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The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease.

Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed. During the last five years, the landscape of the pharmacotherapy of SCD has changed dramatically. Currently, 54 drugs have been used or under consideration to use for the treatment of SCD. These fall into 3 categories: the first category includes the four drugs (Hydroxyurea, L-Glutamine, Crizanlizumab tmca and Voxelotor) that have been approved by the United States Food and Drug Administration (FDA) based on suc

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… The universal administration of HU to children with SCD was successful in Malawi 68 but not in Nigeria 69 where concerns about its long-term safety and toxicity limited its prescription by physicians and acceptability by patients. … Hydroxyurea in Adult Patients with Sickle Cell Disease J Racial Ethn Health Disparities 2019 6 6 1233 43 10.1007/s40615-019-00625-5 31410784 PMC6832819 68 Mvalo T Topazian HM Kamthunzi P Chen JS Kambalame I Mafunga P Real-world experience using hydroxyurea in children with sickle cell disease in Lilongwe, Malawi …

Прогнозирующие детерминанты долгосрочной смертности у пожилых пациентов с новой диагностированной множественной миеломой.

Фон/цели: Множественная миелома (ММ) — опухоль плазменной клетки, диагностированная преимущественно у пожилых людей. Вместе с тем еще предстоит твердо установить значение определения слабой стороны пациента, а также определения наиболее подходящих и надежных инструментов для его оценки. Методы: Это ретроспективное исследование 36 больные в возрасте 65 - лица более старшего возраста, прошедшие комплексную гериатрическую оценку (CGA). Средний возраст пациентов 76 (СД) 6.22) с 33.3% быть женщиной. Оценка пациентов проводилась с использованием индекса упругости Международной рабочей группы по миел

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… Malawi Med. J. 2012;24:69–71. 46. D’Agostino M., Larocca A., Offidani M., Liberati A.M., Gaidano G., Petrucci M.T., Derudas D., Capra A., Zambello R., Cascavilla N., et al. …

Treatment outcomes in HIV infected patients older than 50 years attending an HIV clinic in Harare, Zimbabwe: A cohort study.

There is a growing number of older people living with HIV (OPLHIV). While a significant proportion of this population are adults growing into old age with HIV, there are also new infections among OPLHIV. There is a lack of data describing the outcomes of OPLHIV who commenced antiretroviral therapy (ART) after the age of 50 years in sub-Saharan Africa. We conducted a cohort study of patients who enrolled in care at Newlands Clinic in Harare, Zimbabwe, at ages ≥50 years between February 2004 and March 2020. We examined demographic characteristics, attrition, viral suppression, immunological and

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… Gendered health institutions: examining the organization of health services and men’s use of HIV testing in Malawi . Journal of the International AIDS Society . 2020 ; 23 . doi: 10.1002/jia2.25517 32589346 PMC7319160 15 Grimsrud A , Ameyan W , Ayieko J , Shewchuk T . …

Treatment preferences of patients with relapsed and refractory multiple myeloma: a qualitative study.

BACKGROUND: Multiple myeloma is a haematological malignancy characterized by significant morbidity and mortality. This study sought to develop an in-depth understanding of patients' lived experiences of relapsed or refractory multiple myeloma (RRMM) and its treatment, and to identify which features of treatment were most important to them. METHODS: Qualitative interviews and focus groups (FGs) were conducted with 32 people living with RRMM across Canada. In Phase 1, interviews focused on participants' accounts of their experiences with the disease and its treatment and laid the groundwork for

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… Developing attributes and attribute-levels for a discrete choice experiment on micro health insurance in rural Malawi. BMC Health Serv Res. 2014;14:235. doi: 10.1186/1472-6963-14-235. 20. Wong SF, Norman R, Dunning TL, et al. …

Знания, отношение и практика в отношении множественной миеломы среди медицинского персонала в регионе Энши.

Исследование в районе Энши между Сент-Новым 2023 Оценивая знания, отношение и практику медицинского персонала в отношении множественной миеломы. Это заболевание оказывает значительное воздействие на физическое здоровье, качество жизни и психическое здоровье. Медицинские работники играют важнейшую роль в его профилактике и лечении. При анализе использовались корреляция Пирсона, логистическая регрессия и модель структурных уравнений (SEM). Всего 229 действительные вопросники были собраны вместе с 68.6% :: женщин-участников и 42.4% возраст 31-40 Годы. Знания, отношение и практические оценки 36.27

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… Some observations from medical anthropology research on malaria in pregnancy in Malawi. Anthropol. Matters 11 , (2009). 19. Ritter, L. M., Fagerlie, S. R., Ghobrial, I. M., Vij, R. & Repetto P. …

Пациентский опыт биопсихосоциального воздействия синдрома Гильен-Барре: обзор.

