe side effects that impair quality of life.MethodThe current study identified the active metabolites from the myrrh resin methanolic extract. Then, the extracts were tested for in vitro anti-inflammatory and anti-cancer activity using cancer cell lines and Tamm-Horsfall Protein 1 (Thp-1)

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… Essential oils of some Boswellia spp., Myrrh and Opopanax. Undefined. 2003;18:153–156. 3. US Food and Drug Administration CFR—Code of Federal Regulations Title 21. New Hampshire Ave. …

Emerging Approaches for the Management of Chemotherapy-Induced Peripheral Neuropathy (CIPN): Therapeutic Potential of the C5a/C5aR Axis.

Chemotherapy-induced peripheral neuropathy (CIPN) is the most common neurologic complication of chemotherapy, resulting in symptoms like pain, sensory loss, and numbness in the hands and feet that cause lots of uneasiness in patients with cancer. They often suffer from pain so severe that it interrupts the treatment, thus invalidating the entire chemotherapy-based healing process, and significantly reducing their quality of life. In this paper, we underline the role of the complement system in CIPN, highlighting the relevance of the C5a fragment and its receptor C5aR1, whose activation is thou

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… The approved nutraceutical Opera®, a combination of α-lipoic acid, Boswellia serrata , methylsulfonylmethane, and bromelain, was shown to be able to improve CIPN symptoms in a prospective series of patients treated with neurotoxic chemotherapeutics, with no significant toxicity or interaction [ 109 ] …

Curcumin as a promising therapeutic agent for diabetic neuropathy: from molecular mechanisms to functional recovery.

Diabetes mellitus is an endocrine disorder characterized by prolonged hyperglycemia. It results from either insulin deficiency (type 1 diabetes mellitus, T1DM) or insulin resistance (type 2 diabetes mellitus, T2DM). This condition has emerged as a significant health concern in recent years. Hyperglycemia induces the overproduction of reactive oxygen species (ROS), which can modulate multiple pathways, including AGEs-RAGE, PKC stimulation, NF-κB and PI3K/AKT. These pathways contribute to diabetes-related complications such as inflammation, oxidative stress, insulin resistance, and reduced gluco

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… The supplement contains a blend of withania somnifera root, boswellia serrata stem, curcuma longa rhizome, and zinc. 6 months [ 220 ] NO Notable improvements in endothelial function and reductions in key biomarkers, including MDA, ET-1, IL-6, and TNF-α levels, were observed in the treatment groups. … The supplement contains a blend of withania somnifera root, boswellia serrata stem, curcuma longa rhizome, and zinc. | 6 months | [ 220 ] NO | Notable improvements in endothelial function and reductions in key biomarkers, including MDA, ET-1, IL-6, and TNF-α levels, were observed in the treatment groups …

Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases.

There have been magnificent advancements in the understanding of molecular mechanisms of chronic diseases over the past several years, but these diseases continue to be a considerable cause of death worldwide. Most of the approved medications available for the prevention and treatment of these diseases target only a single gene/protein/pathway and are known to cause severe side effects and are less effective than they are anticipated. Consequently, the development of finer therapeutics that outshine the existing ones is far-reaching. Natural compounds have enormous applications in curbing seve

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… Googling the guggul (commiphora and boswellia) for prevention of chronic diseases. Front. Pharm. 2018;9:686. doi: 10.3389/fphar.2018.00686. 25. Khwairakpam A.D., Bordoloi D., Thakur K.K., Monisha J., Arfuso F., Sethi G., Mishra S., Kumar A.P., Kunnumakkara A.B. …