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Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells.

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the second leading cause of cancer death worldwide. The modern concept of cancer biology indicates that cancer is formed of a small population of cells called cancer stem cells (CSCs), which present both pluripotency and self-renewal properties. These cells are considered responsible for the progression of the disease, recurrence and tumor resistance. Interestingly, some cell signaling pathways participate in CRC survival, proliferation, and self-renewal properties, and most of them are dysregulated in CSCs, includ

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… Epigallocatechin gallate Epigallocatechin gallate (EGCG), also known as epigallocatechin‐3‐gallate, is one of the catechins found in green tea. … Terminated (on the request of the investigational drug provider) NCT01606124 | Polyphenon E in treating patients with high‐risk of colorectal cancer | Advanced colorectal adenomas adenocarcinoma of the colon stage I colon cancer stage II colon cancer stage III colon cancer | Drug: defined green tea catechin …

Redefining Chemoresistance: Natural Bioactives as Molecular Modulators at the Cancer-Tumor Microenvironment Interface.

Therapeutic resistance remains a critical barrier in effective cancer treatment, contributing to disease recurrence, progression, and reduced patient survival. In recent years, natural bioactive compounds have emerged as promising adjuncts in oncology due to their ability to modulate multiple biological processes involved in resistance. This review explores current evidence on the role of natural compounds in influencing cancer cell behavior and their interactions with the tumor microenvironment. By organizing these compounds into chemical families, we provide a structured overview of their po

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… EGCG, the primary catechin in green tea, inhibits tumor-promoting pathways by blocking NF-κB and STAT3 activation, thus reducing the transcription of IL-6, MMP-9, and CD44 [ 160 , 161 , 162 ]. …

Redox Remodeling by Nutraceuticals for Prevention and Treatment of Acute and Chronic Inflammation.

Antioxidant-rich dietary regimens are considered the best practice to maintain health, control inflammation, and prevent inflammatory diseases. Yet, nutraceuticals as food supplements are self-prescribed and purchasable over the counter by healthy individuals for the purpose of beneficial effects on fitness and aging. Hence, the effectiveness, safety, and correct intake of these compounds need to be better explored. Since redox-modulating activity of these compounds appears to be involved in activation and or suppression of immune cells, the preventive use of nutraceuticals is very attractive

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… Beneficial Properties of Green Tea Catechins. Int. J. Mol. Sci. 2020;21:1744. doi: 10.3390/ijms21051744. 47. Vujicic M., Nikolic I., Kontogianni V.G., Saksida T., Charisiadis P., Orescanin-Dusic Z., Blagojevic D., Stosic-Grujicic S., Tzakos A.G., Stojanovic I. …

Status and Future Directions of Therapeutics and Prognosis of Cardiac Amyloidosis.

Accumulation of aberrant proteins in the heart causes cardiac amyloidosis, an uncommon and complicated illness. It can be classified into two main types: light chain (AL) and transthyretin (ATTR). The diagnosis of cardiac amyloidosis is challenging due to its non-specific clinical presentation and lack of definitive diagnostic tests. Diagnostic accuracy has increased with the advent of modern imaging methods, including cardiac magnetic resonance imaging (MRI) and positron emission tomography (PET) scans. Depending on the severity of cardiac amyloidosis, a number of treatments may be attempted

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… Epigallocatechin-3-Gallate (EGCG) Green tea might be a therapeutic option since its most abundant catechin, epigallocatechin-3-gallate (EGCG), is a powerful antioxidant that blocks the development of insoluble amyloid fibrils and stabilizes existing ones, making them less hazardous. 99 , 100 Three phase …

Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review.

PurposePhytosome technology, an advanced lipid-based delivery system, offers a promising solution for enhancing the bioavailability and therapeutic efficacy of secondary metabolites, particularly in cancer treatment. These metabolites, such as flavonoids, terpenoids, and alkaloids, possess significant anticancer potential but are often limited by poor solubility and low absorption. This review aims to investigate how phytosome encapsulation improves the pharmacokinetic profiles and anticancer effectiveness of these bioactive compounds.Patients and methodsThis comprehensive review is based on a

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… Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer. Molecules . 2020;14(25):1–39. 99. Arfin S, Jha NK, Jha SK, et al. Oxidative Stress in Cancer Cell Metabolism. …

Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy.

