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Alpine meadow degradation reshapes diazotroph community assembly and enhances putative recruitment of diazotrophs from legume soils to sedge soils.

INTRODUCTION: Biological nitrogen fixation is a key microbial process sustaining nutrient cycling and plant productivity in nitrogen-limited alpine meadows. However, how alpine meadow degradation reshapes diazotrophic community composition and assembly across different plant species, and how these changes relate to aboveground biomass, remain poorly understood. METHODS: We used the nifH gene as a molecular marker to investigate diazotrophic communities in rhizosphere and bulk soils associated with the legume Oxytropis ochrocephala, and the sedge Carex alatauensis in undegraded and degraded al…

Clinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats.

The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characteriz…

In Vitro Potently Active Anti-Plasmodium and Anti-Toxoplasma Mongolian Plant Extracts.

PURPOSE: Malaria and toxoplasmosis are important public health diseases affecting millions of people and animals each year, and there is a c … x, SI; value ≥ 10), six plants (Galatella dahurica leaf + flower, Leonurus deminutus leaf + flower, Oxytropis trichophysa aerial part, Schultzia crinita whole plant, Leontopodium campestre root, Spirea salicifolia aerial part) inhibited P. falciparum growth at IC50 values of 5.99-64.15 µg/ml (SI values: 10.11-17.02). Amaranthus retroflexus root was highly a …

Lysosomal storage disease in Sida carpinifolia toxicosis: an induced mannosidosis in horses.

REASONS FOR PERFORMING STUDY: This study reports a neurological disease unrecognised until now in ponies in southern Brazil. HYPOTHESIS: Ep … lia spontaneous and experimental poisoning in goats. This disease seems to be similar to Swainsona, Oxytropis and Astragalus toxicosis. POTENTIAL RELEVANCE: S. carpinifolia should be evaluated as a possible cause in the diagnosis of equine neuropathies.

Operant analysis of chronic locoweed intoxication in sheep.

Five sheep were fed a 10% locoweed (Oxytropis sericea) pellet or alfalfa pellets for 3- to 5-wk periods to determine the effects of intermittent locoweed ingestion on operant responding; three controls were fed alfalfa pellets for 22 wk. Sheep were trained to respond to a multiple schedule with a fixed ratio (FR) 5 and fixed interval (FI) 50 s as major elements; performance was reinforced with rolled barley. Locoweed-treated sheep decreased (P < .05) FR response rate after 4 wk of locoweed feeding, but this decrease first appeared during the first recovery period (wk 6). The FR response rate o…

Oxyfadichalcone C inhibits melanoma A375 cell proliferation and metastasis via suppressing PI3K/Akt and MAPK/ERK pathways.

AIMS: Melanoma remains to be one of the most incurable cancers. Discovery of novel antitumor agent for melanoma therapy is expected. We recently isolated Oxyfadichalcone C from Oxytropis falcate and investigated the anti-proliferative and anti-metastatic activity on human melanoma A375 cells in vitro. MAIN METHODS: Cell viability was determined using MTT assay and soft agar cloning formation assay. The effect of Oxyfadichalcone C on cell cycle distribution and apoptosis were analyzed by flow cytometry. Cell metastasis was determined by wound healing assay, Transwell assay and Gelatin zymograp…

Effect of lonophore supplementation on selected serum constituents of sheep consuming locoweed.

The effects of ionophore supplementation on selected serum constituents of sheep consuming locoweed were investigated. Sixteen sheep were allotted by weight to a 2x2 factorial arrangement of treatments: 1) no locoweed, no lasalocid, 2) no locoweed, 0.75 mg lasalocid/kg BW, 3) 0.5 mg swainsonine/kg BW, no lasalocid, 4) 0.5 mg swainsonine/kg BW, 0.75 mg lasalocid/kg BW. Swainsonine was provided by locoweed (Oxytropissericea), and sheep were fed a blue grama based diet at 2.5% BW for a 35 d treatment period. Diets were formulated to be isocaloric and isonitrogenous. Blood samples were collected o…

Ethnopharmacological survey on medicinal plants used in herbal drinks among the traditional communities of Pakistan.

ETHNOPHARMACOLOGICAL RELEVANCE: There is very limited information regarding medicinal plants used by traditional healers in Pakistan, for tr … .28 to 0.09 while Fidelity level (FL) among plants varies from 37.5 to 100. Alternanthera sessilis, Oxytropis lapponica, Millettia pinnata and Salvia bucharica had the highest FL value (100). CONCLUSION: The use of medicinal plants is prevalent in traditional communities of Pakistan. Different herbal preparations are in common practice including various he …

Host filtering overrides simulated climate change: plant species identity shapes phyllosphere fungal communities and putative pathogen proportions in an alpine meadow.

UNLABELLED: Phyllosphere fungal communities play critical ecological roles in plant fitness and nutrient cycling in terrestrial ecosystems. … o-occurring alpine host plants: a forb (Aster diplostephioides), a grass (Elymus nutans), a legume (Oxytropis kansuensis), and a sedge (Kobresia humilis), combining ITS1 metabarcoding with compositional bias-corrected modeling (Analysis of Compositions of Microbiomes with Bias Correction 2). We found that host plant species identity acted as the overriding …

Сердечно-сосудистые заболевания

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Diseases of the Nervous System

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Сердечно-сосудистые заболевания

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… Concurrent ingestion of certain plants such as Astragalus sp. and Oxytropis sp. (locoweed) is known to accentuate and accelerate brisket disease in animals at high elevations. …

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Integumentary System

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