Синдром фоновой гильии-барре (GBS) — острый аутоиммунный расстройство периферической нервной системы, которое может привести к слабости мышц, дыхательной недостаточности и длительной инвалидности. Хотя клинические аспекты были широко изучены, данные о биопсихосоциально-духовном воздействии на взрослых остаются ограниченными.2005) и был представлен в соответствии с руководящими принципами PRISMA-ScR. Поиски литературы проводились в Пуббмеде, Скопусе и EBCOCOhost для исследований, опубликованных с января 2015 и январь 2025. Используя систему PCC, мы включили проверенные первичные исследования по

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… Malawi Med J . 2023;35(3):156–162. doi: 10.4314/mmj.v35i3.4 32. Djordjevic G, Stojanov A, Bozovic I, et al. Six-month prospective study of quality of life in Guillain-Barre syndrome. Acta Neurol Scand . 2020;141(3):236–241. doi: 10.1111/ane.13195 33. Correia I, Bernardes C, Cunha C, et al. …

Mapping Cancer in Africa: A Comprehensive and Comparable Characterization of 34 Cancer Types Using Estimates From GLOBOCAN 2020.

ObjectiveCancer incidence and mortality rates in Africa are increasing, yet their geographic distribution and determinants are incompletely characterized. The present study aims to establish the spatial epidemiology of cancer burden in Africa and delineate the association between cancer burden and the country-level socioeconomic status. The study also examines the forecasts of the cancer burden for 2040 and evaluates infrastructure availability across all African countries.MethodsThe estimates of age, sex, and country-specific incidence and mortality of 34 neoplasms in 54 African countries, we

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… Lesotho | 1,876 [1,711–2,057] | 109 | 74.8 | 1,256 [1,148–1,374] | 0.67 Liberia | 3,552 [2,842–4,439] | 119.3 | 90.5 | 2,603 [2,114–3,205] | 0.73 Libya | 7,661 [7,063–8,309] | 132.2 | 88.2 | 4,750 [4,381–5,150] | 0.62 Madagascar | 20,681 [18,358–23,298] | 124.3 | 87.7 | 13,837 [12,282–15,588] | 0.67 Malawi …

Clinical and Therapeutic Implications of Epstein-Barr Virus in HIV-Related Lymphomas.

The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the prevalence of Epstein-Barr virus (EBV) is high. It has been shown that EBV is involved in different lymphomagenic mechanisms mediated by some of its proteins, contributing to the development of different lymphoma subtypes. Additionally, cooperation between both HIV an

Ready-to-use therapeutic food (RUTF) for home-based nutritional rehabilitation of severe acute malnutrition in children from six months to five years of age.

BACKGROUND: Management of severe acute malnutrition (SAM) in children comprises two potential phases: stabilisation and rehabilitation. Duri … ; effective sample size = 6630), four of which were cluster trials. Eight studies were conducted in Malawi, four in India, and one apiece in Kenya, Zambia, and Cambodia. Six studies received funding or donations from industry whereas eight did not, and one study did not report the funding source.The overall risk of bias was high for six studies, unclear …

The paradoxical relationship between ligamentum flavum hypertrophy and developmental lumbar spinal stenosis.

Genomic sequencing of worldwide butterfly fauna followed by phylogenetic analysis of protein-coding genes informs butterfly classification t … Togo), Ceratrichia notata Grishin, sp. n. (type locality in Central African Republic), and Semalea malawi Grishin, sp. n. (type locality in Malawi). Furthermore, we elevate a tribe to subfamily, resurrect 3 tribes, 3 subtribes, 5 genera (and confirm 1), 3 subgenera, change the rank of 5 currently recognized tribes to subtribes (and confirm 1), 10 genera …

Nanotechnology-Driven Cancer Therapies for Precision Oncology: Advances and Clinical Outlook.