Matrix metalloproteinases (MMPs) are a family of enzymes involved at different stages of cancer progression and metastasis. We previously identified a novel class of bisphosphonic inhibitors, selective for MMPs crucial for bone remodeling, such as MMP-2. Due to the increasing relevance of specific MMPs at various stages of tumor malignancy, we focused on improving potency towards certain isoforms. Here, we tackled MMP-9 because of its confirmed role in tumor invasion, metastasis, angiogenesis, and immuno-response, making it an ideal target for cancer therapy. Using a computational analysis, we

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… Mimic Catechins to Develop Selective MMP-2 Inhibitors. Mon. Chem. 2018;149:1293–1300. doi: 10.1007/s00706-018-2237-4. 34. Pochetti G., Montanari R., Gege C., Chevrier C., Taveras A.G., Mazza F. …

Antioxidant and Antiproliferation Activities of Lemon Verbena (Aloysia citrodora): An In Vitro and In Vivo Study.

Aloysia citrodora (Verbenaceae) is traditionally used to treat various diseases, including bronchitis, insomnia, anxiety, digestive, and heart problems. In this study, this plant's antioxidant and anti-proliferation effects were evaluated. In addition to volatiles extraction, different solvent extracts were prepared. The GC-MS, LC-MS analysis and the Foline-Ciocalteu (F-C) method were used to investigate the phytochemical components of the plant. MTT assay was used to measure the antiproliferative ability for each extract. Antioxidant activity was determined using the 2,2-diphenylpicrylhydrazy

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… Ultrasonic assisted aqueous extraction of catechin and gallic acid from Syzygium cumini seed kernel and evaluation of total phenolic, flavonoid contents and antioxidant activity Chem. Eng. Process. Process Intensif. 2020 149 107841 10.1016/j.cep.2020.107841 124. Brand-Williams W. Cuvelier M.-E. …

New insight into adiponectin role in obesity and obesity-related diseases.

Obesity is a major health problem strongly increasing the risk for various severe related complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders, diabetic retinopathy, and cancer. Adipose tissue is an endocrine organ that produces biologically active molecules defined "adipocytokines," protein hormones with pleiotropic functions involved in the regulation of energy metabolism as well as in appetite, insulin sensitivity, inflammation, atherosclerosis, cell proliferation, and so forth. In obesity, fat accumulation causes dysregulation of adipokine production tha

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… Several new synthetic drugs such as telmisartan, bezafibrate, rimonabant, and natural products such as anthocyanin, xanthohumol, catechins, and sulfatide have been reported to enhance adiponectin production [ 146 – 150 ]. …

Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue.

Purpose: In this study we aimed to estimate the effectiveness of pharmacological, nutraceutical, and phytopharmaceutical treatments on CRF. Methods: Ovid MEDLINE, Ovid Embase, Ovid Psych info, CINHAHL and Cochrane Library databases were searched up to 30 September 2021. Randomized controlled trials of pharmacological, nutraceutical and phytopharmaceutical interventions for treatment of CRF for at least one week duration and have used valid tool to assess severity of CRF as a primary or secondary outcome were considered. Results: 32 eligible studies (4896 patients) were reviewed. For the overal

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… Guarana ( Paullinia cupana ) extract has been used to treat CRF, and it has high concentration of caffeine (2.5 and 5.8% of the fruit’s dry weight) [ 51 , 52 ], theobromine, theophylline (both below 0.3%) and flavonoids (proanthocyanidins, catechins, and epicatechines) [ 53 , 54 ]. …

2024 Clinical Practice Guidelines for the Diagnosis and Pharmacologic Treatment of Overweight and Obesity by the Korean Society for the Study of Obesity.

The Korean Society for the Study of Obesity has published the 9th edition of its Clinical Practice Guidelines to provide updated, evidence-based recommendations for the management of overweight and obesity. Developed through a structured process of systematic literature review and expert consensus, these guidelines incorporate recent clinical evidence for obesity management. Key clinical questions were formulated using the Population, Intervention, Comparison, and Outcome framework and addressed through comprehensive evaluations of randomized controlled trials, cohort studies, systematic revie

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… Catechin- and caffeine-rich teas for control of body weight in humans. Am J Clin Nutr. 2013;98(6 Suppl):1682S–93S. doi: 10.3945/ajcn.113.058396. 118. Yu Z, Samavat H, Dostal AM, Wang R, Torkelson CJ, Yang CS, et al. …

Natural Products/Bioactive Compounds as a Source of Anticancer Drugs.