Cancer continues to pose a global health challenge, with conventional therapies often limited by non-specific toxicity, drug resistance, and an inadequate therapeutic index. Nanotechnology offers transformative opportunities by enabling targeted drug delivery, improved pharmacokinetics, and integrated diagnostic-therapeutic platforms (termed nanotheranostics). This review highlights key nanocarrier systems including liposomes, polymeric nanoparticles, dendrimers, inorganic nanostructures, carbon-based materials, extracellular vesicles, and hybrid platforms with a focus on human studies and cli

Client preferences in noncommunicable diseases management in Australia: A scoping review.

Noncommunicable diseases (NCD) are the leading causes of mortality in Australia. Understanding clients' preferences is essential to implement effective care models that revitalize utilization of services. This study aims to review existing evidence on client preferences of service delivery among people with NCD in Australia. We followed PRISMA extension for scoping review. Articles conducted with discrete choice experiment were included. Clients with NCD in general or one of the five major diseases: cardiac diseases, diabetes, cancer, chronic respiratory diseases, and mental health disorders.

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… Preferences for Hypertension Care in Malawi: A Discrete Choice Experiment Among People Living with Hypertension, With and Without HIV. AIDS Behav. 2025;29(1):246–56. doi: 10.1007/s10461-024-04492-y 71. Lv Y, Qin J, Feng X, Li S, Tang C, Wang H. …

Analysis of the distribution of malignant tumor burden across eight systems in Africa: an epidemiological analysis based on the Global Burden of Disease Study 1990-2021.

ObjectiveAfrica, a continent abundant in natural resources yet facing economic and cultural challenges. This study investigates the burden of cancer in Africa, leveraging data from the Global Burden of Disease Study 2021 to highlight the need for targeted healthcare interventions and policy reforms.Materials and methodsWe analyzed cancer incidence, prevalence, mortality rates, and Disability-Adjusted Life Years per 100 000 population across 54 African countries from 1990 to 2021. The study categorized malignancies into eight major organ systems and utilized the Social Demographic Index (SDI) t

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… Lymphatic and hematopoietic system cancers are most prevalent in Libya, with an ASIR of 24.32, followed by Zimbabwe (ASIR = 19.36), Uganda (ASIR = 16.73), and Malawi (ASIR = 16.67) (Fig. 1 ). Figure 1. Incidence of malignant tumor across eight systems in Africa in 2021. …

Fertility Preservation in Female Patients with Cancer. Part I: Challenges and Future Prospects in Developing Countries; A Narrative Review Study.

While international guidelines on oncofertility practice have been published in developed countries, there is limited information available on oncofertility practice in developing countries, which often face limitations in their cancer health support networks. As survival rates improve in the field of cancer and other diseases, there is a growing need for stronger oncofertility services in developing countries. Given that 50% of cancer patients are under the age of 65, many of these patients are of reproductive age and preserving their fertility health prior to starting treatment is valuable.

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… patient-centered approach to fertility preservation J Assist Reprod Genet 2018 35 1 49 59 29124460 10.1007/s10815-017-1081-5 PMC5758476 77 Azad AD Charles AG Ding Q Trickey AW Wren SM The gender gap and healthcare: associations between gender roles and factors affecting healthcare access in Central Malawi …

Оценка терпимости к засухе на большом числе горных хлопковых заводов (Gosypium hirsutum L.) в рамках различных режимов ирригации на стадии селекции.

Завод по производству хлопка имеет важное значение, поскольку он обеспечивает сырьем различные отрасли промышленности. Несмотря на то, что хлопок, как правило, является устойчивым к засухе, на нем негативно сказывается долгосрочная засуха. Испытание проводилось в соответствии с прикладной экспериментальной конструкцией в качестве полностью произвольной конструкции (CRD) three тиражирование для определения группы экспертов 93 Генотипы хлопка в ответ на засуху в контролируемых условиях 2022. Все генотипы были покрыты водой 80 mL-1 Водные ресурсы100% ирригация, полевая мощность) three Появлялись

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… Screening cotton (Gossypium hirsutum L.) genotypes for drought tolerance under screen house conditions in Malawi. J. Plant Breed. Crop. Sci. 2018;10:48–57. 64. Pawar K.N., Veena V.B. Evaluation of Cotton Genotypes for Drought Tolerance using PEG6000 Water Stress by Slanting Glass Plate Technique. …

Re-estimation of the burden of serious fungal diseases in Uganda.

BACKGROUND: It is of utmost importance to monitor any change in the epidemiology of fungal diseases that may arise from a change in the number of the at-risk population or the availability of local data. OBJECTIVE: We sought to update the 2015 publication on the incidence and prevalence of serious fungal diseases in Uganda. METHODS: Using the Leading International Fungal Education methodology, we reviewed published data on fungal diseases and drivers of fungal diseases in Uganda. Regional or global data were used where there were no Ugandan data. RESULTS: With a population of ~45 million, w

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… Malawi Med J 2003 ; 15 : 91 – 94 . 27528972 PMC3346033 129 Bongomin F Ekeng BE Kwizera R , et al . Fungal diseases in Africa: closing the gaps in diagnosis and treatment through implementation research and advocacy . …

Opioid Use at End-Of-Life Among Nova Scotia Patients With Cancer.

Purpose: To determine the factors associated with opioid analgesic prescriptions as measured by community pharmacy dispensations to all Nova Scotia (NS) patients with cancer at end-of-life from 2005 to 2009. Methods: The NS Cancer Registry and the NS Prescription Monitoring Program (NSPMP) were used to link Nova Scotians who had a cancer diagnosis and received a prescription for opioids in their last year of life (n = 6,186) from 2005 to 2009. The association of factors with opioid dispensations at end-of-life were determined (e.g., patient demographics, type of prescriber, type of cancer, and

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… Assessing and Responding to Palliative Care Needs in Rural Sub-saharan Africa: Results from a Model Intervention and Situation Analysis in Malawi. PLoS One 9 (10), e110457. 10.1371/journal.pone.0110457 Howell D., Marshall D., Brazil K., Taniguchi A., Howard M., Foster G., et al. (2011). …

An overview of cancer health disparities: new approaches and insights and why they matter.

Cancer health disparities remain stubbornly entrenched in the US health care system. The Affordable Care Act was legislation to target these disparities in health outcomes. Expanded access to health care, reduction in tobacco use, uptake of other preventive measures and cancer screening, and improved cancer therapies greatly reduced cancer mortality among women and men and underserved communities in this country. Yet, disparities in cancer outcomes remain. Underserved populations continue to experience an excessive cancer burden. This burden is largely explained by health care disparities, lif

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… This cancer is particularly common on the Korean peninsula due to a combination of regional dietary risk factors and chronic H. pylori infections whereas Malawi in Eastern African is especially impacted by esophageal cancers, having the highest global disease rates due to factors that have yet to be …

HIV-Associated Lymphomas: Updates from Pathogenesis to Treatment Strategies.

HIV-associated lymphoma (HAL) is an aggressive malignancy directly linked to HIV infection and accounts for more than 30% of cancer-related deaths in people living with HIV (PLWH). HAL subtypes, including diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), primary effusion lymphoma (PEL), and plasmablastic lymphoma (PBL), exhibit five to ten times higher incidence rates and distinct molecular profiles compared to HIV-negative lymphomas. Pathogenesis involves HIV-driven CD4+ T-cell depletion, chronic B-cell activation, and oncogenic viral coinfection. First-line therapy combines antir

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… Mature outcomes and prognostic indices in diffuse large B‐cell lymphoma in Malawi: A prospective cohort. Br. J. Haematol. 2019;184(3):364–372. doi: 10.1111/bjh.15625. 74. Zelenetz A.D., Gordon L.I., Chang J.E., et al. NCCN Guidelines® Insights: B-cell lymphomas, version 5.2021. J. Natl. Compr. …

Новые тенденции в нанобиосистемах Змей-Веном-Лоадед: всеобъемлющий обзор.

Достижения в медицинской нанобиотехнологии в значительной степени способствовали применению ядов змеиных токсинов, облегчая разработку новых методов лечения токсинов, производимых животными. Огромное разнообразие видов змей и их ядовые сложности подчеркивают необходимость продолжения исследований. Этот обзор посвящен изучению интеграции яда змеиных ядов с наночастицами, с тем чтобы они могли использоваться в лечении человека в целях разработки методов лечения. Сложная смесь яда змей не только вызывает значительные патологические последствия, но и позволяет получить ценные знания для создания н

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… Experiences and practices of traditional healers on snakebite treatment and prevention in rural Malawi. PLoS Negl. Trop. Dis. 2023;17:e0011653. doi: 10.1371/journal.pntd.0011653. 6. …