Cancer is one of the major deadly diseases globally. The alarming rise in the mortality rate due to this disease attracks attention towards discovering potent anticancer agents to overcome its mortality rate. The discovery of novel and effective anticancer agents from natural sources has been the main point of interest in pharmaceutical research because of attractive natural therapeutic agents with an immense chemical diversity in species of animals, plants, and microorganisms. More than 60% of contemporary anticancer drugs, in one form or another, have originated from natural sources. Plants

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… Preparation of catechin extracts and nanoemulsions from green tea leaf waste and their inhibition effect on prostate cancer cell PC-3 Int. J. Nanomed. 2016 11 1907 1926 10.2147/IJN.S103759 PMC4866752 27226712 41. Hussein N.A.E.M. El-Toukhy M.A.E.-F. Kazem A.H. Ali M.E.-S. Ahmad M.A.E.-R. …

Plant Antimicrobial Peptides as Potential Tool for Topic Treatment of Hidradenitis Suppurativa.

Among chronic skin autoinflammatory diseases, Hidradenitis Suppurativa (HS) stands out for its chronicity, highly variable condition, and profound impact on the patients' quality of life. HS is characterized by suppurative skin lesions in diverse body areas, including deep-seated painful nodules, abscesses, draining sinus, and bridged scars, among others, with typical topography. To date, HS is considered a refractory disease and medical treatments aim to reduce the incidence, the infection, and the pain of the lesions. For this purpose, different classes of drugs, including anti-inflammatory

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… contained in green tea such as epicatechin, epicatechin-3-gallate, epigallocatechin and epigallocatechin-3-gallate reduce ultraviolet B induced inflammation by functioning as an antioxidant ( Draelos, 2017 ); chronic diseases have been targeted by flavonoids with effects on inflammasome regulation and catechin …

Regulation of microRNAs by natural agents: new strategies in cancer therapies.

MicroRNAs (miRNAs) are short noncoding RNA which regulate gene expression by messenger RNA (mRNA) degradation or translation repression. The … ts. Recent studies have shown that natural agents such as curcumin, resveratrol, genistein, epigallocatechin-3-gallate, indole-3-carbinol, and 3,3'-diindolylmethane exert their antiproliferative and/or proapoptotic effects through the regulation of one or more miRNAs. Therefore, this review will look at the regulation of miRNAs by natural agents as a means …

Липидированные мезофорные наночастицы, нагруженные тимокиноном, в качестве нового метода лечения аутоиммунного энцефаломиелита у крыс.

AIMS: Пересечение мозгового барьера (BBB) по-прежнему является серьезной проблемой для доставки терапевтических агентов в центральную нервную систему. Цель этого исследования состояла в том, чтобы оценить потенциал новых наноформуляционных силикатных силиканочастиц (MSN), покрытых липидным двуслойным слоем (LB), с тем чтобы повысить уровень доставки и потенциальное ремиелионирующее воздействие тимокинона (TQ). МЕТОДЫ: Составы характеризовались микроскопией передачи электронов и динамическим рассеиванием света для определения потенциала зета и размера частиц. Экспериментальная аутоиммунная энце

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… Decline in Glutathione peroxidase activity is a reason for brain senescence: consumption of Green tea catechin prevents the decline in its activity and protein oxidative damage in ageing mouse brain. Biogerontology. 2007;8(4):423–30. 10.1007/s10522-007-9085-7. 74. Alrafiah A. …

Биологическая роль мономеров традиционной китайской медицины в нейронных расстройствах.

Традиционная китайская медицина (TCM) является биоактивным соединением, извлекаемым из китайских травяных лекарственных препаратов, обладающих определенной биологической активностью и фармакологическими последствиями, и привлекла большое внимание к лечению нейронных заболеваний. Однако применение мономеров ТХМ ограничено их низкой растворимостью и низкой способностью пересекать барьер кровеносного мозга (ББД). Экзосомы представляют собой небольшие внеклеточные везикли (ЭМ) диаметром от 30 до 150 нм и могут использоваться в качестве носителей наркотиков, которые непосредственно предназначены дл

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… Additionally, epicatechin gallate (ECG), one of the most effective catechins present in various plants and foods, was incorporated into fresh bovine milk-derived exosomes (exosome-ECG). …

Progress and challenges in the treatment of cardiac amyloidosis: a review of the literature.

Cardiac amyloidosis is a restrictive cardiomyopathy determined by the accumulation of amyloid, which is represented by misfolded protein fragments in the cardiac extracellular space. The main classification of systemic amyloidosis is determined by the amyloid precursor proteins causing a very heterogeneous disease spectrum, but the main types of amyloidosis involving the heart are light chain (AL) and transthyretin amyloidosis (ATTR). AL, in which the amyloid precursor is represented by misfolded immunoglobulin light chains, can involve almost any system carrying the worst prognosis among amyl

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… both patients with ATTRv and ATTRwt; withdrawal due to side effects was related to gastrointestinal complaints, but most patients had no adverse events. 107 Oligomer aggregation inhibition Green tea There are some studies that revealed that the polyphenol epigallocatehin gallate, the most abundant catechin …

Chondroprotection and Molecular Mechanism of Action of Phytonutraceuticals on Osteoarthritis.

Osteoarthritis (OA) is a degenerative joint disease and an important cause of incapacitation. There is a lack of drugs and effective treatments that stop or slow the OA progression. Modern pharmacological treatments, such as analgesics, have analgesic effects but do not affect the course of OA. Long-term use of these drugs can lead to serious side effects. Given the OA nature, it is likely that lifelong treatment will be required to stop or slow its progression. Therefore, there is an urgent need for disease-modifying OA treatments that are also safe for clinical use over long periods. Phytonu

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… Trapping of growth factors by catechins: A possible therapeutical target for prevention of proliferative diseases. J. Nutr. Biochem. 2005;16:259–266. doi: 10.1016/j.jnutbio.2004.11.003. 66. Chin K.Y., Ima-Nirwana S. …

New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy.

Phytocompounds have been evaluated for their anti-glioblastoma actions for decades, with promising results from preclinical studies but only limited translation into clinics. Indeed, by targeting multiple signaling pathways deregulated in cancer, they often show high efficacy in the in vitro studies, but their poor bioavailability, low tumor accumulation, and rapid clearance compromise their efficacy in vivo. Here, we present the new avenues in phytocompound research for the improvement of glioblastoma therapy, including the ways to enhance the response to temozolomide using phytochemicals, th

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… In a different investigation, the capacity to decrease MGMT expression in glioma cells was assessed in regards to rutin, catechin, dehydrozingerone, naringenin, and quercetin treatment, both individually and in combination with TMZ [ 24 ]. …

The Link Between the Gut Microbiome and Bone Metastasis.

The gut microbiome is essential for regulating host metabolism, defending against pathogens, and shaping the host's immune system. Mounting evidence highlights that disruption in gut microbial communities significantly impacts cancer development and treatment. Moreover, tumor-associated microbiota, along with its metabolites and toxins, may contribute to cancer progression by promoting epithelial-to-mesenchymal transition, angiogenesis, and metastatic spread to distant organs. Bones, in particular, are common sites for metastasis due to a rich supply of growth and neovascularization factors an

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… Castillo-Pichardo et al. tested the impact of combined supplementation with resveratrol, quercetin, and catechin (5 mg/kg each polyphenol) on mammary tumor progression in a murine model with an injected bone metastatic variant of MDA-MB-435 (ER−) cancer cells. …

Medicinal Plants with Anti-Leukemic Effects: A Review.

Leukemia is a leukocyte cancer that is characterized by anarchic growth of immature immune cells in the bone marrow, blood and spleen. There are many forms of leukemia, and the best course of therapy and the chance of a patient's survival depend on the type of leukemic disease. Different forms of drugs have been used to treat leukemia. Due to the adverse effects associated with such therapies and drug resistance, the search for safer and more effective drugs remains one of the most challenging areas of research. Thus, new therapeutic approaches are important to improving outcomes. Almost half

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… . | Antiproliferation andApoptosis induction | [ 57 , 58 , 59 , 60 ] Olea europaea | Oleaceae | Phenols, oleuropeosides oleuropein/verbascoside, Hydroxytyrosol, Flavons Flavonols (rutin), catechin Phenols (vanillin, tyrosol hydroxytyrosol, caffeic acid and vanillic acid). | Jurkat, K562 cells line andHL60 …